ARM repeat superfamily

DO

Disease Ontology (DO)

	DO term	FDR (all)	SDDO (four levels)	Annotation (direct or inherited)
Disease Ontology (DO)	Peutz-Jeghers syndrome	0.0001097	--	Direct
Disease Ontology (DO)	intestinal disease	0.5913	--	Inherited
Disease Ontology (DO)	disease of anatomical entity	1	--	Inherited
Disease Ontology (DO)	gastrointestinal system disease	0.5135	Moderately Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

HP

Human Phenotype (HP)

	HP term	FDR (all)	SDHP (four levels)	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Monotonic speech	0.0002091	--	Direct
Phenotypic Abnormality (PA)	Abnormality of the cerebrum	0.0003598	--	Direct
Phenotypic Abnormality (PA)	Abnormal speech prosody	0.000747	--	Direct
Phenotypic Abnormality (PA)	Abnormality of head or neck	0.0008914	--	Direct
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0.007162	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of the orbital region	0.01257	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of brain morphology	0.02889	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of hindbrain morphology	0.03564	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.1183	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of the ocular adnexa	0.4917	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of the face	0.9599	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of the metencephalon	1	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0.000413	Least Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of the head	0.0006398	Least Informative	Direct
Phenotypic Abnormality (PA)	Abnormal ocular adnexa morphology	0.0005834	Moderately Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of forebrain morphology	0.6682	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormal cerebellum morphology	0.00002593	Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of the glial cells	0.0008198	Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of the voice	0.3512	Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

MP

Mouse Phenotype (MP)

	MP term	FDR (all)	SDMP (four levels)	Annotation (direct or inherited)
Mammalian Phenotype (MP)	increased renal cystadenoma incidence	0.0000305	--	Direct
Mammalian Phenotype (MP)	embryonic lethality	0.00007545	--	Direct
Mammalian Phenotype (MP)	increased cystadenoma incidence	0.001361	--	Inherited
Mammalian Phenotype (MP)	abnormal organ/body region tumor incidence	0.09633	--	Inherited
Mammalian Phenotype (MP)	increased organ/body region tumor incidence	0.1032	--	Inherited
Mammalian Phenotype (MP)	abnormal survival	0.1079	--	Inherited
Mammalian Phenotype (MP)	abnormal adenoma incidence	0.1221	--	Inherited
Mammalian Phenotype (MP)	abnormal tumor incidence	0.1486	--	Inherited
Mammalian Phenotype (MP)	preweaning lethality	0.1527	--	Inherited
Mammalian Phenotype (MP)	increased tumor incidence	0.1688	--	Inherited
Mammalian Phenotype (MP)	altered tumor susceptibility	0.2461	--	Inherited
Mammalian Phenotype (MP)	renal/urinary system phenotype	0.2605	--	Inherited
Mammalian Phenotype (MP)	increased kidney tumor incidence	0.3217	--	Inherited
Mammalian Phenotype (MP)	abnormal classified tumor incidence	0.3754	--	Inherited
Mammalian Phenotype (MP)	increased classified tumor incidence	0.5305	--	Inherited
Mammalian Phenotype (MP)	mortality/aging	0.006974	Least Informative	Inherited
Mammalian Phenotype (MP)	prenatal lethality	0.001415	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal renal/urinary system morphology	0.06394	Moderately Informative	Inherited
Mammalian Phenotype (MP)	neoplasm	0.2128	Moderately Informative	Inherited
Mammalian Phenotype (MP)	increased urinary system tumor incidence	0.001516	Highly Informative	Inherited
Mammalian Phenotype (MP)	increased adenoma incidence	0.128	Highly Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

WP

Worm Phenotype (WP)

