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Glutathione synthetase ATP-binding domain-like superfamily

Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ATP-grasp [ 56058] (2)
Superfamily:   Glutathione synthetase ATP-binding domain-like [ 56059] (9)
Families:   ATP-binding domain of peptide synthetases [ 56060] (3)
  Lysine biosynthesis enzyme LysX ATP-binding domain [ 103281]
  BC ATP-binding domain-like [ 56067] (6)
  Synapsin C-terminal domain [ 56078] (2)
  Succinyl-CoA synthetase, beta-chain, N-terminal domain [ 56081]
  Pyruvate phosphate dikinase, N-terminal domain [ 56085]
  Eukaryotic glutathione synthetase ATP-binding domain [ 56088]
  Glutathionylspermidine synthase ATP-binding domain-like [ 143890]
  PurP ATP-binding domain-like [ 160804]

HP

Human Phenotype (HP)

HP term FDR (all) SDHP (four levels) Annotation (direct or inherited)
Phenotypic Abnormality (PA)Hyperammonemia0.000009123--Direct
Phenotypic Abnormality (PA)Abnormal circulating carboxylic acid concentration0.0001961--Direct
Phenotypic Abnormality (PA)Abnormal circulating nitrogen compound concentration0.002371--Inherited
Phenotypic Abnormality (PA)Abnormality of urine homeostasis0.02139--Inherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.04812--Inherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.12--Inherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.3152Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.3319Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.00001505Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.0083Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.04937Moderately InformativeInherited
Phenotypic Abnormality (PA)Aciduria0.0001477InformativeDirect
Phenotypic Abnormality (PA)Azotemia0.0002641InformativeDirect

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MP

Mouse Phenotype (MP)

MP term FDR (all) SDMP (four levels) Annotation (direct or inherited)
Mammalian Phenotype (MP)increased synaptic depression0.000006939--Direct
Mammalian Phenotype (MP)environmentally induced seizures0.0001198--Direct
Mammalian Phenotype (MP)abnormal brain wave pattern0.0006442--Direct
Mammalian Phenotype (MP)convulsive seizures0.006728--Inherited
Mammalian Phenotype (MP)abnormal synaptic transmission0.2114--Inherited
Mammalian Phenotype (MP)behavior/neurological phenotype0.2712--Inherited
Mammalian Phenotype (MP)nervous system phenotype0.8774Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.7784Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)seizures0.05356InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.1663InformativeInherited
Mammalian Phenotype (MP)tonic-clonic seizures0.0006188Highly InformativeDirect
Mammalian Phenotype (MP)abnormal synaptic depression0.003176Highly InformativeInherited
Mammalian Phenotype (MP)abnormal seizure response to inducing agent0.009254Highly InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system electrophysiology0.04197Highly InformativeInherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

WP

Worm Phenotype (WP)

