RING finger domain, C3HC4 family

HP

Human Phenotype (HP)

	HP term	FDR (all)	SDHP (four levels)	Annotation (direct or inherited)
Mode of Inheritance (MI)	Somatic mutation	0.0003445	Moderately Informative	Direct

	HP term	FDR (all)	SDHP (four levels)	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormal prostate morphology	0.0006915	--	Direct
Phenotypic Abnormality (PA)	Neoplasm of the breast	0.002604	--	Inherited
Phenotypic Abnormality (PA)	Abnormal breast morphology	0.005279	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of the breast	0.005513	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of the genital system	0.007814	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of male internal genitalia	0.02624	--	Inherited
Phenotypic Abnormality (PA)	Neoplasm by anatomical site	0.097	--	Inherited
Phenotypic Abnormality (PA)	Abnormal internal genitalia	0.3513	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of the male genitalia	0.6024	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of the genitourinary system	0.09462	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormal reproductive system morphology	0.001834	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Neoplasm	0.1171	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Breast carcinoma	0.0002374	Highly Informative	Direct
Phenotypic Abnormality (PA)	Prostate neoplasm	0.0002899	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

MP

Mouse Phenotype (MP)

	MP term	FDR (all)	SDMP (four levels)	Annotation (direct or inherited)
Mammalian Phenotype (MP)	dermatitis	0.00005301	--	Direct
Mammalian Phenotype (MP)	skin inflammation	0.0005997	--	Direct
Mammalian Phenotype (MP)	abnormal chromosome stability	0.001947	--	Inherited
Mammalian Phenotype (MP)	abnormal interleukin-2 secretion	0.0137	--	Inherited
Mammalian Phenotype (MP)	abnormal cell physiology	0.1193	--	Inherited
Mammalian Phenotype (MP)	increased inflammatory response	0.1978	--	Inherited
Mammalian Phenotype (MP)	integument phenotype	0.201	--	Inherited
Mammalian Phenotype (MP)	abnormal cytokine secretion	0.2736	--	Inherited
Mammalian Phenotype (MP)	abnormal interleukin secretion	0.6246	--	Inherited
Mammalian Phenotype (MP)	abnormal immune system physiology	0.8331	--	Inherited
Mammalian Phenotype (MP)	cellular phenotype	0.2909	Least Informative	Inherited
Mammalian Phenotype (MP)	immune system phenotype	0.4183	Least Informative	Inherited
Mammalian Phenotype (MP)	abnormal inflammatory response	0.3435	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal immune serum protein physiology	0.4235	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal skin physiology	0.05592	Informative	Inherited
Mammalian Phenotype (MP)	increased interleukin-2 secretion	0.0005486	Highly Informative	Direct
Mammalian Phenotype (MP)	chromosomal instability	0.0007324	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

WP

Worm Phenotype (WP)

	WP term	FDR (all)	SDWP (four levels)	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	--	Direct
Worm Phenotype (WP)	lethal	0	--	Direct
Worm Phenotype (WP)	fertility variant	0	--	Direct
Worm Phenotype (WP)	Q neuroblast lineage migration variant	0	--	Direct
Worm Phenotype (WP)	development variant	0	--	Direct
Worm Phenotype (WP)	morphology variant	0	--	Direct
Worm Phenotype (WP)	organism development variant	0	--	Direct
Worm Phenotype (WP)	organism morphology variant	0	--	Direct
Worm Phenotype (WP)	organ system physiology variant	0	--	Direct
Worm Phenotype (WP)	reproductive system physiology variant	0	--	Direct
Worm Phenotype (WP)	embryonic development variant	0	--	Direct
Worm Phenotype (WP)	hermaphrodite fertility variant	0	--	Direct
Worm Phenotype (WP)	neuron migration variant	0	--	Direct
Worm Phenotype (WP)	protein interaction variant	0	--	Direct
Worm Phenotype (WP)	fertility reduced	0	--	Direct
Worm Phenotype (WP)	protein aggregation variant	0	--	Direct
Worm Phenotype (WP)	transgene subcellular localization variant	0.00000000007266	--	Direct
Worm Phenotype (WP)	germ cell hypersensitive ionizing radiation	0.00000001609	--	Direct
Worm Phenotype (WP)	germ cell ionizing radiation response variant	0.00006669	--	Direct
Worm Phenotype (WP)	organism ionizing radiation response variant	0.001032	--	Inherited
Worm Phenotype (WP)	gene expression variant	0.02256	--	Inherited
Worm Phenotype (WP)	transgene expression variant	0.134	--	Inherited
Worm Phenotype (WP)	physiology variant	1	--	Inherited
Worm Phenotype (WP)	organism physiology variant	1	--	Inherited
Worm Phenotype (WP)	organism homeostasis metabolism variant	1	--	Inherited
Worm Phenotype (WP)	cell development variant	0.000000008661	Least Informative	Direct
Worm Phenotype (WP)	organism metabolism processing variant	0.0002224	Least Informative	Direct
Worm Phenotype (WP)	organism environmental stimulus response variant	0.2813	Least Informative	Inherited
Worm Phenotype (WP)	cell physiology variant	0.3436	Least Informative	Inherited
Worm Phenotype (WP)	protein protein interaction variant	0	Moderately Informative	Direct
Worm Phenotype (WP)	pattern of transgene expression variant	0.00000001054	Moderately Informative	Direct
Worm Phenotype (WP)	cell homeostasis metabolism variant	0.004086	Moderately Informative	Inherited
Worm Phenotype (WP)	organism stress response variant	0.06108	Moderately Informative	Inherited
Worm Phenotype (WP)	cell migration variant	0	Informative	Direct
Worm Phenotype (WP)	cell stress response variant	0.03101	Informative	Inherited
Worm Phenotype (WP)	germ cell physiology variant	0.09092	Informative	Inherited
Worm Phenotype (WP)	cell ionizing radiation response variant	0.01113	Highly Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

