14-3-3 protein family

DO

Disease Ontology (DO)

	DO term	FDR (all)	SDDO (four levels)	Annotation (direct or inherited)
Disease Ontology (DO)	disease of cellular proliferation	0	--	Direct
Disease Ontology (DO)	cancer	0	--	Direct
Disease Ontology (DO)	central nervous system cancer	0	--	Direct
Disease Ontology (DO)	psychotic disorder	0.00005036	--	Direct
Disease Ontology (DO)	cognitive disorder	0.0001603	--	Direct
Disease Ontology (DO)	organ system cancer	0	Least Informative	Direct
Disease Ontology (DO)	nervous system cancer	0	Moderately Informative	Direct
Disease Ontology (DO)	disease of mental health	0.001295	Moderately Informative	Inherited
Disease Ontology (DO)	meningioma	0	Informative	Direct
Disease Ontology (DO)	schizophrenia	0.00004946	Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

WP

Worm Phenotype (WP)

	WP term	FDR (all)	SDWP (four levels)	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	--	Direct
Worm Phenotype (WP)	developmental timing variant	0	--	Direct
Worm Phenotype (WP)	postembryonic development variant	0	--	Direct
Worm Phenotype (WP)	embryonic lethal	0	--	Direct
Worm Phenotype (WP)	lethal	0	--	Direct
Worm Phenotype (WP)	fertility variant	0	--	Direct
Worm Phenotype (WP)	transgene expression variant	0	--	Direct
Worm Phenotype (WP)	dauer development variant	0	--	Direct
Worm Phenotype (WP)	protein subcellular localization variant	0	--	Direct
Worm Phenotype (WP)	retarded heterochronic variations	0	--	Direct
Worm Phenotype (WP)	development variant	0	--	Direct
Worm Phenotype (WP)	morphology variant	0	--	Direct
Worm Phenotype (WP)	organism development variant	0	--	Direct
Worm Phenotype (WP)	cell morphology variant	0	--	Direct
Worm Phenotype (WP)	organ system morphology variant	0	--	Direct
Worm Phenotype (WP)	organ system physiology variant	0	--	Direct
Worm Phenotype (WP)	organism physiology variant	0	--	Direct
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	--	Direct
Worm Phenotype (WP)	reproductive system physiology variant	0	--	Direct
Worm Phenotype (WP)	transgene subcellular localization variant	0	--	Direct
Worm Phenotype (WP)	gene expression variant	0	--	Direct
Worm Phenotype (WP)	enzyme activity variant	0	--	Direct
Worm Phenotype (WP)	embryonic development variant	0	--	Direct
Worm Phenotype (WP)	larval development variant	0	--	Direct
Worm Phenotype (WP)	gametogenesis variant	0	--	Direct
Worm Phenotype (WP)	hermaphrodite fertility variant	0	--	Direct
Worm Phenotype (WP)	sexually dimorphic physiology variant	0	--	Direct
Worm Phenotype (WP)	developmental growth variant	0	--	Direct
Worm Phenotype (WP)	larval growth variant	0	--	Direct
Worm Phenotype (WP)	sterile progeny	0	--	Direct