	WP term	FDR (all)	SDWP (four levels)	Annotation (direct or inherited)
Worm Phenotype (WP)	development variant	0	--	Direct
Worm Phenotype (WP)	organism development variant	0	--	Direct
Worm Phenotype (WP)	germ cell physiology variant	0.000000000000001794	--	Direct
Worm Phenotype (WP)	sexually dimorphic physiology variant	0.000000000000004479	--	Direct
Worm Phenotype (WP)	organ system development variant	0.0000000000001025	--	Direct
Worm Phenotype (WP)	behavior variant	0.0000003995	--	Direct
Worm Phenotype (WP)	cell number variant	0.0000007765	--	Direct
Worm Phenotype (WP)	microtubule organization biogenesis variant	0.000003641	--	Direct
Worm Phenotype (WP)	accumulated somatic cell corpses	0.00001333	--	Direct
Worm Phenotype (WP)	failure to hatch	0.00001868	--	Direct
Worm Phenotype (WP)	vulva morphology variant	0.00003686	--	Direct
Worm Phenotype (WP)	endoderm absent	0.00005957	--	Direct
Worm Phenotype (WP)	sexually dimorphic development variant	0.00006305	--	Direct
Worm Phenotype (WP)	adult lethal	0.0001133	--	Direct
Worm Phenotype (WP)	gene expression variant	0.000212	--	Direct
Worm Phenotype (WP)	P granule localization defective	0.0002365	--	Direct
Worm Phenotype (WP)	male mating efficiency reduced	0.0002535	--	Direct
Worm Phenotype (WP)	seam cell fusion variant	0.0002776	--	Direct
Worm Phenotype (WP)	V lineages variant	0.0003455	--	Direct
Worm Phenotype (WP)	masculinized	0.0003574	--	Direct
Worm Phenotype (WP)	EMS anterior extension fails early emb	0.0005345	--	Direct
Worm Phenotype (WP)	proximal germ cell proliferation variant	0.0006756	--	Direct
Worm Phenotype (WP)	amphid phasmid neuron morphology variant	0.0007401	--	Direct
Worm Phenotype (WP)	vesicle trafficking variant	0.003111	--	Inherited
Worm Phenotype (WP)	morphology variant	0.01092	--	Inherited
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.01392	--	Inherited
Worm Phenotype (WP)	embryonic cell physiology variant	0.01414	--	Inherited
Worm Phenotype (WP)	organism physiology variant	0.02104	--	Inherited
Worm Phenotype (WP)	epithelial cell morphology variant	0.0572	--	Inherited
Worm Phenotype (WP)	cell position defective early emb	0.06364	--	Inherited
Worm Phenotype (WP)	fertility variant	0.06683	--	Inherited
Worm Phenotype (WP)	reproductive system physiology variant	0.07504	--	Inherited
Worm Phenotype (WP)	organ system physiology variant	0.0775	--	Inherited
Worm Phenotype (WP)	cell position defective	0.09251	--	Inherited
Worm Phenotype (WP)	embryonic development variant	0.09705	--	Inherited
Worm Phenotype (WP)	cell death variant	0.0992	--	Inherited
Worm Phenotype (WP)	gametogenesis variant	0.101	--	Inherited
Worm Phenotype (WP)	germ cell mitosis variant	0.1126	--	Inherited
Worm Phenotype (WP)	cytokinesis variant	0.1248	--	Inherited
Worm Phenotype (WP)	programmed cell death variant	0.2262	--	Inherited
Worm Phenotype (WP)	cell corpse number variant	0.2333	--	Inherited
Worm Phenotype (WP)	nuclear division variant	0.2568	--	Inherited
Worm Phenotype (WP)	cell component morphology variant	0.2587	--	Inherited
Worm Phenotype (WP)	cell type morphology variant	0.2964	--	Inherited
Worm Phenotype (WP)	embryonic lethal	0.3368	--	Inherited
Worm Phenotype (WP)	copulation variant	0.3626	--	Inherited
Worm Phenotype (WP)	sexually dimorphic behavior variant	0.3674	--	Inherited
Worm Phenotype (WP)	hermaphrodite fertility variant	0.3707	--	Inherited
Worm Phenotype (WP)	hermaphrodite sexual development variant	0.3784	--	Inherited
Worm Phenotype (WP)	lineage variant	0.3927	--	Inherited
Worm Phenotype (WP)	organelle organization biogenesis variant	0.4479	--	Inherited
Worm Phenotype (WP)	accumulated cell corpses	0.5315	--	Inherited
Worm Phenotype (WP)	amphid phasmid sensillum morphology variant	0.5338	--	Inherited
Worm Phenotype (WP)	lethal	0.9088	--	Inherited
