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CTD Chemicals (CC): Antigens 
(show info)
Biomedical Ontology
Like Gene Ontology (GO), biomedical ontology such as phenotype ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Biomedical ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI’s thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology Based on YP which is the major contributor to the ‘Ascomycete phenotype ontology’, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- UniProtKB KeyWords (KW) Ontology Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- CTD Diseases (CD) Ontology CD is MEDIC disease vocabulary that is modified by CTD from the "Diseases" [C] branch of Medical Subject Headings (MeSH), combined with genetic disorders from the Online Mendelian Inheritance in OMIM database.
- CTD Chemicals (CC) Ontology CC is chemical vocabulary that is adapted by CTD from the "Chemicals and Drugs" category and Supplementary Concept Records of Medical Subject Headings (MeSH, a hierarchical vocabulary used to index articles for MEDLINE/PubMed).
Jump to [ Top · Hierarchy · Annotations ]
Root: CC Hierarchy (CTD chemicals from Comparative Toxicogenomics Database)
| Shortest distance to current term (+ for parents, - for children) |
CC term [CC ID] <#Children> |
#Domains (Superfamily|Family) |
#Supra-domain (Single|Duplex|Triple) |
| + + 2: | Chemicals [MESH:D] <13> |
| + 1: | Biological Factors [MESH:D001685] <39> | (253|342) |
(261|248|150) |
| 0: | Antigens [MESH:D000941] <67> | (36|48) |
(36|16|7) |
| - 1: | Antigens, Bacterial [MESH:D000942] <278> | (28|34) |
(29|12|7) |
| - 1: | Antigens, Neoplasm [MESH:D000951] <265> | (0|0) |
(0|0|0) |
| - 1: | Antigens, Plant [MESH:D052179] <194> | (1|1) |
(1|0|0) |
| - 1: | Antigens, Protozoan [MESH:D000953] <144> | (0|0) |
(0|0|0) |
| - 1: | Antigens, Surface [MESH:D000954] <140> | (0|0) |
(0|0|0) |
| - 1: | Allergens [MESH:D000485] <138> | (0|0) |
(0|0|0) |
| - 1: | Autoantigens [MESH:D001324] <111> | (0|0) |
(0|0|0) |
| - 1: | Antigens, Helminth [MESH:D000947] <96> | (0|0) |
(0|0|0) |
| - 1: | Antigens, Viral [MESH:D000956] <53> | (1|1) |
(1|0|0) |
| - 1: | Isoantigens [MESH:D007519] <34> | (0|0) |
(0|0|0) |
| - 1: | Antigens, Dermatophagoides [MESH:D039741] <26> | (2|2) |
(2|0|0) |
| - 1: | Antigens, Fungal [MESH:D000946] <26> | (0|0) |
(0|0|0) |
| - 1: | Vaccines, Synthetic [MESH:D014614] <23> | (1|0) |
(1|0|0) |
| - 1: | Antigens, Nuclear [MESH:D034961] <21> | (0|0) |
(0|0|0) |
| - 1: | Superantigens [MESH:D018089] <14> | (1|0) |
(1|0|0) |
| - 1: | Epitopes [MESH:D000939] <11> | (8|14) |
(8|6|2) |
| - 1: | Antigens, Archaeal [MESH:D019845] <1> | (0|0) |
(0|0|0) |
| - 1: | Antigens, Heterophile [MESH:D015478] <1> | (0|0) |
(0|0|0) |
| - 1: | 19-DEJ-1 antigen [MESH:C089136] | (0|0) |
(0|0|0) |
| - 1: | AKAP17A protein, human [MESH:C077916] | (0|0) |
(0|0|0) |
| - 1: | Alzheimer's disease antigen [MESH:C056167] | (0|0) |
(0|0|0) |
| - 1: | Antigen-Antibody Complex [MESH:D000936] | (0|0) |
(0|0|0) |
| - 1: | Antigens, T-Independent [MESH:D000955] | (0|0) |
(0|0|0) |
| - 1: | B109 protein, rat [MESH:C092593] | (0|0) |
(0|0|0) |
| - 1: | D47 antigen [MESH:C042182] | (0|0) |
(0|0|0) |
| - 1: | FLIII3 protein, human [MESH:C106683] | (0|0) |
(0|0|0) |
| - 1: | GOR protein, human [MESH:C433683] | (0|0) |
(0|0|0) |
| - 1: | IFI44 protein, human [MESH:C065888] | (0|0) |
(0|0|0) |