WP term FDR (all) SDWP (four levels) Annotation (direct or inherited)
Worm Phenotype (WP)embryonic lethal0--Direct
Worm Phenotype (WP)lethal0--Direct
Worm Phenotype (WP)fertility variant0--Direct
Worm Phenotype (WP)development variant0--Direct
Worm Phenotype (WP)morphology variant0--Direct
Worm Phenotype (WP)organism development variant0--Direct
Worm Phenotype (WP)organ system physiology variant0--Direct
Worm Phenotype (WP)organism physiology variant0--Direct
Worm Phenotype (WP)organism homeostasis metabolism variant0--Direct
Worm Phenotype (WP)reproductive system physiology variant0--Direct
Worm Phenotype (WP)embryonic development variant0--Direct
Worm Phenotype (WP)hermaphrodite fertility variant0--Direct
Worm Phenotype (WP)amphid neuron dye filling defect0.0000000002177--Direct
Worm Phenotype (WP)amphid neuron morphology variant0.000000009626--Direct
Worm Phenotype (WP)negative chemotaxis variant0.0000004406--Direct
Worm Phenotype (WP)copulation variant0.000002901--Direct
Worm Phenotype (WP)sexually dimorphic behavior variant0.000002977--Direct
Worm Phenotype (WP)amphid phasmid neuron morphology variant0.00002388--Direct
Worm Phenotype (WP)chemosensory behavior variant0.0000897--Direct
Worm Phenotype (WP)amphid phasmid sensillum morphology variant0.0000988--Direct
Worm Phenotype (WP)body wall muscle myosin organization defective0.0002621--Direct
Worm Phenotype (WP)male mating efficiency reduced0.0005891--Direct
Worm Phenotype (WP)organism pigmentation variant0.001798--Inherited
Worm Phenotype (WP)chemosensory response variant0.002601--Inherited
Worm Phenotype (WP)striated muscle morphology variant0.021--Inherited
Worm Phenotype (WP)muscle cell morphology variant0.05124--Inherited
Worm Phenotype (WP)behavior variant0.1703--Inherited
Worm Phenotype (WP)chemical response variant0.2424--Inherited
Worm Phenotype (WP)muscle system morphology variant0.2871--Inherited
Worm Phenotype (WP)cell type morphology variant0.6246--Inherited
Worm Phenotype (WP)physiology variant1--Inherited
Worm Phenotype (WP)male behavior variant1--Inherited
Worm Phenotype (WP)body wall muscle morphology variant1--Inherited
Worm Phenotype (WP)organ system morphology variant0.000799Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.004754Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.1041Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.1648Least InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.0868Moderately InformativeInherited
Worm Phenotype (WP)male mating variant0.000002681InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.00003581InformativeDirect
Worm Phenotype (WP)pigmentation variant0.002592InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.01719InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.09338InformativeInherited
Worm Phenotype (WP)osmotic avoidance variant0.00000001899Highly InformativeDirect
Worm Phenotype (WP)dye filling defect0.00001538Highly InformativeDirect
Worm Phenotype (WP)clear0.00009858Highly InformativeDirect
Worm Phenotype (WP)body wall muscle thick filament variant0.0002807Highly InformativeDirect

LINKTO: Domain2BO Download and Domain2BO Algorithm

YP

Yeast Phenotype (YP)

YP term FDR (all) SDYP (four levels) Annotation (direct or inherited)
Yeast Phenotype (YP)cellular processes0--Direct
Yeast Phenotype (YP)stress resistance0--Direct
Yeast Phenotype (YP)competitive fitness0--Direct
Yeast Phenotype (YP)fitness0--Direct
Yeast Phenotype (YP)prion state0.0003629--Direct
Yeast Phenotype (YP)metabolism and growth0.3189Least InformativeInherited
Yeast Phenotype (YP)nutrient utilization0.2944Moderately InformativeInherited
Yeast Phenotype (YP)utilization of nitrogen source0.0006524InformativeDirect
Yeast Phenotype (YP)prion formation0.0002569Highly InformativeDirect

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FA

Fly Anatomy (FA)

FA term FDR (all) SDFA (four levels) Annotation (direct or inherited)
Fly Anatomy (FA)organism0--Direct
Fly Anatomy (FA)multicellular structure0--Direct
Fly Anatomy (FA)anatomical structure1--Inherited
Fly Anatomy (FA)material anatomical entity1--Inherited

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ZA

Zebrafish Anatomy (ZA)

ZA term FDR (all) SDZA (four levels) Annotation (direct or inherited)
Zebrafish Anatomy (ZA)whole organism0--Direct
Zebrafish Anatomy (ZA)anatomical system0--Direct
Zebrafish Anatomy (ZA)cavitated compound organ0--Direct
Zebrafish Anatomy (ZA)anatomical group0--Direct
Zebrafish Anatomy (ZA)anatomical structure1--Inherited
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cardiovascular system0Moderately InformativeDirect
Zebrafish Anatomy (ZA)sensory system0Moderately InformativeDirect
Zebrafish Anatomy (ZA)portion of tissue0Moderately InformativeDirect
Zebrafish Anatomy (ZA)anatomical cluster0Moderately InformativeDirect
Zebrafish Anatomy (ZA)post-vent region0InformativeDirect
Zebrafish Anatomy (ZA)pericardial region0InformativeDirect
Zebrafish Anatomy (ZA)heart0Highly InformativeDirect

