dcGO - A comprehensive domain-centric ontology resource for post-genomic research on functions, phenotypes, diseases and more   
  
  

FHA domain family

Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SMAD/FHA domain [ 49878]
Superfamily:   SMAD/FHA domain [ 49879] (4)
Family:   FHA domain [ 49885] (11)

DO

Disease Ontology (DO)

DO term FDR (all) SDDO (four levels) Annotation (direct or inherited)
Disease Ontology (DO)retinal cancer0.0005914--Direct
Disease Ontology (DO)autosomal dominant disease0.002332--Inherited
Disease Ontology (DO)autosomal genetic disease0.0182--Inherited
Disease Ontology (DO)monogenic disease0.02117--Inherited
Disease Ontology (DO)sensory system cancer0.03378--Inherited
Disease Ontology (DO)disease of cellular proliferation0.2268--Inherited
Disease Ontology (DO)cancer0.9459--Inherited
Disease Ontology (DO)ocular cancer1--Inherited
Disease Ontology (DO)organ system cancer0.0902Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.006076Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.03391Moderately InformativeInherited
Disease Ontology (DO)hereditary breast ovarian cancer syndrome0.0004942InformativeDirect
Disease Ontology (DO)retinal cell cancer0.0005714InformativeDirect

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HP

Human Phenotype (HP)

HP term FDR (all) SDHP (four levels) Annotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormal saccadic eye movements0.00003923--Direct
Phenotypic Abnormality (PA)Neuroepithelial neoplasm0.0002523--Direct
Phenotypic Abnormality (PA)Nervous tissue neoplasm0.0002689--Direct
Phenotypic Abnormality (PA)Sloping forehead0.0008926--Direct
Phenotypic Abnormality (PA)Abnormal myelination0.00682--Inherited
Phenotypic Abnormality (PA)Morphological abnormality of the central nervous system0.008053--Inherited
Phenotypic Abnormality (PA)Neoplasm of the central nervous system0.01048--Inherited
Phenotypic Abnormality (PA)Neoplasm of the nervous system0.01081--Inherited
Phenotypic Abnormality (PA)Abnormality of eye movement0.04237--Inherited
Phenotypic Abnormality (PA)Neoplasm by anatomical site0.08301--Inherited
Phenotypic Abnormality (PA)Abnormality of the head0.1255--Inherited
Phenotypic Abnormality (PA)Abnormality of head or neck0.1304--Inherited
Phenotypic Abnormality (PA)Abnormality of the nervous system0.1322--Inherited
Phenotypic Abnormality (PA)Reduced tendon reflexes0.166--Inherited
Phenotypic Abnormality (PA)Neuroectodermal neoplasm1--Inherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.0172Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.07876Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.179Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.245Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.6134Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.01987Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.09554Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal peripheral nervous system morphology0.1084Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.1236Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.3417Moderately InformativeInherited
Phenotypic Abnormality (PA)Malignant neoplasm of the central nervous system0.0002869InformativeDirect
Phenotypic Abnormality (PA)Abnormality of muscle size0.009676InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.05599InformativeInherited
Phenotypic Abnormality (PA)Abnormal reflex0.07175InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.2891InformativeInherited
Phenotypic Abnormality (PA)Abnormal peripheral myelination0.00006996Highly InformativeDirect
Phenotypic Abnormality (PA)Skeletal muscle atrophy0.0001798Highly InformativeDirect
Phenotypic Abnormality (PA)Areflexia0.0007444Highly InformativeDirect

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MP

Mouse Phenotype (MP)

