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Ribonuclease H-like superfamily

Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Ribonuclease H-like motif [ 53066] (7)
Superfamily:   Ribonuclease H-like [ 53098] (14)
Families:   Ribonuclease H [ 53099] (4)
  Retroviral integrase, catalytic domain [ 53107]
  mu transposase, core domain [ 53112]
  Transposase inhibitor (Tn5 transposase) [ 53115]
  DnaQ-like 3'-5' exonuclease [ 53118] (15)
  RuvC resolvase [ 53134]
  Mitochondrial resolvase ydc2 catalytic domain [ 69533]
  Putative Holliday junction resolvase RuvX [ 102485] (3)
  CAF1-like ribonuclease [ 102492] (2)
  PIWI domain [ 110640] (3)
  TM1739-like [ 142505]
  Hermes transposase-like [ 142508]
  Tex RuvX-like domain-like [ 159635]
  Prp8 beta-finger domain-like [ 159638]

HP

Human Phenotype (HP)

HP term FDR (all) SDHP (four levels) Annotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of male external genitalia0.0000476--Direct
Phenotypic Abnormality (PA)Demyelinating peripheral neuropathy0.00005167--Direct
Phenotypic Abnormality (PA)Abnormal external genitalia0.00006654--Direct
Phenotypic Abnormality (PA)Abnormality of the male genitalia0.00007008--Direct
Phenotypic Abnormality (PA)Glucose intolerance0.00007283--Direct
Phenotypic Abnormality (PA)Abnormality of the genital system0.0001516--Direct
Phenotypic Abnormality (PA)Hypogonadism0.0005868--Direct
Phenotypic Abnormality (PA)Progressive microcephaly0.0007265--Direct
Phenotypic Abnormality (PA)Abnormal glucose homeostasis0.01045--Inherited
Phenotypic Abnormality (PA)Abnormal adipose tissue morphology0.01159--Inherited
Phenotypic Abnormality (PA)Abnormal axial skeleton morphology0.01203--Inherited
Phenotypic Abnormality (PA)Abnormality of head or neck0.0158--Inherited
Phenotypic Abnormality (PA)Neoplasm of the breast0.01732--Inherited
Phenotypic Abnormality (PA)Abnormality of the breast0.01778--Inherited
Phenotypic Abnormality (PA)Decreased head circumference0.02005--Inherited
Phenotypic Abnormality (PA)Neoplasm by anatomical site0.03135--Inherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the cerebrum0.04568--Inherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.06162--Inherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.06173--Inherited
Phenotypic Abnormality (PA)Abnormality of the nervous system0.09278--Inherited
Phenotypic Abnormality (PA)Abnormality of the cerebrum0.1371--Inherited
Phenotypic Abnormality (PA)Abnormal peripheral nervous system morphology0.2601--Inherited
Phenotypic Abnormality (PA)Abnormality of skull size0.2976--Inherited
Phenotypic Abnormality (PA)Puberty and gonadal disorders0.4185--Inherited
Phenotypic Abnormality (PA)Morphological abnormality of the central nervous system0.5164--Inherited
Phenotypic Abnormality (PA)Abnormality of brain morphology0.5313--Inherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.01283Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.01466Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.04756Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1183Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.1231Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.000462Moderately InformativeDirect
Phenotypic Abnormality (PA)Neoplasm0.03793Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.05586Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skull morphology0.3171Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.337Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.467Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.4741Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the voice0.00009786InformativeDirect
Phenotypic Abnormality (PA)Lipodystrophy0.0002335InformativeDirect
Phenotypic Abnormality (PA)Abnormal breast morphology0.01738InformativeInherited
Phenotypic Abnormality (PA)Microcephaly0.01942InformativeInherited
Phenotypic Abnormality (PA)Abnormality of reproductive system physiology0.2267InformativeInherited
Phenotypic Abnormality (PA)Peripheral neuropathy0.3142InformativeInherited
Phenotypic Abnormality (PA)Breast carcinoma0.0008246Highly InformativeDirect
Phenotypic Abnormality (PA)Postnatal microcephaly0.04838Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal myelination0.2295Highly InformativeInherited

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WP

Worm Phenotype (WP)

WP term FDR (all) SDWP (four levels) Annotation (direct or inherited)
Worm Phenotype (WP)lethal0--Direct
Worm Phenotype (WP)development variant0--Direct
Worm Phenotype (WP)organism development variant0--Direct
Worm Phenotype (WP)21U RNA expression variant0.000000000001218--Direct
Worm Phenotype (WP)siRNA expression variant0.00000003158--Direct
Worm Phenotype (WP)somatic transgene silencing variant0.00001235--Direct
Worm Phenotype (WP)RNAi enhanced0.0002058--Direct
Worm Phenotype (WP)gene expression variant0.5967--Inherited
Worm Phenotype (WP)organism physiology variant0.8165--Inherited
Worm Phenotype (WP)organism homeostasis metabolism variant0.8829--Inherited
Worm Phenotype (WP)physiology variant1--Inherited
Worm Phenotype (WP)organism metabolism processing variant0.8533Least InformativeInherited
Worm Phenotype (WP)RNA expression variant0.000000002584InformativeDirect
Worm Phenotype (WP)maintenance of gene silencing variant0.00000008421InformativeDirect
Worm Phenotype (WP)RNAi response variant0.00000000008595Highly InformativeDirect
Worm Phenotype (WP)transgene silencing variant0.5247Highly InformativeInherited

