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CTD Diseases (CD): Musculoskeletal Diseases 
(show info)
Biomedical Ontology
Like Gene Ontology (GO), biomedical ontology such as phenotype ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Biomedical ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI’s thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology Based on YP which is the major contributor to the ‘Ascomycete phenotype ontology’, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- UniProtKB KeyWords (KW) Ontology Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- CTD Diseases (CD) Ontology CD is MEDIC disease vocabulary that is modified by CTD from the "Diseases" [C] branch of Medical Subject Headings (MeSH), combined with genetic disorders from the Online Mendelian Inheritance in OMIM database.
- CTD Chemicals (CC) Ontology CC is chemical vocabulary that is adapted by CTD from the "Chemicals and Drugs" category and Supplementary Concept Records of Medical Subject Headings (MeSH, a hierarchical vocabulary used to index articles for MEDLINE/PubMed).
Jump to [ Top · Hierarchy · Annotations ]
Root: CD Hierarchy (CTD diseases from Comparative Toxicogenomics Database)
Jump to [ Top · Hierarchy ]
Superfamily( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| TSP type-3 repeat | 0 | DIRECT |
| Homeodomain-like | 0.00002053 | DIRECT |
| Growth factor receptor domain | 0.00005802 | DIRECT |
| Cytokine | 0.0001896 | DIRECT |
| TB module/8-cys domain | 0.0002134 | DIRECT |
| Nucleotide-diphospho-sugar transferases | 0.0003902 | DIRECT |
| p53-like transcription factors | 0.0003906 | DIRECT |
| EGF/Laminin | 0.0003984 | DIRECT |
| Tropomyosin | 0.0007554 | DIRECT |
| 4-helical cytokines | 0.001201 | INHERITED FROM: Arthritis, Experimental |
| Hemopexin-like domain | 0.006006 | INHERITED FROM: Bone Resorption || Osteolysis |
| Myosin rod fragments | 0.01292 | INHERITED FROM: Muscular Diseases |
| PGBD-like | 0.0196 | INHERITED FROM: Bone Resorption || Osteolysis |
| SMAD MH1 domain | 0.03899 | INHERITED FROM: Craniofacial Abnormalities |
| Metalloproteases ("zincins"), catalytic domain | 0.06616 | INHERITED FROM: Osteolysis |
| CalX-like | 0.132 | INHERITED FROM: Dysostoses || Synostosis |
| Kelch motif | 0.1738 | INHERITED FROM: Myopathies, Structural, Congenital || Myopathies, Nemaline |
| Calponin-homology domain, CH-domain | 0.187 | INHERITED FROM: Muscular Disorders, Atrophic || Muscular Dystrophies |
| vWA-like | 0.2888 | INHERITED FROM: Contracture || Scleroatonic muscular dystrophy || Bethlem myopathy |
| Nicotinic receptor ligand binding domain-like | 0.34 | INHERITED FROM: MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE || Arthrogryposis |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.34 | INHERITED FROM: MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE || Arthrogryposis |
| Kringle-like | 0.3511 | INHERITED FROM: Bone Neoplasms |
| Acetyl-CoA synthetase-like | 0.381 | INHERITED FROM: Arthritis, Experimental |
| WD40 repeat-like | 0.4894 | INHERITED FROM: Polydactyly || Short Rib-Polydactyly Syndrome |
| DEATH domain | 0.496 | INHERITED FROM: Spondylitis |
| Spectrin repeat | 0.5322 | INHERITED FROM: Muscular Disorders, Atrophic || Muscular Dystrophies |
| HMG-box | 0.7004 | INHERITED FROM: Hand Deformities || Hand Deformities, Congenital |
| POZ domain | 0.7381 | INHERITED FROM: Myopathies, Nemaline |
| Voltage-gated potassium channels | 0.8775 | INHERITED FROM: Paralyses, Familial Periodic |
LINKTO: Domain2BO Download and Domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Family( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Thrombospondin C-terminal domain | 0 | DIRECT |
| C5 cytosine-specific DNA methylase, DCM | 0 | DIRECT |
| Filamin repeat (rod domain) | 0 | DIRECT |
| TSP type-3 repeat | 0 | DIRECT |
| Homeodomain | 0.0000006532 | DIRECT |
| TB module/8-cys domain | 0.0001599 | DIRECT |
| Long-chain cytokines | 0.0002216 | DIRECT |
| Tropomyosin | 0.0006131 | DIRECT |
| Growth factor receptor domain | 0.001072 | INHERITED FROM: Arachnodactyly |
| EGF-type module | 0.001858 | INHERITED FROM: Spinal Curvatures |
| Fibroblast growth factors (FGF) | 0.002211 | INHERITED FROM: Jaw Abnormalities || Maxillofacial Abnormalities || Cleft Palate || Jaw Diseases |
