Multidrug efflux transporter AcrB transmembrane domain superfamily

DO

Disease Ontology (DO)

	DO term	FDR (all)	SDDO (four levels)	Annotation (direct or inherited)
Disease Ontology (DO)	coronary artery disease	0.00009615	--	Direct
Disease Ontology (DO)	vascular disease	0.008618	--	Inherited
Disease Ontology (DO)	cardiovascular system disease	0.05153	--	Inherited
Disease Ontology (DO)	disease of anatomical entity	0.06205	--	Inherited
Disease Ontology (DO)	artery disease	0.005037	Moderately Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

HP

Human Phenotype (HP)

	HP term	FDR (all)	SDHP (four levels)	Annotation (direct or inherited)
	Variable expressivity	0	--	Direct
	Phenotypic variability	1	--	Inherited
Mode of Inheritance (MI)	Heterogeneous	0.0001774	Informative	Direct

	HP term	FDR (all)	SDHP (four levels)	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	--	Direct
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0	--	Direct
Phenotypic Abnormality (PA)	Short distal phalanx of finger	0.00009783	--	Direct
Phenotypic Abnormality (PA)	Abnormal distal phalanx morphology of finger	0.000215	--	Direct
Phenotypic Abnormality (PA)	Coloboma	0.0004354	--	Direct
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia of the phalanges of the hand	0.0005989	--	Direct
Phenotypic Abnormality (PA)	Short finger	0.000969	--	Direct
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia of fingers	0.001568	--	Inherited
Phenotypic Abnormality (PA)	Abnormality iris morphology	0.003042	--	Inherited
Phenotypic Abnormality (PA)	Aplasia/hypoplasia involving bones of the upper limbs	0.006274	--	Inherited
Phenotypic Abnormality (PA)	Aplasia/hypoplasia involving bones of the extremities	0.009999	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of finger	0.04547	--	Inherited
Phenotypic Abnormality (PA)	Abnormal digit morphology	0.07448	--	Inherited
Phenotypic Abnormality (PA)	Aplasia/hypoplasia involving the skeleton	0.07811	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of the hand	0.08376	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of limb bone	0.147	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0.2002	--	Inherited
Phenotypic Abnormality (PA)	Abnormal appendicular skeleton morphology	0.2192	--	Inherited
Phenotypic Abnormality (PA)	Abnormal eye morphology	0.5406	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of the musculature	0	Least Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0	Least Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0	Least Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of the digestive system	0	Least Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0.1784	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the eye	0.1789	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of limbs	0.229	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the gastrointestinal tract	0	Moderately Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of higher mental function	0	Moderately Informative	Direct
Phenotypic Abnormality (PA)	Neurodevelopmental abnormality	0	Moderately Informative	Direct
Phenotypic Abnormality (PA)	Abnormal anterior eye segment morphology	0.06372	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the upper limb	0.1018	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of limb bone morphology	0.1053	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Intellectual disability	0	Informative	Direct
Phenotypic Abnormality (PA)	Abnormal uvea morphology	0.00649	Informative	Inherited
Phenotypic Abnormality (PA)	Abnormal finger phalanx morphology	0.01138	Informative	Inherited
Phenotypic Abnormality (PA)	Aplasia/hypoplasia of the extremities	0.01197	Informative	Inherited
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia of the distal phalanges of the hand	0.0001051	Highly Informative	Direct
Phenotypic Abnormality (PA)	Iris coloboma	0.0001377	Highly Informative	Direct
Phenotypic Abnormality (PA)	Short phalanx of finger	0.000388	Highly Informative	Direct
Phenotypic Abnormality (PA)	Abnormal hand morphology	0.002202	Highly Informative	Inherited
Phenotypic Abnormality (PA)	Aplasia/hypoplasia involving bones of the hand	0.004969	Highly Informative	Inherited
Phenotypic Abnormality (PA)	Short digit	0.007351	Highly Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

MP

Mouse Phenotype (MP)