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YP

Yeast Phenotype (YP)

YP term FDR (all) SDYP (four levels) Annotation (direct or inherited)
Yeast Phenotype (YP)cellular processes0--Direct

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FP

Fly Phenotype (FP)

FP term FDR (all) SDFP (four levels) Annotation (direct or inherited)
Fly Phenotype (FP)melanotic mass phenotype0.0001318--Direct
Fly Phenotype (FP)phenotype0.5939--Inherited

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FA

Fly Anatomy (FA)

FA term FDR (all) SDFA (four levels) Annotation (direct or inherited)
Fly Anatomy (FA)organism0--Direct
Fly Anatomy (FA)multicellular structure0--Direct
Fly Anatomy (FA)anatomical structure1--Inherited
Fly Anatomy (FA)material anatomical entity1--Inherited

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ZA

Zebrafish Anatomy (ZA)

ZA term FDR (all) SDZA (four levels) Annotation (direct or inherited)
Zebrafish Anatomy (ZA)whole organism0--Direct
Zebrafish Anatomy (ZA)anatomical structure1--Inherited

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XA

Xenopus Anatomy (XA)

XA term FDR (all) SDXA (four levels) Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)anatomical structure0--Direct
Xenopus ANatomical entity (XAN)male organism0.000002222--Direct
Xenopus ANatomical entity (XAN)gonad0.0000163--Direct
Xenopus ANatomical entity (XAN)genital system0.00006878--Direct
Xenopus ANatomical entity (XAN)trunk region0.0004476--Direct
Xenopus ANatomical entity (XAN)male genitalia0.008966--Inherited
Xenopus ANatomical entity (XAN)compound organ0.06815--Inherited
Xenopus ANatomical entity (XAN)anatomical region0.1416--Inherited
Xenopus ANatomical entity (XAN)organism subdivision0.1913--Inherited
Xenopus ANatomical entity (XAN)anatomical group0.2431--Inherited
Xenopus ANatomical entity (XAN)multicellular anatomical structure0.3903--Inherited
Xenopus ANatomical entity (XAN)anatomical system1--Inherited
Xenopus ANatomical entity (XAN)whole organism1--Inherited
Xenopus ANatomical entity (XAN)trunk0.0004384Least InformativeDirect
Xenopus ANatomical entity (XAN)urogenital system0.0007411Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0.02408Least InformativeInherited
Xenopus ANatomical entity (XAN)testis0.000002165Moderately InformativeDirect
 
XA term FDR (all) SDXA (four levels) Annotation (direct or inherited)
Xenopus DEvelopment stage (XDE)NF stage0--Direct

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EC

Enzyme Commission (EC)

EC term FDR (all) SDEC (four levels) Annotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0--Direct
Enzyme Commission (EC)Endodeoxyribonucleases producing other than 5'-phosphomonoesters0--Direct
Enzyme Commission (EC)Ribonuclease H0--Direct
Enzyme Commission (EC)Aspartic endopeptidases0--Direct
Enzyme Commission (EC)Exodeoxyribonuclease I0.0000000299--Direct
Enzyme Commission (EC)Exodeoxyribonuclease III0.00001409--Direct
Enzyme Commission (EC)Transferases1--Inherited
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)DNA-directed DNA polymerase0InformativeDirect
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides1InformativeInherited
Enzyme Commission (EC)RNA-directed DNA polymerase0Highly InformativeDirect
Enzyme Commission (EC)HIV-1 retropepsin0Highly InformativeDirect
Enzyme Commission (EC)Exoribonuclease H0.0000000035Highly InformativeDirect
Enzyme Commission (EC)Retroviral ribonuclease H0.000000007947Highly InformativeDirect
Enzyme Commission (EC)HIV-2 retropepsin0.0000202Highly InformativeDirect
Enzyme Commission (EC)dUTP diphosphatase0.00003319Highly InformativeDirect
Enzyme Commission (EC)Exodeoxyribonucleases producing 5'-phosphomonoesters1Highly InformativeInherited

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CC

CTD Chemicals (CC)

CC term FDR (all) SDCC (four levels) Annotation (direct or inherited)
CTD Chemicals (CC)Organic Chemicals0--Direct

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Distribution on sTOL

Plot distribution on species Tree Of Life (sTOL) for this domain, i.e., present or absent across genomes/tips
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