CTD Chemicals (CC): Fatty Acids, Monounsaturated

Biomedical Ontology
Like Gene Ontology (GO), biomedical ontology such as phenotype ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Biomedical ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI’s thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology
Based on YP which is the major contributor to the ‘Ascomycete phenotype ontology’, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
UniProtKB KeyWords (KW) Ontology
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
CTD Diseases (CD) Ontology
CD is MEDIC disease vocabulary that is modified by CTD from the "Diseases" [C] branch of Medical Subject Headings (MeSH), combined with genetic disorders from the Online Mendelian Inheritance in OMIM database.
CTD Chemicals (CC) Ontology
CC is chemical vocabulary that is adapted by CTD from the "Chemicals and Drugs" category and Supplementary Concept Records of Medical Subject Headings (MeSH, a hierarchical vocabulary used to index articles for MEDLINE/PubMed).

Superfamily

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Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain	0	Direct
Apolipoprotein A-I	0	Direct
Thiolase-like	0.0000000001902	Direct
Caspase-like	0.0000000005114	Direct
Acyl-CoA dehydrogenase C-terminal domain-like	0.0000007211	Direct
Acyl-CoA dehydrogenase NM domain-like	0.0000007211	Direct
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain	0.000006231	Direct
ClpP/crotonase	0.00001935	Direct
Flavoproteins	0.00003433	Direct
Glycerol-3-phosphate (1)-acyltransferase	0.00007804	Direct
Acetyl-CoA synthetase-like	0.0001199	Direct
DEATH domain	0.000599	Direct
Band 7/SPFH domain	0.0007951	Direct
Thioesterase/thiol ester dehydrase-isomerase	0.0007951	Direct
CoA-dependent acyltransferases	0.001172	Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like	0.002252	Inherited
Protein kinase-like (PK-like)	0.01434	Inherited
Bcl-2 inhibitors of programmed cell death	0.03292	Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.03926	Inherited
Terpenoid synthases	0.03926	Inherited
FabD/lysophospholipase-like	0.03926	Inherited
Riboflavin synthase domain-like	0.03926	Inherited
Cyclin-like	0.1461	Inherited
Cytochrome P450	0.2917	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

Family

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
Apolipoprotein A-I	0	Direct
Nitric oxide (NO) synthase oxygenase domain	0	Direct
Isoprenyl diphosphate synthases	0	Direct
Caspase catalytic domain	0.000000005782	Direct
Thiolase-related	0.000000005996	Direct
L domain	0.000003543	Direct
Caspase recruitment domain, CARD	0.000005506	Direct
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain	0.000005952	Direct
HCDH C-domain-like	0.000005952	Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains	0.00006253	Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain	0.00006253	Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like	0.00007599	Direct
NADPH-cytochrome p450 reductase-like	0.00007599	Direct
Acetyl-CoA synthetase-like	0.0001434	Direct
Choline/Carnitine O-acyltransferase	0.0001649	Direct
Cytochrome p450 reductase N-terminal domain-like	0.0001649	Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain	0.0003311	Direct
Crotonase-like	0.005093	Inherited
Alcohol dehydrogenase-like, C-terminal domain	0.006329	Inherited
Bcl-2 inhibitors of programmed cell death	0.02632	Inherited
Cyclin	0.1198	Inherited
Cytochrome P450	0.1986	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

Supra-domain (Single|Duplex|Triple)

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Supra-domain (Single)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Apolipoprotein A-I	0	Direct
Nitric oxide (NO) synthase oxygenase domain	0	Direct
Thiolase-like	0.00000000007663	Direct
Caspase-like	0.0000000002079	Direct
Acyl-CoA dehydrogenase C-terminal domain-like	0.0000003295	Direct
Acyl-CoA dehydrogenase NM domain-like	0.0000003295	Direct
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain	0.000003019	Direct
ClpP/crotonase	0.000009739	Direct
Flavoproteins	0.00001762	Direct
Glycerol-3-phosphate (1)-acyltransferase	0.00004138	Direct
Acetyl-CoA synthetase-like	0.00006475	Direct
DEATH domain	0.0003486	Direct
Band 7/SPFH domain	0.0004693	Direct
Thioesterase/thiol ester dehydrase-isomerase	0.0004693	Direct
CoA-dependent acyltransferases	0.0007056	Direct
6-phosphogluconate dehydrogenase C-terminal domain-like	0.001402	Inherited
Protein kinase-like (PK-like)	0.009866	Inherited
Bcl-2 inhibitors of programmed cell death	0.0238	Inherited
Riboflavin synthase domain-like	0.02865	Inherited
FabD/lysophospholipase-like	0.02865	Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.02865	Inherited
Terpenoid synthases	0.02865	Inherited
Cyclin-like	0.1149	Inherited
Cytochrome P450	0.2405	Inherited

LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

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Supra-domain (Duplex) in N- to C-terminal order

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Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
53901,53901 53901 - Thiolase-like 53901 - Thiolase-like	0.000000002232	Direct
47986,52129 47986 - DEATH domain 52129 - Caspase-like	0.0000001809	Direct
56645,47203 56645 - Acyl-CoA dehydrogenase NM domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like	0.0000003295	Direct
57184,52058 57184 - Growth factor receptor domain 52058 - L domain-like	0.000001657	Direct
52058,57184 52058 - L domain-like 57184 - Growth factor receptor domain	0.000001657	Direct
54637,54637 54637 - Thioesterase/thiol ester dehydrase-isomerase 54637 - Thioesterase/thiol ester dehydrase-isomerase	0.00001426	Direct
52777,52777 52777 - CoA-dependent acyltransferases 52777 - CoA-dependent acyltransferases	0.00009005	Direct
55550,158235 55550 - SH2 domain 158235 - SOCS box-like	0.0001716	Direct
50729,56112 50729 - PH domain-like 56112 - Protein kinase-like (PK-like)	0.0001716	Direct
50129,51735 50129 - GroES-like 51735 - NAD(P)-binding Rossmann-fold domains	0.005899	Inherited
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain	0.04819	Inherited
47954,47954 47954 - Cyclin-like 47954 - Cyclin-like	0.1045	Inherited

LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

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Supra-domain (Triple) in N- to C-terminal order

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Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
52058,57184,52058 52058 - L domain-like 57184 - Growth factor receptor domain 52058 - L domain-like	0.000001657	Direct