E set domains superfamily

DO

Disease Ontology (DO)

	DO term	FDR (all)	SDDO (four levels)	Annotation (direct or inherited)
Disease Ontology (DO)	dermatitis herpetiformis	0.0000008338	--	Direct
Disease Ontology (DO)	autoimmune disease of skin and connective tissue	0.0003726	--	Direct
Disease Ontology (DO)	dermatitis	0.08302	--	Inherited
Disease Ontology (DO)	integumentary system disease	0.09405	--	Inherited
Disease Ontology (DO)	hypersensitivity reaction disease	0.5176	--	Inherited
Disease Ontology (DO)	immune system disease	0.5939	--	Inherited
Disease Ontology (DO)	disease of anatomical entity	0.6435	--	Inherited
Disease Ontology (DO)	skin disease	0.078	Moderately Informative	Inherited
Disease Ontology (DO)	hypersensitivity reaction type II disease	0.5345	Moderately Informative	Inherited
Disease Ontology (DO)	bullous skin disease	0.01667	Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

HP

Human Phenotype (HP)

	HP term	FDR (all)	SDHP (four levels)	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormal blood monovalent inorganic cation concentration	0.00087	--	Direct
Phenotypic Abnormality (PA)	Abnormality of renin-angiotensin system	0.0008921	--	Direct
Phenotypic Abnormality (PA)	Abnormal magnesium concentration	0.001322	--	Inherited
Phenotypic Abnormality (PA)	Alkalosis	0.002891	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of adrenal physiology	0.009443	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of the adrenal glands	0.04258	--	Inherited
Phenotypic Abnormality (PA)	Adrenal overactivity	0.09556	--	Inherited
Phenotypic Abnormality (PA)	Abnormal blood ion concentration	0.1218	--	Inherited
Phenotypic Abnormality (PA)	Abnormal blood potassium concentration	0.4254	--	Inherited
Phenotypic Abnormality (PA)	Abnormal blood inorganic cation concentration	0.5912	--	Inherited
Phenotypic Abnormality (PA)	Abnormal homeostasis	0.5927	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of metabolism/homeostasis	0.1588	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormal circulating metabolite concentration	0.3834	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the endocrine system	0.5442	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of acid-base homeostasis	0.5625	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormal blood cation concentration	0.04221	Informative	Inherited
Phenotypic Abnormality (PA)	Hypokalemia	0.000302	Highly Informative	Direct
Phenotypic Abnormality (PA)	Metabolic alkalosis	0.0004275	Highly Informative	Direct
Phenotypic Abnormality (PA)	Hyperaldosteronism	0.0007119	Highly Informative	Direct
Phenotypic Abnormality (PA)	Abnormal circulating renin	0.0007119	Highly Informative	Direct
Phenotypic Abnormality (PA)	Hypomagnesemia	0.0008921	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

MP

Mouse Phenotype (MP)