MP term FDR (all) SDMP (four levels) Annotation (direct or inherited)
Mammalian Phenotype (MP)abnormal mortality induced by ionizing radiation0.000004973--Direct
Mammalian Phenotype (MP)abnormal chromosome stability0.000009029--Direct
Mammalian Phenotype (MP)increased mammary adenocarcinoma incidence0.0003296--Direct
Mammalian Phenotype (MP)increased cellular sensitivity to ionizing radiation0.0004877--Direct
Mammalian Phenotype (MP)microcephaly0.0007485--Direct
Mammalian Phenotype (MP)abnormal class switch recombination0.00078--Direct
Mammalian Phenotype (MP)abnormal response to radiation0.0009935--Direct
Mammalian Phenotype (MP)abnormal induced cell death0.005952--Inherited
Mammalian Phenotype (MP)abnormal head size0.008408--Inherited
Mammalian Phenotype (MP)abnormal apocrine gland morphology0.02195--Inherited
Mammalian Phenotype (MP)increased carcinoma incidence0.02927--Inherited
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.02941--Inherited
Mammalian Phenotype (MP)increased integument system tumor incidence0.02965--Inherited
Mammalian Phenotype (MP)increased classified tumor incidence0.04786--Inherited
Mammalian Phenotype (MP)abnormal classified tumor incidence0.04944--Inherited
Mammalian Phenotype (MP)increased organ/body region tumor incidence0.05767--Inherited
Mammalian Phenotype (MP)abnormal organ/body region tumor incidence0.06178--Inherited
Mammalian Phenotype (MP)abnormal B cell physiology0.06654--Inherited
Mammalian Phenotype (MP)abnormal lymphopoiesis0.06904--Inherited
Mammalian Phenotype (MP)increased tumor incidence0.08986--Inherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.09504--Inherited
Mammalian Phenotype (MP)abnormal tumor incidence0.1259--Inherited
Mammalian Phenotype (MP)altered tumor susceptibility0.1314--Inherited
Mammalian Phenotype (MP)abnormal cell physiology0.1779--Inherited
Mammalian Phenotype (MP)abnormal definitive hematopoiesis0.1789--Inherited
Mammalian Phenotype (MP)homeostasis/metabolism phenotype0.2046--Inherited
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.2077--Inherited
Mammalian Phenotype (MP)abnormal lymphocyte physiology0.2211--Inherited
Mammalian Phenotype (MP)abnormal exocrine gland morphology0.2313--Inherited
Mammalian Phenotype (MP)abnormal hemopoiesis0.2817--Inherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.3326--Inherited
Mammalian Phenotype (MP)integument phenotype0.4041--Inherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.4223--Inherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.4277--Inherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.4388--Inherited
Mammalian Phenotype (MP)abnormal leukocyte morphology0.4465--Inherited
Mammalian Phenotype (MP)abnormal immune system cell morphology0.4539--Inherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.4729--Inherited
Mammalian Phenotype (MP)abnormal hematopoietic system physiology0.522--Inherited
Mammalian Phenotype (MP)abnormal hematopoietic cell morphology0.5293--Inherited
Mammalian Phenotype (MP)abnormal immune system physiology0.6354--Inherited
Mammalian Phenotype (MP)abnormal immune system morphology0.6382--Inherited
Mammalian Phenotype (MP)abnormal hematopoietic system morphology/development0.6475--Inherited
Mammalian Phenotype (MP)abnormal gland morphology0.7723--Inherited
Mammalian Phenotype (MP)cellular phenotype0.2979Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.4186Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.4274Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.5737Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.7836Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.8024Least InformativeInherited
Mammalian Phenotype (MP)abnormal B cell morphology0.02347Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.051Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.06151Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.1233Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.1678Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.1909Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.2363Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.395Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.4077Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.4093Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.00147InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.02195InformativeInherited
Mammalian Phenotype (MP)increased gland tumor incidence0.02543InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.03496InformativeInherited
Mammalian Phenotype (MP)increased malignant tumor incidence0.3155InformativeInherited
Mammalian Phenotype (MP)chromosomal instability0.000004205Highly InformativeDirect
Mammalian Phenotype (MP)abnormal DNA repair0.0001003Highly InformativeDirect
Mammalian Phenotype (MP)increased mammary gland tumor incidence0.001696Highly InformativeInherited
Mammalian Phenotype (MP)increased adenocarcinoma incidence0.006424Highly InformativeInherited
Mammalian Phenotype (MP)increased sensitivity to induced cell death0.3527Highly InformativeInherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

WP

Worm Phenotype (WP)

WP term FDR (all) SDWP (four levels) Annotation (direct or inherited)
Worm Phenotype (WP)postembryonic development variant0--Direct
Worm Phenotype (WP)embryonic lethal0--Direct
Worm Phenotype (WP)lethal0--Direct
Worm Phenotype (WP)fertility variant0--Direct
Worm Phenotype (WP)development variant0--Direct
Worm Phenotype (WP)morphology variant0--Direct
Worm Phenotype (WP)organism development variant0--Direct
Worm Phenotype (WP)organism morphology variant0--Direct
Worm Phenotype (WP)organ system physiology variant0--Direct
Worm Phenotype (WP)organism physiology variant0--Direct
Worm Phenotype (WP)organism homeostasis metabolism variant0--Direct
Worm Phenotype (WP)reproductive system physiology variant0--Direct
Worm Phenotype (WP)maternal sterile0--Direct
Worm Phenotype (WP)hermaphrodite sterile0--Direct
Worm Phenotype (WP)embryonic development variant0--Direct
Worm Phenotype (WP)hermaphrodite fertility variant0--Direct
Worm Phenotype (WP)hermaphrodite fertility reduced0--Direct
Worm Phenotype (WP)fertility reduced0--Direct
Worm Phenotype (WP)axon branching variant0.000007394--Direct
Worm Phenotype (WP)neurite morphology variant0.0005623--Direct
Worm Phenotype (WP)neuronal outgrowth variant0.0009485--Direct
Worm Phenotype (WP)neuron morphology variant0.001584--Inherited
Worm Phenotype (WP)neuron development variant0.01984--Inherited
Worm Phenotype (WP)nervous system morphology variant0.02776--Inherited
Worm Phenotype (WP)cell component morphology variant0.1316--Inherited
Worm Phenotype (WP)organ system morphology variant0.2398--Inherited
Worm Phenotype (WP)cell morphology variant0.2513--Inherited
Worm Phenotype (WP)physiology variant1--Inherited
Worm Phenotype (WP)sterile1--Inherited
Worm Phenotype (WP)cell development variant0.1194Least InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.1018Moderately InformativeInherited
Worm Phenotype (WP)axon outgrowth variant0.000835InformativeDirect
Worm Phenotype (WP)axon morphology variant0.0004056Highly InformativeDirect