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XA

Xenopus Anatomy (XA)

XA term FDR (all) SDXA (four levels) Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)anatomical structure0--Direct

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AP

Arabidopsis Plant Ontology (AP)

AP term FDR (all) SDAP (four levels) Annotation (direct or inherited)
Plant ANatomical entity (PAN)stomatal complex0--Direct
Plant ANatomical entity (PAN)epidermal cell0--Direct
Plant ANatomical entity (PAN)epidermis0--Direct
Plant ANatomical entity (PAN)shoot epidermis0--Direct
Plant ANatomical entity (PAN)plant cell0--Direct
Plant ANatomical entity (PAN)shoot system0--Direct
Plant ANatomical entity (PAN)portion of plant tissue0--Direct
Plant ANatomical entity (PAN)shoot epidermal cell0--Direct
Plant ANatomical entity (PAN)collective plant structure0--Direct
Plant ANatomical entity (PAN)petal0.0003652--Direct
Plant ANatomical entity (PAN)corolla0.0003652--Direct
Plant ANatomical entity (PAN)cauline leaf0.000389--Direct
Plant ANatomical entity (PAN)plant embryo0.0004686--Direct
Plant ANatomical entity (PAN)perianth0.002042--Inherited
Plant ANatomical entity (PAN)vascular leaf0.008289--Inherited
Plant ANatomical entity (PAN)phyllome0.02868--Inherited
Plant ANatomical entity (PAN)reproductive shoot system0.04415--Inherited
Plant ANatomical entity (PAN)plant organ0.08609--Inherited
Plant ANatomical entity (PAN)multi-tissue plant structure0.09637--Inherited
Plant ANatomical entity (PAN)plant structure1--Inherited
Plant ANatomical entity (PAN)collective plant organ structure1--Inherited
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.005276Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure0.009628Least InformativeInherited
Plant ANatomical entity (PAN)flower0.01653Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.1357Least InformativeInherited
 
AP term FDR (all) SDAP (four levels) Annotation (direct or inherited)
Plant structure DEvelopment stage (PDE)whole plant development stage0--Direct
Plant structure DEvelopment stage (PDE)sporophyte vegetative stage0--Direct
Plant structure DEvelopment stage (PDE)floral organ differentiation stage0--Direct
Plant structure DEvelopment stage (PDE)corolla development stage0--Direct
Plant structure DEvelopment stage (PDE)flowering stage0--Direct
Plant structure DEvelopment stage (PDE)plant embryo stage0--Direct
Plant structure DEvelopment stage (PDE)collective plant organ structure development stage0--Direct
Plant structure DEvelopment stage (PDE)plant organ development stage0--Direct
Plant structure DEvelopment stage (PDE)reproductive shoot system development stage0--Direct
Plant structure DEvelopment stage (PDE)collective phyllome structure development stage0--Direct
Plant structure DEvelopment stage (PDE)floral organ formation stage0--Direct
Plant structure DEvelopment stage (PDE)flower development stage1--Inherited
Plant structure DEvelopment stage (PDE)life of whole plant stage1--Inherited
Plant structure DEvelopment stage (PDE)shoot system development stage1--Inherited
Plant structure DEvelopment stage (PDE)sporophyte development stage1--Inherited

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EC

Enzyme Commission (EC)

