dcGO - A comprehensive domain-centric ontology resource for post-genomic research on functions, phenotypes, diseases and more   
  
  

GLA-domain superfamily

Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   GLA-domain [ 57629]
Superfamily:   GLA-domain [ 57630]
Families:   GLA-domain [ 57631] (6)

DO

Disease Ontology (DO)

DO term FDR (all) SDDO (four levels) Annotation (direct or inherited)
Disease Ontology (DO)disease of anatomical entity0--Direct
Disease Ontology (DO)blood coagulation disease0.0000000002508--Direct
Disease Ontology (DO)vascular disease0.000009182--Direct
Disease Ontology (DO)acute pancreatitis0.00001185--Direct
Disease Ontology (DO)kidney disease0.00001583--Direct
Disease Ontology (DO)arteriosclerotic cardiovascular disease0.00004997--Direct
Disease Ontology (DO)acute myocardial infarction0.0001109--Direct
Disease Ontology (DO)cardiovascular system disease0.002226--Inherited
Disease Ontology (DO)vasculitis0.0357--Inherited
Disease Ontology (DO)coronary artery disease0.04743--Inherited
Disease Ontology (DO)arteriosclerosis0.05668--Inherited
Disease Ontology (DO)hematopoietic system disease0.00002096Moderately InformativeDirect
Disease Ontology (DO)syndrome0.0002617Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.000533Moderately InformativeDirect
Disease Ontology (DO)endocrine system disease0.006293Moderately InformativeInherited
Disease Ontology (DO)artery disease0.4826Moderately InformativeInherited
Disease Ontology (DO)inherited blood coagulation disease0.00003779InformativeDirect
Disease Ontology (DO)atherosclerosis0.00004929InformativeDirect
Disease Ontology (DO)pancreas disease0.1591InformativeInherited
Disease Ontology (DO)myocardial infarction0.911InformativeInherited
Disease Ontology (DO)Behcet's disease0.00006451Highly InformativeDirect
Disease Ontology (DO)pancreatitis0.0002036Highly InformativeDirect

LINKTO: Domain2BO Download and Domain2BO Algorithm

HP

Human Phenotype (HP)

HP term FDR (all) SDHP (four levels) Annotation (direct or inherited)
Variable expressivity0--Direct
Phenotypic variability1--Inherited
Phenotypic Abnormality (PA)Abnormality of coagulation0.00000001102--Direct
Phenotypic Abnormality (PA)Post-partum hemorrhage0.00000001397--Direct
Phenotypic Abnormality (PA)Internal hemorrhage0.0000001766--Direct
Phenotypic Abnormality (PA)Venous thrombosis0.000002726--Direct
Phenotypic Abnormality (PA)Abnormal prothrombin time0.000005543--Direct
Phenotypic Abnormality (PA)Abnormality of pulmonary circulation0.00001586--Direct
Phenotypic Abnormality (PA)Abnormal vascular physiology0.001411--Inherited
Phenotypic Abnormality (PA)Abnormality of brain morphology0.03233--Inherited
Phenotypic Abnormality (PA)Morphological abnormality of the central nervous system0.05192--Inherited
Phenotypic Abnormality (PA)Abnormality of prothrombin0.1806--Inherited
Phenotypic Abnormality (PA)Abnormality of the nervous system0.2814--Inherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.3153--Inherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.08099Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2813Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.7255Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.001986Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.0416Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.1673Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.179Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.3539Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the coagulation cascade0.0000000006877InformativeDirect
Phenotypic Abnormality (PA)Abnormal bleeding0.000003778InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.00003604InformativeDirect
Phenotypic Abnormality (PA)Abnormal thrombosis0.001328InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood circulation0.001666InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.06208InformativeInherited
Phenotypic Abnormality (PA)Deep venous thrombosis0.000000001034Highly InformativeDirect
Phenotypic Abnormality (PA)Intramuscular hematoma0.00000001397Highly InformativeDirect
Phenotypic Abnormality (PA)Joint hemorrhage0.000000181Highly InformativeDirect
Phenotypic Abnormality (PA)Prolonged prothrombin time0.000004853Highly InformativeDirect
Phenotypic Abnormality (PA)Prolonged bleeding following procedure0.0008073Highly InformativeDirect

LINKTO: Domain2BO Download and Domain2BO Algorithm

MP

Mouse Phenotype (MP)

