Calponin-homology domain, CH-domain family

HP

Human Phenotype (HP)

	HP term	FDR (all)	SDHP (four levels)	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Pectus excavatum	0.0001551	--	Direct
Phenotypic Abnormality (PA)	Abnormality of the musculature of the upper limbs	0.00119	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of the scapula	0.01259	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of cardiovascular system electrophysiology	0.01524	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of the upper limb	0.04035	--	Inherited
Phenotypic Abnormality (PA)	Abnormal tendon morphology	0.07655	--	Inherited
Phenotypic Abnormality (PA)	Cardiac conduction abnormality	0.08781	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of joint mobility	0.09456	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0.09797	--	Inherited
Phenotypic Abnormality (PA)	Limb joint contracture	0.181	--	Inherited
Phenotypic Abnormality (PA)	Abnormal axial skeleton morphology	0.3467	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of the foot	0.5205	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of the shoulder girdle musculature	0.5614	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of limbs	0.05021	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0.07083	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the musculature	0.08534	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the cardiovascular system	0.1191	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of connective tissue	0.02196	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormal cardiovascular system physiology	0.03812	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormal skeletal muscle morphology	0.04159	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the lower limb	0.06642	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the thorax	0.1961	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of skeletal physiology	0.4911	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the musculature of the limbs	0.01486	Informative	Inherited
Phenotypic Abnormality (PA)	Abnormal adipose tissue morphology	0.01764	Informative	Inherited
Phenotypic Abnormality (PA)	Flexion contracture	0.08357	Informative	Inherited
Phenotypic Abnormality (PA)	Decreased cervical spine flexion due to contractures of posterior cervical muscles	0.00002532	Highly Informative	Direct
Phenotypic Abnormality (PA)	Lipodystrophy	0.0001637	Highly Informative	Direct
Phenotypic Abnormality (PA)	Scapular winging	0.0003314	Highly Informative	Direct
Phenotypic Abnormality (PA)	Contractures of the joints of the lower limbs	0.0004388	Highly Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of the musculature of the lower limbs	0.0005218	Highly Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of the Achilles tendon	0.0008386	Highly Informative	Direct
Phenotypic Abnormality (PA)	Heart block	0.0009955	Highly Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of the sternum	0.002264	Highly Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

MP

Mouse Phenotype (MP)