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	--	Direct
Worm Phenotype (WP)	larval physiology variant	0	--	Direct
Worm Phenotype (WP)	gonad morphology variant	0	--	Direct
Worm Phenotype (WP)	protein interaction variant	0	--	Direct
Worm Phenotype (WP)	fertility reduced	0	--	Direct
Worm Phenotype (WP)	endocytic transport variant	0	--	Direct
Worm Phenotype (WP)	oocyte physiology variant	0	--	Direct
Worm Phenotype (WP)	receptor mediated endocytosis defective	0	--	Direct
Worm Phenotype (WP)	vesicle trafficking variant	0	--	Direct
Worm Phenotype (WP)	glutathione levels variant	0	--	Direct
Worm Phenotype (WP)	reduced levels of reduced glutathione	0	--	Direct
Worm Phenotype (WP)	physiology variant	1	--	Inherited
Worm Phenotype (WP)	sterile	1	--	Inherited
Worm Phenotype (WP)	organism metabolism processing variant	0	Least Informative	Direct
Worm Phenotype (WP)	larval lethal	0	Least Informative	Direct
Worm Phenotype (WP)	larval arrest	0	Least Informative	Direct
Worm Phenotype (WP)	progeny variant	0	Least Informative	Direct
Worm Phenotype (WP)	cell development variant	0	Least Informative	Direct
Worm Phenotype (WP)	cell physiology variant	0	Least Informative	Direct
Worm Phenotype (WP)	organism environmental stimulus response variant	0	Least Informative	Direct
Worm Phenotype (WP)	protein expression variant	0	Moderately Informative	Direct
Worm Phenotype (WP)	organ system development variant	0	Moderately Informative	Direct
Worm Phenotype (WP)	reproductive system morphology variant	0	Moderately Informative	Direct
Worm Phenotype (WP)	germ cell development variant	0	Moderately Informative	Direct
Worm Phenotype (WP)	germ cell differentiation variant	0	Moderately Informative	Direct
Worm Phenotype (WP)	pattern of transgene expression variant	0	Moderately Informative	Direct
Worm Phenotype (WP)	level of transgene expression variant	0	Moderately Informative	Direct
Worm Phenotype (WP)	protein protein interaction variant	0	Moderately Informative	Direct
Worm Phenotype (WP)	life span variant	0	Informative	Direct
Worm Phenotype (WP)	hermaphrodite physiology variant	0	Informative	Direct
Worm Phenotype (WP)	germ cell physiology variant	0	Informative	Direct
Worm Phenotype (WP)	transgene expression reduced	0	Informative	Direct
Worm Phenotype (WP)	pattern protein expression variant	0	Informative	Direct
Worm Phenotype (WP)	endocytic transport defect	0	Informative	Direct
Worm Phenotype (WP)	dauer larva physiology variant	1	Informative	Inherited
Worm Phenotype (WP)	enzyme activity reduced	0	Highly Informative	Direct
Worm Phenotype (WP)	shortened life span	0	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