	MP term	FDR (all)	SDMP (four levels)	Annotation (direct or inherited)
Mammalian Phenotype (MP)	hypotonia	0.000167	--	Direct
Mammalian Phenotype (MP)	abnormal circulating amylase level	0.0002853	--	Direct
Mammalian Phenotype (MP)	abnormal B cell activation	0.0006553	--	Direct
Mammalian Phenotype (MP)	abnormal intersomitic vessel morphology	0.0009018	--	Direct
Mammalian Phenotype (MP)	abnormal abdominal lymph node morphology	0.01213	--	Inherited
Mammalian Phenotype (MP)	abnormal lymphocyte physiology	0.016	--	Inherited
Mammalian Phenotype (MP)	abnormal thymus lobule morphology	0.05119	--	Inherited
Mammalian Phenotype (MP)	abnormal muscle tone	0.057	--	Inherited
Mammalian Phenotype (MP)	muscle phenotype	0.06843	--	Inherited
Mammalian Phenotype (MP)	abnormal immune system physiology	0.09345	--	Inherited
Mammalian Phenotype (MP)	abnormal blood cell physiology	0.09997	--	Inherited
Mammalian Phenotype (MP)	abnormal B cell physiology	0.1285	--	Inherited
Mammalian Phenotype (MP)	abnormal endocrine gland morphology	0.1341	--	Inherited
Mammalian Phenotype (MP)	abnormal hematopoietic system physiology	0.1889	--	Inherited
Mammalian Phenotype (MP)	endocrine/exocrine gland phenotype	0.2064	--	Inherited
Mammalian Phenotype (MP)	abnormal enzyme/coenzyme level	0.2097	--	Inherited
Mammalian Phenotype (MP)	abnormal immune cell physiology	0.2714	--	Inherited
Mammalian Phenotype (MP)	abnormal circulating protein level	0.2735	--	Inherited
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.2807	--	Inherited
Mammalian Phenotype (MP)	abnormal cell-mediated immunity	0.2854	--	Inherited
Mammalian Phenotype (MP)	abnormal adaptive immunity	0.3183	--	Inherited
Mammalian Phenotype (MP)	abnormal immune system morphology	0.3602	--	Inherited
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0.388	--	Inherited
Mammalian Phenotype (MP)	abnormal blood homeostasis	0.904	--	Inherited
Mammalian Phenotype (MP)	abnormal cardiovascular system morphology	0.9996	--	Inherited
Mammalian Phenotype (MP)	cardiovascular system phenotype	0.01179	Least Informative	Inherited
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.3372	Least Informative	Inherited
Mammalian Phenotype (MP)	abnormal homeostasis	0.3708	Least Informative	Inherited
Mammalian Phenotype (MP)	immune system phenotype	0.4513	Least Informative	Inherited
Mammalian Phenotype (MP)	abnormal immune system organ morphology	0.04015	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal leukocyte physiology	0.05632	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal muscle physiology	0.09482	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell physiology	0.1406	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal protein level	0.3038	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal gland morphology	0.3057	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal blood vessel morphology	0.3676	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal B cell proliferation	0.000008349	Informative	Direct
Mammalian Phenotype (MP)	abnormal thymus morphology	0.006198	Informative	Inherited
Mammalian Phenotype (MP)	abnormal circulating enzyme level	0.07918	Informative	Inherited
Mammalian Phenotype (MP)	abnormal lymph node morphology	0.09103	Informative	Inherited
Mammalian Phenotype (MP)	abnormal thymus medulla morphology	0.00005434	Highly Informative	Direct
Mammalian Phenotype (MP)	abnormal mesenteric lymph node morphology	0.0003672	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

WP

Worm Phenotype (WP)

	WP term	FDR (all)	SDWP (four levels)	Annotation (direct or inherited)
Worm Phenotype (WP)	lethal	0	--	Direct
Worm Phenotype (WP)	development variant	0	--	Direct
Worm Phenotype (WP)	organism development variant	0	--	Direct
Worm Phenotype (WP)	embryonic cell lineage variant	0.0002221	--	Direct
Worm Phenotype (WP)	lineage variant	0.01393	--	Inherited
Worm Phenotype (WP)	physiology variant	1	--	Inherited
Worm Phenotype (WP)	cell development variant	0.643	Least Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

YP

Yeast Phenotype (YP)

	YP term	FDR (all)	SDYP (four levels)	Annotation (direct or inherited)
Yeast Phenotype (YP)	competitive fitness	0	--	Direct
Yeast Phenotype (YP)	fitness	0	--	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

FA

Fly Anatomy (FA)

	FA term	FDR (all)	SDFA (four levels)	Annotation (direct or inherited)
Fly Anatomy (FA)	multicellular structure	0	--	Direct
Fly Anatomy (FA)	embryonic hemocoel	0.00003944	--	Direct
Fly Anatomy (FA)	embryonic hemocyte	0.00003944	--	Direct
Fly Anatomy (FA)	hemocoel	0.003729	--	Inherited
Fly Anatomy (FA)	immaterial anatomical entity	0.006954	--	Inherited
Fly Anatomy (FA)	hemocyte	0.01075	--	Inherited
Fly Anatomy (FA)	somatic cell	0.03251	--	Inherited
Fly Anatomy (FA)	circulatory system	0.07323	--	Inherited
Fly Anatomy (FA)	organ system	0.2906	--	Inherited
Fly Anatomy (FA)	organism	0.6176	--	Inherited
Fly Anatomy (FA)	anatomical structure	1	--	Inherited
Fly Anatomy (FA)	material anatomical entity	1	--	Inherited
Fly Anatomy (FA)	cell	0.08863	Least Informative	Inherited
Fly Anatomy (FA)	anatomical space	0.006332	Informative	Inherited
Fly Anatomy (FA)	head mesoderm derived embryonic hemocyte	0.000026	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

ZA

Zebrafish Anatomy (ZA)

	ZA term	FDR (all)	SDZA (four levels)	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	--	Direct
Zebrafish Anatomy (ZA)	anatomical structure	1	--	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

