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Plant structure DEvelopment stage (PDE): seed development stage  
(show info)
Biomedical Ontology
Like Gene Ontology (GO), biomedical ontology such as phenotype ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Biomedical ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI’s thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology Based on YP which is the major contributor to the ‘Ascomycete phenotype ontology’, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- UniProtKB KeyWords (KW) Ontology Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- CTD Diseases (CD) Ontology CD is MEDIC disease vocabulary that is modified by CTD from the "Diseases" [C] branch of Medical Subject Headings (MeSH), combined with genetic disorders from the Online Mendelian Inheritance in OMIM database.
- CTD Chemicals (CC) Ontology CC is chemical vocabulary that is adapted by CTD from the "Chemicals and Drugs" category and Supplementary Concept Records of Medical Subject Headings (MeSH, a hierarchical vocabulary used to index articles for MEDLINE/PubMed).
Jump to [ Top · Hierarchy · Annotations ]
Root: AP Hierarchy (arabidopsis plant ontology with 2 sub-ontologies AN, DE)
Jump to [ Top · Hierarchy ]
Family( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Proteasome subunits | 0.000000000006435 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.00000003993 | DIRECT |
| 14-3-3 protein | 0.0000003016 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.000001078 | DIRECT |
| CoA-binding domain | 0.000004347 | DIRECT |
| S-adenosylmethionine synthetase | 0.000004347 | DIRECT |
| Actin/HSP70 | 0.000006498 | DIRECT |
| FAD/NAD-linked reductases, N-terminal and central domains | 0.00001253 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.00001354 | DIRECT |
| GroEL-like chaperone, apical domain | 0.00001768 | DIRECT |
| GroEL-like chaperone, intermediate domain | 0.00001768 | DIRECT |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0.00001768 | DIRECT |
| GroEL chaperone, ATPase domain | 0.00001768 | DIRECT |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0.00002106 | DIRECT |
| Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 0.00003103 | DIRECT |
| Lactate & malate dehydrogenases, C-terminal domain | 0.00003426 | DIRECT |
| LDH N-terminal domain-like | 0.00003426 | DIRECT |
| Germin/Seed storage 7S protein | 0.00004237 | DIRECT |
| Succinyl-CoA synthetase domains | 0.00006124 | DIRECT |
| PDI-like | 0.0001011 | DIRECT |
| GAPDH-like | 0.0001386 | DIRECT |
| Citrate synthase | 0.0001386 | DIRECT |
| Group II chaperonin (CCT, TRIC), apical domain | 0.0001592 | DIRECT |
| Class I aldolase | 0.0001592 | DIRECT |
| RecA protein-like (ATPase-domain) | 0.00024 | DIRECT |
| Pathogenesis-related protein 10 (PR10)-like | 0.0002687 | DIRECT |
| Formate/glycerate dehydrogenases, substrate-binding domain | 0.0002687 | DIRECT |
| CAT-like | 0.0002687 | DIRECT |
| Tyrosine-dependent oxidoreductases | 0.0003589 | DIRECT |
| Mannose-binding lectins | 0.0004912 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0.0006746 | DIRECT |
| Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain | 0.000758 | DIRECT |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Proteasome subunits | 0.000000000006435 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.00000003993 | Direct |
| 14-3-3 protein | 0.0000003016 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.000001078 | Direct |
| CoA-binding domain | 0.000004347 | Direct |
| S-adenosylmethionine synthetase | 0.000004347 | Direct |
| Actin/HSP70 | 0.000006498 | Direct |
| FAD/NAD-linked reductases, N-terminal and central domains | 0.00001253 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.00001354 | Direct |
| GroEL-like chaperone, apical domain | 0.00001768 | Direct |
| GroEL-like chaperone, intermediate domain | 0.00001768 | Direct |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0.00001768 | Direct |
| GroEL chaperone, ATPase domain | 0.00001768 | Direct |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0.00002106 | Direct |
| Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain | 0.00003103 | Direct |
| Lactate & malate dehydrogenases, C-terminal domain | 0.00003426 | Direct |
| LDH N-terminal domain-like | 0.00003426 | Direct |
| Germin/Seed storage 7S protein | 0.00004237 | Direct |
| Succinyl-CoA synthetase domains | 0.00006124 | Direct |
| PDI-like | 0.0001011 | Direct |
| GAPDH-like | 0.0001386 | Direct |
| Citrate synthase | 0.0001386 | Direct |
| Group II chaperonin (CCT, TRIC), apical domain | 0.0001592 | Direct |
| Class I aldolase | 0.0001592 | Direct |
| RecA protein-like (ATPase-domain) | 0.00024 | Direct |
| Pathogenesis-related protein 10 (PR10)-like | 0.0002687 | Direct |
| Formate/glycerate dehydrogenases, substrate-binding domain | 0.0002687 | Direct |
| CAT-like | 0.0002687 | Direct |
| Tyrosine-dependent oxidoreductases | 0.0003589 | Direct |
| Mannose-binding lectins | 0.0004912 | Direct |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0.0006746 | Direct |
| Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain | 0.000758 | Direct |
LINKTO: Domain2BO Download and Domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Single)( show details)