| Interleukin-1 (IL-1) | 0.002336 | INHERITED FROM: Myositis || Arthritis, Rheumatoid || Arthritis |
| Myosin rod fragments | 0.00372 | INHERITED FROM: Muscular Diseases |
| Hemopexin-like domain | 0.005226 | INHERITED FROM: Bone Resorption || Osteolysis |
| Transforming growth factor (TGF)-beta | 0.007431 | INHERITED FROM: Osteoarthritis || Jaw Abnormalities || Cleft Palate |
| Exostosin | 0.008328 | INHERITED FROM: Osteochondrodysplasias || Bone Diseases || Bone Diseases, Developmental |
| Hect, E3 ligase catalytic domain | 0.01735 | INHERITED FROM: Craniofacial Abnormalities |
| MMP N-terminal domain | 0.01736 | INHERITED FROM: Bone Resorption || Osteolysis |
| BRK domain-like | 0.02478 | INHERITED FROM: Craniofacial Abnormalities |
| I set domains | 0.03071 | INHERITED FROM: Ankylosis || Syndactyly |
| SMAD MH1 domain | 0.03387 | INHERITED FROM: Craniofacial Abnormalities |
| SMAD domain | 0.03387 | INHERITED FROM: Craniofacial Abnormalities |
| Matrix metalloproteases, catalytic domain | 0.0346 | INHERITED FROM: Bone Resorption || Osteolysis |
| Histone lysine methyltransferases | 0.0744 | INHERITED FROM: Craniofacial Abnormalities |
| CalX-beta domain | 0.1191 | INHERITED FROM: Dysostoses || Synostosis |
| Kelch motif | 0.1622 | INHERITED FROM: Myopathies, Structural, Congenital || Myopathies, Nemaline |
| Calponin-homology domain, CH-domain | 0.1823 | INHERITED FROM: Muscular Disorders, Atrophic || Muscular Dystrophies |
| Integrin A (or I) domain | 0.2184 | INHERITED FROM: Contracture || Scleroatonic muscular dystrophy || Bethlem myopathy |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.3341 | INHERITED FROM: MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE || Arthrogryposis |
| Nicotinic receptor ligand binding domain-like | 0.3341 | INHERITED FROM: MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE || Arthrogryposis |
| Acetyl-CoA synthetase-like | 0.3649 | INHERITED FROM: Arthritis, Experimental |
| Leucine zipper domain | 0.414 | INHERITED FROM: Arthritis, Juvenile |
| G proteins | 0.4353 | INHERITED FROM: Noonan Syndrome |
| Spectrin repeat | 0.4824 | INHERITED FROM: Muscular Disorders, Atrophic || Muscular Dystrophies |
| HMG-box | 0.6979 | INHERITED FROM: Hand Deformities || Hand Deformities, Congenital |
| Canonical RBD | 0.7362 | INHERITED FROM: Muscular Disorders, Atrophic || Muscular Dystrophies |
LINKTO: Domain2BO Download and Domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Single)( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| TSP type-3 repeat | 0 | DIRECT |
| Homeodomain-like | 0.00001057 | DIRECT |
| Growth factor receptor domain | 0.00003124 | DIRECT |
| Cytokine | 0.0001098 | DIRECT |
| TB module/8-cys domain | 0.0001245 | DIRECT |
| Nucleotide-diphospho-sugar transferases | 0.0002369 | DIRECT |
| p53-like transcription factors | 0.0002376 | DIRECT |
| EGF/Laminin | 0.0002425 | DIRECT |
| Tropomyosin | 0.000477 | DIRECT |
| 4-helical cytokines | 0.0007946 | DIRECT |
| Hemopexin-like domain | 0.004309 | INHERITED FROM: Bone Resorption || Osteolysis |
| Myosin rod fragments | 0.009452 | INHERITED FROM: Muscular Diseases |
| Hect, E3 ligase catalytic domain | 0.01461 | INHERITED FROM: Craniofacial Abnormalities |
| PGBD-like | 0.01478 | INHERITED FROM: Bone Resorption || Osteolysis |
| Cystine-knot cytokines | 0.02125 | INHERITED FROM: Cleft Palate |
| BRK domain-like | 0.02251 | INHERITED FROM: Craniofacial Abnormalities |
| Nuclear receptor coactivator interlocking domain | 0.02251 | INHERITED FROM: Bone Diseases |
| Notch domain | 0.02251 | INHERITED FROM: Bone Diseases |
| SMAD MH1 domain | 0.03068 | INHERITED FROM: Craniofacial Abnormalities |
| Metalloproteases ("zincins"), catalytic domain | 0.05361 | INHERITED FROM: Osteolysis |
| CalX-like | 0.112 | INHERITED FROM: Dysostoses || Synostosis |
| Kelch motif | 0.1498 | INHERITED FROM: Myopathies, Structural, Congenital || Myopathies, Nemaline |
| Calponin-homology domain, CH-domain | 0.1621 | INHERITED FROM: Muscular Disorders, Atrophic || Muscular Dystrophies |
| vWA-like | 0.2576 | INHERITED FROM: Bethlem myopathy || Scleroatonic muscular dystrophy || Contracture |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.3074 | INHERITED FROM: MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE || Arthrogryposis |
