TSP-1 type 1 repeat family

DO

Disease Ontology (DO)

	DO term	FDR (all)	SDDO (four levels)	Annotation (direct or inherited)
Disease Ontology (DO)	peripheral nerve sheath neoplasm	0.00000316	--	Direct
Disease Ontology (DO)	musculoskeletal system disease	0.003427	--	Inherited
Disease Ontology (DO)	disease of anatomical entity	0.04848	--	Inherited
Disease Ontology (DO)	bone disease	0.06829	--	Inherited
Disease Ontology (DO)	bone inflammation disease	0.3491	--	Inherited
Disease Ontology (DO)	cancer	0.4237	--	Inherited
Disease Ontology (DO)	disease of cellular proliferation	0.4715	--	Inherited
Disease Ontology (DO)	organ system cancer	0.285	Least Informative	Inherited
Disease Ontology (DO)	connective tissue disease	0.0001237	Moderately Informative	Direct
Disease Ontology (DO)	nervous system cancer	0.3345	Moderately Informative	Inherited
Disease Ontology (DO)	arthritis	0.00005094	Informative	Direct
Disease Ontology (DO)	peripheral nervous system neoplasm	0.1037	Informative	Inherited
Disease Ontology (DO)	neurofibroma	0.0000003753	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

HP

Human Phenotype (HP)

	HP term	FDR (all)	SDHP (four levels)	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Recurrent gram-negative bacterial infections	0.00003243	--	Direct
Phenotypic Abnormality (PA)	Abnormality of humoral immunity	0.0002527	--	Direct
Phenotypic Abnormality (PA)	Abnormality of the epiphysis of the femoral head	0.0008463	--	Direct
Phenotypic Abnormality (PA)	Abnormality of femoral epiphysis	0.0009305	--	Direct
Phenotypic Abnormality (PA)	Abnormality of the femoral head	0.00123	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of lower limb epiphysis morphology	0.002234	--	Inherited
Phenotypic Abnormality (PA)	Recurrent bacterial infections	0.009869	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of limb epiphysis morphology	0.01553	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of the femoral neck or head region	0.02413	--	Inherited
Phenotypic Abnormality (PA)	Abnormal appendicular skeleton morphology	0.09993	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of limb bone	0.1297	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of femur morphology	0.1741	--	Inherited
Phenotypic Abnormality (PA)	Abnormal eye morphology	0.4518	--	Inherited
Phenotypic Abnormality (PA)	Unusual infection	0.5072	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0.7725	--	Inherited
Phenotypic Abnormality (PA)	Abnormality of limbs	0.1906	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the immune system	0.3514	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0.7074	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the eye	0.8362	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of immune system physiology	0.1413	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of the lower limb	0.301	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormal anterior eye segment morphology	0.3511	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of limb bone morphology	0.5558	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of complement system	0.00003145	Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of the lens	0.1709	Informative	Inherited
Phenotypic Abnormality (PA)	Abnormal lower limb bone morphology	0.237	Informative	Inherited
Phenotypic Abnormality (PA)	Abnormality of long bone morphology	0.2681	Informative	Inherited
Phenotypic Abnormality (PA)	Recurrent infections	0.7602	Informative	Inherited
Phenotypic Abnormality (PA)	Recurrent Neisserial infections	0.000001761	Highly Informative	Direct
Phenotypic Abnormality (PA)	Ectopia lentis	0.0008328	Highly Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of epiphysis morphology	0.1794	Highly Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

MP

Mouse Phenotype (MP)

	MP term	FDR (all)	SDMP (four levels)	Annotation (direct or inherited)
Mammalian Phenotype (MP)	increased compact bone thickness	0.0003641	--	Direct
Mammalian Phenotype (MP)	abnormal compact bone thickness	0.01464	--	Inherited
Mammalian Phenotype (MP)	skeleton phenotype	0.172	--	Inherited
Mammalian Phenotype (MP)	abnormal skeleton morphology	0.5743	--	Inherited
Mammalian Phenotype (MP)	abnormal bone structure	0.3612	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal compact bone morphology	0.06648	Highly Informative	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

WP

Worm Phenotype (WP)

	WP term	FDR (all)	SDWP (four levels)	Annotation (direct or inherited)
Worm Phenotype (WP)	lethal	0	--	Direct
Worm Phenotype (WP)	development variant	0	--	Direct
Worm Phenotype (WP)	organism development variant	0	--	Direct
Worm Phenotype (WP)	basement membrane remodeling variant	0.0000001126	--	Direct
Worm Phenotype (WP)	physiology variant	1	--	Inherited
Worm Phenotype (WP)	pericellular component development variant	0.000001027	Moderately Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

FA

Fly Anatomy (FA)

