HSP20-like chaperones superfamily

DO

Disease Ontology (DO)

	DO term	FDR (all)	SDDO (four levels)	Annotation (direct or inherited)
Disease Ontology (DO)	disease of anatomical entity	0.7397	--	Inherited
Disease Ontology (DO)	nervous system disease	0.04468	Least Informative	Inherited
Disease Ontology (DO)	peripheral nervous system disease	0.000001035	Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

HP

Human Phenotype (HP)

	HP term	FDR (all)	SDHP (four levels)	Annotation (direct or inherited)
Mode of Inheritance (MI)	Autosomal dominant inheritance	0	Least Informative	Direct

	HP term	FDR (all)	SDHP (four levels)	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Hyporeflexia of lower limbs	0.000000006458	--	Direct
Phenotypic Abnormality (PA)	Distal muscle weakness	0.000015	--	Direct
Phenotypic Abnormality (PA)	Distal lower limb muscle weakness	0.00004887	--	Direct
Phenotypic Abnormality (PA)	Limb muscle weakness	0.00005167	--	Direct
Phenotypic Abnormality (PA)	Areflexia of lower limbs	0.00005949	--	Direct
Phenotypic Abnormality (PA)	EMG abnormality	0.00009431	--	Direct
Phenotypic Abnormality (PA)	Hyporeflexia	0.0003784	--	Direct
Phenotypic Abnormality (PA)	Reduced tendon reflexes	0.001558	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of the musculature of the limbs	0.003241	--	Inherited
Phenotypic Abnormality (PA)	Muscle weakness	0.01356	--	Inherited
Phenotypic Abnormality (PA)	Lower limb muscle weakness	0.1453	--	Inherited
Phenotypic Abnormality (PA)	Abnormal muscle physiology	0.2133	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.338	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of limbs	0.03242	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0.2553	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the musculature	0.3079	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormal skeletal muscle morphology	0.08487	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of movement	0.1803	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the lower limb	0.3727	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormal reflex	0.02651	Informative	Inherited
Phenotypic Abnormality (PA)	Areflexia	0.1535	Highly Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

WP

Worm Phenotype (WP)

	WP term	FDR (all)	SDWP (four levels)	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	--	Direct
Worm Phenotype (WP)	postembryonic development variant	0	--	Direct
Worm Phenotype (WP)	larval arrest	0	--	Direct
Worm Phenotype (WP)	lethal	0	--	Direct
Worm Phenotype (WP)	fertility variant	0	--	Direct
Worm Phenotype (WP)	development variant	0	--	Direct
Worm Phenotype (WP)	organism development variant	0	--	Direct
Worm Phenotype (WP)	organ system physiology variant	0	--	Direct
Worm Phenotype (WP)	organism physiology variant	0	--	Direct
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	--	Direct
Worm Phenotype (WP)	reproductive system physiology variant	0	--	Direct
Worm Phenotype (WP)	developmental growth variant	0	--	Direct
Worm Phenotype (WP)	fertility reduced	0	--	Direct
Worm Phenotype (WP)	locomotion variant	0.000000000000009842	--	Direct
Worm Phenotype (WP)	behavior variant	0.00000000001145	--	Direct
Worm Phenotype (WP)	protein aggregation variant	0.00000000001564	--	Direct
Worm Phenotype (WP)	transgene subcellular localization variant	0.00000000001633	--	Direct
Worm Phenotype (WP)	protein protein interaction variant	0.00000000002208	--	Direct
Worm Phenotype (WP)	cadmium response variant	0.00002005	--	Direct
Worm Phenotype (WP)	peptide uptake by intestinal cell variant	0.0008299	--	Direct
Worm Phenotype (WP)	uptake by intestinal cell defective	0.000896	--	Direct
Worm Phenotype (WP)	epithelial cell physiology variant	0.001064	--	Inherited
Worm Phenotype (WP)	gene expression variant	0.09065	--	Inherited
Worm Phenotype (WP)	transgene expression variant	0.111	--	Inherited
Worm Phenotype (WP)	chemical response variant	0.5684	--	Inherited
Worm Phenotype (WP)	physiology variant	1	--	Inherited
Worm Phenotype (WP)	larval development variant	0	Least Informative	Direct
Worm Phenotype (WP)	larval growth variant	0	Least Informative	Direct
Worm Phenotype (WP)	organism behavior variant	0.000000000009769	Least Informative	Direct
Worm Phenotype (WP)	organism metabolism processing variant	0.0000001668	Least Informative	Direct
Worm Phenotype (WP)	organism environmental stimulus response variant	0.0236	Least Informative	Inherited
Worm Phenotype (WP)	cell physiology variant	0.4991	Least Informative	Inherited
Worm Phenotype (WP)	protein interaction variant	0.00001098	Moderately Informative	Direct
Worm Phenotype (WP)	movement variant	0.0001273	Moderately Informative	Direct
Worm Phenotype (WP)	pattern of transgene expression variant	0.005588	Moderately Informative	Inherited
Worm Phenotype (WP)	organism stress response variant	0.009603	Moderately Informative	Inherited
Worm Phenotype (WP)	metal response variant	0.001506	Informative	Inherited
Worm Phenotype (WP)	chemical hypersensitive	0.03621	Informative	Inherited
Worm Phenotype (WP)	organism pathogen response variant	0.2777	Informative	Inherited
Worm Phenotype (WP)	cadmium hypersensitive	0.000007744	Highly Informative	Direct
Worm Phenotype (WP)	pathogen susceptibility increased	0.000008997	Highly Informative	Direct
Worm Phenotype (WP)	epithelial system physiology variant	0.002745	Highly Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