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YP

Yeast Phenotype (YP)

YP term FDR (all) SDYP (four levels) Annotation (direct or inherited)
Yeast Phenotype (YP)cellular processes0--Direct
Yeast Phenotype (YP)stress resistance0--Direct

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FP

Fly Phenotype (FP)

FP term FDR (all) SDFP (four levels) Annotation (direct or inherited)
Fly Phenotype (FP)phenotype0--Direct
Fly Phenotype (FP)increased mortality during development0--Direct
Fly Phenotype (FP)increased mortality0Least InformativeDirect

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FA

Fly Anatomy (FA)

FA term FDR (all) SDFA (four levels) Annotation (direct or inherited)
Fly Anatomy (FA)organism0--Direct
Fly Anatomy (FA)organ system0--Direct
Fly Anatomy (FA)organism subdivision0--Direct
Fly Anatomy (FA)multicellular structure0--Direct
Fly Anatomy (FA)anatomical structure1--Inherited
Fly Anatomy (FA)material anatomical entity1--Inherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1--Inherited
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)developing material anatomical entity0Moderately InformativeDirect

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ZA

Zebrafish Anatomy (ZA)

ZA term FDR (all) SDZA (four levels) Annotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0--Direct
Zebrafish Anatomy (ZA)whole organism0--Direct
Zebrafish Anatomy (ZA)anatomical system0--Direct
Zebrafish Anatomy (ZA)anatomical group0--Direct
Zebrafish Anatomy (ZA)anatomical structure1--Inherited
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

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XA

Xenopus Anatomy (XA)

XA term FDR (all) SDXA (four levels) Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)anatomical structure0--Direct

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AP

Arabidopsis Plant Ontology (AP)

AP term FDR (all) SDAP (four levels) Annotation (direct or inherited)
Plant ANatomical entity (PAN)plant cell0--Direct
Plant ANatomical entity (PAN)shoot system0--Direct
Plant ANatomical entity (PAN)collective plant structure0--Direct
Plant ANatomical entity (PAN)gamete0.0001529--Direct
Plant ANatomical entity (PAN)plant structure1--Inherited
Plant ANatomical entity (PAN)collective plant organ structure1--Inherited
Plant ANatomical entity (PAN)plant sperm cell0.00003632InformativeDirect
 
AP term FDR (all) SDAP (four levels) Annotation (direct or inherited)
Plant structure DEvelopment stage (PDE)whole plant development stage0--Direct
Plant structure DEvelopment stage (PDE)sporophyte vegetative stage0--Direct
Plant structure DEvelopment stage (PDE)plant embryo stage0--Direct
Plant structure DEvelopment stage (PDE)life of whole plant stage1--Inherited
Plant structure DEvelopment stage (PDE)sporophyte development stage1--Inherited
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect

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EC

Enzyme Commission (EC)

EC term FDR (all) SDEC (four levels) Annotation (direct or inherited)
Enzyme Commission (EC)With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen0--Direct
Enzyme Commission (EC)Zeaxanthin epoxidase0--Direct
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0--Direct
Enzyme Commission (EC)Exodeoxyribonucleases producing 5'-phosphomonoesters0--Direct
Enzyme Commission (EC)Adenosine-5'-diphospho-5'-(DNA) diphosphatase0--Direct
Enzyme Commission (EC)Exodeoxyribonucleases producing 3'-phosphomonoesters0--Direct
Enzyme Commission (EC)Non-specific serine/threonine protein kinase3.693e-16--Direct
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0.00004533--Direct
Enzyme Commission (EC)Transferring phosphorus-containing groups0.1469--Inherited
Enzyme Commission (EC)Carbon-oxygen lyases0.4542--Inherited
Enzyme Commission (EC)Transferases0.00003283Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.0958Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.6136Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0.00000001286Moderately InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.00000005402Moderately InformativeDirect
Enzyme Commission (EC)Lyases1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.000000000002195InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.0000001024InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0.00006781Highly InformativeDirect