	FA term	FDR (all)	SDFA (four levels)	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	--	Direct
Fly Anatomy (FA)	organ system	0	--	Direct
Fly Anatomy (FA)	multicellular structure	0	--	Direct
Fly Anatomy (FA)	anatomical structure	1	--	Inherited
Fly Anatomy (FA)	material anatomical entity	1	--	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

ZA

Zebrafish Anatomy (ZA)

	ZA term	FDR (all)	SDZA (four levels)	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	--	Direct
Zebrafish Anatomy (ZA)	anatomical system	0	--	Direct
Zebrafish Anatomy (ZA)	anatomical group	0	--	Direct
Zebrafish Anatomy (ZA)	anatomical structure	1	--	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

XA

Xenopus Anatomy (XA)

	XA term	FDR (all)	SDXA (four levels)	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	--	Direct
Xenopus ANatomical entity (XAN)	rectal diverticulum	0.00004223	--	Direct
Xenopus ANatomical entity (XAN)	hypochord	0.00008474	--	Direct
Xenopus ANatomical entity (XAN)	cloaca	0.006403	--	Inherited
Xenopus ANatomical entity (XAN)	endoderm	0.0257	--	Inherited
Xenopus ANatomical entity (XAN)	anatomical region	0.999	--	Inherited
Xenopus ANatomical entity (XAN)	anatomical group	1	--	Inherited
Xenopus ANatomical entity (XAN)	anatomical system	1	--	Inherited
Xenopus ANatomical entity (XAN)	whole organism	1	--	Inherited
Xenopus ANatomical entity (XAN)	primary germ layer	1	--	Inherited
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	1	--	Inherited
Xenopus ANatomical entity (XAN)	embryo	1	Least Informative	Inherited
Xenopus ANatomical entity (XAN)	urogenital system	1	Least Informative	Inherited
Xenopus ANatomical entity (XAN)	tissue	1	Least Informative	Inherited
Xenopus ANatomical entity (XAN)	tail region	0.6991	Moderately Informative	Inherited
Xenopus ANatomical entity (XAN)	multi-tissue structure	0.7201	Moderately Informative	Inherited
Xenopus ANatomical entity (XAN)	alimentary system	1	Moderately Informative	Inherited
Xenopus ANatomical entity (XAN)	urinary system	0.2651	Informative	Inherited
Xenopus ANatomical entity (XAN)	tail bud	0.1226	Highly Informative	Inherited

	XA term	FDR (all)	SDXA (four levels)	Annotation (direct or inherited)
Xenopus DEvelopment stage (XDE)	NF stage 45	0	--	Direct
Xenopus DEvelopment stage (XDE)	tadpole stage	0.1841	--	Inherited
Xenopus DEvelopment stage (XDE)	NF stage	0.4931	--	Inherited
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0.2144	Least Informative	Inherited
Xenopus DEvelopment stage (XDE)	premetamorphosis stage	0.0000000000001273	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

EC

Enzyme Commission (EC)

	EC term	FDR (all)	SDEC (four levels)	Annotation (direct or inherited)
Enzyme Commission (EC)	ADAMTS-4 endopeptidase	0.000000001646	--	Direct
Enzyme Commission (EC)	Procollagen N-endopeptidase	0.00000112	--	Direct
Enzyme Commission (EC)	Hydrolases	0	Least Informative	Direct
Enzyme Commission (EC)	Acting on peptide bonds (peptidases)	0	Moderately Informative	Direct
Enzyme Commission (EC)	Metalloendopeptidases	0	Highly Informative	Direct

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CD

CTD Diseases (CD)

	CD term	FDR (all)	SDCD (four levels)	Annotation (direct or inherited)
CTD Diseases (CD)	Neisseriaceae Infections	0.00000008771	--	Direct
CTD Diseases (CD)	Meningitis	0.0000003876	--	Direct
CTD Diseases (CD)	Primary Immunodeficiency Diseases	0.0006653	--	Direct
CTD Diseases (CD)	Bacterial Infections	0.001518	--	Inherited
CTD Diseases (CD)	Bacterial Infections and Mycoses	0.003281	--	Inherited
CTD Diseases (CD)	Immunologic Deficiency Syndromes	0.01452	--	Inherited
CTD Diseases (CD)	Congenital, Hereditary, and Neonatal Diseases and Abnormalities	0.687	--	Inherited
CTD Diseases (CD)	Central Nervous System Diseases	0.7046	--	Inherited
CTD Diseases (CD)	Genetic Diseases, Inborn	0.5671	Least Informative	Inherited
CTD Diseases (CD)	Nervous System Diseases	0.9749	Least Informative	Inherited
CTD Diseases (CD)	Infections	0.1053	Moderately Informative	Inherited
CTD Diseases (CD)	Immune System Diseases	0.1124	Moderately Informative	Inherited
CTD Diseases (CD)	Hereditary Complement Deficiency Diseases	0.000001617	Informative	Direct
CTD Diseases (CD)	Gram-Negative Bacterial Infections	0.00004087	Highly Informative	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