Worm Phenotype (WP)	hermaphrodite reproductive system morphology variant	0.9172	--	Inherited
Worm Phenotype (WP)	growth variant	1	--	Inherited
Worm Phenotype (WP)	physiology variant	1	--	Inherited
Worm Phenotype (WP)	organism morphology variant	1	--	Inherited
Worm Phenotype (WP)	male behavior variant	1	--	Inherited
Worm Phenotype (WP)	cell morphology variant	0	Least Informative	Direct
Worm Phenotype (WP)	cell physiology variant	0	Least Informative	Direct
Worm Phenotype (WP)	cell development variant	0.0000000000001642	Least Informative	Direct
Worm Phenotype (WP)	organism metabolism processing variant	0.000000000003181	Least Informative	Direct
Worm Phenotype (WP)	organ system morphology variant	0.000000001658	Least Informative	Direct
Worm Phenotype (WP)	organism behavior variant	0.0000002876	Least Informative	Direct
Worm Phenotype (WP)	endocytic transport variant	0.000000000000003586	Moderately Informative	Direct
Worm Phenotype (WP)	early embryonic lethal	0.0000000000002001	Moderately Informative	Direct
Worm Phenotype (WP)	protein expression variant	0.000000001134	Moderately Informative	Direct
Worm Phenotype (WP)	cell division variant	0.01179	Moderately Informative	Inherited
Worm Phenotype (WP)	cell organization biogenesis variant	0.02248	Moderately Informative	Inherited
Worm Phenotype (WP)	reproductive system morphology variant	0.02751	Moderately Informative	Inherited
Worm Phenotype (WP)	germ cell morphology variant	0.0342	Moderately Informative	Inherited
Worm Phenotype (WP)	apoptosis variant	0.1362	Moderately Informative	Inherited
Worm Phenotype (WP)	germ cell development variant	0.5459	Moderately Informative	Inherited
Worm Phenotype (WP)	nervous system morphology variant	0.7901	Moderately Informative	Inherited
Worm Phenotype (WP)	brood size variant	0.0000000001437	Informative	Direct
Worm Phenotype (WP)	embryonic cell organization biogenesis variant	0.00000001179	Informative	Direct
Worm Phenotype (WP)	cytokinesis variant emb	0.000001243	Informative	Direct
Worm Phenotype (WP)	sick	0.00001519	Informative	Direct
Worm Phenotype (WP)	vesicle organization variant	0.00001794	Informative	Direct
Worm Phenotype (WP)	pigmentation variant	0.00009454	Informative	Direct
Worm Phenotype (WP)	germ cell cytoplasmic morphology variant	0.01652	Informative	Inherited
Worm Phenotype (WP)	male mating variant	0.03485	Informative	Inherited
Worm Phenotype (WP)	sensillum morphology variant	0.1411	Informative	Inherited
Worm Phenotype (WP)	cytoskeleton organization biogenesis variant	0.2966	Informative	Inherited
Worm Phenotype (WP)	gastrulation variant	0.00001089	Highly Informative	Direct
Worm Phenotype (WP)	embryonic arrest	0.00001734	Highly Informative	Direct
Worm Phenotype (WP)	developmental morphology variant	0.00006844	Highly Informative	Direct
Worm Phenotype (WP)	seam cell morphology variant	0.00007073	Highly Informative	Direct
Worm Phenotype (WP)	RNAi response variant	0.0002022	Highly Informative	Direct
Worm Phenotype (WP)	hatching variant	0.000222	Highly Informative	Direct
Worm Phenotype (WP)	cell polarity variant	0.0003268	Highly Informative	Direct
Worm Phenotype (WP)	dye filling defect	0.0003573	Highly Informative	Direct
Worm Phenotype (WP)	epithelial system physiology variant	0.0008012	Highly Informative	Direct
Worm Phenotype (WP)	nuclear number variant	0.0008031	Highly Informative	Direct
Worm Phenotype (WP)	cell fusion variant	0.1034	Highly Informative	Inherited
Worm Phenotype (WP)	sex determination variant	0.1751	Highly Informative	Inherited
Worm Phenotype (WP)	P granule abnormal	0.442	Highly Informative	Inherited
Worm Phenotype (WP)	postembryonic cell lineage variant	0.4785	Highly Informative	Inherited
Worm Phenotype (WP)	germline proliferation variant	0.8295	Highly Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