| Nicotinic receptor ligand binding domain-like | 0.3074 | INHERITED FROM: MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE || Arthrogryposis |
| Kringle-like | 0.3182 | INHERITED FROM: Bone Neoplasms |
| Acetyl-CoA synthetase-like | 0.3473 | INHERITED FROM: Arthritis, Experimental |
| Leucine zipper domain | 0.3847 | INHERITED FROM: Arthritis, Juvenile |
| Rhodanese/Cell cycle control phosphatase | 0.3957 | INHERITED FROM: Arthritis, Juvenile |
| WD40 repeat-like | 0.455 | INHERITED FROM: Short Rib-Polydactyly Syndrome || Polydactyly |
| DEATH domain | 0.4617 | INHERITED FROM: Spondylitis |
| Spectrin repeat | 0.4985 | INHERITED FROM: Muscular Disorders, Atrophic || Muscular Dystrophies |
| HMG-box | 0.6685 | INHERITED FROM: Hand Deformities, Congenital || Hand Deformities || Upper Extremity Deformities, Congenital |
| POZ domain | 0.7071 | INHERITED FROM: Myopathies, Nemaline |
| Voltage-gated potassium channels | 0.854 | INHERITED FROM: Paralyses, Familial Periodic |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Duplex) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | DIRECT |
57196,57581
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0 | DIRECT |
57581,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | DIRECT |
57184,57581
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | DIRECT |
103647,49899
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57581,57184
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0 | DIRECT |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.0000113 | DIRECT |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.000683 | DIRECT |
90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0.004362 | INHERITED FROM: Muscular Diseases |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.007426 | INHERITED FROM: Spinal Curvatures |
57184,57603
57184 - Growth factor receptor domain
57603 - FnI-like domain | 0.00747 | INHERITED FROM: Joint Diseases |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.01478 | INHERITED FROM: Bone Resorption || Osteolysis |
50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0.02082 | INHERITED FROM: Musculoskeletal Abnormalities |
53300,53300
53300 - vWA-like
53300 - vWA-like | 0.02251 | INHERITED FROM: Bethlem myopathy || Scleroatonic muscular dystrophy || Contracture || Muscular Disorders, Atrophic || Muscular Diseases || Muscular Dystrophies |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.05413 | INHERITED FROM: Bone Diseases, Developmental |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.05413 | INHERITED FROM: Arthritis |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.06277 | INHERITED FROM: Cleft Palate || Syndactyly |
52821,52799
52821 - Rhodanese/Cell cycle control phosphatase
52799 - (Phosphotyrosine protein) phosphatases II | 0.07543 | INHERITED FROM: Arthritis, Juvenile |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.2394 | INHERITED FROM: Muscular Disorders, Atrophic || Muscular Dystrophies |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.2904 | INHERITED FROM: Muscular Disorders, Atrophic || Muscular Dystrophies |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.3074 | INHERITED FROM: MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE || Arthrogryposis |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | Direct |
57196,57581
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0 | Direct |
57581,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | Direct |
57184,57581
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | Direct |
103647,49899
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57581,57184
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0 | Direct |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.0000113 | Direct |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.000683 | Direct |
90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0.004362 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.007426 | Inherited |
57184,57603
57184 - Growth factor receptor domain
57603 - FnI-like domain | 0.00747 | Inherited |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.01478 | Inherited |
50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0.02082 | Inherited |
53300,53300
53300 - vWA-like