MP term FDR (all) SDMP (four levels) Annotation (direct or inherited)
Mammalian Phenotype (MP)homeostasis/metabolism phenotype0--Direct
Mammalian Phenotype (MP)abnormal blood homeostasis0--Direct
Mammalian Phenotype (MP)abnormal hemostasis0.000007068--Direct
Mammalian Phenotype (MP)abnormal trabecular bone thickness0.0001808--Direct
Mammalian Phenotype (MP)abnormal blood circulation0.0102--Inherited
Mammalian Phenotype (MP)skeleton phenotype0.04665--Inherited
Mammalian Phenotype (MP)abnormal bone structure0.07122--Inherited
Mammalian Phenotype (MP)abnormal adipose tissue morphology0.09642--Inherited
Mammalian Phenotype (MP)adipose tissue phenotype0.1011--Inherited
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.001703Least InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.00005618Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.8206Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.0000000004396InformativeDirect
Mammalian Phenotype (MP)hemorrhage0.0000003316InformativeDirect
Mammalian Phenotype (MP)abnormal adipose tissue amount0.05039InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.05644InformativeInherited
Mammalian Phenotype (MP)increased total body fat amount0.0008724Highly InformativeDirect

LINKTO: Domain2BO Download and Domain2BO Algorithm

ZA

Zebrafish Anatomy (ZA)

ZA term FDR (all) SDZA (four levels) Annotation (direct or inherited)
Zebrafish Anatomy (ZA)whole organism0--Direct
Zebrafish Anatomy (ZA)anatomical system0--Direct
Zebrafish Anatomy (ZA)anatomical group0--Direct
Zebrafish Anatomy (ZA)anatomical structure1--Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

XA

Xenopus Anatomy (XA)

XA term FDR (all) SDXA (four levels) Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)anatomical structure0--Direct
Xenopus ANatomical entity (XAN)anatomical group0--Direct
Xenopus ANatomical entity (XAN)organism subdivision0--Direct
Xenopus ANatomical entity (XAN)compound organ0--Direct
Xenopus ANatomical entity (XAN)multicellular anatomical structure0--Direct
Xenopus ANatomical entity (XAN)whole organism1--Inherited
 
XA term FDR (all) SDXA (four levels) Annotation (direct or inherited)
Xenopus DEvelopment stage (XDE)NF stage0--Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

EC

Enzyme Commission (EC)

EC term FDR (all) SDEC (four levels) Annotation (direct or inherited)
Enzyme Commission (EC)Coagulation factor Xa0--Direct
Enzyme Commission (EC)Coagulation factor IXa0.000000000001045--Direct
Enzyme Commission (EC)Coagulation factor VIIa0.00000000002153--Direct
Enzyme Commission (EC)Thrombin0.0000000003808--Direct
Enzyme Commission (EC)Protein C (activated)0.0000000007062--Direct
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect

LINKTO: Domain2BO Download and Domain2BO Algorithm

CD

CTD Diseases (CD)

CD term FDR (all) SDCD (four levels) Annotation (direct or inherited)
CTD Diseases (CD)Cardiovascular Diseases0--Direct
CTD Diseases (CD)Blood Coagulation Disorders, Inherited0.0000000000004429--Direct
CTD Diseases (CD)Hematologic Diseases0.000008282--Direct
CTD Diseases (CD)Congenital, Hereditary, and Neonatal Diseases and Abnormalities0.01373--Inherited
CTD Diseases (CD)Pathologic Processes0.2052--Inherited
CTD Diseases (CD)Pathological Conditions, Signs and Symptoms0.3383Least InformativeInherited
CTD Diseases (CD)Genetic Diseases, Inborn0.3486Least InformativeInherited
CTD Diseases (CD)Hemic and Lymphatic Diseases0.0001057Moderately InformativeDirect
CTD Diseases (CD)Vascular Diseases0.05997Moderately InformativeInherited
CTD Diseases (CD)Blood Coagulation Disorders0.00000000001142InformativeDirect
CTD Diseases (CD)Embolism and Thrombosis0.0000002178InformativeDirect
CTD Diseases (CD)Hemorrhage0.00006449InformativeDirect
CTD Diseases (CD)Thrombosis0.00000000000003421Highly InformativeDirect
CTD Diseases (CD)Thrombophilia0.0000006767Highly InformativeDirect

LINKTO: Domain2BO Download and Domain2BO Algorithm

CC

CTD Chemicals (CC)

