PDZ domain-like superfamily

DO

Disease Ontology (DO)

	DO term	FDR (all)	SDDO (four levels)	Annotation (direct or inherited)
Disease Ontology (DO)	Usher syndrome	0.0001921	--	Direct
Disease Ontology (DO)	monogenic disease	0.8569	--	Inherited
Disease Ontology (DO)	autosomal genetic disease	0.9009	--	Inherited
Disease Ontology (DO)	genetic disease	0.4856	Moderately Informative	Inherited
Disease Ontology (DO)	autosomal recessive disease	0.2182	Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

HP

Human Phenotype (HP)

HP term	FDR (all)	SDHP (four levels)	Annotation (direct or inherited)
Variable expressivity	0	--	Direct
Phenotypic variability	1	--	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

MP

Mouse Phenotype (MP)

	MP term	FDR (all)	SDMP (four levels)	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal synaptic transmission	0.0000038	--	Direct
Mammalian Phenotype (MP)	abnormal behavioral response to addictive substance	0.0001597	--	Direct
Mammalian Phenotype (MP)	decreased vocalization	0.0003189	--	Direct
Mammalian Phenotype (MP)	abnormal vocalization	0.01302	--	Inherited
Mammalian Phenotype (MP)	abnormal hair cell morphology	0.01339	--	Inherited
Mammalian Phenotype (MP)	abnormal cochlear sensory epithelium morphology	0.01339	--	Inherited
Mammalian Phenotype (MP)	abnormal organ of Corti morphology	0.01376	--	Inherited
Mammalian Phenotype (MP)	abnormal scala media morphology	0.02394	--	Inherited
Mammalian Phenotype (MP)	abnormal cochlear labyrinth morphology	0.02394	--	Inherited
Mammalian Phenotype (MP)	abnormal cochlea morphology	0.03216	--	Inherited
Mammalian Phenotype (MP)	abnormal membranous labyrinth morphology	0.04204	--	Inherited
Mammalian Phenotype (MP)	abnormal mechanoreceptor morphology	0.04731	--	Inherited
Mammalian Phenotype (MP)	abnormal inner ear morphology	0.07433	--	Inherited
Mammalian Phenotype (MP)	abnormal ear morphology	0.1994	--	Inherited
Mammalian Phenotype (MP)	behavior/neurological phenotype	0.2211	--	Inherited
Mammalian Phenotype (MP)	abnormal somatic sensory system morphology	0.4125	--	Inherited
Mammalian Phenotype (MP)	abnormal embryonic tissue morphology	0.4368	--	Inherited
Mammalian Phenotype (MP)	abnormal embryo morphology	0.6639	--	Inherited
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.927	--	Inherited
Mammalian Phenotype (MP)	nervous system phenotype	0.00000341	Least Informative	Direct
Mammalian Phenotype (MP)	abnormal nervous system physiology	0.1511	Moderately Informative	Inherited
Mammalian Phenotype (MP)	hearing/vestibular/ear phenotype	0.3614	Moderately Informative	Inherited
Mammalian Phenotype (MP)	embryo phenotype	0.777	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal somatic nervous system morphology	0.8304	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal nervous system development	0.8992	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal behavior	1	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal cochlear hair cell morphology	0.01119	Informative	Inherited
Mammalian Phenotype (MP)	abnormal behavioral response to xenobiotic	0.08961	Informative	Inherited
Mammalian Phenotype (MP)	abnormal neural tube morphology	0.5527	Informative	Inherited
Mammalian Phenotype (MP)	craniorachischisis	0.0001179	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal cochlear hair cell stereociliary bundle morphology	0.0002623	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

WP

Worm Phenotype (WP)