XA

Xenopus Anatomy (XA)

	XA term	FDR (all)	SDXA (four levels)	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	skin	0	--	Direct
Xenopus ANatomical entity (XAN)	head region	0	--	Direct
Xenopus ANatomical entity (XAN)	central nervous system	0	--	Direct
Xenopus ANatomical entity (XAN)	anatomical structure	0	--	Direct
Xenopus ANatomical entity (XAN)	anatomical group	0	--	Direct
Xenopus ANatomical entity (XAN)	primary germ layer	0	--	Direct
Xenopus ANatomical entity (XAN)	organism subdivision	0	--	Direct
Xenopus ANatomical entity (XAN)	compound organ	0	--	Direct
Xenopus ANatomical entity (XAN)	anatomical region	0	--	Direct
Xenopus ANatomical entity (XAN)	visual system	0	--	Direct
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	--	Direct
Xenopus ANatomical entity (XAN)	peripheral nervous system	0.0000004291	--	Direct
Xenopus ANatomical entity (XAN)	cranial ganglion	0.000005672	--	Direct
Xenopus ANatomical entity (XAN)	early embryonic cell	0.00001578	--	Direct
Xenopus ANatomical entity (XAN)	blastomere	0.00001636	--	Direct
Xenopus ANatomical entity (XAN)	larval alimentary system	0.00005457	--	Direct
Xenopus ANatomical entity (XAN)	immune system	0.0005908	--	Direct
Xenopus ANatomical entity (XAN)	muscular system	0.02315	--	Inherited
Xenopus ANatomical entity (XAN)	cell	0.04781	--	Inherited
Xenopus ANatomical entity (XAN)	anatomical system	1	--	Inherited
Xenopus ANatomical entity (XAN)	whole organism	1	--	Inherited
Xenopus ANatomical entity (XAN)	embryo	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	nervous system	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	head	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	tissue	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	ectoderm	0	Moderately Informative	Direct
Xenopus ANatomical entity (XAN)	brain	0	Moderately Informative	Direct
Xenopus ANatomical entity (XAN)	multi-tissue structure	0	Moderately Informative	Direct
Xenopus ANatomical entity (XAN)	embryonic structure	0	Moderately Informative	Direct
Xenopus ANatomical entity (XAN)	sensory system	0	Moderately Informative	Direct
Xenopus ANatomical entity (XAN)	musculoskeletal system	0.08196	Moderately Informative	Inherited
Xenopus ANatomical entity (XAN)	alimentary system	0.09403	Moderately Informative	Inherited
Xenopus ANatomical entity (XAN)	dermal system	0	Informative	Direct
Xenopus ANatomical entity (XAN)	eye	0	Informative	Direct
Xenopus ANatomical entity (XAN)	surface structure	0	Informative	Direct
Xenopus ANatomical entity (XAN)	pharyngeal region	0	Informative	Direct
Xenopus ANatomical entity (XAN)	spinal cord	0.00002618	Informative	Direct
Xenopus ANatomical entity (XAN)	anatomical space	0.0002968	Informative	Direct
Xenopus ANatomical entity (XAN)	endocrine system	0.0009356	Informative	Direct
Xenopus ANatomical entity (XAN)	mesenchyme	0.001293	Informative	Inherited
Xenopus ANatomical entity (XAN)	mesoderm	0.002104	Informative	Inherited
Xenopus ANatomical entity (XAN)	ganglion	0.00000263	Highly Informative	Direct
Xenopus ANatomical entity (XAN)	pronephric mesenchyme	0.00002543	Highly Informative	Direct
Xenopus ANatomical entity (XAN)	fin	0.0003452	Highly Informative	Direct
Xenopus ANatomical entity (XAN)	thymus	0.0007211	Highly Informative	Direct
Xenopus ANatomical entity (XAN)	somite	0.0009298	Highly Informative	Direct

	XA term	FDR (all)	SDXA (four levels)	Annotation (direct or inherited)
Xenopus DEvelopment stage (XDE)	tadpole stage	0	--	Direct
Xenopus DEvelopment stage (XDE)	metamorphosing tadpole stage	0	--	Direct
Xenopus DEvelopment stage (XDE)	climax stage	0	--	Direct
Xenopus DEvelopment stage (XDE)	NF stage	0	--	Direct
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0	Least Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

AP

Arabidopsis Plant Ontology (AP)

	AP term	FDR (all)	SDAP (four levels)	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	shoot system	0	--	Direct
Plant ANatomical entity (PAN)	collective plant structure	0	--	Direct
Plant ANatomical entity (PAN)	plant structure	1	--	Inherited
Plant ANatomical entity (PAN)	collective plant organ structure	1	--	Inherited

	AP term	FDR (all)	SDAP (four levels)	Annotation (direct or inherited)
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	--	Inherited
Plant structure DEvelopment stage (PDE)	seed development stage	0.0000003016	Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

KW

UniProtKB KeyWords (KW)

	KW term	FDR (all)	SDKW (four levels)	Annotation (direct or inherited)
Cellular component	Cytoplasm	0	--	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

CC

CTD Chemicals (CC)