EC term FDR (all) SDEC (four levels) Annotation (direct or inherited)
Enzyme Commission (EC)ATP citrate synthase0--Direct
Enzyme Commission (EC)Inositol-tetrakisphosphate 1-kinase0--Direct
Enzyme Commission (EC)Inositol-1,3,4-trisphosphate 5/6-kinase0--Direct
Enzyme Commission (EC)Inositol-hexakisphosphate kinase0--Direct
Enzyme Commission (EC)Diphosphoinositol-pentakisphosphate kinase0--Direct
Enzyme Commission (EC)Phosphotransferases with paired acceptors0--Direct
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0--Direct
Enzyme Commission (EC)Forming carbon-sulfur bonds0--Direct
Enzyme Commission (EC)Succinate--CoA ligase (ADP-forming)0--Direct
Enzyme Commission (EC)Forming carbon-nitrogen bonds0--Direct
Enzyme Commission (EC)Glutathione synthase0--Direct
Enzyme Commission (EC)D-alanine--D-alanine ligase0--Direct
Enzyme Commission (EC)Biotin carboxylase0--Direct
Enzyme Commission (EC)5-(carboxyamino)imidazole ribonucleotide synthase0--Direct
Enzyme Commission (EC)Formate--phosphoribosylaminoimidazolecarboxamide ligase0--Direct
Enzyme Commission (EC)Beta-citrylglutamate synthase0.000000002583--Direct
Enzyme Commission (EC)Pyruvate, phosphate dikinase0.0000002868--Direct
Enzyme Commission (EC)Carbamoyl-phosphate synthase (ammonia)0.000002343--Direct
Enzyme Commission (EC)Pyruvate, water dikinase0.000003071--Direct
Enzyme Commission (EC)Tubulin--tyrosine ligase0.0001993--Direct
Enzyme Commission (EC)N-acetylaspartylglutamate synthase0.0004526--Direct
Enzyme Commission (EC)Transferases1--Inherited
Enzyme Commission (EC)Acyltransferases1--Inherited
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0.6693InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor1InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Phosphoribosylamine--glycine ligase0Highly InformativeDirect
Enzyme Commission (EC)Carbamoyl-phosphate synthase (glutamine-hydrolyzing)0Highly InformativeDirect
Enzyme Commission (EC)Forming carbon-carbon bonds0Highly InformativeDirect
Enzyme Commission (EC)Phosphoribosylglycinamide formyltransferase0.0000000001035Highly InformativeDirect
Enzyme Commission (EC)Urea carboxylase0.00008886Highly InformativeDirect
Enzyme Commission (EC)Acyl groups converted into alkyl groups on transfer0.004582Highly InformativeInherited
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited
Enzyme Commission (EC)Acid--ammonia (or amine) ligases (amide synthases)1Highly InformativeInherited

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CC

CTD Chemicals (CC)

CC term FDR (all) SDCC (four levels) Annotation (direct or inherited)
CTD Chemicals (CC)Organic Chemicals0--Direct
CTD Chemicals (CC)O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate0.0002958--Direct
CTD Chemicals (CC)GW 40640.0005791--Direct
CTD Chemicals (CC)Monosaccharides0.0007868--Direct
CTD Chemicals (CC)Sugars0.001673--Inherited
CTD Chemicals (CC)Organothiophosphates0.3456--Inherited
CTD Chemicals (CC)Heterocyclic Compounds0.7554--Inherited
CTD Chemicals (CC)Heterocyclic Compounds, 1-Ring0.8325--Inherited
CTD Chemicals (CC)Inorganic Chemicals1--Inherited
CTD Chemicals (CC)Carbohydrates0.4212Least InformativeInherited
CTD Chemicals (CC)Sulfur Compounds0.5055Least InformativeInherited
CTD Chemicals (CC)Azoles0.7241Least InformativeInherited
CTD Chemicals (CC)Organophosphorus Compounds0.6609Moderately InformativeInherited
CTD Chemicals (CC)Hexoses0.0007156InformativeDirect
CTD Chemicals (CC)Organothiophosphorus Compounds0.3511InformativeInherited
CTD Chemicals (CC)Organophosphates0.4517InformativeInherited
CTD Chemicals (CC)Isoxazoles0.5527InformativeInherited
CTD Chemicals (CC)Chlorpyrifos0.006068Highly InformativeInherited

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Distribution on sTOL

Plot distribution on species Tree Of Life (sTOL) for this domain, i.e., present or absent across genomes/tips
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