YP

Yeast Phenotype (YP)

	YP term	FDR (all)	SDYP (four levels)	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	--	Direct
Yeast Phenotype (YP)	stress resistance	0	--	Direct
Yeast Phenotype (YP)	competitive fitness	0	--	Direct
Yeast Phenotype (YP)	fitness	0	--	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

FP

Fly Phenotype (FP)

	FP term	FDR (all)	SDFP (four levels)	Annotation (direct or inherited)
Fly Phenotype (FP)	fertile	0.0003186	Moderately Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

XA

Xenopus Anatomy (XA)

	XA term	FDR (all)	SDXA (four levels)	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	--	Direct

	XA term	FDR (all)	SDXA (four levels)	Annotation (direct or inherited)
Xenopus DEvelopment stage (XDE)	NF stage	0	--	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

AP

Arabidopsis Plant Ontology (AP)

	AP term	FDR (all)	SDAP (four levels)	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	leaf trichome	0.00000001483	--	Direct
Plant ANatomical entity (PAN)	leaf epidermis	0.0000002403	--	Direct
Plant ANatomical entity (PAN)	phyllome epidermis	0.0000003295	--	Direct
Plant ANatomical entity (PAN)	phyllome trichome	0.00002091	--	Direct
Plant ANatomical entity (PAN)	shoot system	0.1	--	Inherited
Plant ANatomical entity (PAN)	portion of plant tissue	0.1583	--	Inherited
Plant ANatomical entity (PAN)	shoot epidermis	0.2478	--	Inherited
Plant ANatomical entity (PAN)	epidermis	0.3554	--	Inherited
Plant ANatomical entity (PAN)	collective plant structure	0.5163	--	Inherited
Plant ANatomical entity (PAN)	leaf	0.7873	--	Inherited
Plant ANatomical entity (PAN)	phyllome	1	--	Inherited
Plant ANatomical entity (PAN)	plant organ	1	--	Inherited
Plant ANatomical entity (PAN)	plant structure	1	--	Inherited
Plant ANatomical entity (PAN)	collective plant organ structure	1	--	Inherited
Plant ANatomical entity (PAN)	multi-tissue plant structure	1	--	Inherited
Plant ANatomical entity (PAN)	trichome	0.00008578	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

EC

Enzyme Commission (EC)

	EC term	FDR (all)	SDEC (four levels)	Annotation (direct or inherited)
Enzyme Commission (EC)	RING-type E3 ubiquitin transferase	0	--	Direct
Enzyme Commission (EC)	Cellulose synthase (UDP-forming)	0	--	Direct
Enzyme Commission (EC)	RBR-type E3 ubiquitin transferase	0.00000000000003702	--	Direct
Enzyme Commission (EC)	Hexosyltransferases	0.0003113	--	Direct
Enzyme Commission (EC)	Transferases	0	Least Informative	Direct
Enzyme Commission (EC)	Acyltransferases	0	Moderately Informative	Direct
Enzyme Commission (EC)	Aminoacyltransferases	0	Informative	Direct
Enzyme Commission (EC)	Glycosyltransferases	1	Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

CC

CTD Chemicals (CC)

	CC term	FDR (all)	SDCC (four levels)	Annotation (direct or inherited)
CTD Chemicals (CC)	Anisoles	0.0008329	--	Direct
CTD Chemicals (CC)	Inorganic Chemicals	0.3229	--	Inherited
CTD Chemicals (CC)	Transition Elements	0.3558	--	Inherited
CTD Chemicals (CC)	Hydrocarbons, Aromatic	0.3638	--	Inherited
CTD Chemicals (CC)	Organic Chemicals	0.4026	--	Inherited
CTD Chemicals (CC)	Metals, Heavy	0.4436	--	Inherited
CTD Chemicals (CC)	Phenyl Ethers	0.4654	--	Inherited
CTD Chemicals (CC)	Hydrocarbons, Cyclic	0.4895	--	Inherited
CTD Chemicals (CC)	Hydrocarbons	0.6302	--	Inherited
CTD Chemicals (CC)	Heterocyclic Compounds, 1-Ring	0.728	--	Inherited
CTD Chemicals (CC)	Benzene Derivatives	0.7312	--	Inherited
CTD Chemicals (CC)	Heterocyclic Compounds	0.7431	--	Inherited
CTD Chemicals (CC)	Phenols	0.5003	Least Informative	Inherited
CTD Chemicals (CC)	Metals	0.6099	Least Informative	Inherited
CTD Chemicals (CC)	Elements	0.7508	Least Informative	Inherited
CTD Chemicals (CC)	Ethers	0.4424	Moderately Informative	Inherited
CTD Chemicals (CC)	Methyl Ethers	0.0009889	Informative	Direct
CTD Chemicals (CC)	Azepines	0.1524	Informative	Inherited
CTD Chemicals (CC)	Gold	0.0001598	Highly Informative	Direct
CTD Chemicals (CC)	K 7174	0.0005518	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

Distribution on sTOL

Plot distribution on species Tree Of Life (sTOL) for this domain, i.e., present or absent across genomes/tips

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RING finger domain, C3HC4 family