| - 1: | MP84 antigen, human [MESH:C118613] | (0|0) |
(0|0|0) |
| - 1: | Ma1 antigen [MESH:C117985] | (0|0) |
(0|0|0) |
| - 1: | NP-190 protein, Sus scrofa [MESH:C113677] | (0|0) |
(0|0|0) |
| - 1: | Nalp5 protein, mouse [MESH:C416503] | (0|0) |
(0|0|0) |
| - 1: | Spag1 protein, mouse [MESH:C404906] | (0|0) |
(0|0|0) |
| - 1: | T3-3A1 antigen [MESH:C051383] | (0|0) |
(0|0|0) |
| - 1: | TAg5 protein, Glossina morsitans morsitans [MESH:C428611] | (0|0) |
(0|0|0) |
| - 1: | TCHH protein, human [MESH:C479420] | (0|0) |
(0|0|0) |
| - 1: | Xh antigen [MESH:C009691] | (0|0) |
(0|0|0) |
| - 1: | acrin 1 [MESH:C403409] | (0|0) |
(0|0|0) |
| - 1: | acrin 2 [MESH:C403408] | (0|0) |
(0|0|0) |
| - 1: | acrin 3 [MESH:C421403] | (0|0) |
(0|0|0) |
| - 1: | adrenal microsomal antigen [MESH:C055727] | (0|0) |
(0|0|0) |
| - 1: | antigen 4C5 [MESH:C105538] | (0|0) |
(0|0|0) |
| - 1: | antigen NU-T2 DEJ [MESH:C097642] | (0|0) |
(0|0|0) |
| - 1: | antigen pso p27 [MESH:C097643] | (0|0) |
(0|0|0) |
| - 1: | chondroitin sulfate proteoglycan 4 [MESH:C030607] | (0|0) |
(0|0|0) |
| - 1: | erythrocyte antigen z [MESH:C109798] | (0|0) |
(0|0|0) |
| - 1: | factor II clotting antigen [MESH:C055042] | (0|0) |
(0|0|0) |
| - 1: | factor VII clotting antigen [MESH:C042580] | (0|0) |
(0|0|0) |
| - 1: | factor VII related antigen [MESH:C031500] | (0|0) |
(0|0|0) |
| - 1: | factor X antigen [MESH:C010515] | (0|0) |
(0|0|0) |
| - 1: | fecal antigen-1, normal [MESH:C035221] | (0|0) |
(0|0|0) |
| - 1: | fertilization antigen [MESH:C054151] | (0|0) |
(0|0|0) |
| - 1: | fetal sulfoglycoprotein antigen, human [MESH:C024533] | (0|0) |
(0|0|0) |
| - 1: | fibrinogen-related antigen [MESH:C023456] | (0|0) |
(0|0|0) |
| - 1: | interspecific embryonic antigen-2 [MESH:C038171] | (0|0) |
(0|0|0) |
| - 1: | latexin protein, rat [MESH:C086812] | (0|0) |
(0|0|0) |
| - 1: | mesangial matrix antigen [MESH:C049900] | (0|0) |
(0|0|0) |
| - 1: | neurospecific brain antigen 10-40-4, human [MESH:C484014] | (0|0) |
(0|0|0) |
| - 1: | neurospecific brain antigen 10-40-4, rat [MESH:C044667] | (0|0) |
(0|0|0) |
| - 1: | pericentrin [MESH:C086178] | (0|0) |
(0|0|0) |
| - 1: | platelet and T cell antigen 1 ligand [MESH:C445782] | (0|0) |
(0|0|0) |
| - 1: | poly(Glu(56)Lys(35)Phe(9))(GLphi) antigen [MESH:C030459] | (0|0) |
(0|0|0) |
| - 1: | psi-3 antigen [MESH:C044287] | (0|0) |
(0|0|0) |
| - 1: | renal tubular antigen [MESH:C035812] | (0|0) |
(0|0|0) |
| - 1: | sensitin [MESH:C012031] | (0|0) |
(0|0|0) |
| - 1: | subolesin, tick [MESH:C550207] | (0|0) |
(0|0|0) |
| - 1: | ubiquitous tissue antigen [MESH:C026908] | (0|0) |
(0|0|0) |
Jump to [ Top · Hierarchy ]
Superfamily( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Interleukin 8-like chemokines | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Indolic compounds 2,3-dioxygenase-like | 0 | DIRECT |
| Toll/Interleukin receptor TIR domain | 0 | DIRECT |
| Mitochondrial cytochrome c oxidase subunit VIIa | 0 | DIRECT |
| STAT | 0 | DIRECT |
| Ribosomal protein S18 | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| DEATH domain | 0.000000000000005478 | DIRECT |
| 4-helical cytokines | 0.00000000000001094 | DIRECT |
| Caspase-like | 0.000000002654 | DIRECT |
| TNF-like | 0.000002148 | DIRECT |
| Cytokine | 0.000002675 | DIRECT |
| Cystine-knot cytokines | 0.000002916 | DIRECT |
| p53-like transcription factors | 0.00000422 | DIRECT |