CC term FDR (all) SDCC (four levels) Annotation (direct or inherited)
CTD Chemicals (CC)Heterocyclic Compounds, Fused-Ring0--Direct
CTD Chemicals (CC)Carboxylic Acids0--Direct
CTD Chemicals (CC)Fatty Acids0--Direct
CTD Chemicals (CC)Heterocyclic Compounds0--Direct
CTD Chemicals (CC)Heterocyclic Compounds, 1-Ring0--Direct
CTD Chemicals (CC)Heterocyclic Compounds, 2-Ring0--Direct
CTD Chemicals (CC)Inorganic Chemicals0--Direct
CTD Chemicals (CC)Lipids0--Direct
CTD Chemicals (CC)Organic Chemicals0--Direct
CTD Chemicals (CC)Pentanoic Acids0--Direct
CTD Chemicals (CC)Valerates0--Direct
CTD Chemicals (CC)Valproic Acid0--Direct
CTD Chemicals (CC)Reproductive Control Agents0.0000000000000073--Direct
CTD Chemicals (CC)Warfarin0.000000000001113--Direct
CTD Chemicals (CC)CMF protocol0.00000000003533--Direct
CTD Chemicals (CC)estradiol valerate-dienogest0.000000000111--Direct
CTD Chemicals (CC)Norpregnenes0.000000000167--Direct
CTD Chemicals (CC)dienogest0.0000000008617--Direct
CTD Chemicals (CC)estradiol, norethindrone drug combination0.000000001232--Direct
CTD Chemicals (CC)Norpregnatrienes0.000000005784--Direct
CTD Chemicals (CC)aspalathin0.0000000323--Direct
CTD Chemicals (CC)nothofagin0.0000000323--Direct
CTD Chemicals (CC)Estrogenic Steroids, Alkylated0.0000001225--Direct
CTD Chemicals (CC)Calcium Chloride0.0000005591--Direct
CTD Chemicals (CC)norgestimate, ethinyl estradiol drug combination0.000002134--Direct
CTD Chemicals (CC)Heparin0.000008194--Direct
CTD Chemicals (CC)Thiazolidinediones0.00004875--Direct
CTD Chemicals (CC)Pregnenediones0.00007984--Direct
CTD Chemicals (CC)Medroxyprogesterone0.0001036--Direct
CTD Chemicals (CC)Glycosaminoglycans0.005219--Inherited
CTD Chemicals (CC)Corpus Luteum Hormones0.006497--Inherited
CTD Chemicals (CC)Progesterone Congeners0.006837--Inherited
CTD Chemicals (CC)Stilbenes0.008206--Inherited
CTD Chemicals (CC)Estradiol0.01629--Inherited
CTD Chemicals (CC)Pregnenes0.02099--Inherited
CTD Chemicals (CC)Pharmacologic Actions0.02214--Inherited
CTD Chemicals (CC)Hydroxyprogesterones0.02317--Inherited
CTD Chemicals (CC)Gonadal Hormones0.02468--Inherited
CTD Chemicals (CC)Hormones, Hormone Substitutes, and Hormone Antagonists0.02863--Inherited
CTD Chemicals (CC)Pterins0.03129--Inherited
CTD Chemicals (CC)Desogestrel0.03275--Inherited
CTD Chemicals (CC)Hydrochloric Acid0.03563--Inherited
CTD Chemicals (CC)Uracil0.05506--Inherited
CTD Chemicals (CC)Chromones0.06815--Inherited
CTD Chemicals (CC)Benzene Derivatives0.2146--Inherited
CTD Chemicals (CC)Estradiol Congeners0.2552--Inherited
CTD Chemicals (CC)Pigments, Biological0.2684--Inherited
CTD Chemicals (CC)Polycyclic Compounds0.2956--Inherited
CTD Chemicals (CC)Physiological Effects of Drugs0.3002--Inherited
CTD Chemicals (CC)Pyrans0.4274--Inherited
CTD Chemicals (CC)Platinum Compounds0.5338--Inherited
CTD Chemicals (CC)Hydrocarbons, Aromatic0.6283--Inherited
CTD Chemicals (CC)Hydrocarbons, Cyclic0.6741--Inherited
CTD Chemicals (CC)Aminopterin0.7366--Inherited
CTD Chemicals (CC)Hydrocarbons0.831--Inherited
CTD Chemicals (CC)Acids, Noncarboxylic1--Inherited
CTD Chemicals (CC)Anions1--Inherited
CTD Chemicals (CC)Estrenes1--Inherited
CTD Chemicals (CC)Ethinyl Estradiol1--Inherited
CTD Chemicals (CC)Hormones1--Inherited