XA

Xenopus Anatomy (XA)

	XA term	FDR (all)	SDXA (four levels)	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	--	Direct

	XA term	FDR (all)	SDXA (four levels)	Annotation (direct or inherited)
Xenopus DEvelopment stage (XDE)	NF stage 43	0.0001149	--	Direct
Xenopus DEvelopment stage (XDE)	NF stage	0.8858	--	Inherited
Xenopus DEvelopment stage (XDE)	tailbud stage	0.9789	--	Inherited
Xenopus DEvelopment stage (XDE)	embryonic stage	0.001232	Moderately Informative	Inherited
Xenopus DEvelopment stage (XDE)	late tailbud stage	0.2942	Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

AP

Arabidopsis Plant Ontology (AP)

	AP term	FDR (all)	SDAP (four levels)	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	pollen sac	0.0001068	--	Direct
Plant ANatomical entity (PAN)	microgametophyte	0.0001087	--	Direct
Plant ANatomical entity (PAN)	microsporangium	0.0001156	--	Direct
Plant ANatomical entity (PAN)	multi-tissue plant structure	0.03424	--	Inherited
Plant ANatomical entity (PAN)	sporophyll	0.07196	--	Inherited
Plant ANatomical entity (PAN)	phyllome	0.2182	--	Inherited
Plant ANatomical entity (PAN)	collective plant structure	0.7043	--	Inherited
Plant ANatomical entity (PAN)	shoot system	0.9507	--	Inherited
Plant ANatomical entity (PAN)	plant organ	0.9775	--	Inherited
Plant ANatomical entity (PAN)	plant structure	1	--	Inherited
Plant ANatomical entity (PAN)	collective plant organ structure	1	--	Inherited
Plant ANatomical entity (PAN)	sporangium	0.0003658	Least Informative	Direct
Plant ANatomical entity (PAN)	microsporophyll	0.02604	Least Informative	Inherited
Plant ANatomical entity (PAN)	whole plant	0.06154	Least Informative	Inherited
Plant ANatomical entity (PAN)	pollen	0.000106	Moderately Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

EC

Enzyme Commission (EC)