| Leucine zipper domain | 0.000004466 | DIRECT |
| Thioredoxin-like | 0.000009377 | DIRECT |
| 4Fe-4S ferredoxins | 0.00005634 | DIRECT |
| GST C-terminal domain-like | 0.00006915 | DIRECT |
| PGBD-like | 0.00007864 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.0001231 | DIRECT |
| Class II aaRS and biotin synthetases | 0.0001562 | DIRECT |
| TNF receptor-like | 0.0002121 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.0002895 | DIRECT |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.0003902 | DIRECT |
| Riboflavin synthase domain-like | 0.0003902 | DIRECT |
| HIN-2000 domain-like | 0.0005238 | DIRECT |
| Flavoproteins | 0.0006206 | DIRECT |
| NAD(P)-linked oxidoreductase | 0.0006949 | DIRECT |
| Bcl-2 inhibitors of programmed cell death | 0.002045 | INHERITED FROM: Polysaccharides, Bacterial || Antigens, Bacterial |
| Hemopexin-like domain | 0.00275 | INHERITED FROM: Lipopolysaccharides || Antigens, Bacterial |
| A DNA-binding domain in eukaryotic transcription factors | 0.005049 | INHERITED FROM: Epitopes || Dinitrochlorobenzene |
| 2Fe-2S ferredoxin-like | 0.005162 | INHERITED FROM: Polysaccharides, Bacterial || Antigens, Bacterial |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.005162 | INHERITED FROM: Epitopes || Dinitrochlorobenzene |
| TIMP-like | 0.01893 | INHERITED FROM: lipopolysaccharide, E. coli O26-B6 |
| Cytochrome P450 | 0.03622 | INHERITED FROM: HIV Antigens || HIV Envelope Protein gp41 || Antigens, Viral |
LINKTO: Domain2BO Download and Domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Family( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Interleukin 8-like chemokines | 0 | DIRECT |
| Mitochondrial cytochrome c oxidase subunit VIIa | 0 | DIRECT |
| STAT | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Ferredoxin domains from multidomain proteins | 0 | DIRECT |
| Ribosomal protein S18 | 0 | DIRECT |
| STAT DNA-binding domain | 0 | DIRECT |
| Toll/Interleukin receptor TIR domain | 0.000000000000002313 | DIRECT |
| Short-chain cytokines | 0.00000000006283 | DIRECT |
| Interleukin-1 (IL-1) | 0.0000000005793 | DIRECT |
| Caspase catalytic domain | 0.00000000667 | DIRECT |
| TNF-like | 0.000002003 | DIRECT |
| Glutathione S-transferase (GST), C-terminal domain | 0.00000233 | DIRECT |
| Leucine zipper domain | 0.000007659 | DIRECT |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.00004066 | DIRECT |
| Rel/Dorsal transcription factors, DNA-binding domain | 0.00004748 | DIRECT |
| DEATH domain, DD | 0.00008012 | DIRECT |
| Glutathione S-transferase (GST), N-terminal domain | 0.00009276 | DIRECT |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.00009671 | DIRECT |
| MMP N-terminal domain | 0.00009671 | DIRECT |
| TNF receptor-like | 0.00009671 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.0001391 | DIRECT |
| Glutathione peroxidase-like | 0.0002783 | DIRECT |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.0002826 | DIRECT |
| NADPH-cytochrome p450 reductase-like | 0.0002826 | DIRECT |
| DEATH effector domain, DED | 0.0005176 | DIRECT |
| HIN-200/IF120x domain | 0.0005176 | DIRECT |
| Tissue inhibitor of metalloproteinases, TIMP | 0.0005176 | DIRECT |
| Matrix metalloproteases, catalytic domain | 0.0006128 | DIRECT |
| Aldo-keto reductases (NADP) | 0.0007964 | DIRECT |
| Long-chain cytokines | 0.0008283 | DIRECT |
| Platelet-derived growth factor-like | 0.000838 | DIRECT |