	MP term	FDR (all)	SDMP (four levels)	Annotation (direct or inherited)
Mammalian Phenotype (MP)	decreased sterol level	0.00009389	--	Direct
Mammalian Phenotype (MP)	abnormal liver cholesterol level	0.0001129	--	Direct
Mammalian Phenotype (MP)	abnormal circulating LDL cholesterol level	0.0001144	--	Direct
Mammalian Phenotype (MP)	abnormal circulating non-HDL cholesterol level	0.0001534	--	Direct
Mammalian Phenotype (MP)	abnormal cholesterol homeostasis	0.0009076	--	Direct
Mammalian Phenotype (MP)	abnormal sterol level	0.0009151	--	Direct
Mammalian Phenotype (MP)	abnormal lipoprotein level	0.002491	--	Inherited
Mammalian Phenotype (MP)	abnormal liver morphology	0.008504	--	Inherited
Mammalian Phenotype (MP)	abnormal lipid level	0.008979	--	Inherited
Mammalian Phenotype (MP)	abnormal hepatobiliary system morphology	0.01134	--	Inherited
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.1131	--	Inherited
Mammalian Phenotype (MP)	abnormal circulating cholesterol level	0.2545	--	Inherited
Mammalian Phenotype (MP)	abnormal blood homeostasis	0.3812	--	Inherited
Mammalian Phenotype (MP)	abnormal homeostasis	0.6323	Least Informative	Inherited
Mammalian Phenotype (MP)	abnormal lipid homeostasis	0.01553	Moderately Informative	Inherited
Mammalian Phenotype (MP)	liver/biliary system phenotype	0.01637	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal cholesterol level	0.0008581	Informative	Direct
Mammalian Phenotype (MP)	abnormal circulating lipoprotein level	0.001959	Informative	Inherited
Mammalian Phenotype (MP)	abnormal circulating lipid level	0.004096	Informative	Inherited
Mammalian Phenotype (MP)	decreased cholesterol level	0.00009389	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

WP

Worm Phenotype (WP)

