Enzyme Commission (EC): Protein-serine/threonine kinases 

Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children)	EC term [EC ID] <#Children>	#Domains (Superfamily|Family)	#Supra-domain (Single|Duplex|Triple)
+ + + 3:	root [root] <7>
+ + 2:	Transferases [2] <10>	(445|680)	(444|535|275)
+ 1:	Transferring phosphorus-containing groups [2.7] <15>	(255|337)	(254|318|190)
0:	Protein-serine/threonine kinases [2.7.11] <35>	(59|62)	(58|92|40)
- 1:	Calcium/calmodulin-dependent protein kinase [2.7.11.17]	(1|1)	(1|1|0)
- 1:	Cyclin-dependent kinase [2.7.11.22]	(0|0)	(0|0|0)
- 1:	Dephospho-[reductase kinase] kinase [2.7.11.3]	(0|0)	(0|0|0)
- 1:	Fas-activated serine/threonine kinase [2.7.11.8]	(0|0)	(0|0|0)
- 1:	I-kappa-B kinase [2.7.11.10]	(0|0)	(0|0|0)
- 1:	Mitogen-activated protein kinase [2.7.11.24]	(0|0)	(0|0|0)
- 1:	Mitogen-activated protein kinase kinase kinase [2.7.11.25]	(3|3)	(3|2|0)
- 1:	Non-specific serine/threonine protein kinase [2.7.11.1]	(34|39)	(34|61|25)
- 1:	Phosphorylase kinase [2.7.11.19]	(0|0)	(0|0|0)
- 1:	Polo kinase [2.7.11.21]	(1|2)	(1|2|1)
- 1:	Protein kinase C [2.7.11.13]	(5|6)	(5|8|4)
- 1:	Receptor protein serine/threonine kinase [2.7.11.30]	(1|1)	(1|0|0)
- 1:	Rhodopsin kinase [2.7.11.14]	(1|1)	(1|1|0)
- 1:	Transferred entry: 2.7.11.32 [2.7.11.n1]	(0|0)	(0|0|0)
- 1:	Transferred entry: 2.7.11.33 [2.7.11.n2]	(0|0)	(0|0|0)
- 1:	Tropomyosin kinase [2.7.11.28]	(0|0)	(0|0|0)
- 1:	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase [2.7.11.4]	(2|2)	(2|1|0)
- 1:	[Acetyl-CoA carboxylase] kinase [2.7.11.27]	(1|1)	(1|1|0)
- 1:	[Beta-adrenergic-receptor] kinase [2.7.11.15]	(2|2)	(2|2|1)
- 1:	[Elongation factor 2] kinase [2.7.11.20]	(1|1)	(1|0|0)
- 1:	[G-protein-coupled receptor] kinase [2.7.11.16]	(1|1)	(1|1|0)
- 1:	[Goodpasture-antigen-binding protein] kinase [2.7.11.9]	(0|0)	(0|0|0)
- 1:	[Hydroxymethylglutaryl-CoA reductase (NADPH)] kinase [2.7.11.31]	(1|1)	(1|1|0)
- 1:	[Isocitrate dehydrogenase (NADP(+))] kinase [2.7.11.5]	(0|0)	(0|0|0)
- 1:	[Low-density-lipoprotein receptor] kinase [2.7.11.29]	(0|0)	(0|0|0)
- 1:	[Myosin heavy-chain] kinase [2.7.11.7]	(1|2)	(1|0|0)
- 1:	[Myosin light-chain] kinase [2.7.11.18]	(2|2)	(2|4|4)
- 1:	[Pyruvate dehydrogenase (acetyl-transferring)] kinase [2.7.11.2]	(2|2)	(2|1|0)
- 1:	[Pyruvate, phosphate dikinase] kinase [2.7.11.32]	(1|0)	(1|0|0)
- 1:	[Pyruvate, water dikinase] kinase [2.7.11.33]	(1|0)	(1|0|0)
- 1:	[RNA-polymerase]-subunit kinase [2.7.11.23]	(0|0)	(0|0|0)
- 1:	[Tau protein] kinase [2.7.11.26]	(1|2)	(1|1|0)
- 1:	[Tyrosine 3-monooxygenase] kinase [2.7.11.6]	(0|0)	(0|0|0)
- 1:	cAMP-dependent protein kinase [2.7.11.11]	(1|0)	(0|1|0)
- 1:	cGMP-dependent protein kinase [2.7.11.12]	(1|1)	(1|2|1)