	MP term	FDR (all)	SDMP (four levels)	Annotation (direct or inherited)
Mammalian Phenotype (MP)	increased transitional stage T1 B cell number	0.000008789	--	Direct
Mammalian Phenotype (MP)	decreased transitional stage T2 B cell number	0.00005292	--	Direct
Mammalian Phenotype (MP)	abnormal transitional stage T1 B cell morphology	0.00006594	--	Direct
Mammalian Phenotype (MP)	abnormal transitional stage T2 B cell morphology	0.00008126	--	Direct
Mammalian Phenotype (MP)	abnormal exercise endurance	0.00008337	--	Direct
Mammalian Phenotype (MP)	increased transitional stage B cell number	0.0003796	--	Direct
Mammalian Phenotype (MP)	intestinal ulcer	0.0006523	--	Direct
Mammalian Phenotype (MP)	muscle phenotype	0.0008595	--	Direct
Mammalian Phenotype (MP)	decreased transitional stage B cell number	0.001654	--	Inherited
Mammalian Phenotype (MP)	abnormal intestinal epithelium morphology	0.07846	--	Inherited
Mammalian Phenotype (MP)	digestive/alimentary phenotype	0.08585	--	Inherited
Mammalian Phenotype (MP)	abnormal B cell number	0.09395	--	Inherited
Mammalian Phenotype (MP)	abnormal mature B cell morphology	0.09601	--	Inherited
Mammalian Phenotype (MP)	abnormal immature B cell morphology	0.1061	--	Inherited
Mammalian Phenotype (MP)	abnormal immature B cell number	0.1252	--	Inherited
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.1589	--	Inherited
Mammalian Phenotype (MP)	decreased leukocyte cell number	0.1917	--	Inherited
Mammalian Phenotype (MP)	increased B cell number	0.2211	--	Inherited
Mammalian Phenotype (MP)	decreased lymphocyte cell number	0.2987	--	Inherited
Mammalian Phenotype (MP)	abnormal leukocyte cell number	0.3434	--	Inherited
Mammalian Phenotype (MP)	abnormal cell physiology	0.3666	--	Inherited
Mammalian Phenotype (MP)	abnormal hematopoietic cell number	0.3801	--	Inherited
Mammalian Phenotype (MP)	abnormal mononuclear cell morphology	0.4438	--	Inherited
Mammalian Phenotype (MP)	abnormal leukocyte morphology	0.4805	--	Inherited
Mammalian Phenotype (MP)	abnormal immune system cell morphology	0.4912	--	Inherited
Mammalian Phenotype (MP)	abnormal lymphopoiesis	0.5591	--	Inherited
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0.5954	--	Inherited
Mammalian Phenotype (MP)	abnormal lymphocyte morphology	0.6429	--	Inherited
Mammalian Phenotype (MP)	increased leukocyte cell number	0.6476	--	Inherited
Mammalian Phenotype (MP)	abnormal definitive hematopoiesis	0.6727	--	Inherited
Mammalian Phenotype (MP)	abnormal hemopoiesis	0.6884	--	Inherited
Mammalian Phenotype (MP)	abnormal leukopoiesis	0.7527	--	Inherited
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0.7747	--	Inherited
Mammalian Phenotype (MP)	abnormal immune system morphology	0.988	--	Inherited
Mammalian Phenotype (MP)	immune system phenotype	0.1111	Least Informative	Inherited
Mammalian Phenotype (MP)	cellular phenotype	0.4769	Least Informative	Inherited
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.5268	Least Informative	Inherited
Mammalian Phenotype (MP)	abnormal digestive system morphology	0.02384	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal B cell morphology	0.1326	Moderately Informative	Inherited
Mammalian Phenotype (MP)	decreased hematopoietic cell number	0.2237	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell morphology	0.2313	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal lymphocyte cell number	0.5414	Moderately Informative	Inherited
Mammalian Phenotype (MP)	increased hematopoietic cell number	0.5474	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal blood cell morphology	0.6836	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal blood cell morphology/development	0.7803	Moderately Informative	Inherited
Mammalian Phenotype (MP)	decreased B cell number	0.03721	Informative	Inherited
Mammalian Phenotype (MP)	abnormal metabolism	0.08728	Informative	Inherited
Mammalian Phenotype (MP)	abnormal B cell differentiation	0.2853	Informative	Inherited
Mammalian Phenotype (MP)	abnormal intestine morphology	0.3093	Informative	Inherited
Mammalian Phenotype (MP)	increased lymphocyte cell number	0.6137	Informative	Inherited
Mammalian Phenotype (MP)	abnormal cell adhesion	0.0008154	Highly Informative	Direct
Mammalian Phenotype (MP)	increased immature B cell number	0.002977	Highly Informative	Inherited
Mammalian Phenotype (MP)	abnormal transitional stage B cell morphology	0.005007	Highly Informative	Inherited
Mammalian Phenotype (MP)	gastrointestinal ulcer	0.007196	Highly Informative	Inherited
Mammalian Phenotype (MP)	decreased immature B cell number	0.1186	Highly Informative	Inherited
Mammalian Phenotype (MP)	abnormal intestinal mucosa morphology	0.9208	Highly Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

WP

Worm Phenotype (WP)