YP

Yeast Phenotype (YP)

	YP term	FDR (all)	SDYP (four levels)	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	--	Direct
Yeast Phenotype (YP)	stress resistance	0	--	Direct
Yeast Phenotype (YP)	competitive fitness	0	--	Direct
Yeast Phenotype (YP)	fitness	0	--	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

FA

Fly Anatomy (FA)

	FA term	FDR (all)	SDFA (four levels)	Annotation (direct or inherited)
Fly Anatomy (FA)	multicellular structure	0	--	Direct
Fly Anatomy (FA)	anatomical structure	1	--	Inherited
Fly Anatomy (FA)	material anatomical entity	1	--	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

ZA

Zebrafish Anatomy (ZA)

	ZA term	FDR (all)	SDZA (four levels)	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	--	Direct
Zebrafish Anatomy (ZA)	anatomical system	0	--	Direct
Zebrafish Anatomy (ZA)	anatomical group	0	--	Direct
Zebrafish Anatomy (ZA)	anatomical structure	1	--	Inherited
Zebrafish Anatomy (ZA)	nervous system	0	Least Informative	Direct
Zebrafish Anatomy (ZA)	organism subdivision	0	Least Informative	Direct
Zebrafish Anatomy (ZA)	head	0	Moderately Informative	Direct
Zebrafish Anatomy (ZA)	portion of tissue	0	Moderately Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

XA

Xenopus Anatomy (XA)

	XA term	FDR (all)	SDXA (four levels)	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	--	Direct
Xenopus ANatomical entity (XAN)	anatomical group	0	--	Direct
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	--	Direct
Xenopus ANatomical entity (XAN)	skeletal muscle	0.0002209	--	Direct
Xenopus ANatomical entity (XAN)	muscular system	0.001598	--	Inherited
Xenopus ANatomical entity (XAN)	anatomical system	1	--	Inherited
Xenopus ANatomical entity (XAN)	whole organism	1	--	Inherited
Xenopus ANatomical entity (XAN)	tissue	0.0589	Least Informative	Inherited
Xenopus ANatomical entity (XAN)	musculoskeletal system	0.0003926	Moderately Informative	Direct
Xenopus ANatomical entity (XAN)	muscle	0.002991	Informative	Inherited

	XA term	FDR (all)	SDXA (four levels)	Annotation (direct or inherited)
Xenopus DEvelopment stage (XDE)	NF stage	0	--	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

AP

Arabidopsis Plant Ontology (AP)

	AP term	FDR (all)	SDAP (four levels)	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	shoot system	0	--	Direct
Plant ANatomical entity (PAN)	collective plant structure	0	--	Direct
Plant ANatomical entity (PAN)	plant structure	1	--	Inherited
Plant ANatomical entity (PAN)	collective plant organ structure	1	--	Inherited

	AP term	FDR (all)	SDAP (four levels)	Annotation (direct or inherited)
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	--	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

EC

Enzyme Commission (EC)

	EC term	FDR (all)	SDEC (four levels)	Annotation (direct or inherited)
Enzyme Commission (EC)	Cytochrome-b5 reductase	0	--	Direct
Enzyme Commission (EC)	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase	0	--	Direct
Enzyme Commission (EC)	Prostaglandin-E synthase	0.0000000000004526	--	Direct
Enzyme Commission (EC)	Ubiquitinyl hydrolase 1	0.0000006394	--	Direct
Enzyme Commission (EC)	Hydro-lyases	0.00001195	--	Direct
Enzyme Commission (EC)	Lyases	0.007354	Least Informative	Inherited
Enzyme Commission (EC)	Oxidoreductases	0.02137	Least Informative	Inherited
Enzyme Commission (EC)	Hydrolases	0.2812	Least Informative	Inherited
Enzyme Commission (EC)	Carbon-oxygen lyases	0.00008667	Moderately Informative	Direct
Enzyme Commission (EC)	Acting on peptide bonds (peptidases)	0.006651	Moderately Informative	Inherited
Enzyme Commission (EC)	Isomerases	0.05682	Moderately Informative	Inherited
Enzyme Commission (EC)	Acting on NADH or NADPH	0.0000000000006736	Informative	Direct
Enzyme Commission (EC)	Omega peptidases	0.000002168	Informative	Direct
Enzyme Commission (EC)	Intramolecular oxidoreductases	0.00167	Informative	Inherited
Enzyme Commission (EC)	With a heme protein as acceptor	0	Highly Informative	Direct
Enzyme Commission (EC)	Other intramolecular oxidoreductases	0.0000000001322	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