Superfamily

Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
PH domain-like	0	DIRECT
EF-hand	0	DIRECT
KA1-like	0	DIRECT
WD40 repeat-like	0	DIRECT
L domain-like	0	DIRECT
ARM repeat	0	DIRECT
TAF(II)230 TBP-binding fragment	0	DIRECT
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
alpha-D-mannose-specific plant lectins	0	DIRECT
A DNA-binding domain in eukaryotic transcription factors	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
MAST3 pre-PK domain-like	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
RNI-like	0	DIRECT
Ankyrin repeat	0	DIRECT
Polo-box domain	0	DIRECT
Spectrin repeat	0	DIRECT
C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
NTF2-like	0	DIRECT
DEATH domain	0	DIRECT
Tricorn protease domain 2	0	DIRECT
PDZ domain-like	0	DIRECT
Snake toxin-like	0	DIRECT
Penicillin-binding protein 2x (pbp-2x), c-terminal domain	0	DIRECT
alpha-ketoacid dehydrogenase kinase, N-terminal domain	0	DIRECT
L27 domain	0	DIRECT
Cysteine-rich domain	0	DIRECT
G protein-binding domain	0	DIRECT
RCC1/BLIP-II	0	DIRECT
HR1 repeat	0	DIRECT
Doublecortin (DC)	0	DIRECT
Protein kinase-like (PK-like)	0	DIRECT
Concanavalin A-like lectins/glucanases	0.00000000000000377	DIRECT
CAD & PB1 domains	0.00000000000002342	DIRECT
MIT domain	0.0000000000007927	DIRECT
SMAD/FHA domain	0.000000000001123	DIRECT
CRAL/TRIO domain	0.000000000001465	DIRECT
cAMP-binding domain-like	0.000000000006902	DIRECT
Myosin rod fragments	0.00000000008977	DIRECT
Ubiquitin-like	0.0000000002786	DIRECT
beta-sandwich domain of Sec23/24	0.0000000003885	DIRECT
TPR-like	0.0000002613	DIRECT
GTPase activation domain, GAP	0.0000004897	DIRECT
UBA-like	0.00000271	DIRECT
Chaperone J-domain	0.000003086	DIRECT
HCP-like	0.000004509	DIRECT
Cyclin-like	0.00002377	DIRECT
SH3-domain	0.00003455	DIRECT
C-type lectin-like	0.00005201	DIRECT
SCOP hierarchy in SUPERFAMILY	0.0001132	DIRECT
PX domain	0.0002854	DIRECT
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0.001342	INHERITED FROM: [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase || [Pyruvate dehydrogenase (acetyl-transferring)] kinase
Bromodomain	0.001914	INHERITED FROM: Non-specific serine/threonine protein kinase
SAM/Pointed domain	0.005992	INHERITED FROM: Mitogen-activated protein kinase kinase kinase
Immunoglobulin	0.02447	INHERITED FROM: [Myosin light-chain] kinase
Fibronectin type III	0.1475	INHERITED FROM: [Myosin light-chain] kinase
PYP-like sensor domain (PAS domain)	0.915	INHERITED FROM: Non-specific serine/threonine protein kinase
P-loop containing nucleoside triphosphate hydrolases	1	INHERITED FROM: [Pyruvate, phosphate dikinase] kinase