CC

CTD Chemicals (CC)

	CC term	FDR (all)	SDCC (four levels)	Annotation (direct or inherited)
CTD Chemicals (CC)	Heterocyclic Compounds, Fused-Ring	0	--	Direct
CTD Chemicals (CC)	Heterocyclic Compounds	0	--	Direct
CTD Chemicals (CC)	Heterocyclic Compounds, 1-Ring	0	--	Direct
CTD Chemicals (CC)	Heterocyclic Compounds, 2-Ring	0	--	Direct
CTD Chemicals (CC)	Organic Chemicals	0	--	Direct
CTD Chemicals (CC)	Diamines	0.000007454	--	Direct
CTD Chemicals (CC)	Gold Sodium Thiomalate	0.000008431	--	Direct
CTD Chemicals (CC)	Thiomalates	0.00001012	--	Direct
CTD Chemicals (CC)	Malates	0.00001312	--	Direct
CTD Chemicals (CC)	bazedoxifene	0.0002633	--	Direct
CTD Chemicals (CC)	Hydrocarbons, Aromatic	0.0006587	--	Direct
CTD Chemicals (CC)	Hydrocarbons, Cyclic	0.001347	--	Inherited
CTD Chemicals (CC)	Prednisolone	0.004787	--	Inherited
CTD Chemicals (CC)	Polycyclic Compounds	0.006104	--	Inherited
CTD Chemicals (CC)	Hydrocarbons	0.0129	--	Inherited
CTD Chemicals (CC)	Pyrenes	0.01948	--	Inherited
CTD Chemicals (CC)	Inorganic Chemicals	0.1456	--	Inherited
CTD Chemicals (CC)	Pregnadienetriols	0.1892	--	Inherited
CTD Chemicals (CC)	Acids, Acyclic	0.2182	--	Inherited
CTD Chemicals (CC)	Carboxylic Acids	0.5699	--	Inherited
CTD Chemicals (CC)	Steroids	1	--	Inherited
CTD Chemicals (CC)	Amines	0.0007974	Least Informative	Direct
CTD Chemicals (CC)	Polycyclic Aromatic Hydrocarbons	0.02054	Least Informative	Inherited
CTD Chemicals (CC)	Azoles	0.07256	Least Informative	Inherited
CTD Chemicals (CC)	Pyrimidines	0.3386	Least Informative	Inherited
CTD Chemicals (CC)	Fused-Ring Compounds	0.4303	Least Informative	Inherited
CTD Chemicals (CC)	Sulfur Compounds	0.9717	Least Informative	Inherited
CTD Chemicals (CC)	Indoles	0.9961	Least Informative	Inherited
CTD Chemicals (CC)	Benzopyrenes	0.00007925	Moderately Informative	Direct
CTD Chemicals (CC)	Polyamines	0.000772	Moderately Informative	Direct
CTD Chemicals (CC)	Pyridines	0.002489	Moderately Informative	Inherited
CTD Chemicals (CC)	Pyrazoles	0.07377	Moderately Informative	Inherited
CTD Chemicals (CC)	Organometallic Compounds	0.1314	Moderately Informative	Inherited
CTD Chemicals (CC)	Pregnanes	0.4151	Moderately Informative	Inherited
CTD Chemicals (CC)	Aldehydes	0.5947	Moderately Informative	Inherited
CTD Chemicals (CC)	Hydroxy Acids	0.893	Moderately Informative	Inherited
CTD Chemicals (CC)	Ethylenediamines	0.000002631	Informative	Direct
CTD Chemicals (CC)	Aminopyridines	0.0001105	Informative	Direct
CTD Chemicals (CC)	Dioxoles	0.0009015	Informative	Direct
CTD Chemicals (CC)	Dicarboxylic Acids	0.01447	Informative	Inherited
CTD Chemicals (CC)	Sulfhydryl Compounds	0.2407	Informative	Inherited
CTD Chemicals (CC)	Pregnadienes	0.5499	Informative	Inherited
CTD Chemicals (CC)	Organogold Compounds	0.0001787	Highly Informative	Direct
CTD Chemicals (CC)	benzo(e)pyrene	0.0002346	Highly Informative	Direct
CTD Chemicals (CC)	propionaldehyde	0.0003036	Highly Informative	Direct
CTD Chemicals (CC)	dorsomorphin	0.0004795	Highly Informative	Direct
CTD Chemicals (CC)	Methylprednisolone	0.0005754	Highly Informative	Direct

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Distribution on sTOL

Plot distribution on species Tree Of Life (sTOL) for this domain, i.e., present or absent across genomes/tips

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TSP-1 type 1 repeat family