	EC term	FDR (all)	SDEC (four levels)	Annotation (direct or inherited)
Enzyme Commission (EC)	Nitrate reductase (NADH)	0	--	Direct
Enzyme Commission (EC)	Sulfite oxidase	0	--	Direct
Enzyme Commission (EC)	Transferases	0	--	Direct
Enzyme Commission (EC)	Protein-glutamine gamma-glutamyltransferase	0	--	Direct
Enzyme Commission (EC)	1,4-alpha-glucan branching enzyme	0	--	Direct
Enzyme Commission (EC)	Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compounds	0	--	Direct
Enzyme Commission (EC)	Limit dextrin alpha-1,6-maltotetraose-hydrolase	0	--	Direct
Enzyme Commission (EC)	Togavirin	0	--	Direct
Enzyme Commission (EC)	Acting on ATP; involved in cellular and subcellular movement	0	--	Direct
Enzyme Commission (EC)	Protein xylosyltransferase	5.111e-16	--	Direct
Enzyme Commission (EC)	Tyrosinase	0.00000000000002683	--	Direct
Enzyme Commission (EC)	Gingipain R	0.000000000008186	--	Direct
Enzyme Commission (EC)	Nitrate reductase (NADPH)	0.00000000001013	--	Direct
Enzyme Commission (EC)	Cyclomaltodextrin glucanotransferase	0.0000000000114	--	Direct
Enzyme Commission (EC)	4-alpha-D-((1->4)-alpha-D-glucano)trehalose trehalohydrolase	0.00000000001993	--	Direct
Enzyme Commission (EC)	Pullulanase	0.00000000001993	--	Direct
Enzyme Commission (EC)	Isoamylase	0.00000000001993	--	Direct
Enzyme Commission (EC)	Aldehyde oxidase	0.00000007742	--	Direct
Enzyme Commission (EC)	Methyltransferases	0.000008279	--	Direct
Enzyme Commission (EC)	Neopullulanase	0.00001762	--	Direct
Enzyme Commission (EC)	Acyltransferases	1	--	Inherited
Enzyme Commission (EC)	Hydrolases	2.574e-16	Least Informative	Direct
Enzyme Commission (EC)	Oxidoreductases	1	Least Informative	Inherited
Enzyme Commission (EC)	Transferring phosphorus-containing groups	1	Least Informative	Inherited
Enzyme Commission (EC)	Aminoacyltransferases	0	Moderately Informative	Direct
Enzyme Commission (EC)	Glycosyltransferases	0	Moderately Informative	Direct
Enzyme Commission (EC)	Glycosylases	0	Moderately Informative	Direct
Enzyme Commission (EC)	Acting on peptide bonds (peptidases)	0	Moderately Informative	Direct
Enzyme Commission (EC)	Acting on acid anhydrides	0.0000000759	Moderately Informative	Direct
Enzyme Commission (EC)	Nucleotidyltransferases	0.0001353	Moderately Informative	Direct
Enzyme Commission (EC)	Transferring one-carbon groups	1	Moderately Informative	Inherited
Enzyme Commission (EC)	Acting on other nitrogenous compounds as donors	0	Informative	Direct
Enzyme Commission (EC)	Hexosyltransferases	0	Informative	Direct
Enzyme Commission (EC)	Protein-tyrosine kinases	0	Informative	Direct
Enzyme Commission (EC)	RNA-directed RNA polymerase	0	Informative	Direct
Enzyme Commission (EC)	Serine endopeptidases	0	Informative	Direct
Enzyme Commission (EC)	RNA helicase	0	Informative	Direct
Enzyme Commission (EC)	In phosphorus-containing anhydrides	0.0000000000002478	Informative	Direct
Enzyme Commission (EC)	Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate	0.05928	Informative	Inherited
Enzyme Commission (EC)	Acting on a sulfur group of donors	0.06477	Informative	Inherited
Enzyme Commission (EC)	Cysteine endopeptidases	0.9242	Informative	Inherited
Enzyme Commission (EC)	Acting on the aldehyde or oxo group of donors	1	Informative	Inherited
Enzyme Commission (EC)	Pentosyltransferases	1	Informative	Inherited
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	Highly Informative	Direct
Enzyme Commission (EC)	mRNA (guanine-N(7)-)-methyltransferase	0	Highly Informative	Direct
Enzyme Commission (EC)	Methyltransferase cap1	0	Highly Informative	Direct
Enzyme Commission (EC)	Receptor protein-tyrosine kinase	0	Highly Informative	Direct
Enzyme Commission (EC)	Flavivirin	0	Highly Informative	Direct
Enzyme Commission (EC)	Nucleoside-triphosphate phosphatase	0	Highly Informative	Direct
Enzyme Commission (EC)	With another compound as one donor, and incorporation of one atom of oxygen	0.0000000000006135	Highly Informative	Direct
Enzyme Commission (EC)	With oxygen as acceptor	0.0000000001849	Highly Informative	Direct
Enzyme Commission (EC)	With oxygen as acceptor	0.0000004246	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

CD

CTD Diseases (CD)

	CD term	FDR (all)	SDCD (four levels)	Annotation (direct or inherited)
CTD Diseases (CD)	Wounds and Injuries	0.01105	Informative	Inherited
CTD Diseases (CD)	Heat Stress Disorders	0.00000952	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

CC

CTD Chemicals (CC)