	WP term	FDR (all)	SDWP (four levels)	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	--	Direct
Worm Phenotype (WP)	lethal	0	--	Direct
Worm Phenotype (WP)	development variant	0	--	Direct
Worm Phenotype (WP)	morphology variant	0	--	Direct
Worm Phenotype (WP)	organism development variant	0	--	Direct
Worm Phenotype (WP)	organism morphology variant	0	--	Direct
Worm Phenotype (WP)	organ system physiology variant	0	--	Direct
Worm Phenotype (WP)	embryonic development variant	0	--	Direct
Worm Phenotype (WP)	cell junction variant	0.0000009799	--	Direct
Worm Phenotype (WP)	presynaptic region physiology variant	0.00001274	--	Direct
Worm Phenotype (WP)	population fitness variant	0.00004421	--	Direct
Worm Phenotype (WP)	cell membrane morphology variant	0.00008569	--	Direct
Worm Phenotype (WP)	epithelial morphology variant	0.0001062	--	Direct
Worm Phenotype (WP)	body behavior variant	0.0001373	--	Direct
Worm Phenotype (WP)	transmission of nerve impulse variant	0.0001693	--	Direct
Worm Phenotype (WP)	organism segment behavior variant	0.0002184	--	Direct
Worm Phenotype (WP)	muscle system physiology variant	0.0002396	--	Direct
Worm Phenotype (WP)	acetylcholinesterase inhibitor response variant	0.0002493	--	Direct
Worm Phenotype (WP)	excess seam cells	0.0002625	--	Direct
Worm Phenotype (WP)	synaptogenesis variant	0.0003961	--	Direct
Worm Phenotype (WP)	fewer seam cells	0.0004327	--	Direct
Worm Phenotype (WP)	epithelial system morphology variant	0.0005445	--	Direct
Worm Phenotype (WP)	ventral enclosure variant	0.0006452	--	Direct
Worm Phenotype (WP)	organism region behavior variant	0.0008084	--	Direct
Worm Phenotype (WP)	organelle organization biogenesis variant	0.00469	--	Inherited
Worm Phenotype (WP)	organ system development variant	0.006821	--	Inherited
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.007203	--	Inherited
Worm Phenotype (WP)	organism physiology variant	0.009221	--	Inherited
Worm Phenotype (WP)	muscle dystrophy	0.0113	--	Inherited
Worm Phenotype (WP)	gene expression variant	0.06917	--	Inherited
Worm Phenotype (WP)	behavior variant	0.09133	--	Inherited
Worm Phenotype (WP)	chemical response variant	0.1371	--	Inherited
Worm Phenotype (WP)	cell component morphology variant	0.1727	--	Inherited
Worm Phenotype (WP)	cell number variant	0.217	--	Inherited
Worm Phenotype (WP)	nervous system development variant	0.3213	--	Inherited
Worm Phenotype (WP)	cell type morphology variant	0.9162	--	Inherited
Worm Phenotype (WP)	physiology variant	1	--	Inherited
Worm Phenotype (WP)	cell development variant	0.004731	Least Informative	Inherited
Worm Phenotype (WP)	cell morphology variant	0.009595	Least Informative	Inherited
Worm Phenotype (WP)	organ system morphology variant	0.03161	Least Informative	Inherited
Worm Phenotype (WP)	organism behavior variant	0.08539	Least Informative	Inherited
Worm Phenotype (WP)	cell physiology variant	0.1639	Least Informative	Inherited
Worm Phenotype (WP)	organism metabolism processing variant	0.4984	Least Informative	Inherited
Worm Phenotype (WP)	organism environmental stimulus response variant	0.7837	Least Informative	Inherited
Worm Phenotype (WP)	protein expression variant	0.0006695	Moderately Informative	Direct
Worm Phenotype (WP)	drug response variant	0.003208	Moderately Informative	Inherited
Worm Phenotype (WP)	neuron development variant	0.007982	Moderately Informative	Inherited
Worm Phenotype (WP)	nervous system morphology variant	0.02156	Moderately Informative	Inherited
Worm Phenotype (WP)	cell organization biogenesis variant	0.52	Moderately Informative	Inherited
Worm Phenotype (WP)	germ cell morphology variant	0.557	Moderately Informative	Inherited
Worm Phenotype (WP)	cell division variant	0.8364	Moderately Informative	Inherited
Worm Phenotype (WP)	aldicarb response variant	0.000004045	Informative	Direct
Worm Phenotype (WP)	chemical resistant	0.0001879	Informative	Direct
Worm Phenotype (WP)	drug resistant	0.0005288	Informative	Direct
Worm Phenotype (WP)	cytoskeleton organization biogenesis variant	0.005956	Informative	Inherited
Worm Phenotype (WP)	nervous system physiology variant	0.008787	Informative	Inherited
Worm Phenotype (WP)	cell number increased	0.1018	Informative	Inherited
Worm Phenotype (WP)	epithelial system development variant	0.6436	Informative	Inherited
Worm Phenotype (WP)	oocyte morphology variant	0.9132	Informative	Inherited
Worm Phenotype (WP)	cell polarity variant	0.000001805	Highly Informative	Direct
Worm Phenotype (WP)	synapse morphology variant	0.000004519	Highly Informative	Direct
Worm Phenotype (WP)	actin organization biogenesis variant	0.000004779	Highly Informative	Direct
Worm Phenotype (WP)	gastrulation variant	0.00004792	Highly Informative	Direct
Worm Phenotype (WP)	body muscle dystrophy	0.00005076	Highly Informative	Direct
Worm Phenotype (WP)	body elongation variant	0.0003499	Highly Informative	Direct
Worm Phenotype (WP)	cell division polarity variant	0.0004139	Highly Informative	Direct
Worm Phenotype (WP)	ovulation variant	0.0004335	Highly Informative	Direct
Worm Phenotype (WP)	endomitotic oocytes	0.0007092	Highly Informative	Direct
Worm Phenotype (WP)	epithelial development variant	0.009502	Highly Informative	Inherited
Worm Phenotype (WP)	synaptic transmission variant	0.01939	Highly Informative	Inherited
Worm Phenotype (WP)	cell number decreased	0.04081	Highly Informative	Inherited

