Enzyme Commission (EC): RNA helicase

Biomedical Ontology
Like Gene Ontology (GO), biomedical ontology such as phenotype ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Biomedical ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI’s thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology
Based on YP which is the major contributor to the ‘Ascomycete phenotype ontology’, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
UniProtKB KeyWords (KW) Ontology
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
CTD Diseases (CD) Ontology
CD is MEDIC disease vocabulary that is modified by CTD from the "Diseases" [C] branch of Medical Subject Headings (MeSH), combined with genetic disorders from the Online Mendelian Inheritance in OMIM database.
CTD Chemicals (CC) Ontology
CC is chemical vocabulary that is adapted by CTD from the "Chemicals and Drugs" category and Supplementary Concept Records of Medical Subject Headings (MeSH, a hierarchical vocabulary used to index articles for MEDLINE/PubMed).

Superfamily

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Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
Positive stranded ssRNA viruses	0	Direct
Replicase NSP9	0	Direct
EndoU-like	0	Direct
Flavivirus capsid protein C	0	Direct
Viral leader polypeptide zinc finger	0	Direct
E set domains	0	Direct
Trypsin-like serine proteases	0	Direct
Macro domain-like	0	Direct
Coronavirus NSP10-like	0	Direct
Coronavirus NSP8-like	0	Direct
P-loop containing nucleoside triphosphate hydrolases	0	Direct
AN1-like Zinc finger	0	Direct
NSP3A-like	0	Direct
Viral glycoprotein, central and dimerisation domains	0	Direct
Coronavirus NSP7-like	0	Direct
Tudor/PWWP/MBT	0	Direct
DNA/RNA polymerases	0	Direct
R3H domain	0.000000000000001518	Direct
RNA-binding domain, RBD	0.00000000000001388	Direct
SARS Nsp1-like	0.000000005841	Direct
S-adenosyl-L-methionine-dependent methyltransferases	0.00000001645	Direct
WW domain	0.000001557	Direct
Ribonuclease Rh-like	0.000008437	Direct
Retrovirus zinc finger-like domains	0.00002095	Direct
Clavaminate synthase-like	0.0001701	Direct
CCCH zinc finger	0.000405	Direct
NTF2-like	0.0008174	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

Family

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
Tandem AAA-ATPase domain	0	Direct
XPF/Rad1/Mus81 nuclease	0	Direct
Viral proteases	0	Direct
GUCT domain	0	Direct
Viral cysteine protease of trypsin fold	0	Direct
NSP3A-like	0	Direct
RNA helicase	0	Direct
Nsp15 N-terminal domain-like	0	Direct
Viral glycoprotein, central and dimerisation domains	0	Direct
Coronavirus NSP7-like	0	Direct
AN1-like Zinc finger	0	Direct
Picornaviridae-like VP (VP1, VP2, VP3 and VP4)	0	Direct
Class II viral fusion proteins C-terminal domain	0	Direct
Flavivirus capsid protein C	0	Direct
Nsp15 C-terminal domain-like	0	Direct
Coronavirus NSP10-like	0	Direct
Tudor domain	0	Direct
NTF2-like	0	Direct
Coronavirus NSP8-like	0	Direct
Macro domain	0	Direct
mRNA cap methylase	0	Direct
RNA-dependent RNA-polymerase	0	Direct
Viral leader polypeptide zinc finger	0	Direct
Replicase NSP9	0	Direct
R3H domain	7.357e-16	Direct
SARS Nsp1-like	0.000000003316	Direct
AlkB-like	0.000000007246	Direct
SPRY domain	0.00000007492	Direct
WW domain	0.0000008253	Direct
Ribonuclease Rh-like	0.000004772	Direct
Retrovirus zinc finger-like domains	0.00001288	Direct
Canonical RBD	0.0002457	Direct
CCCH zinc finger	0.0002652	Direct

LINKTO: Domain2BO Download and Domain2BO Algorithm

Supra-domain (Single|Duplex|Triple)