	WP term	FDR (all)	SDWP (four levels)	Annotation (direct or inherited)
Worm Phenotype (WP)	postembryonic development variant	0	--	Direct
Worm Phenotype (WP)	embryonic lethal	0	--	Direct
Worm Phenotype (WP)	lethal	0	--	Direct
Worm Phenotype (WP)	body morphology variant	0	--	Direct
Worm Phenotype (WP)	fertility variant	0	--	Direct
Worm Phenotype (WP)	body size variant	0	--	Direct
Worm Phenotype (WP)	development variant	0	--	Direct
Worm Phenotype (WP)	morphology variant	0	--	Direct
Worm Phenotype (WP)	organism development variant	0	--	Direct
Worm Phenotype (WP)	organ system physiology variant	0	--	Direct
Worm Phenotype (WP)	reproductive system physiology variant	0	--	Direct
Worm Phenotype (WP)	locomotion variant	0	--	Direct
Worm Phenotype (WP)	maternal sterile	0	--	Direct
Worm Phenotype (WP)	hermaphrodite sterile	0	--	Direct
Worm Phenotype (WP)	vulva morphology variant	0	--	Direct
Worm Phenotype (WP)	everted vulva	0	--	Direct
Worm Phenotype (WP)	intestinal morphology variant	0	--	Direct
Worm Phenotype (WP)	embryonic development variant	0	--	Direct
Worm Phenotype (WP)	hermaphrodite fertility variant	0	--	Direct
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	--	Direct
Worm Phenotype (WP)	fertility reduced	0	--	Direct
Worm Phenotype (WP)	intestinal vacuole	0	--	Direct
Worm Phenotype (WP)	body length variant	0	--	Direct
Worm Phenotype (WP)	body width variant	0	--	Direct
Worm Phenotype (WP)	behavior variant	0.0000000000001202	--	Direct
Worm Phenotype (WP)	tail development variant	0.0000000001033	--	Direct
Worm Phenotype (WP)	organism segment development variant	0.0000000001039	--	Direct
Worm Phenotype (WP)	body region development variant	0.000000001135	--	Direct
Worm Phenotype (WP)	cuticle morphology variant	0.000001104	--	Direct
Worm Phenotype (WP)	hermaphrodite reproductive system morphology variant	0.00002958	--	Direct
Worm Phenotype (WP)	multiple alae	0.00004924	--	Direct
Worm Phenotype (WP)	alae secretion variant	0.00007119	--	Direct
Worm Phenotype (WP)	positive chemotaxis defective	0.00008537	--	Direct
Worm Phenotype (WP)	embryo osmotic integrity defective early emb	0.0005919	--	Direct
Worm Phenotype (WP)	egg integrity defective early emb	0.0009295	--	Direct
Worm Phenotype (WP)	chemosensory response variant	0.002601	--	Inherited
Worm Phenotype (WP)	odorant positive chemotaxis variant	0.07711	--	Inherited
Worm Phenotype (WP)	chemosensory behavior variant	0.1162	--	Inherited
Worm Phenotype (WP)	chemical response variant	0.1321	--	Inherited
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.1557	--	Inherited
Worm Phenotype (WP)	organism physiology variant	0.1728	--	Inherited
Worm Phenotype (WP)	positive chemotaxis variant	0.2394	--	Inherited
Worm Phenotype (WP)	organism morphology variant	0.5008	--	Inherited
Worm Phenotype (WP)	eggshell formation variant	0.7661	--	Inherited
Worm Phenotype (WP)	physiology variant	1	--	Inherited
Worm Phenotype (WP)	sterile	1	--	Inherited
Worm Phenotype (WP)	organ system morphology variant	0	Least Informative	Direct
Worm Phenotype (WP)	larval development variant	0	Least Informative	Direct
Worm Phenotype (WP)	organism behavior variant	0.00000000000009802	Least Informative	Direct
Worm Phenotype (WP)	organism environmental stimulus response variant	0.1669	Least Informative	Inherited
Worm Phenotype (WP)	cell physiology variant	0.261	Least Informative	Inherited
Worm Phenotype (WP)	body region morphology variant	0	Moderately Informative	Direct
Worm Phenotype (WP)	organism segment morphology variant	0	Moderately Informative	Direct
Worm Phenotype (WP)	reproductive system morphology variant	0.000003046	Moderately Informative	Direct
Worm Phenotype (WP)	movement variant	0.000004802	Moderately Informative	Direct
Worm Phenotype (WP)	early embryonic lethal	0.3002	Moderately Informative	Inherited
Worm Phenotype (WP)	small	0.000000008524	Informative	Direct
Worm Phenotype (WP)	pericellular component morphology variant	0.000002699	Informative	Direct
Worm Phenotype (WP)	odorant chemosensory response variant	0.0000158	Informative	Direct
Worm Phenotype (WP)	chemotaxis variant	0.0003262	Informative	Direct
Worm Phenotype (WP)	alimentary system morphology variant	0	Highly Informative	Direct
Worm Phenotype (WP)	body vacuole	0	Highly Informative	Direct
Worm Phenotype (WP)	molt variant	0	Highly Informative	Direct
Worm Phenotype (WP)	pericellular component physiology variant	0.00000000005748	Highly Informative	Direct
Worm Phenotype (WP)	male tail development variant	0.00000000008515	Highly Informative	Direct
Worm Phenotype (WP)	cell secretion variant	0.000000004119	Highly Informative	Direct
Worm Phenotype (WP)	odorant positive chemotaxis defective	0.000008427	Highly Informative	Direct
Worm Phenotype (WP)	epithelial system physiology variant	0.000009071	Highly Informative	Direct
Worm Phenotype (WP)	osmotic integrity variant	0.002295	Highly Informative	Inherited
Worm Phenotype (WP)	alae morphology variant	0.1348	Highly Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

FP

Fly Phenotype (FP)

	FP term	FDR (all)	SDFP (four levels)	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	--	Direct
Fly Phenotype (FP)	increased mortality during development	0	--	Direct
Fly Phenotype (FP)	increased mortality	0	Least Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

FA

Fly Anatomy (FA)