Family

Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
alpha-D-mannose-specific plant lectins	0	DIRECT
Polygalacturonase inhibiting protein PGIP	0	DIRECT
RIO1-like kinases	0	DIRECT
LIM domain	0	DIRECT
Ssp2 C-terminal domain-like	0	DIRECT
alpha-ketoacid dehydrogenase kinase, N-terminal domain	0	DIRECT
Protein kinases, catalytic subunit	0	DIRECT
Myosin rod fragments	0	DIRECT
MAST3 pre-PK domain-like	0	DIRECT
L27 domain	0	DIRECT
Swapped Polo-box domain	0	DIRECT
Polo-box duplicated region	0	DIRECT
Calmodulin-like	0	DIRECT
Legume lectins	0	DIRECT
Doublecortin (DC)	0	DIRECT
beta-lactamase inhibitor protein-II, BLIP-II	0	DIRECT
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	0	DIRECT
Ankyrin repeat	0	DIRECT
MHCK/EF2 kinase	0	DIRECT
Phoshoinositide 3-kinase (PI3K), catalytic domain	0	DIRECT
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)	0	DIRECT
HR1 repeat	0	DIRECT
alpha-ketoacid dehydrogenase kinase, C-terminal domain	0	DIRECT
Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	0	DIRECT
TAF(II)230 TBP-binding fragment	0	DIRECT
Kinase associated domain 1, KA1	0	DIRECT
RhoA-binding domain	0	DIRECT
DEATH domain, DD	0	DIRECT
Extracellular domain of cell surface receptors	0	DIRECT
Pleckstrin-homology domain (PH domain)	0	DIRECT
Cyclin	0	DIRECT
Spectrin repeat	0	DIRECT
Synaptotagmin-like (S variant)	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
PLC-like (P variant)	0	DIRECT
Ras-binding domain, RBD	5.532e-16	DIRECT
RWD domain	0.00000000000004253	DIRECT
PB1 domain	0.00000000000005117	DIRECT
MIT domain	0.0000000000003396	DIRECT
cAMP-binding domain	0.000000000001583	DIRECT
FHA domain	0.000000000002195	DIRECT
Regulator of chromosome condensation RCC1	0.000000000007734	DIRECT
Motor proteins	0.00000000009439	DIRECT
Quinoprotein alcohol dehydrogenase-like	0.000000001231	DIRECT
WD40-repeat	0.0000001361	DIRECT
BCR-homology GTPase activation domain (BH-domain)	0.0000005076	DIRECT
Chaperone J-domain	0.000003068	DIRECT
PDZ domain	0.000006263	DIRECT
Sulfatase-modifying factor-like	0.00001494	DIRECT
Tetratricopeptide repeat (TPR)	0.00004023	DIRECT
SH3-domain	0.00009838	DIRECT
UBA domain	0.0001517	DIRECT
I set domains	0.0002304	DIRECT
PX domain	0.0003633	DIRECT
Bromodomain	0.002137	INHERITED FROM: Non-specific serine/threonine protein kinase
Caspase recruitment domain, CARD	0.002337	INHERITED FROM: Non-specific serine/threonine protein kinase
Flavin-binding PAS domain	0.003677	INHERITED FROM: Non-specific serine/threonine protein kinase
Phoshoinositide 3-kinase (PI3K) helical domain	0.1678	INHERITED FROM: Non-specific serine/threonine protein kinase
Fibronectin type III	0.2002	INHERITED FROM: [Myosin light-chain] kinase
Histidine kinase	0.2846	INHERITED FROM: Non-specific serine/threonine protein kinase
SAM (sterile alpha motif) domain	1	INHERITED FROM: Mitogen-activated protein kinase kinase kinase

Supra-domain (Single|Duplex|Triple)

Supra-domain (Single)

Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
RCC1/BLIP-II	0	DIRECT
C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
EF-hand	0	DIRECT
Cysteine-rich domain	0	DIRECT
TAF(II)230 TBP-binding fragment	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
MAST3 pre-PK domain-like	0	DIRECT
alpha-D-mannose-specific plant lectins	0	DIRECT
A DNA-binding domain in eukaryotic transcription factors	0	DIRECT
Ankyrin repeat	0	DIRECT
WD40 repeat-like	0	DIRECT
DEATH domain	0	DIRECT
G protein-binding domain	0	DIRECT
PH domain-like	0	DIRECT
HR1 repeat	0	DIRECT
Penicillin-binding protein 2x (pbp-2x), c-terminal domain	0	DIRECT
NTF2-like	0	DIRECT
Polo-box domain	0	DIRECT
L domain-like	0	DIRECT
PDZ domain-like	0	DIRECT
KA1-like	0	DIRECT
Doublecortin (DC)	0	DIRECT
Snake toxin-like	0	DIRECT
alpha-ketoacid dehydrogenase kinase, N-terminal domain	0	DIRECT
RNI-like	0	DIRECT
Tricorn protease domain 2	0	DIRECT
L27 domain	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	0	DIRECT
ARM repeat	0	DIRECT
Protein kinase-like (PK-like)	0	DIRECT
Spectrin repeat	0	DIRECT
Concanavalin A-like lectins/glucanases	0.000000000000002635	DIRECT
CAD & PB1 domains	0.00000000000001651	DIRECT
MIT domain	0.0000000000005678	DIRECT
SMAD/FHA domain	0.0000000000008056	DIRECT
CRAL/TRIO domain	0.000000000001053	DIRECT
cAMP-binding domain-like	0.000000000004984	DIRECT
Myosin rod fragments	0.00000000006589	DIRECT
Ubiquitin-like	0.0000000002059	DIRECT
beta-sandwich domain of Sec23/24	0.0000000002873	DIRECT
TPR-like	0.0000002012	DIRECT
GTPase activation domain, GAP	0.0000003791	DIRECT
UBA-like	0.000002126	DIRECT
Chaperone J-domain	0.000002423	DIRECT
HCP-like	0.000003544	DIRECT
Cyclin-like	0.00001893	DIRECT
SH3-domain	0.0000276	DIRECT
C-type lectin-like	0.00004167	DIRECT
PX domain	0.0002322	DIRECT
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0.00111	INHERITED FROM: [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase || [Pyruvate dehydrogenase (acetyl-transferring)] kinase
Bromodomain	0.001591	INHERITED FROM: Non-specific serine/threonine protein kinase
SAM/Pointed domain	0.005042	INHERITED FROM: Mitogen-activated protein kinase kinase kinase
Immunoglobulin	0.02096	INHERITED FROM: [Myosin light-chain] kinase
Fibronectin type III	0.1296	INHERITED FROM: [Myosin light-chain] kinase
PYP-like sensor domain (PAS domain)	0.8451	INHERITED FROM: Non-specific serine/threonine protein kinase
P-loop containing nucleoside triphosphate hydrolases	1	INHERITED FROM: [Pyruvate, phosphate dikinase] kinase

