EF-hand modules in multidomain proteins family

DO

Disease Ontology (DO)

	DO term	FDR (all)	SDDO (four levels)	Annotation (direct or inherited)
Disease Ontology (DO)	Duchenne muscular dystrophy	0.0000002741	--	Direct
Disease Ontology (DO)	muscle tissue disease	0.002243	--	Inherited
Disease Ontology (DO)	muscular disease	0.002587	--	Inherited
Disease Ontology (DO)	disease of anatomical entity	0.2307	--	Inherited
Disease Ontology (DO)	musculoskeletal system disease	0.2412	--	Inherited
Disease Ontology (DO)	myopathy	1	Informative	Inherited
Disease Ontology (DO)	muscular dystrophy	0.0000636	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

MP

Mouse Phenotype (MP)

	MP term	FDR (all)	SDMP (four levels)	Annotation (direct or inherited)
Mammalian Phenotype (MP)	dystrophic muscle	0.00001498	--	Direct
Mammalian Phenotype (MP)	skeletal muscle necrosis	0.0000192	--	Direct
Mammalian Phenotype (MP)	kyphosis	0.0007612	--	Direct
Mammalian Phenotype (MP)	abnormal interleukin-2 secretion	0.0287	--	Inherited
Mammalian Phenotype (MP)	abnormal immune system physiology	0.06427	--	Inherited
Mammalian Phenotype (MP)	muscle phenotype	0.2514	--	Inherited
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.2993	--	Inherited
Mammalian Phenotype (MP)	abnormal cytokine secretion	0.3097	--	Inherited
Mammalian Phenotype (MP)	abnormal interleukin secretion	0.3465	--	Inherited
Mammalian Phenotype (MP)	abnormal skeleton morphology	0.4497	--	Inherited
Mammalian Phenotype (MP)	abnormal somatic nervous system morphology	0.4557	--	Inherited
Mammalian Phenotype (MP)	skeleton phenotype	0.5018	--	Inherited
Mammalian Phenotype (MP)	nervous system phenotype	0.1343	Least Informative	Inherited
Mammalian Phenotype (MP)	immune system phenotype	0.2519	Least Informative	Inherited
Mammalian Phenotype (MP)	abnormal immune serum protein physiology	0.01564	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal axial skeleton morphology	0.1842	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal muscle morphology	0.3572	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal skeletal muscle morphology	0.03993	Informative	Inherited
Mammalian Phenotype (MP)	abnormal vertebral column morphology	0.04617	Informative	Inherited
Mammalian Phenotype (MP)	increased interleukin-2 secretion	0.00009073	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal somatic motor system morphology	0.0005281	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal spine curvature	0.00241	Highly Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

WP

Worm Phenotype (WP)

	WP term	FDR (all)	SDWP (four levels)	Annotation (direct or inherited)
Worm Phenotype (WP)	postembryonic development variant	0	--	Direct
Worm Phenotype (WP)	embryonic lethal	0	--	Direct
Worm Phenotype (WP)	lethal	0	--	Direct
Worm Phenotype (WP)	fertility variant	0	--	Direct
Worm Phenotype (WP)	development variant	0	--	Direct
Worm Phenotype (WP)	morphology variant	0	--	Direct
Worm Phenotype (WP)	organism development variant	0	--	Direct
Worm Phenotype (WP)	organism morphology variant	0	--	Direct
Worm Phenotype (WP)	organ system physiology variant	0	--	Direct
Worm Phenotype (WP)	reproductive system physiology variant	0	--	Direct
Worm Phenotype (WP)	maternal sterile	0	--	Direct
Worm Phenotype (WP)	hermaphrodite sterile	0	--	Direct
Worm Phenotype (WP)	embryonic development variant	0	--	Direct
Worm Phenotype (WP)	hermaphrodite fertility variant	0	--	Direct
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	--	Direct
Worm Phenotype (WP)	fertility reduced	0	--	Direct
Worm Phenotype (WP)	muscle system physiology variant	0.00000004976	--	Direct
Worm Phenotype (WP)	striated muscle morphology variant	0.00005254	--	Direct
Worm Phenotype (WP)	muscle system morphology variant	0.00005718	--	Direct
Worm Phenotype (WP)	cell morphology variant	0.001544	--	Inherited
Worm Phenotype (WP)	muscle cell morphology variant	0.01246	--	Inherited
Worm Phenotype (WP)	gene expression variant	0.0129	--	Inherited
Worm Phenotype (WP)	organ system morphology variant	0.0216	--	Inherited
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.6893	--	Inherited
Worm Phenotype (WP)	organism physiology variant	0.7034	--	Inherited
Worm Phenotype (WP)	physiology variant	1	--	Inherited
Worm Phenotype (WP)	sterile	1	--	Inherited
Worm Phenotype (WP)	organism environmental stimulus response variant	0.003947	Least Informative	Inherited
Worm Phenotype (WP)	cell physiology variant	0.004736	Least Informative	Inherited
Worm Phenotype (WP)	organism metabolism processing variant	0.02517	Least Informative	Inherited
Worm Phenotype (WP)	protein expression variant	0.00002804	Moderately Informative	Direct
Worm Phenotype (WP)	cell type morphology variant	0.0003817	Moderately Informative	Direct
Worm Phenotype (WP)	cell homeostasis metabolism variant	0.0734	Moderately Informative	Inherited
Worm Phenotype (WP)	organism stress response variant	0.1946	Moderately Informative	Inherited
Worm Phenotype (WP)	muscle cell physiology variant	0.00000002631	Informative	Direct
Worm Phenotype (WP)	cell stress response variant	0.00002519	Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