	FA term	FDR (all)	SDFA (four levels)	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	--	Direct
Fly Anatomy (FA)	tagma	0	--	Direct
Fly Anatomy (FA)	organ system	0	--	Direct
Fly Anatomy (FA)	multicellular structure	0	--	Direct
Fly Anatomy (FA)	embryonic/larval cuticle	0.002006	--	Inherited
Fly Anatomy (FA)	cuticle	0.01948	--	Inherited
Fly Anatomy (FA)	integumentary system	0.1721	--	Inherited
Fly Anatomy (FA)	anatomical structure	1	--	Inherited
Fly Anatomy (FA)	material anatomical entity	1	--	Inherited
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	--	Inherited
Fly Anatomy (FA)	larva	0	Least Informative	Direct
Fly Anatomy (FA)	organism subdivision	0	Least Informative	Direct
Fly Anatomy (FA)	head	0	Moderately Informative	Direct
Fly Anatomy (FA)	acellular anatomical structure	0.02569	Moderately Informative	Inherited
Fly Anatomy (FA)	embryonic/larval integumentary system	0.004583	Informative	Inherited
Fly Anatomy (FA)	embryonic/first instar larval cuticle	0.0005797	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

ZA

Zebrafish Anatomy (ZA)

	ZA term	FDR (all)	SDZA (four levels)	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	--	Direct
Zebrafish Anatomy (ZA)	hyosymplectic cartilage	0.00003231	--	Direct
Zebrafish Anatomy (ZA)	skeletal muscle cell	0.0000687	--	Direct
Zebrafish Anatomy (ZA)	dorsal hyoid arch	0.0002177	--	Direct
Zebrafish Anatomy (ZA)	striated muscle cell	0.0005563	--	Direct
Zebrafish Anatomy (ZA)	retinal ganglion cell layer	0.000792	--	Direct
Zebrafish Anatomy (ZA)	pharyngeal arch 2	0.004418	--	Inherited
Zebrafish Anatomy (ZA)	musculature system	0.006565	--	Inherited
Zebrafish Anatomy (ZA)	muscle	0.006735	--	Inherited
Zebrafish Anatomy (ZA)	cranial cartilage	0.01395	--	Inherited
Zebrafish Anatomy (ZA)	cartilage element	0.01691	--	Inherited
Zebrafish Anatomy (ZA)	retina	0.02397	--	Inherited
Zebrafish Anatomy (ZA)	skeletal element	0.02658	--	Inherited
Zebrafish Anatomy (ZA)	posterior segment eye	0.02814	--	Inherited
Zebrafish Anatomy (ZA)	splanchnocranium	0.03172	--	Inherited
Zebrafish Anatomy (ZA)	electrically active cell	0.04302	--	Inherited
Zebrafish Anatomy (ZA)	cranium	0.0471	--	Inherited
Zebrafish Anatomy (ZA)	visual system	0.1119	--	Inherited
Zebrafish Anatomy (ZA)	anatomical system	0.6371	--	Inherited
Zebrafish Anatomy (ZA)	anatomical group	0.6667	--	Inherited
Zebrafish Anatomy (ZA)	cavitated compound organ	0.7934	--	Inherited
Zebrafish Anatomy (ZA)	anatomical structure	1	--	Inherited
Zebrafish Anatomy (ZA)	electrically responsive cell	1	--	Inherited
Zebrafish Anatomy (ZA)	cell	0.09166	Least Informative	Inherited
Zebrafish Anatomy (ZA)	organism subdivision	0.4496	Least Informative	Inherited
Zebrafish Anatomy (ZA)	nervous system	0.529	Least Informative	Inherited
Zebrafish Anatomy (ZA)	compound organ	0.6545	Least Informative	Inherited
Zebrafish Anatomy (ZA)	multi-tissue structure	0.6912	Least Informative	Inherited
Zebrafish Anatomy (ZA)	sensory system	0.19	Moderately Informative	Inherited
Zebrafish Anatomy (ZA)	portion of tissue	0.235	Moderately Informative	Inherited
Zebrafish Anatomy (ZA)	head	0.3334	Moderately Informative	Inherited
Zebrafish Anatomy (ZA)	anatomical cluster	0.5742	Moderately Informative	Inherited
Zebrafish Anatomy (ZA)	skeletal muscle	0.0001767	Informative	Direct
Zebrafish Anatomy (ZA)	muscle cell	0.0149	Informative	Inherited
Zebrafish Anatomy (ZA)	pharyngeal arch	0.04359	Informative	Inherited
Zebrafish Anatomy (ZA)	skeletal system	0.06334	Informative	Inherited
Zebrafish Anatomy (ZA)	eye	0.1098	Informative	Inherited
Zebrafish Anatomy (ZA)	suspensorium	0.001219	Highly Informative	Inherited
Zebrafish Anatomy (ZA)	pharyngeal arch 2 skeleton	0.003201	Highly Informative	Inherited
Zebrafish Anatomy (ZA)	pharyngeal arch cartilage	0.008351	Highly Informative	Inherited
Zebrafish Anatomy (ZA)	retinal neural layer	0.00901	Highly Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