KW

UniProtKB KeyWords (KW)

	KW term	FDR (all)	SDKW (four levels)	Annotation (direct or inherited)
Biological process	Stress response	0	Moderately Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

CC

CTD Chemicals (CC)

	CC term	FDR (all)	SDCC (four levels)	Annotation (direct or inherited)
CTD Chemicals (CC)	Organic Chemicals	0	--	Direct
CTD Chemicals (CC)	Ditiocarb	0.0001063	--	Direct
CTD Chemicals (CC)	tripterine	0.0002309	--	Direct
CTD Chemicals (CC)	Sulfides	0.001638	--	Inherited
CTD Chemicals (CC)	Hydrogen Sulfide	0.001676	--	Inherited
CTD Chemicals (CC)	Purine Nucleotides	0.1243	--	Inherited
CTD Chemicals (CC)	Ribonucleotides	0.1344	--	Inherited
CTD Chemicals (CC)	Heterocyclic Compounds, 2-Ring	0.509	--	Inherited
CTD Chemicals (CC)	Heterocyclic Compounds	0.5216	--	Inherited
CTD Chemicals (CC)	Heterocyclic Compounds, Fused-Ring	0.5805	--	Inherited
CTD Chemicals (CC)	Metals, Heavy	0.6126	--	Inherited
CTD Chemicals (CC)	Lipids	0.7158	--	Inherited
CTD Chemicals (CC)	Fatty Acids	0.7481	--	Inherited
CTD Chemicals (CC)	Hydrocarbons	0.8092	--	Inherited
CTD Chemicals (CC)	Inorganic Chemicals	0.8928	--	Inherited
CTD Chemicals (CC)	Carboxylic Acids	0.9153	--	Inherited
CTD Chemicals (CC)	Nucleic Acids, Nucleotides, and Nucleosides	0.9821	--	Inherited
CTD Chemicals (CC)	Acids, Noncarboxylic	1	--	Inherited
CTD Chemicals (CC)	Anions	1	--	Inherited
CTD Chemicals (CC)	Heterocyclic Compounds, 1-Ring	1	--	Inherited
CTD Chemicals (CC)	Ions	1	--	Inherited
CTD Chemicals (CC)	Acids	0.3628	Least Informative	Inherited
CTD Chemicals (CC)	Metals	0.4814	Least Informative	Inherited
CTD Chemicals (CC)	Electrolytes	0.4939	Least Informative	Inherited
CTD Chemicals (CC)	Terpenes	0.5517	Least Informative	Inherited
CTD Chemicals (CC)	Indoles	0.5861	Least Informative	Inherited
CTD Chemicals (CC)	Sulfur Compounds	0.7123	Least Informative	Inherited
CTD Chemicals (CC)	Elements	0.8359	Least Informative	Inherited
CTD Chemicals (CC)	Acids, Acyclic	0.9781	Least Informative	Inherited
CTD Chemicals (CC)	Fatty Acids, Volatile	1	Least Informative	Inherited
CTD Chemicals (CC)	Acetates	0.0009127	Moderately Informative	Direct
CTD Chemicals (CC)	Piperidines	0.02117	Moderately Informative	Inherited
CTD Chemicals (CC)	Gases	0.1451	Moderately Informative	Inherited
CTD Chemicals (CC)	Carbamates	0.1586	Moderately Informative	Inherited
CTD Chemicals (CC)	Nucleotides	0.1851	Moderately Informative	Inherited
CTD Chemicals (CC)	Purines	0.4849	Moderately Informative	Inherited
CTD Chemicals (CC)	Transition Elements	0.5451	Moderately Informative	Inherited
CTD Chemicals (CC)	Disulfides	0.0001665	Informative	Direct
CTD Chemicals (CC)	Thiocarbamates	0.0008583	Informative	Direct
CTD Chemicals (CC)	Coordination Complexes	0.01006	Informative	Inherited
CTD Chemicals (CC)	Triterpenes	0.02599	Informative	Inherited
CTD Chemicals (CC)	Adenine Nucleotides	0.111	Informative	Inherited
CTD Chemicals (CC)	N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine	0.00000000004477	Highly Informative	Direct
CTD Chemicals (CC)	Silver	0.00008256	Highly Informative	Direct
CTD Chemicals (CC)	Disulfiram	0.00008426	Highly Informative	Direct
CTD Chemicals (CC)	PCI 5002	0.0004858	Highly Informative	Direct
CTD Chemicals (CC)	Adenosine Triphosphate	0.000942	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

Distribution on sTOL

Plot distribution on species Tree Of Life (sTOL) for this domain, i.e., present or absent across genomes/tips

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HSP20-like chaperones superfamily