FP

Fly Phenotype (FP)

	FP term	FDR (all)	SDFP (four levels)	Annotation (direct or inherited)
Fly Phenotype (FP)	viable	0	Least Informative	Direct
Fly Phenotype (FP)	fertile	0	Moderately Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

FA

Fly Anatomy (FA)

	FA term	FDR (all)	SDFA (four levels)	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	--	Direct
Fly Anatomy (FA)	embryonic/larval nervous system	0	--	Direct
Fly Anatomy (FA)	organ system	0	--	Direct
Fly Anatomy (FA)	multicellular structure	0	--	Direct
Fly Anatomy (FA)	anatomical structure	1	--	Inherited
Fly Anatomy (FA)	material anatomical entity	1	--	Inherited
Fly Anatomy (FA)	larva	0	Least Informative	Direct
Fly Anatomy (FA)	nervous system	0	Least Informative	Direct
Fly Anatomy (FA)	organ system subdivision	0	Least Informative	Direct
Fly Anatomy (FA)	peripheral nervous system	0	Moderately Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

ZA

Zebrafish Anatomy (ZA)

	ZA term	FDR (all)	SDZA (four levels)	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	--	Direct
Zebrafish Anatomy (ZA)	anatomical system	0	--	Direct
Zebrafish Anatomy (ZA)	anatomical group	0	--	Direct
Zebrafish Anatomy (ZA)	anatomical structure	1	--	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

XA

Xenopus Anatomy (XA)

	XA term	FDR (all)	SDXA (four levels)	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	--	Direct

	XA term	FDR (all)	SDXA (four levels)	Annotation (direct or inherited)
Xenopus DEvelopment stage (XDE)	NF stage	0	--	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

EC

Enzyme Commission (EC)

	EC term	FDR (all)	SDEC (four levels)	Annotation (direct or inherited)
Enzyme Commission (EC)	Diacylglycerol kinase (ATP)	0	--	Direct
Enzyme Commission (EC)	Phosphoinositide phospholipase C	0	--	Direct
Enzyme Commission (EC)	RING-type E3 ubiquitin transferase	0.000000000000001101	--	Direct
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0.1903	--	Inherited
Enzyme Commission (EC)	Hydrolases	0.0000000000001042	Least Informative	Direct
Enzyme Commission (EC)	Transferases	0.3872	Least Informative	Inherited
Enzyme Commission (EC)	Acting on ester bonds	0	Moderately Informative	Direct
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as acceptor	0.0000006683	Moderately Informative	Direct
Enzyme Commission (EC)	Acyltransferases	0.00001523	Moderately Informative	Direct
Enzyme Commission (EC)	Aminoacyltransferases	0.000000000001569	Informative	Direct
Enzyme Commission (EC)	Phosphoric diester hydrolases	0	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

Distribution on sTOL

Plot distribution on species Tree Of Life (sTOL) for this domain, i.e., present or absent across genomes/tips

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EF-hand modules in multidomain proteins family