YP

Yeast Phenotype (YP)

	YP term	FDR (all)	SDYP (four levels)	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0.1885	--	Inherited
Yeast Phenotype (YP)	metabolism and growth	0.4541	Least Informative	Inherited
Yeast Phenotype (YP)	intracellular transport	0.001582	Informative	Inherited
Yeast Phenotype (YP)	protein transport	0.0004348	Highly Informative	Direct
Yeast Phenotype (YP)	protein/peptide distribution	0.0006663	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

FP

Fly Phenotype (FP)

	FP term	FDR (all)	SDFP (four levels)	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0.00004337	--	Direct
Fly Phenotype (FP)	lethal - all die before end of pupal stage	0.00006895	--	Direct
Fly Phenotype (FP)	lethal - all die before end of P-stage	0.1074	--	Inherited
Fly Phenotype (FP)	increased mortality during development	0.2255	--	Inherited
Fly Phenotype (FP)	increased mortality	0.02597	Least Informative	Inherited
Fly Phenotype (FP)	lethal	0.3643	Moderately Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

ZA

Zebrafish Anatomy (ZA)

	ZA term	FDR (all)	SDZA (four levels)	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	--	Direct
Zebrafish Anatomy (ZA)	anatomical structure	1	--	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

XA

Xenopus Anatomy (XA)

	XA term	FDR (all)	SDXA (four levels)	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	male organism	0.000000000000001546	--	Direct
Xenopus ANatomical entity (XAN)	gonad	0.00000000002791	--	Direct
Xenopus ANatomical entity (XAN)	genital system	0.00000000004768	--	Direct
Xenopus ANatomical entity (XAN)	egg	0.00004517	--	Direct
Xenopus ANatomical entity (XAN)	male genitalia	0.00008237	--	Direct
Xenopus ANatomical entity (XAN)	trunk region	0.0001057	--	Direct
Xenopus ANatomical entity (XAN)	compound organ	0.0002218	--	Direct
Xenopus ANatomical entity (XAN)	central nervous system	0.0002469	--	Direct
Xenopus ANatomical entity (XAN)	cell	0.0007097	--	Direct
Xenopus ANatomical entity (XAN)	anatomical region	0.003449	--	Inherited
Xenopus ANatomical entity (XAN)	organism subdivision	0.01589	--	Inherited
Xenopus ANatomical entity (XAN)	anatomical group	0.04341	--	Inherited
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0.1599	--	Inherited
Xenopus ANatomical entity (XAN)	gamete	0.3642	--	Inherited
Xenopus ANatomical entity (XAN)	anatomical structure	1	--	Inherited
Xenopus ANatomical entity (XAN)	anatomical system	1	--	Inherited
Xenopus ANatomical entity (XAN)	whole organism	1	--	Inherited
Xenopus ANatomical entity (XAN)	urogenital system	0.000000004775	Least Informative	Direct
Xenopus ANatomical entity (XAN)	trunk	0.00002299	Least Informative	Direct
Xenopus ANatomical entity (XAN)	cavitated compound organ	0.002867	Least Informative	Inherited
Xenopus ANatomical entity (XAN)	nervous system	0.003362	Least Informative	Inherited
Xenopus ANatomical entity (XAN)	testis	0.000000000000001546	Moderately Informative	Direct
Xenopus ANatomical entity (XAN)	germ cell	0.008339	Moderately Informative	Inherited
Xenopus ANatomical entity (XAN)	anatomical entity in vitro	0.0004128	Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

AP

Arabidopsis Plant Ontology (AP)