	WP term	FDR (all)	SDWP (four levels)	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	--	Direct
Worm Phenotype (WP)	lethal	0	--	Direct
Worm Phenotype (WP)	fertility variant	0	--	Direct
Worm Phenotype (WP)	development variant	0	--	Direct
Worm Phenotype (WP)	organism development variant	0	--	Direct
Worm Phenotype (WP)	organ system physiology variant	0	--	Direct
Worm Phenotype (WP)	reproductive system physiology variant	0	--	Direct
Worm Phenotype (WP)	embryonic development variant	0	--	Direct
Worm Phenotype (WP)	fertility reduced	0	--	Direct
Worm Phenotype (WP)	cleavage furrow initiation defective early emb	0.00000005833	--	Direct
Worm Phenotype (WP)	striated muscle morphology variant	0.00000008763	--	Direct
Worm Phenotype (WP)	cell morphology variant	0.0000004764	--	Direct
Worm Phenotype (WP)	reduced brood size	0.00000282	--	Direct
Worm Phenotype (WP)	cleavage furrow defective	0.000008857	--	Direct
Worm Phenotype (WP)	muscle system morphology variant	0.00001587	--	Direct
Worm Phenotype (WP)	mitochondria alignment variant	0.00002897	--	Direct
Worm Phenotype (WP)	muscle system physiology variant	0.00003269	--	Direct
Worm Phenotype (WP)	body wall muscle myosin organization defective	0.00004522	--	Direct
Worm Phenotype (WP)	organ system morphology variant	0.001242	--	Inherited
Worm Phenotype (WP)	neuronal outgrowth variant	0.003027	--	Inherited
Worm Phenotype (WP)	cytokinesis variant	0.003817	--	Inherited
Worm Phenotype (WP)	cytokinesis defective early emb	0.00645	--	Inherited
Worm Phenotype (WP)	muscle cell morphology variant	0.007586	--	Inherited
Worm Phenotype (WP)	mitochondria spacing variant	0.02269	--	Inherited
Worm Phenotype (WP)	neuron development variant	0.08785	--	Inherited
Worm Phenotype (WP)	body wall muscle thick filament variant	0.1104	--	Inherited
Worm Phenotype (WP)	organelle organization biogenesis variant	0.125	--	Inherited
Worm Phenotype (WP)	morphology variant	0.5848	--	Inherited
Worm Phenotype (WP)	hermaphrodite fertility variant	0.8842	--	Inherited
Worm Phenotype (WP)	cell component morphology variant	0.899	--	Inherited
Worm Phenotype (WP)	physiology variant	1	--	Inherited
Worm Phenotype (WP)	body wall muscle morphology variant	1	--	Inherited
Worm Phenotype (WP)	cell physiology variant	0.0007016	Least Informative	Direct
Worm Phenotype (WP)	cell development variant	0.1233	Least Informative	Inherited
Worm Phenotype (WP)	early embryonic lethal	0.005464	Moderately Informative	Inherited
Worm Phenotype (WP)	organ system development variant	0.006487	Moderately Informative	Inherited
Worm Phenotype (WP)	cell type morphology variant	0.01246	Moderately Informative	Inherited
Worm Phenotype (WP)	cell organization biogenesis variant	0.2298	Moderately Informative	Inherited
Worm Phenotype (WP)	cell division variant	0.4273	Moderately Informative	Inherited
Worm Phenotype (WP)	brood size variant	0.000006972	Informative	Direct
Worm Phenotype (WP)	cytokinesis variant emb	0.0004076	Informative	Direct
Worm Phenotype (WP)	muscle cell physiology variant	0.0005779	Informative	Direct
Worm Phenotype (WP)	axon outgrowth variant	0.002613	Informative	Inherited
Worm Phenotype (WP)	mitochondria morphology variant	0.005952	Informative	Inherited
Worm Phenotype (WP)	cytoskeleton organization biogenesis variant	0.01796	Informative	Inherited
Worm Phenotype (WP)	epithelial system development variant	0.04458	Informative	Inherited
Worm Phenotype (WP)	cell component localization variant	0.06443	Informative	Inherited
Worm Phenotype (WP)	body wall muscle sarcomere morphology variant	0.6293	Informative	Inherited
Worm Phenotype (WP)	actin organization biogenesis variant	0.000006313	Highly Informative	Direct
Worm Phenotype (WP)	cleavage furrow defective early emb	0.000007926	Highly Informative	Direct
Worm Phenotype (WP)	axon guidance variant	0.0004382	Highly Informative	Direct
Worm Phenotype (WP)	exploded through vulva	0.0009154	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

YP

Yeast Phenotype (YP)

	YP term	FDR (all)	SDYP (four levels)	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	--	Direct
Yeast Phenotype (YP)	stress resistance	0	--	Direct
Yeast Phenotype (YP)	competitive fitness	0	--	Direct
Yeast Phenotype (YP)	fitness	0	--	Direct
Yeast Phenotype (YP)	resistance to chemicals	0	Least Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

FA

Fly Anatomy (FA)