Supra-domain (Duplex) in N- to C-terminal order

Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
56112,103243 56112 - Protein kinase-like (PK-like) 103243 - KA1-like	0	DIRECT
56112,54427 56112 - Protein kinase-like (PK-like) 54427 - NTF2-like	0	DIRECT
56112,50729 56112 - Protein kinase-like (PK-like) 50729 - PH domain-like	0	DIRECT
56112,48403 56112 - Protein kinase-like (PK-like) 48403 - Ankyrin repeat	0	DIRECT
51110,51110 51110 - alpha-D-mannose-specific plant lectins 51110 - alpha-D-mannose-specific plant lectins	0	DIRECT
48097,56112 48097 - Regulator of G-protein signaling, RGS 56112 - Protein kinase-like (PK-like)	0	DIRECT
49562,57889 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 57889 - Cysteine-rich domain	0	DIRECT
48403,56112 48403 - Ankyrin repeat 56112 - Protein kinase-like (PK-like)	0	DIRECT
56112,116846 56112 - Protein kinase-like (PK-like) 116846 - MIT domain	0	DIRECT
101288,101288 101288 - L27 domain 101288 - L27 domain	0	DIRECT
82615,82615 82615 - Polo-box domain 82615 - Polo-box domain	0	DIRECT
46785,56112 46785 - "Winged helix" DNA-binding domain 56112 - Protein kinase-like (PK-like)	0	DIRECT
56112,50978 56112 - Protein kinase-like (PK-like) 50978 - WD40 repeat-like	0	DIRECT
55073,56112 55073 - Nucleotide cyclase 56112 - Protein kinase-like (PK-like)	0	DIRECT
46585,49562 46585 - HR1 repeat 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
89837,89837 89837 - Doublecortin (DC) 89837 - Doublecortin (DC)	0	DIRECT
57889,57889 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain	0	DIRECT
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat	0	DIRECT
69012,55874 69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0	DIRECT
52087,46966 52087 - CRAL/TRIO domain 46966 - Spectrin repeat	0	DIRECT
52058,52540 52058 - L domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
47212,56112 47212 - FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) 56112 - Protein kinase-like (PK-like)	0	DIRECT
50156,50044 50156 - PDZ domain-like 50044 - SH3-domain	0	DIRECT
52058,52047 52058 - L domain-like 52047 - RNI-like	0	DIRECT
57889,49562 57889 - Cysteine-rich domain 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
50156,56112 50156 - PDZ domain-like 56112 - Protein kinase-like (PK-like)	0	DIRECT
57889,50729 57889 - Cysteine-rich domain 50729 - PH domain-like	0	DIRECT
56112,47473 56112 - Protein kinase-like (PK-like) 47473 - EF-hand	0	DIRECT
116846,116846 116846 - MIT domain 116846 - MIT domain	0	DIRECT
49562,48350 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48350 - GTPase activation domain, GAP	0	DIRECT
56112,52799 56112 - Protein kinase-like (PK-like) 52799 - (Phosphotyrosine protein) phosphatases II	0	DIRECT
54236,57889 54236 - Ubiquitin-like 57889 - Cysteine-rich domain	0	DIRECT
50044,56112 50044 - SH3-domain 56112 - Protein kinase-like (PK-like)	0	DIRECT
53067,56112 53067 - Actin-like ATPase domain 56112 - Protein kinase-like (PK-like)	0	DIRECT
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0	DIRECT
50729,69322 50729 - PH domain-like 69322 - Tricorn protease domain 2	0	DIRECT
49899,56112 49899 - Concanavalin A-like lectins/glucanases 56112 - Protein kinase-like (PK-like)	0	DIRECT
50044,52540 50044 - SH3-domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
56112,101288 56112 - Protein kinase-like (PK-like) 101288 - L27 domain	0	DIRECT
56112,48726 56112 - Protein kinase-like (PK-like) 48726 - Immunoglobulin	0	DIRECT
52047,52058 52047 - RNI-like 52058 - L domain-like	0	DIRECT
54277,57889 54277 - CAD & PB1 domains 57889 - Cysteine-rich domain	0	DIRECT
50729,56112 50729 - PH domain-like 56112 - Protein kinase-like (PK-like)	0	DIRECT
52058,52058 52058 - L domain-like 52058 - L domain-like	0	DIRECT
49562,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 56112 - Protein kinase-like (PK-like)	0	DIRECT
52047,52047 52047 - RNI-like 52047 - RNI-like	0	DIRECT
48371,48371 48371 - ARM repeat 48371 - ARM repeat	0	DIRECT
56112,90257 56112 - Protein kinase-like (PK-like) 90257 - Myosin rod fragments	0	DIRECT