	AP term	FDR (all)	SDAP (four levels)	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	plant cell	0.0000007573	--	Direct
Plant ANatomical entity (PAN)	flower bud	0.00002384	--	Direct
Plant ANatomical entity (PAN)	reproductive bud	0.00002839	--	Direct
Plant ANatomical entity (PAN)	stomatal complex	0.00006295	--	Direct
Plant ANatomical entity (PAN)	shoot epidermis	0.000253	--	Direct
Plant ANatomical entity (PAN)	microsporangium	0.0003509	--	Direct
Plant ANatomical entity (PAN)	portion of plant tissue	0.00117	--	Inherited
Plant ANatomical entity (PAN)	pollen sac	0.001964	--	Inherited
Plant ANatomical entity (PAN)	epidermis	0.002681	--	Inherited
Plant ANatomical entity (PAN)	microgametophyte	0.00311	--	Inherited
Plant ANatomical entity (PAN)	shoot system	0.09284	--	Inherited
Plant ANatomical entity (PAN)	sporophyll	0.09346	--	Inherited
Plant ANatomical entity (PAN)	epidermal cell	0.3128	--	Inherited
Plant ANatomical entity (PAN)	phyllome	0.3642	--	Inherited
Plant ANatomical entity (PAN)	shoot epidermal cell	0.4329	--	Inherited
Plant ANatomical entity (PAN)	collective plant structure	0.7668	--	Inherited
Plant ANatomical entity (PAN)	reproductive shoot system	0.8063	--	Inherited
Plant ANatomical entity (PAN)	plant organ	1	--	Inherited
Plant ANatomical entity (PAN)	plant structure	1	--	Inherited
Plant ANatomical entity (PAN)	collective plant organ structure	1	--	Inherited
Plant ANatomical entity (PAN)	multi-tissue plant structure	1	--	Inherited
Plant ANatomical entity (PAN)	guard cell	0.00006124	Least Informative	Direct
Plant ANatomical entity (PAN)	sporangium	0.0003798	Least Informative	Direct
Plant ANatomical entity (PAN)	whole plant	0.03804	Least Informative	Inherited
Plant ANatomical entity (PAN)	microsporophyll	0.09409	Least Informative	Inherited
Plant ANatomical entity (PAN)	pollen	0.0002784	Moderately Informative	Direct
Plant ANatomical entity (PAN)	bud	0.000122	Highly Informative	Direct

	AP term	FDR (all)	SDAP (four levels)	Annotation (direct or inherited)
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0.0004989	--	Direct
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0.001136	--	Inherited
Plant structure DEvelopment stage (PDE)	androecium development stage	0.002053	--	Inherited
Plant structure DEvelopment stage (PDE)	plant embryo stage	0.02632	--	Inherited
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0.3458	--	Inherited
Plant structure DEvelopment stage (PDE)	whole plant development stage	0.3573	--	Inherited
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0.4473	--	Inherited
Plant structure DEvelopment stage (PDE)	flower development stage	1	--	Inherited
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	--	Inherited
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	--	Inherited
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	--	Inherited
Plant structure DEvelopment stage (PDE)	F mature embryo stage	0.0005929	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	D bilateral stage	0.0009097	Least Informative	Direct
Plant structure DEvelopment stage (PDE)	pollen development stage	0.0002554	Moderately Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

EC

Enzyme Commission (EC)

	EC term	FDR (all)	SDEC (four levels)	Annotation (direct or inherited)
Enzyme Commission (EC)	Deoxyhypusine monooxygenase	0	--	Direct
Enzyme Commission (EC)	Transferases	0	--	Direct
Enzyme Commission (EC)	Acyltransferases	0	--	Direct
Enzyme Commission (EC)	Phosphatidylinositol 3-kinase	0	--	Direct
Enzyme Commission (EC)	Phosphatidylinositol-4,5-bisphosphate 3-kinase	0	--	Direct
Enzyme Commission (EC)	1-phosphatidylinositol 4-kinase	0	--	Direct
Enzyme Commission (EC)	Ether hydrolases	0	--	Direct
Enzyme Commission (EC)	Phosphatidylinositol-4-phosphate 3-kinase	0.000000000000005258	--	Direct
Enzyme Commission (EC)	Epoxyqueuosine reductase	0.0000000000009208	--	Direct
Enzyme Commission (EC)	With other acceptors	0.000000000002495	--	Direct
Enzyme Commission (EC)	Aminopeptidase B	0.0000000001707	--	Direct
Enzyme Commission (EC)	Ubiquitinyl hydrolase 1	0.000000009223	--	Direct
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0.000000000006522	Least Informative	Direct
Enzyme Commission (EC)	Oxidoreductases	0.4393	Least Informative	Inherited
Enzyme Commission (EC)	Hydrolases	0.7723	Least Informative	Inherited
Enzyme Commission (EC)	Aminoacyltransferases	0	Moderately Informative	Direct
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	Moderately Informative	Direct
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as acceptor	0.0000353	Moderately Informative	Direct
Enzyme Commission (EC)	Acting on peptide bonds (peptidases)	0.01301	Moderately Informative	Inherited
Enzyme Commission (EC)	Glycosylases	0.7277	Moderately Informative	Inherited
Enzyme Commission (EC)	Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate	0	Informative	Direct
Enzyme Commission (EC)	Non-specific serine/threonine protein kinase	0.0000000001055	Informative	Direct
Enzyme Commission (EC)	Omega peptidases	0.000002692	Informative	Direct
Enzyme Commission (EC)	RING-type E3 ubiquitin transferase	0.0000317	Informative	Direct
Enzyme Commission (EC)	Hydrolyzing N-glycosyl compounds	0.004722	Informative	Inherited
Enzyme Commission (EC)	Acting on CH or CH(2) groups	0.006195	Informative	Inherited
Enzyme Commission (EC)	Miscellaneous	0	Highly Informative	Direct
Enzyme Commission (EC)	Acting on ether bonds	0	Highly Informative	Direct
Enzyme Commission (EC)	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase	0.0000000000001691	Highly Informative	Direct
Enzyme Commission (EC)	HECT-type E3 ubiquitin transferase	0.0000000136	Highly Informative	Direct
Enzyme Commission (EC)	Aminopeptidases	0.007381	Highly Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