	FA term	FDR (all)	SDFA (four levels)	Annotation (direct or inherited)
Fly Anatomy (FA)	multicellular structure	0	--	Direct
Fly Anatomy (FA)	indirect flight muscle	0.0004004	--	Direct
Fly Anatomy (FA)	skeletal muscle of mesothorax	0.001413	--	Inherited
Fly Anatomy (FA)	skeletal muscle of thorax	0.00146	--	Inherited
Fly Anatomy (FA)	somatic muscle	0.00276	--	Inherited
Fly Anatomy (FA)	abdominal nerve	0.003366	--	Inherited
Fly Anatomy (FA)	adult muscle system	0.004808	--	Inherited
Fly Anatomy (FA)	muscle system	0.006845	--	Inherited
Fly Anatomy (FA)	segmental nerve	0.007736	--	Inherited
Fly Anatomy (FA)	neuron projection bundle	0.01423	--	Inherited
Fly Anatomy (FA)	adult segment	0.06494	--	Inherited
Fly Anatomy (FA)	adult somatic muscle	0.08289	--	Inherited
Fly Anatomy (FA)	adult tagma	0.08764	--	Inherited
Fly Anatomy (FA)	organism subdivision	0.1103	--	Inherited
Fly Anatomy (FA)	embryonic/larval nervous system	0.1272	--	Inherited
Fly Anatomy (FA)	larval abdomen	0.1275	--	Inherited
Fly Anatomy (FA)	cell	0.2242	--	Inherited
Fly Anatomy (FA)	mesothoracic segment	0.2391	--	Inherited
Fly Anatomy (FA)	organ system	0.2423	--	Inherited
Fly Anatomy (FA)	abdominal segment	0.4851	--	Inherited
Fly Anatomy (FA)	adult thorax	0.5002	--	Inherited
Fly Anatomy (FA)	thorax	0.6495	--	Inherited
Fly Anatomy (FA)	adult thoracic segment	0.6867	--	Inherited
Fly Anatomy (FA)	organism	0.7443	--	Inherited
Fly Anatomy (FA)	thoracic segment	0.9006	--	Inherited
Fly Anatomy (FA)	anatomical structure	1	--	Inherited
Fly Anatomy (FA)	material anatomical entity	1	--	Inherited
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	--	Inherited
Fly Anatomy (FA)	tagma	0.09367	Least Informative	Inherited
Fly Anatomy (FA)	adult	0.1134	Least Informative	Inherited
Fly Anatomy (FA)	segment	0.1202	Least Informative	Inherited
Fly Anatomy (FA)	somatic cell	0.128	Least Informative	Inherited
Fly Anatomy (FA)	nervous system	0.3157	Least Informative	Inherited
Fly Anatomy (FA)	organ system subdivision	0.3274	Least Informative	Inherited
Fly Anatomy (FA)	larva	0.6815	Least Informative	Inherited
Fly Anatomy (FA)	multi-cell-component structure	0.01212	Moderately Informative	Inherited
Fly Anatomy (FA)	peripheral nervous system	0.08898	Moderately Informative	Inherited
Fly Anatomy (FA)	adult mesothoracic segment	0.1665	Moderately Informative	Inherited
Fly Anatomy (FA)	larval segment	0.2982	Moderately Informative	Inherited
Fly Anatomy (FA)	larval tagma	0.5127	Moderately Informative	Inherited
Fly Anatomy (FA)	abdomen	0.5927	Moderately Informative	Inherited
Fly Anatomy (FA)	syncytium	0.004059	Informative	Inherited
Fly Anatomy (FA)	muscle cell	0.008124	Informative	Inherited
Fly Anatomy (FA)	larval abdominal segment	0.08048	Informative	Inherited
Fly Anatomy (FA)	embryonic/larval peripheral nervous system	0.08508	Informative	Inherited
Fly Anatomy (FA)	nerve	0.1067	Informative	Inherited
Fly Anatomy (FA)	flight muscle	0.0007025	Highly Informative	Direct
Fly Anatomy (FA)	abdominal segmental nerve	0.0008909	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

ZA

Zebrafish Anatomy (ZA)

	ZA term	FDR (all)	SDZA (four levels)	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	--	Direct
Zebrafish Anatomy (ZA)	anatomical structure	1	--	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