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FP

Fly Phenotype (FP)

	FP term	FDR (all)	SDFP (four levels)	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0.09537	--	Inherited
Fly Phenotype (FP)	cell polarity defective	0.0009457	Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

FA

Fly Anatomy (FA)

	FA term	FDR (all)	SDFA (four levels)	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	--	Direct
Fly Anatomy (FA)	organ system	0	--	Direct
Fly Anatomy (FA)	multicellular structure	0	--	Direct
Fly Anatomy (FA)	anatomical structure	1	--	Inherited
Fly Anatomy (FA)	material anatomical entity	1	--	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

ZA

Zebrafish Anatomy (ZA)

	ZA term	FDR (all)	SDZA (four levels)	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	--	Direct
Zebrafish Anatomy (ZA)	central canal	0.00003094	--	Direct
Zebrafish Anatomy (ZA)	neural rod	0.00009911	--	Direct
Zebrafish Anatomy (ZA)	neuroepithelial cell	0.0006806	--	Direct
Zebrafish Anatomy (ZA)	ventricular system	0.07517	--	Inherited
Zebrafish Anatomy (ZA)	anatomical group	0.3355	--	Inherited
Zebrafish Anatomy (ZA)	cavitated compound organ	0.5191	--	Inherited
Zebrafish Anatomy (ZA)	anatomical system	0.7163	--	Inherited
Zebrafish Anatomy (ZA)	anatomical structure	1	--	Inherited
Zebrafish Anatomy (ZA)	multi-tissue structure	0.1774	Least Informative	Inherited
Zebrafish Anatomy (ZA)	nervous system	0.453	Least Informative	Inherited
Zebrafish Anatomy (ZA)	compound organ	0.6585	Least Informative	Inherited
Zebrafish Anatomy (ZA)	cell	0.9517	Least Informative	Inherited
Zebrafish Anatomy (ZA)	portion of tissue	0.3787	Moderately Informative	Inherited
Zebrafish Anatomy (ZA)	central nervous system	0.7391	Moderately Informative	Inherited
Zebrafish Anatomy (ZA)	spinal cord	0.006205	Highly Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

XA

Xenopus Anatomy (XA)

	XA term	FDR (all)	SDXA (four levels)	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	--	Direct

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AP

Arabidopsis Plant Ontology (AP)