KW

UniProtKB KeyWords (KW)

	KW term	FDR (all)	SDKW (four levels)	Annotation (direct or inherited)
Biological process	Virulence	0.000000000003948	Moderately Informative	Direct

	KW term	FDR (all)	SDKW (four levels)	Annotation (direct or inherited)
Cellular component	Phycobilisome	0.000000000002097	Moderately Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

CD

CTD Diseases (CD)

	CD term	FDR (all)	SDCD (four levels)	Annotation (direct or inherited)
CTD Diseases (CD)	Adenocarcinoma Of Esophagus	0.0003128	--	Direct
CTD Diseases (CD)	Genomic Instability	0.0004103	--	Direct
CTD Diseases (CD)	Esophageal Diseases	0.4467	--	Inherited
CTD Diseases (CD)	Neoplasms by Histologic Type	0.4566	--	Inherited
CTD Diseases (CD)	Neoplasms by Site	0.5831	--	Inherited
CTD Diseases (CD)	Pathologic Processes	0.6291	--	Inherited
CTD Diseases (CD)	Carcinoma	0.7419	--	Inherited
CTD Diseases (CD)	Gastrointestinal Neoplasms	0.8125	--	Inherited
CTD Diseases (CD)	Pathological Conditions, Signs and Symptoms	0.2904	Least Informative	Inherited
CTD Diseases (CD)	Neoplasms	0.6954	Least Informative	Inherited
CTD Diseases (CD)	Digestive System Diseases	1	Least Informative	Inherited
CTD Diseases (CD)	Neoplasms, Glandular and Epithelial	0.3669	Moderately Informative	Inherited
CTD Diseases (CD)	Gastrointestinal Diseases	0.961	Moderately Informative	Inherited
CTD Diseases (CD)	Digestive System Neoplasms	0.9619	Moderately Informative	Inherited
CTD Diseases (CD)	Adenocarcinoma	0.2253	Informative	Inherited
CTD Diseases (CD)	Head and Neck Neoplasms	0.3828	Informative	Inherited
CTD Diseases (CD)	Esophageal Neoplasms	0.3494	Highly Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

CC

CTD Chemicals (CC)