XA

Xenopus Anatomy (XA)

	XA term	FDR (all)	SDXA (four levels)	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	--	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

AP

Arabidopsis Plant Ontology (AP)

	AP term	FDR (all)	SDAP (four levels)	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	shoot system	0	--	Direct
Plant ANatomical entity (PAN)	collective plant structure	0	--	Direct
Plant ANatomical entity (PAN)	plant structure	1	--	Inherited
Plant ANatomical entity (PAN)	collective plant organ structure	1	--	Inherited

	AP term	FDR (all)	SDAP (four levels)	Annotation (direct or inherited)
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	flowering stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	flower development stage	1	--	Inherited
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	--	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

EC

Enzyme Commission (EC)

	EC term	FDR (all)	SDEC (four levels)	Annotation (direct or inherited)
Enzyme Commission (EC)	F-actin monooxygenase	0	--	Direct
Enzyme Commission (EC)	Oxidoreductases	0.000000000000004716	Least Informative	Direct
Enzyme Commission (EC)	Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate	0	Informative	Direct
Enzyme Commission (EC)	With NADH or NADPH as one donor, and incorporation of one atom of oxygen	0	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

CD

CTD Diseases (CD)

	CD term	FDR (all)	SDCD (four levels)	Annotation (direct or inherited)
CTD Diseases (CD)	Muscular Disorders, Atrophic	0.0001644	--	Direct
CTD Diseases (CD)	Congenital, Hereditary, and Neonatal Diseases and Abnormalities	0.6979	--	Inherited
CTD Diseases (CD)	Genetic Diseases, Inborn	0.5556	Least Informative	Inherited
CTD Diseases (CD)	Nervous System Diseases	0.6786	Least Informative	Inherited
CTD Diseases (CD)	Neuromuscular Diseases	0.1115	Moderately Informative	Inherited
CTD Diseases (CD)	Musculoskeletal Diseases	0.1823	Moderately Informative	Inherited
CTD Diseases (CD)	Muscular Diseases	0.02895	Informative	Inherited
CTD Diseases (CD)	Muscular Dystrophies	0.0001528	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

CC

CTD Chemicals (CC)

	CC term	FDR (all)	SDCC (four levels)	Annotation (direct or inherited)
CTD Chemicals (CC)	Organic Chemicals	0	--	Direct
CTD Chemicals (CC)	Hormones, Hormone Substitutes, and Hormone Antagonists	0.00001473	--	Direct
CTD Chemicals (CC)	Hydrocarbons, Aromatic	0.03234	--	Inherited
CTD Chemicals (CC)	Polycyclic Compounds	0.03415	--	Inherited
CTD Chemicals (CC)	Physiological Effects of Drugs	0.03724	--	Inherited
CTD Chemicals (CC)	Hydrocarbons, Cyclic	0.05412	--	Inherited
CTD Chemicals (CC)	Pharmacologic Actions	0.1662	--	Inherited
CTD Chemicals (CC)	Hydrocarbons	0.2329	--	Inherited
CTD Chemicals (CC)	Benzene Derivatives	0.432	--	Inherited
CTD Chemicals (CC)	Peptides	0.4799	--	Inherited
CTD Chemicals (CC)	Amines	0.00008868	Least Informative	Direct
CTD Chemicals (CC)	Chemical Actions and Uses	0.0002007	Least Informative	Direct
CTD Chemicals (CC)	Polycyclic Aromatic Hydrocarbons	0.000674	Least Informative	Direct
CTD Chemicals (CC)	Amino Acids, Peptides, and Proteins	0.009089	Least Informative	Inherited
CTD Chemicals (CC)	Phenols	0.6359	Least Informative	Inherited
CTD Chemicals (CC)	Oligopeptides	0.06329	Moderately Informative	Inherited
CTD Chemicals (CC)	Glutathione	0.1146	Informative	Inherited
CTD Chemicals (CC)	Hydroquinones	0.1904	Informative	Inherited
CTD Chemicals (CC)	2,3,5-(triglutathion-S-yl)hydroquinone	0.0002756	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

Distribution on sTOL

Plot distribution on species Tree Of Life (sTOL) for this domain, i.e., present or absent across genomes/tips

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Calponin-homology domain, CH-domain family