57716,50156 57716 - Glucocorticoid receptor-like (DNA-binding domain) 50156 - PDZ domain-like	0	DIRECT
47986,56112 47986 - DEATH domain 56112 - Protein kinase-like (PK-like)	0	DIRECT
48726,56112 48726 - Immunoglobulin 56112 - Protein kinase-like (PK-like)	0	DIRECT
52058,56112 52058 - L domain-like 56112 - Protein kinase-like (PK-like)	0	DIRECT
56112,48371 56112 - Protein kinase-like (PK-like) 48371 - ARM repeat	0	DIRECT
56112,50998 56112 - Protein kinase-like (PK-like) 50998 - Quinoprotein alcohol dehydrogenase-like	0	DIRECT
50998,56112 50998 - Quinoprotein alcohol dehydrogenase-like 56112 - Protein kinase-like (PK-like)	0	DIRECT
56112,54928 56112 - Protein kinase-like (PK-like) 54928 - RNA-binding domain, RBD	0	DIRECT
101288,50156 101288 - L27 domain 50156 - PDZ domain-like	0	DIRECT
46585,46585 46585 - HR1 repeat 46585 - HR1 repeat	0	DIRECT
53850,56112 53850 - Periplasmic binding protein-like II 56112 - Protein kinase-like (PK-like)	0	DIRECT
50044,48065 50044 - SH3-domain 48065 - DBL homology domain (DH-domain)	0	DIRECT
52047,56112 52047 - RNI-like 56112 - Protein kinase-like (PK-like)	0	DIRECT
47370,47370 47370 - Bromodomain 47370 - Bromodomain	0	DIRECT
51206,56112 51206 - cAMP-binding domain-like 56112 - Protein kinase-like (PK-like)	0	DIRECT
81995,56112 81995 - beta-sandwich domain of Sec23/24 56112 - Protein kinase-like (PK-like)	0	DIRECT
55021,56112 55021 - ACT-like 56112 - Protein kinase-like (PK-like)	0	DIRECT
56112,50985 56112 - Protein kinase-like (PK-like) 50985 - RCC1/BLIP-II	0	DIRECT
56112,55681 56112 - Protein kinase-like (PK-like) 55681 - Class II aaRS and biotin synthetases	0	DIRECT
56112,48452 56112 - Protein kinase-like (PK-like) 48452 - TPR-like	0	DIRECT
64268,56112 64268 - PX domain 56112 - Protein kinase-like (PK-like)	0	DIRECT
-9,-7 -9 - PDB -7 - CATH	0	DIRECT
56112,82615 56112 - Protein kinase-like (PK-like) 82615 - Polo-box domain	0	DIRECT
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0.000000000000003506	DIRECT
49879,56112 49879 - SMAD/FHA domain 56112 - Protein kinase-like (PK-like)	0.0000000000004242	DIRECT
56112,56112 56112 - Protein kinase-like (PK-like) 56112 - Protein kinase-like (PK-like)	0.0000000000007233	DIRECT
49265,56112 49265 - Fibronectin type III 56112 - Protein kinase-like (PK-like)	0.0000000000007552	DIRECT
51206,51206 51206 - cAMP-binding domain-like 51206 - cAMP-binding domain-like	0.00000000002334	DIRECT
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III	0.000000006698	DIRECT
49265,48726 49265 - Fibronectin type III 48726 - Immunoglobulin	0.00000001183	DIRECT
-7,56112 -7 - CATH 56112 - Protein kinase-like (PK-like)	0.000004908	DIRECT
48403,47769 48403 - Ankyrin repeat 47769 - SAM/Pointed domain	0.00000552	DIRECT
50729,57889 50729 - PH domain-like 57889 - Cysteine-rich domain	0.000007771	DIRECT
54768,54768 54768 - dsRNA-binding domain-like 54768 - dsRNA-binding domain-like	0.00001078	DIRECT
50729,50044 50729 - PH domain-like 50044 - SH3-domain	0.00002623	DIRECT
48403,52540 48403 - Ankyrin repeat 52540 - P-loop containing nucleoside triphosphate hydrolases	0.00004757	DIRECT
56112,50044 56112 - Protein kinase-like (PK-like) 50044 - SH3-domain	0.000116	DIRECT
52799,49562 52799 - (Phosphotyrosine protein) phosphatases II 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)	0.0001818	DIRECT
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like)	0.0007725	DIRECT
56112,52540 56112 - Protein kinase-like (PK-like) 52540 - P-loop containing nucleoside triphosphate hydrolases	0.001409	INHERITED FROM: Non-specific serine/threonine protein kinase
53850,53850 53850 - Periplasmic binding protein-like II 53850 - Periplasmic binding protein-like II	0.01388	INHERITED FROM: Non-specific serine/threonine protein kinase
57850,48371 57850 - RING/U-box 48371 - ARM repeat	0.01946	INHERITED FROM: Mitogen-activated protein kinase kinase kinase
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat	0.08866	INHERITED FROM: Non-specific serine/threonine protein kinase
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin	0.4463	INHERITED FROM: [Myosin light-chain] kinase