	CC term	FDR (all)	SDCC (four levels)	Annotation (direct or inherited)
CTD Chemicals (CC)	Enzyme Inhibitors	0.000000001626	--	Direct
CTD Chemicals (CC)	Polycyclic Compounds	0.0000002317	--	Direct
CTD Chemicals (CC)	Lipids	0.00007439	--	Direct
CTD Chemicals (CC)	Hydrocarbons	0.0001851	--	Direct
CTD Chemicals (CC)	Benzophenoneidum	0.0003208	--	Direct
CTD Chemicals (CC)	Valproic Acid	0.000397	--	Direct
CTD Chemicals (CC)	Pentanoic Acids	0.0004152	--	Direct
CTD Chemicals (CC)	Organic Chemicals	0.01398	--	Inherited
CTD Chemicals (CC)	Heterocyclic Compounds, Fused-Ring	0.01458	--	Inherited
CTD Chemicals (CC)	Inorganic Chemicals	0.01795	--	Inherited
CTD Chemicals (CC)	Heterocyclic Compounds, Bridged-Ring	0.02285	--	Inherited
CTD Chemicals (CC)	Heterocyclic Compounds	0.05683	--	Inherited
CTD Chemicals (CC)	Valerates	0.05994	--	Inherited
CTD Chemicals (CC)	Pyrenes	0.0627	--	Inherited
CTD Chemicals (CC)	Heterocyclic Compounds, 2-Ring	0.09093	--	Inherited
CTD Chemicals (CC)	Carboxylic Acids	0.2921	--	Inherited
CTD Chemicals (CC)	Heterocyclic Compounds, 1-Ring	0.455	--	Inherited
CTD Chemicals (CC)	Hydrocarbons, Aromatic	0.4604	--	Inherited
CTD Chemicals (CC)	Peptides	0.4963	--	Inherited
CTD Chemicals (CC)	Pharmacologic Actions	0.6789	--	Inherited
CTD Chemicals (CC)	Fatty Acids	0.694	--	Inherited
CTD Chemicals (CC)	Aniline Compounds	0.8926	--	Inherited
CTD Chemicals (CC)	Hydrocarbons, Cyclic	0.8971	--	Inherited
CTD Chemicals (CC)	Benzene Derivatives	0.9923	--	Inherited
CTD Chemicals (CC)	Sulfones	1	--	Inherited
CTD Chemicals (CC)	Acids, Acyclic	0.008193	Least Informative	Inherited
CTD Chemicals (CC)	Amines	0.02828	Least Informative	Inherited
CTD Chemicals (CC)	Polycyclic Aromatic Hydrocarbons	0.09498	Least Informative	Inherited
CTD Chemicals (CC)	Azoles	0.1976	Least Informative	Inherited
CTD Chemicals (CC)	Chemical Actions and Uses	0.2391	Least Informative	Inherited
CTD Chemicals (CC)	Amides	0.3112	Least Informative	Inherited
CTD Chemicals (CC)	Sulfur Compounds	0.3529	Least Informative	Inherited
CTD Chemicals (CC)	Fatty Acids, Volatile	0.5377	Least Informative	Inherited
CTD Chemicals (CC)	Amino Acids, Peptides, and Proteins	0.609	Least Informative	Inherited
CTD Chemicals (CC)	Pyrimidines	0.9328	Least Informative	Inherited
CTD Chemicals (CC)	Phenols	1	Least Informative	Inherited
CTD Chemicals (CC)	Molecular Mechanisms of Pharmacological Action	0.000000006269	Moderately Informative	Direct
CTD Chemicals (CC)	Oligopeptides	0.09851	Moderately Informative	Inherited
CTD Chemicals (CC)	Benzopyrenes	0.3266	Moderately Informative	Inherited
CTD Chemicals (CC)	Organophosphorus Compounds	0.4951	Moderately Informative	Inherited
CTD Chemicals (CC)	Sulfonamides	1	Moderately Informative	Inherited
CTD Chemicals (CC)	Thiazoles	1	Moderately Informative	Inherited
CTD Chemicals (CC)	Dihydroxydihydrobenzopyrenes	0.00000381	Informative	Direct
CTD Chemicals (CC)	Glutathione	0.07692	Informative	Inherited
CTD Chemicals (CC)	Hydroquinones	0.08203	Informative	Inherited
CTD Chemicals (CC)	Triazines	0.1596	Informative	Inherited
CTD Chemicals (CC)	Benzothiazoles	0.3533	Informative	Inherited
CTD Chemicals (CC)	Bridged Bicyclo Compounds, Heterocyclic	0.8923	Informative	Inherited
CTD Chemicals (CC)	dicrotophos	0.0000002149	Highly Informative	Direct
CTD Chemicals (CC)	1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1	0.000004542	Highly Informative	Direct
CTD Chemicals (CC)	N-(6-(6-chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)benzo(d)thiazol-2-yl)acetamide	0.0000121	Highly Informative	Direct
CTD Chemicals (CC)	2,3,5-(triglutathion-S-yl)hydroquinone	0.00003116	Highly Informative	Direct
CTD Chemicals (CC)	ZSTK474	0.00006738	Highly Informative	Direct

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ARM repeat superfamily