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CD

CTD Diseases (CD)

CD term FDR (all) SDCD (four levels) Annotation (direct or inherited)
CTD Diseases (CD)Ataxia0.0007914--Direct
CTD Diseases (CD)Dyskinesias0.01837--Inherited
CTD Diseases (CD)Central Nervous System Diseases0.08653--Inherited
CTD Diseases (CD)Neurologic Manifestations0.1392--Inherited
CTD Diseases (CD)Nutritional and Metabolic Diseases0.1439--Inherited
CTD Diseases (CD)Metabolic Diseases0.1184Least InformativeInherited
CTD Diseases (CD)Nervous System Diseases0.2803Least InformativeInherited
CTD Diseases (CD)Pathological Conditions, Signs and Symptoms0.4348Least InformativeInherited
CTD Diseases (CD)Neuromuscular Diseases0.01771Moderately InformativeInherited
CTD Diseases (CD)Signs and Symptoms0.2965Moderately InformativeInherited
CTD Diseases (CD)Peripheral Nervous System Diseases0.0005928InformativeDirect
CTD Diseases (CD)Movement Disorders0.01223InformativeInherited
CTD Diseases (CD)DNA Repair-Deficiency Disorders0.000361Highly InformativeDirect

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CC

CTD Chemicals (CC)

CC term FDR (all) SDCC (four levels) Annotation (direct or inherited)
CTD Chemicals (CC)Inorganic Chemicals0--Direct
CTD Chemicals (CC)Organic Chemicals0--Direct
CTD Chemicals (CC)Palmitic Acid0.00004183--Direct
CTD Chemicals (CC)Oligodeoxyribonucleotides0.00005968--Direct
CTD Chemicals (CC)Pyrogallol0.00006584--Direct
CTD Chemicals (CC)fludarabine0.0001258--Direct
CTD Chemicals (CC)Oligonucleotides0.0001307--Direct
CTD Chemicals (CC)Vidarabine0.0001334--Direct
CTD Chemicals (CC)Palmitic Acids0.0001374--Direct
CTD Chemicals (CC)Polynucleotides0.0004693--Direct
CTD Chemicals (CC)myristicin0.0006209--Direct
CTD Chemicals (CC)Benzyl Compounds0.007324--Inherited
CTD Chemicals (CC)Fatty Acids0.1052--Inherited
CTD Chemicals (CC)Nucleotides0.1469--Inherited
CTD Chemicals (CC)Ribonucleosides0.1546--Inherited
CTD Chemicals (CC)Heterocyclic Compounds, Fused-Ring0.186--Inherited
CTD Chemicals (CC)Lipids0.1928--Inherited
CTD Chemicals (CC)Glycosides0.2639--Inherited
CTD Chemicals (CC)Hydrocarbons, Aromatic0.3934--Inherited
CTD Chemicals (CC)Heterocyclic Compounds0.4295--Inherited
CTD Chemicals (CC)Hydrocarbons0.43--Inherited
CTD Chemicals (CC)Nucleic Acids, Nucleotides, and Nucleosides0.7269--Inherited
CTD Chemicals (CC)Heterocyclic Compounds, 1-Ring0.7595--Inherited
CTD Chemicals (CC)Hydrocarbons, Cyclic0.8063--Inherited
CTD Chemicals (CC)Heterocyclic Compounds, 2-Ring0.8662--Inherited
CTD Chemicals (CC)Benzene Derivatives0.9731--Inherited
CTD Chemicals (CC)Carbohydrates0.3557Least InformativeInherited
CTD Chemicals (CC)Phenols0.7866Least InformativeInherited
CTD Chemicals (CC)Purines0.5469Moderately InformativeInherited
CTD Chemicals (CC)Nucleosides0.8633Moderately InformativeInherited
CTD Chemicals (CC)Purine Nucleosides0.04811InformativeInherited
CTD Chemicals (CC)Dioxoles0.6902InformativeInherited
CTD Chemicals (CC)CPG-oligonucleotide0.00003212Highly InformativeDirect
CTD Chemicals (CC)Dioxolanes0.0001958Highly InformativeDirect
CTD Chemicals (CC)Arabinonucleosides0.0734Highly InformativeInherited
CTD Chemicals (CC)Adenosine0.08876Highly InformativeInherited

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Distribution on sTOL

Plot distribution on species Tree Of Life (sTOL) for this domain, i.e., present or absent across genomes/tips
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