Highlighted in gray are those with FDR>0.001
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Duplex) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like | 0.000000002165 | DIRECT |
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0.000000002165 | DIRECT |
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.0000000193 | DIRECT |
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0.0000001242 | DIRECT |
51905,55424 51905 - FAD/NAD(P)-binding domain 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.0000003769 | DIRECT |
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.000001572 | DIRECT |
55973,55973 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase | 0.000002131 | DIRECT |
51735,56327 51735 - NAD(P)-binding Rossmann-fold domains 56327 - LDH C-terminal domain-like | 0.00001442 | DIRECT |
51101,51101 51101 - Mannose-binding lectins 51101 - Mannose-binding lectins | 0.00001442 | DIRECT |
52518,52922 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52922 - TK C-terminal domain-like | 0.00001442 | DIRECT |
51735,55347 51735 - NAD(P)-binding Rossmann-fold domains 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0.00003147 | DIRECT |
52833,52833 52833 - Thioredoxin-like 52833 - Thioredoxin-like | 0.0001504 | DIRECT |
52283,51735 52283 - Formate/glycerate dehydrogenase catalytic domain-like 51735 - NAD(P)-binding Rossmann-fold domains | 0.0005846 | DIRECT |
52833,47616 52833 - Thioredoxin-like 47616 - GST C-terminal domain-like | 0.0009819 | DIRECT |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like | 0.000000002165 | Direct |
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0.000000002165 | Direct |
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.0000000193 | Direct |
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0.0000001242 | Direct |
51905,55424 51905 - FAD/NAD(P)-binding domain 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.0000003769 | Direct |
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.000001572 | Direct |
55973,55973 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase | 0.000002131 | Direct |
51735,56327 51735 - NAD(P)-binding Rossmann-fold domains 56327 - LDH C-terminal domain-like | 0.00001442 | Direct |
51101,51101 51101 - Mannose-binding lectins 51101 - Mannose-binding lectins | 0.00001442 | Direct |
52518,52922 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52922 - TK C-terminal domain-like | 0.00001442 | Direct |
51735,55347 51735 - NAD(P)-binding Rossmann-fold domains 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 0.00003147 | Direct |
52833,52833 52833 - Thioredoxin-like 52833 - Thioredoxin-like | 0.0001504 | Direct |
52283,51735 52283 - Formate/glycerate dehydrogenase catalytic domain-like 51735 - NAD(P)-binding Rossmann-fold domains | 0.0005846 | Direct |
52833,47616 52833 - Thioredoxin-like 47616 - GST C-terminal domain-like | 0.0009819 | Direct |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Triple) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
48592,54849,52029 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0.000000002165 | DIRECT |
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.0000000193 | DIRECT |
51101,51101,51101 51101 - Mannose-binding lectins 51101 - Mannose-binding lectins 51101 - Mannose-binding lectins | 0.000001301 | DIRECT |
53067,100920,100934 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.000001572 | DIRECT |
55973,55973,55973 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase | 0.000002131 | DIRECT |
52833,52833,52833 52833 - Thioredoxin-like 52833 - Thioredoxin-like 52833 - Thioredoxin-like | 0.0003821 | DIRECT |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
48592,54849,52029 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0.000000002165 | Direct |
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.0000000193 | Direct |
51101,51101,51101 51101 - Mannose-binding lectins 51101 - Mannose-binding lectins 51101 - Mannose-binding lectins | 0.000001301 | Direct |
53067,100920,100934 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.000001572 | Direct |
55973,55973,55973 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase | 0.000002131 | Direct |
52833,52833,52833 52833 - Thioredoxin-like 52833 - Thioredoxin-like 52833 - Thioredoxin-like | 0.0003821 | Direct |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Plot distribution on species Tree Of Life (sTOL) for Superfamily and/or Family domains annotated by this AP term
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Plot tree as:
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Download Newick format tree:
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( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Plot distribution on species Tree Of Life (sTOL) for single supra-domains annotated by this AP term
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Plot tree as:
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Download Newick format tree:
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Browsing in TREE OF LIFE:
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( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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