	AP term	FDR (all)	SDAP (four levels)	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	shoot apex	0	--	Direct
Plant ANatomical entity (PAN)	phyllome	0	--	Direct
Plant ANatomical entity (PAN)	shoot system	0	--	Direct
Plant ANatomical entity (PAN)	plant organ	0	--	Direct
Plant ANatomical entity (PAN)	vascular leaf	0	--	Direct
Plant ANatomical entity (PAN)	plant axis	0	--	Direct
Plant ANatomical entity (PAN)	reproductive shoot system	0	--	Direct
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	--	Direct
Plant ANatomical entity (PAN)	collective plant structure	0	--	Direct
Plant ANatomical entity (PAN)	plant structure	1	--	Inherited
Plant ANatomical entity (PAN)	collective plant organ structure	1	--	Inherited
Plant ANatomical entity (PAN)	flower	0	Least Informative	Direct
Plant ANatomical entity (PAN)	collective phyllome structure	0	Least Informative	Direct
Plant ANatomical entity (PAN)	shoot axis	0	Least Informative	Direct
Plant ANatomical entity (PAN)	leaf	0	Least Informative	Direct

	AP term	FDR (all)	SDAP (four levels)	Annotation (direct or inherited)
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	corolla development stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	--	Direct
Plant structure DEvelopment stage (PDE)	flower development stage	1	--	Inherited
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	--	Inherited
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	--	Inherited
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	--	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

EC

Enzyme Commission (EC)

	EC term	FDR (all)	SDEC (four levels)	Annotation (direct or inherited)
Enzyme Commission (EC)	C-terminal processing peptidase	0	--	Direct
Enzyme Commission (EC)	Peptidase Do	0	--	Direct
Enzyme Commission (EC)	HtrA2 peptidase	0	--	Direct
Enzyme Commission (EC)	S2P endopeptidase	0	--	Direct
Enzyme Commission (EC)	Nitric-oxide synthase (NADPH)	0.0000000000002089	--	Direct
Enzyme Commission (EC)	Acyltransferases	0.332	--	Inherited
Enzyme Commission (EC)	Transferases	1	--	Inherited
Enzyme Commission (EC)	Acting on ester bonds	1	--	Inherited
Enzyme Commission (EC)	Hydrolases	0	Least Informative	Direct
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0.01085	Least Informative	Inherited
Enzyme Commission (EC)	Oxidoreductases	1	Least Informative	Inherited
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	Moderately Informative	Direct
Enzyme Commission (EC)	Acting on peptide bonds (peptidases)	0	Moderately Informative	Direct
Enzyme Commission (EC)	Aminoacyltransferases	0.0005318	Moderately Informative	Direct
Enzyme Commission (EC)	Phosphoric monoester hydrolases	0.0008281	Moderately Informative	Direct
Enzyme Commission (EC)	Serine endopeptidases	0	Informative	Direct
Enzyme Commission (EC)	Protein-tyrosine-phosphatase	0.0000000009357	Informative	Direct
Enzyme Commission (EC)	RING-type E3 ubiquitin transferase	0.0000152	Informative	Direct
Enzyme Commission (EC)	Non-specific serine/threonine protein kinase	0.0004172	Informative	Direct
Enzyme Commission (EC)	Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate	0.001853	Informative	Inherited
Enzyme Commission (EC)	Metalloendopeptidases	0.2857	Informative	Inherited
Enzyme Commission (EC)	With NADH or NADPH as one donor, and incorporation of one atom of oxygen	0.0000002543	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

CD

CTD Diseases (CD)