XA

Xenopus Anatomy (XA)

	XA term	FDR (all)	SDXA (four levels)	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	--	Direct
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	--	Direct
Xenopus ANatomical entity (XAN)	whole organism	1	--	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

EC

Enzyme Commission (EC)

	EC term	FDR (all)	SDEC (four levels)	Annotation (direct or inherited)
Enzyme Commission (EC)	Hydroxymethylglutaryl-CoA reductase (NADPH)	0	--	Direct
Enzyme Commission (EC)	Heme o synthase	0	--	Direct
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than methyl groups	0.00002239	--	Direct
Enzyme Commission (EC)	Transferases	0.5783	--	Inherited
Enzyme Commission (EC)	Oxidoreductases	0.000003303	Least Informative	Direct
Enzyme Commission (EC)	Acting on the CH-OH group of donors	0.00000000004223	Moderately Informative	Direct
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.0000000000201	Informative	Direct
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than methyl groups	1	Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

CD

CTD Diseases (CD)

	CD term	FDR (all)	SDCD (four levels)	Annotation (direct or inherited)
CTD Diseases (CD)	Gastrointestinal Stromal Tumors	0.00000001364	--	Direct
CTD Diseases (CD)	Neoplasms, Connective Tissue	0.000001587	--	Direct
CTD Diseases (CD)	Neoplasms, Connective and Soft Tissue	0.0008361	--	Direct
CTD Diseases (CD)	Neoplasms by Histologic Type	0.001646	--	Inherited
CTD Diseases (CD)	Neoplasms by Site	0.007473	--	Inherited
CTD Diseases (CD)	Skin and Connective Tissue Diseases	0.007634	--	Inherited
CTD Diseases (CD)	Gastrointestinal Neoplasms	0.2711	--	Inherited
CTD Diseases (CD)	Digestive System Diseases	0.004573	Least Informative	Inherited
CTD Diseases (CD)	Neoplasms	0.02357	Least Informative	Inherited
CTD Diseases (CD)	Digestive System Neoplasms	0.0001531	Moderately Informative	Direct
CTD Diseases (CD)	Gastrointestinal Diseases	0.1379	Moderately Informative	Inherited
CTD Diseases (CD)	Connective Tissue Diseases	0.04808	Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

CC

CTD Chemicals (CC)

	CC term	FDR (all)	SDCC (four levels)	Annotation (direct or inherited)
CTD Chemicals (CC)	Heterocyclic Compounds, Fused-Ring	0	--	Direct
CTD Chemicals (CC)	Heterocyclic Compounds	0	--	Direct
CTD Chemicals (CC)	Heterocyclic Compounds, 1-Ring	0	--	Direct
CTD Chemicals (CC)	Organic Chemicals	0	--	Direct
CTD Chemicals (CC)	Cholestanes	0.1779	--	Inherited
CTD Chemicals (CC)	Lipids	0.5381	--	Inherited
CTD Chemicals (CC)	Polycyclic Compounds	0.7159	--	Inherited
CTD Chemicals (CC)	Steroids	1	--	Inherited
CTD Chemicals (CC)	Fused-Ring Compounds	0.2819	Least Informative	Inherited
CTD Chemicals (CC)	Membrane Lipids	0.1424	Moderately Informative	Inherited
CTD Chemicals (CC)	Sterols	0.115	Informative	Inherited
CTD Chemicals (CC)	Cholestenes	0.1156	Informative	Inherited
CTD Chemicals (CC)	Cholesterol	0.0002729	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

Distribution on sTOL

Plot distribution on species Tree Of Life (sTOL) for this domain, i.e., present or absent across genomes/tips

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Multidrug efflux transporter AcrB transmembrane domain superfamily