	CC term	FDR (all)	SDCC (four levels)	Annotation (direct or inherited)
CTD Chemicals (CC)	Heterocyclic Compounds, Fused-Ring	0	--	Direct
CTD Chemicals (CC)	Benzene Derivatives	0	--	Direct
CTD Chemicals (CC)	Carboxylic Acids	0	--	Direct
CTD Chemicals (CC)	Fatty Acids	0	--	Direct
CTD Chemicals (CC)	Heterocyclic Compounds	0	--	Direct
CTD Chemicals (CC)	Heterocyclic Compounds, 1-Ring	0	--	Direct
CTD Chemicals (CC)	Heterocyclic Compounds, 2-Ring	0	--	Direct
CTD Chemicals (CC)	Hydrocarbons	0	--	Direct
CTD Chemicals (CC)	Hydrocarbons, Aromatic	0	--	Direct
CTD Chemicals (CC)	Hydrocarbons, Cyclic	0	--	Direct
CTD Chemicals (CC)	Inorganic Chemicals	0	--	Direct
CTD Chemicals (CC)	Lipids	0	--	Direct
CTD Chemicals (CC)	Organic Chemicals	0	--	Direct
CTD Chemicals (CC)	Polycyclic Compounds	0	--	Direct
CTD Chemicals (CC)	Pyrans	0	--	Direct
CTD Chemicals (CC)	Tobacco Smoke Pollution	0	--	Direct
CTD Chemicals (CC)	Oxygen Compounds	0	--	Direct
CTD Chemicals (CC)	Metals, Heavy	0	--	Direct
CTD Chemicals (CC)	Isothiocyanates	0.0000001202	--	Direct
CTD Chemicals (CC)	Fullerenes	0.0000002206	--	Direct
CTD Chemicals (CC)	Carbon	0.000001946	--	Direct
CTD Chemicals (CC)	Aspirin	0.0005738	--	Direct
CTD Chemicals (CC)	Caffeine	0.0006179	--	Direct
CTD Chemicals (CC)	Phenylacetates	0.002676	--	Inherited
CTD Chemicals (CC)	Hydroxybenzoates	0.006226	--	Inherited
CTD Chemicals (CC)	Anions	1	--	Inherited
CTD Chemicals (CC)	Ions	1	--	Inherited
CTD Chemicals (CC)	Benzopyrans	0	Least Informative	Direct
CTD Chemicals (CC)	Electrolytes	0	Least Informative	Direct
CTD Chemicals (CC)	Elements	0	Least Informative	Direct
CTD Chemicals (CC)	Metals	0	Least Informative	Direct
CTD Chemicals (CC)	Polycyclic Aromatic Hydrocarbons	0	Least Informative	Direct
CTD Chemicals (CC)	Sulfur Compounds	0	Least Informative	Direct
CTD Chemicals (CC)	Terpenes	0	Least Informative	Direct
CTD Chemicals (CC)	Complex Mixtures	0	Least Informative	Direct
CTD Chemicals (CC)	Macrocyclic Compounds	0	Least Informative	Direct
CTD Chemicals (CC)	Acids, Carbocyclic	0.0822	Least Informative	Inherited
CTD Chemicals (CC)	Phenols	0.3733	Least Informative	Inherited
CTD Chemicals (CC)	Aldehydes	0	Moderately Informative	Direct
CTD Chemicals (CC)	Oxides	0	Moderately Informative	Direct
CTD Chemicals (CC)	Particulate Matter	0	Moderately Informative	Direct
CTD Chemicals (CC)	Fatty Acids, Unsaturated	0.0008958	Moderately Informative	Direct
CTD Chemicals (CC)	Purines	0.02326	Moderately Informative	Inherited
CTD Chemicals (CC)	Hydroxy Acids	0.04902	Moderately Informative	Inherited
CTD Chemicals (CC)	Alkaloids	0.2885	Moderately Informative	Inherited
CTD Chemicals (CC)	Benzoates	0.3274	Moderately Informative	Inherited
CTD Chemicals (CC)	Smoke	0	Informative	Direct
CTD Chemicals (CC)	Isocyanates	0.00000002177	Informative	Direct
CTD Chemicals (CC)	Benzaldehydes	0.0000001229	Informative	Direct
CTD Chemicals (CC)	Diclofenac	0.0004104	Informative	Direct
CTD Chemicals (CC)	Salicylates	0.001278	Informative	Inherited
CTD Chemicals (CC)	Purinones	0.001936	Informative	Inherited
CTD Chemicals (CC)	bromovanin	0.0000000000423	Highly Informative	Direct
CTD Chemicals (CC)	Nanotubes, Carbon	0.0000001629	Highly Informative	Direct
CTD Chemicals (CC)	Xanthines	0.01949	Highly Informative	Inherited