53300 - vWA-like | 0.02251 | Inherited |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.05413 | Inherited |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.05413 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.06277 | Inherited |
52821,52799
52821 - Rhodanese/Cell cycle control phosphatase
52799 - (Phosphotyrosine protein) phosphatases II | 0.07543 | Inherited |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.2394 | Inherited |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.2904 | Inherited |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.3074 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Triple) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57196,57196,57581
57196 - EGF/Laminin
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0 | DIRECT |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | DIRECT |
57581,57184,57581
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | DIRECT |
57184,57581,57196
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | DIRECT |
103647,103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | DIRECT |
57581,57196,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | DIRECT |
57184,57581,57184
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0 | DIRECT |
57196,57581,57196
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | DIRECT |
57581,57196,57581
57581 - TB module/8-cys domain
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0 | DIRECT |
57196,57581,57184
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0 | DIRECT |
103647,103647,49899
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57184,57184,57581
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | DIRECT |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.0001708 | DIRECT |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.0003578 | DIRECT |
57184,57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.0005237 | DIRECT |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.007624 | INHERITED FROM: Jaw Abnormalities || Cleft Palate || Syndactyly |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.04997 | INHERITED FROM: Limb Deformities, Congenital |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.2081 | INHERITED FROM: Muscular Disorders, Atrophic || Muscular Dystrophies |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57196,57196,57581
57196 - EGF/Laminin
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0 | Direct |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | Direct |
57581,57184,57581
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | Direct |
57184,57581,57196
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | Direct |
103647,103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | Direct |
57581,57196,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | Direct |
57184,57581,57184
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0 | Direct |
57196,57581,57196
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | Direct |
57581,57196,57581
57581 - TB module/8-cys domain
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0 | Direct |
57196,57581,57184
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0 | Direct |
103647,103647,49899
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57184,57184,57581
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | Direct |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.0001708 | Direct |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.0003578 | Direct |
57184,57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.0005237 | Direct |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.007624 | Inherited |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.04997 | Inherited |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.2081 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Plot distribution on species Tree Of Life (sTOL) for Superfamily and/or Family domains annotated by this CD term
 |
Plot tree as:
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Download Newick format tree:
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( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Plot distribution on species Tree Of Life (sTOL) for single supra-domains annotated by this CD term
|
Plot tree as:
| |
Download Newick format tree:
| |
Browsing in TREE OF LIFE:
|
( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|
|
> BO Hierarchy > Musculoskeletal Diseases