	CC term	FDR (all)	SDCC (four levels)	Annotation (direct or inherited)
CTD Chemicals (CC)	Harmala Alkaloids	0.0000003476	--	Direct
CTD Chemicals (CC)	scoparone	0.000002352	--	Direct
CTD Chemicals (CC)	Barium	0.00001251	--	Direct
CTD Chemicals (CC)	Potassium	0.00004292	--	Direct
CTD Chemicals (CC)	Thallium	0.00004911	--	Direct
CTD Chemicals (CC)	Benzoxazoles	0.00009479	--	Direct
CTD Chemicals (CC)	Tosyllysine Chloromethyl Ketone	0.0007833	--	Direct
CTD Chemicals (CC)	Benzodioxoles	0.005319	--	Inherited
CTD Chemicals (CC)	Pyrans	0.02932	--	Inherited
CTD Chemicals (CC)	Heterocyclic Compounds, 2-Ring	0.03916	--	Inherited
CTD Chemicals (CC)	Alkynes	0.1364	--	Inherited
CTD Chemicals (CC)	Heterocyclic Compounds	0.1402	--	Inherited
CTD Chemicals (CC)	Heterocyclic Compounds, Fused-Ring	0.2003	--	Inherited
CTD Chemicals (CC)	Alkenes	0.2119	--	Inherited
CTD Chemicals (CC)	Metals, Heavy	0.2205	--	Inherited
CTD Chemicals (CC)	Sulfones	0.2332	--	Inherited
CTD Chemicals (CC)	Polycyclic Compounds	0.3387	--	Inherited
CTD Chemicals (CC)	Indole Alkaloids	0.3524	--	Inherited
CTD Chemicals (CC)	Inorganic Chemicals	0.4165	--	Inherited
CTD Chemicals (CC)	Hydrocarbons, Cyclic	0.4349	--	Inherited
CTD Chemicals (CC)	Hydrocarbons	0.4825	--	Inherited
CTD Chemicals (CC)	Aniline Compounds	0.533	--	Inherited
CTD Chemicals (CC)	Benzene Derivatives	0.833	--	Inherited
CTD Chemicals (CC)	Hydrocarbons, Aromatic	0.8606	--	Inherited
CTD Chemicals (CC)	Heterocyclic Compounds, 1-Ring	0.8665	--	Inherited
CTD Chemicals (CC)	Organic Chemicals	0.9138	--	Inherited
CTD Chemicals (CC)	Biological Factors	0.0001466	Least Informative	Direct
CTD Chemicals (CC)	Benzopyrans	0.1325	Least Informative	Inherited
CTD Chemicals (CC)	Metals	0.2443	Least Informative	Inherited
CTD Chemicals (CC)	Polycyclic Aromatic Hydrocarbons	0.2483	Least Informative	Inherited
CTD Chemicals (CC)	Amino Acids, Peptides, and Proteins	0.5236	Least Informative	Inherited
CTD Chemicals (CC)	Elements	0.5249	Least Informative	Inherited
CTD Chemicals (CC)	Hydrocarbons, Acyclic	0.583	Least Informative	Inherited
CTD Chemicals (CC)	Sulfur Compounds	0.6452	Least Informative	Inherited
CTD Chemicals (CC)	Indoles	0.7386	Least Informative	Inherited
CTD Chemicals (CC)	Amines	0.7639	Least Informative	Inherited
CTD Chemicals (CC)	Amides	0.8508	Least Informative	Inherited
CTD Chemicals (CC)	Carbohydrates	0.8673	Least Informative	Inherited
CTD Chemicals (CC)	Naphthalenes	0.0008706	Moderately Informative	Direct
CTD Chemicals (CC)	Heterocyclic Compounds, 3-Ring	0.03601	Moderately Informative	Inherited
CTD Chemicals (CC)	Pyridines	0.09707	Moderately Informative	Inherited
CTD Chemicals (CC)	Piperidines	0.1982	Moderately Informative	Inherited
CTD Chemicals (CC)	Polysaccharides	0.4005	Moderately Informative	Inherited
CTD Chemicals (CC)	Alkaloids	0.4299	Moderately Informative	Inherited
CTD Chemicals (CC)	Amino Acids	0.5058	Moderately Informative	Inherited
CTD Chemicals (CC)	Metals, Light	0.006921	Informative	Inherited
CTD Chemicals (CC)	Toluene	0.07819	Informative	Inherited
CTD Chemicals (CC)	Polyunsaturated Alkamides	0.1027	Informative	Inherited
CTD Chemicals (CC)	Dioxoles	0.2584	Informative	Inherited
CTD Chemicals (CC)	Coumarins	0.6286	Informative	Inherited
CTD Chemicals (CC)	Metals, Alkali	0.000001145	Highly Informative	Direct
CTD Chemicals (CC)	Calcimycin	0.00001225	Highly Informative	Direct
CTD Chemicals (CC)	Carbolines	0.00001438	Highly Informative	Direct
CTD Chemicals (CC)	fucoidan	0.00005991	Highly Informative	Direct
CTD Chemicals (CC)	piperine	0.0001368	Highly Informative	Direct
CTD Chemicals (CC)	Gold Compounds	0.0003977	Highly Informative	Direct
CTD Chemicals (CC)	2-anisidine	0.0007151	Highly Informative	Direct
CTD Chemicals (CC)	Amino Acid Chloromethyl Ketones	0.006173	Highly Informative	Inherited
CTD Chemicals (CC)	Metals, Alkaline Earth	0.02522	Highly Informative	Inherited
CTD Chemicals (CC)	Tosyl Compounds	0.1156	Highly Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

Distribution on sTOL

Plot distribution on species Tree Of Life (sTOL) for this domain, i.e., present or absent across genomes/tips

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E set domains superfamily