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Supra-domain (Single)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Flavivirus capsid protein C	0	Direct
Coronavirus NSP8-like	0	Direct
Replicase NSP9	0	Direct
DNA/RNA polymerases	0	Direct
Coronavirus NSP10-like	0	Direct
EndoU-like	0	Direct
Viral leader polypeptide zinc finger	0	Direct
Macro domain-like	0	Direct
Trypsin-like serine proteases	0	Direct
Coronavirus NSP7-like	0	Direct
Positive stranded ssRNA viruses	0	Direct
Viral glycoprotein, central and dimerisation domains	0	Direct
NSP3A-like	0	Direct
Tudor/PWWP/MBT	0	Direct
E set domains	0	Direct
AN1-like Zinc finger	0	Direct
P-loop containing nucleoside triphosphate hydrolases	0	Direct
R3H domain	0.000000000000001059	Direct
RNA-binding domain, RBD	0.000000000000009757	Direct
SARS Nsp1-like	0.000000004392	Direct
S-adenosyl-L-methionine-dependent methyltransferases	0.00000001245	Direct
WW domain	0.000001217	Direct
Ribonuclease Rh-like	0.000006659	Direct
Retrovirus zinc finger-like domains	0.00001667	Direct
Clavaminate synthase-like	0.0001379	Direct
CCCH zinc finger	0.0003302	Direct
NTF2-like	0.0006725	Direct

LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

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Supra-domain (Duplex) in N- to C-terminal order

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Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
56672,52540 56672 - DNA/RNA polymerases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
52540,142877 52540 - P-loop containing nucleoside triphosphate hydrolases 142877 - EndoU-like	0	Direct
52540,54928 52540 - P-loop containing nucleoside triphosphate hydrolases 54928 - RNA-binding domain, RBD	0	Direct
52540,48403 52540 - P-loop containing nucleoside triphosphate hydrolases 48403 - Ankyrin repeat	0	Direct
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
56983,81296 56983 - Viral glycoprotein, central and dimerisation domains 81296 - E set domains	0	Direct
50494,52540 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
53335,142877 53335 - S-adenosyl-L-methionine-dependent methyltransferases 142877 - EndoU-like	0	Direct
52540,56672 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases	0	Direct
52980,47781 52980 - Restriction endonuclease-like 47781 - RuvA domain 2-like	0	Direct
52540,57756 52540 - P-loop containing nucleoside triphosphate hydrolases 57756 - Retrovirus zinc finger-like domains	0	Direct
101816,144246 101816 - Replicase NSP9 144246 - Coronavirus NSP10-like	0	Direct
140367,143076 140367 - Coronavirus NSP7-like 143076 - Coronavirus NSP8-like	0	Direct
53335,56672 53335 - S-adenosyl-L-methionine-dependent methyltransferases 56672 - DNA/RNA polymerases	0	Direct
49899,52540 49899 - Concanavalin A-like lectins/glucanases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
53335,52949 53335 - S-adenosyl-L-methionine-dependent methyltransferases 52949 - Macro domain-like	0	Direct
52540,-8 52540 - P-loop containing nucleoside triphosphate hydrolases -8 - ECOD	0	Direct
52540,49899 52540 - P-loop containing nucleoside triphosphate hydrolases 49899 - Concanavalin A-like lectins/glucanases	0	Direct
143076,101816 143076 - Coronavirus NSP8-like 101816 - Replicase NSP9	0	Direct
50494,56672 50494 - Trypsin-like serine proteases 56672 - DNA/RNA polymerases	0.000000000002457	Direct
159936,52949 159936 - NSP3A-like 52949 - Macro domain-like	0.000000004392	Direct
-8,52540 -8 - ECOD 52540 - P-loop containing nucleoside triphosphate hydrolases	0.000000008929	Direct
48403,52540 48403 - Ankyrin repeat 52540 - P-loop containing nucleoside triphosphate hydrolases	0.00000003468	Direct
159936,53335 159936 - NSP3A-like 53335 - S-adenosyl-L-methionine-dependent methyltransferases	0.0000001282	Direct
57756,57756 57756 - Retrovirus zinc finger-like domains 57756 - Retrovirus zinc finger-like domains	0.00000772	Direct
56672,88633 56672 - DNA/RNA polymerases 88633 - Positive stranded ssRNA viruses	0.00001041	Direct

LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

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Supra-domain (Triple) in N- to C-terminal order

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Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
51197,52540,56672 51197 - Clavaminate synthase-like 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases	0	Direct
143076,101816,144246 143076 - Coronavirus NSP8-like 101816 - Replicase NSP9 144246 - Coronavirus NSP10-like	0	Direct
140367,143076,101816 140367 - Coronavirus NSP7-like 143076 - Coronavirus NSP8-like 101816 - Replicase NSP9	0	Direct
50494,52540,52540 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
56672,52540,52540 56672 - DNA/RNA polymerases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
52540,52540,142877 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 142877 - EndoU-like	0	Direct
52540,52540,56672 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases	0	Direct
52540,48403,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 48403 - Ankyrin repeat 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct
52540,49899,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 49899 - Concanavalin A-like lectins/glucanases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	Direct