Supra-domain (Triple) in N- to C-terminal order

Highlighted in gray are those with FDR>0.001

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
56112,48403,52540 56112 - Protein kinase-like (PK-like) 48403 - Ankyrin repeat 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
52047,52047,56112 52047 - RNI-like 52047 - RNI-like 56112 - Protein kinase-like (PK-like)	0	DIRECT
52047,52047,52058 52047 - RNI-like 52047 - RNI-like 52058 - L domain-like	0	DIRECT
57716,57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0	DIRECT
52058,52058,56112 52058 - L domain-like 52058 - L domain-like 56112 - Protein kinase-like (PK-like)	0	DIRECT
57889,49562,56112 57889 - Cysteine-rich domain 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 56112 - Protein kinase-like (PK-like)	0	DIRECT
48726,49265,48726 48726 - Immunoglobulin 49265 - Fibronectin type III 48726 - Immunoglobulin	0	DIRECT
57889,57889,49562 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
48097,56112,50729 48097 - Regulator of G-protein signaling, RGS 56112 - Protein kinase-like (PK-like) 50729 - PH domain-like	0	DIRECT
46585,46585,46585 46585 - HR1 repeat 46585 - HR1 repeat 46585 - HR1 repeat	0	DIRECT
48065,50729,50044 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like 50044 - SH3-domain	0	DIRECT
101288,50156,50044 101288 - L27 domain 50156 - PDZ domain-like 50044 - SH3-domain	0	DIRECT
57716,50156,56112 57716 - Glucocorticoid receptor-like (DNA-binding domain) 50156 - PDZ domain-like 56112 - Protein kinase-like (PK-like)	0	DIRECT
101288,101288,50156 101288 - L27 domain 101288 - L27 domain 50156 - PDZ domain-like	0	DIRECT
56112,82615,82615 56112 - Protein kinase-like (PK-like) 82615 - Polo-box domain 82615 - Polo-box domain	0	DIRECT
52047,52058,56112 52047 - RNI-like 52058 - L domain-like 56112 - Protein kinase-like (PK-like)	0	DIRECT
49562,57889,57889 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain	0	DIRECT
57889,50729,69322 57889 - Cysteine-rich domain 50729 - PH domain-like 69322 - Tricorn protease domain 2	0	DIRECT
56112,101288,101288 56112 - Protein kinase-like (PK-like) 101288 - L27 domain 101288 - L27 domain	0	DIRECT
56112,116846,116846 56112 - Protein kinase-like (PK-like) 116846 - MIT domain 116846 - MIT domain	0	DIRECT
50156,50044,52540 50156 - PDZ domain-like 50044 - SH3-domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
51206,51206,56112 51206 - cAMP-binding domain-like 51206 - cAMP-binding domain-like 56112 - Protein kinase-like (PK-like)	0	DIRECT
48726,49265,56112 48726 - Immunoglobulin 49265 - Fibronectin type III 56112 - Protein kinase-like (PK-like)	0	DIRECT
56112,48726,48726 56112 - Protein kinase-like (PK-like) 48726 - Immunoglobulin 48726 - Immunoglobulin	0	DIRECT
49265,56112,48726 49265 - Fibronectin type III 56112 - Protein kinase-like (PK-like) 48726 - Immunoglobulin	0	DIRECT
56112,52799,49562 56112 - Protein kinase-like (PK-like) 52799 - (Phosphotyrosine protein) phosphatases II 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
48726,48726,56112 48726 - Immunoglobulin 48726 - Immunoglobulin 56112 - Protein kinase-like (PK-like)	0	DIRECT
52087,46966,46966 52087 - CRAL/TRIO domain 46966 - Spectrin repeat 46966 - Spectrin repeat	0	DIRECT
-9,-7,56112 -9 - PDB -7 - CATH 56112 - Protein kinase-like (PK-like)	0	DIRECT
49265,48726,49265 49265 - Fibronectin type III 48726 - Immunoglobulin 49265 - Fibronectin type III	0	DIRECT
50044,48065,50729 50044 - SH3-domain 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0	DIRECT
53850,53850,56112 53850 - Periplasmic binding protein-like II 53850 - Periplasmic binding protein-like II 56112 - Protein kinase-like (PK-like)	0	DIRECT
52058,52047,52058 52058 - L domain-like 52047 - RNI-like 52058 - L domain-like	0	DIRECT
57716,57716,50156 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) 50156 - PDZ domain-like	0	DIRECT
52058,52058,52058 52058 - L domain-like 52058 - L domain-like 52058 - L domain-like	0.000000000009925	DIRECT
52058,52047,56112 52058 - L domain-like 52047 - RNI-like 56112 - Protein kinase-like (PK-like)	0.0000000001983	DIRECT
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III	0.00000009997	DIRECT
49265,48726,48726 49265 - Fibronectin type III 48726 - Immunoglobulin 48726 - Immunoglobulin	0.0000007051	DIRECT
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like)	0.07743	INHERITED FROM: Non-specific serine/threonine protein kinase
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin	0.1502	INHERITED FROM: [Myosin light-chain] kinase