	CD term	FDR (all)	SDCD (four levels)	Annotation (direct or inherited)
CTD Diseases (CD)	Deaf-Blind Disorders	0.0003492	--	Direct
CTD Diseases (CD)	Usher Syndromes	0.0008965	--	Direct
CTD Diseases (CD)	Vision Disorders	0.001805	--	Inherited
CTD Diseases (CD)	Retinal Degeneration	0.047	--	Inherited
CTD Diseases (CD)	Blindness	0.06002	--	Inherited
CTD Diseases (CD)	Retinal Diseases	0.114	--	Inherited
CTD Diseases (CD)	Sensation Disorders	0.116	--	Inherited
CTD Diseases (CD)	Otorhinolaryngologic Diseases	0.1229	--	Inherited
CTD Diseases (CD)	Hearing Loss, Sensorineural	0.1292	--	Inherited
CTD Diseases (CD)	Deafness	0.2017	--	Inherited
CTD Diseases (CD)	Eye Diseases, Hereditary	0.2318	--	Inherited
CTD Diseases (CD)	Hearing Disorders	0.24	--	Inherited
CTD Diseases (CD)	Ear Diseases	0.2526	--	Inherited
CTD Diseases (CD)	Retinal Dystrophies	0.2906	--	Inherited
CTD Diseases (CD)	Signs and Symptoms	0.4295	--	Inherited
CTD Diseases (CD)	Congenital, Hereditary, and Neonatal Diseases and Abnormalities	0.9677	--	Inherited
CTD Diseases (CD)	Nervous System Diseases	0.7835	Least Informative	Inherited
CTD Diseases (CD)	Pathological Conditions, Signs and Symptoms	0.7995	Least Informative	Inherited
CTD Diseases (CD)	Genetic Diseases, Inborn	0.8792	Least Informative	Inherited
CTD Diseases (CD)	Neurologic Manifestations	0.2227	Moderately Informative	Inherited
CTD Diseases (CD)	Congenital Abnormalities	0.7955	Moderately Informative	Inherited
CTD Diseases (CD)	Eye Diseases	0.4999	Informative	Inherited
CTD Diseases (CD)	Abnormalities, Multiple	0.722	Informative	Inherited
CTD Diseases (CD)	Retinitis Pigmentosa	0.034	Highly Informative	Inherited
CTD Diseases (CD)	Hearing Loss	0.05836	Highly Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

CC

CTD Chemicals (CC)

	CC term	FDR (all)	SDCC (four levels)	Annotation (direct or inherited)
CTD Chemicals (CC)	Heterocyclic Compounds	0	--	Direct
CTD Chemicals (CC)	Heterocyclic Compounds, 2-Ring	0.0004052	--	Direct
CTD Chemicals (CC)	Polyamines	0.002203	--	Inherited
CTD Chemicals (CC)	Polycyclic Compounds	0.002741	--	Inherited
CTD Chemicals (CC)	Hydrocarbons	0.04993	--	Inherited
CTD Chemicals (CC)	Mycotoxins	0.0589	--	Inherited
CTD Chemicals (CC)	Heterocyclic Compounds, Fused-Ring	0.1557	--	Inherited
CTD Chemicals (CC)	Pyrans	0.1659	--	Inherited
CTD Chemicals (CC)	Toxins, Biological	0.1775	--	Inherited
CTD Chemicals (CC)	Heterocyclic Compounds, 1-Ring	0.4109	--	Inherited
CTD Chemicals (CC)	Organic Chemicals	0.4999	--	Inherited
CTD Chemicals (CC)	Pyrenes	0.5301	--	Inherited
CTD Chemicals (CC)	Hydrocarbons, Cyclic	0.5414	--	Inherited
CTD Chemicals (CC)	Hydrocarbons, Aromatic	0.6985	--	Inherited
CTD Chemicals (CC)	Polycyclic Aromatic Hydrocarbons	0.0006516	Least Informative	Direct
CTD Chemicals (CC)	Amines	0.01161	Least Informative	Inherited
CTD Chemicals (CC)	Biological Factors	0.213	Least Informative	Inherited
CTD Chemicals (CC)	Benzopyrans	0.4501	Least Informative	Inherited
CTD Chemicals (CC)	Diamines	0.00009503	Moderately Informative	Direct
CTD Chemicals (CC)	Benzopyrenes	0.006355	Moderately Informative	Inherited
CTD Chemicals (CC)	Pyridines	0.01345	Moderately Informative	Inherited
CTD Chemicals (CC)	Aflatoxins	0.1325	Moderately Informative	Inherited
CTD Chemicals (CC)	aflatoxin B2	0.0005774	Informative	Direct
CTD Chemicals (CC)	Aminopyridines	0.0009052	Informative	Direct
CTD Chemicals (CC)	benzo(e)pyrene	0.0003028	Highly Informative	Direct

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Distribution on sTOL

Plot distribution on species Tree Of Life (sTOL) for this domain, i.e., present or absent across genomes/tips

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PDZ domain-like superfamily