CTD Chemicals (CC)Ions1--Inherited
CTD Chemicals (CC)Methotrexate1--Inherited
CTD Chemicals (CC)Norpregnanes1--Inherited
CTD Chemicals (CC)Steroids1--Inherited
CTD Chemicals (CC)Acids, Acyclic0Least InformativeDirect
CTD Chemicals (CC)Fatty Acids, Volatile0Least InformativeDirect
CTD Chemicals (CC)Fused-Ring Compounds0.01369Least InformativeInherited
CTD Chemicals (CC)Chemical Actions and Uses0.03512Least InformativeInherited
CTD Chemicals (CC)Azoles0.07984Least InformativeInherited
CTD Chemicals (CC)Electrolytes0.1958Least InformativeInherited
CTD Chemicals (CC)Acids0.2318Least InformativeInherited
CTD Chemicals (CC)Pyrimidines0.2427Least InformativeInherited
CTD Chemicals (CC)Sulfur Compounds0.331Least InformativeInherited
CTD Chemicals (CC)Biological Factors0.4351Least InformativeInherited
CTD Chemicals (CC)Carbohydrates0.4447Least InformativeInherited
CTD Chemicals (CC)Benzopyrans0.5044Least InformativeInherited
CTD Chemicals (CC)Thiazoles0.001907Moderately InformativeInherited
CTD Chemicals (CC)Chlorine Compounds0.003656Moderately InformativeInherited
CTD Chemicals (CC)Polysaccharides0.007531Moderately InformativeInherited
CTD Chemicals (CC)Benzylidene Compounds0.01632Moderately InformativeInherited
CTD Chemicals (CC)Pregnanes0.02249Moderately InformativeInherited
CTD Chemicals (CC)Flavonoids0.04641Moderately InformativeInherited
CTD Chemicals (CC)Ketones0.05618Moderately InformativeInherited
CTD Chemicals (CC)Nitrogen Compounds0.07918Moderately InformativeInherited
CTD Chemicals (CC)Pyrimidinones0.1333Moderately InformativeInherited
CTD Chemicals (CC)Estranes0.2659Moderately InformativeInherited
CTD Chemicals (CC)Gonadal Steroid Hormones1Moderately InformativeInherited
CTD Chemicals (CC)Norsteroids0.000002394InformativeDirect
CTD Chemicals (CC)Coumarins0.001844InformativeInherited
CTD Chemicals (CC)Fluorouracil0.002777InformativeInherited
CTD Chemicals (CC)Propiophenones0.01209InformativeInherited
CTD Chemicals (CC)Therapeutic Uses0.0151InformativeInherited
CTD Chemicals (CC)Chlorides0.02314InformativeInherited
CTD Chemicals (CC)Pteridines0.03263InformativeInherited
CTD Chemicals (CC)Testosterone Congeners0.1025InformativeInherited
CTD Chemicals (CC)Progesterone0.7602InformativeInherited
CTD Chemicals (CC)Cisplatin1InformativeInherited
CTD Chemicals (CC)4-Hydroxycoumarins0.000000002875Highly InformativeDirect
CTD Chemicals (CC)Calcium Compounds0.0000001794Highly InformativeDirect
CTD Chemicals (CC)Nandrolone0.0000002114Highly InformativeDirect
CTD Chemicals (CC)Tamoxifen0.00006178Highly InformativeDirect
CTD Chemicals (CC)Medroxyprogesterone Acetate0.00009922Highly InformativeDirect
CTD Chemicals (CC)Gestodene0.0001367Highly InformativeDirect
CTD Chemicals (CC)Chalcones0.0003993Highly InformativeDirect
CTD Chemicals (CC)ethinyl estradiol-desogestrel combination0.0004534Highly InformativeDirect
CTD Chemicals (CC)Norethindrone0.005951Highly InformativeInherited
CTD Chemicals (CC)Norgestrel0.4878Highly InformativeInherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

Distribution on sTOL

Plot distribution on species Tree Of Life (sTOL) for this domain, i.e., present or absent across genomes/tips
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