| Cytochrome p450 reductase N-terminal domain-like | 0.000838 | DIRECT |
| Transforming growth factor (TGF)-beta | 0.0009353 | DIRECT |
| Bcl-2 inhibitors of programmed cell death | 0.002263 | INHERITED FROM: Polysaccharides, Bacterial || Antigens, Bacterial |
| Hemopexin-like domain | 0.003287 | INHERITED FROM: Lipopolysaccharides || Antigens, Bacterial |
| Interferon regulatory factor | 0.003675 | INHERITED FROM: Polysaccharides, Bacterial || Lipopolysaccharides || Antigens, Bacterial |
| Caspase recruitment domain, CARD | 0.004407 | INHERITED FROM: Polysaccharides, Bacterial || Lipopolysaccharides || Antigens, Bacterial |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.005245 | INHERITED FROM: Epitopes || Dinitrochlorobenzene |
| Interleukin 17F, IL-17F | 0.005245 | INHERITED FROM: Polysaccharides, Bacterial || Lipopolysaccharides || Antigens, Bacterial |
| A DNA-binding domain in eukaryotic transcription factors | 0.005587 | INHERITED FROM: Epitopes || Dinitrochlorobenzene |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.006145 | INHERITED FROM: Polysaccharides, Bacterial || Lipopolysaccharides || Antigens, Bacterial |
| Pyrin domain, PYD | 0.006725 | INHERITED FROM: Dinitrochlorobenzene |
| C2 set domains | 0.02682 | INHERITED FROM: lipopolysaccharide, E coli O55-B5 |
| Papain-like | 0.02839 | INHERITED FROM: Dinitrochlorobenzene |
| FAD/NAD-linked reductases, N-terminal and central domains | 0.03788 | INHERITED FROM: Epitopes || Dinitrochlorobenzene |
| Cytochrome P450 | 0.08533 | INHERITED FROM: HIV Antigens || HIV Envelope Protein gp41 || Antigens, Viral |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Interleukin 8-like chemokines | 0 | Direct |
| Mitochondrial cytochrome c oxidase subunit VIIa | 0 | Direct |
| STAT | 0 | Direct |
| Transcription factor STAT-4 N-domain | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Ferredoxin domains from multidomain proteins | 0 | Direct |
| Ribosomal protein S18 | 0 | Direct |
| STAT DNA-binding domain | 0 | Direct |
| Toll/Interleukin receptor TIR domain | 0.000000000000002313 | Direct |
| Short-chain cytokines | 0.00000000006283 | Direct |
| Interleukin-1 (IL-1) | 0.0000000005793 | Direct |
| Caspase catalytic domain | 0.00000000667 | Direct |
| TNF-like | 0.000002003 | Direct |
| Glutathione S-transferase (GST), C-terminal domain | 0.00000233 | Direct |
| Leucine zipper domain | 0.000007659 | Direct |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.00004066 | Direct |
| Rel/Dorsal transcription factors, DNA-binding domain | 0.00004748 | Direct |
| DEATH domain, DD | 0.00008012 | Direct |
| Glutathione S-transferase (GST), N-terminal domain | 0.00009276 | Direct |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.00009671 | Direct |
| MMP N-terminal domain | 0.00009671 | Direct |
| TNF receptor-like | 0.00009671 | Direct |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.0001391 | Direct |
| Glutathione peroxidase-like | 0.0002783 | Direct |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.0002826 | Direct |
| NADPH-cytochrome p450 reductase-like | 0.0002826 | Direct |
| DEATH effector domain, DED | 0.0005176 | Direct |
| HIN-200/IF120x domain | 0.0005176 | Direct |
| Tissue inhibitor of metalloproteinases, TIMP | 0.0005176 | Direct |
| Matrix metalloproteases, catalytic domain | 0.0006128 | Direct |
| Aldo-keto reductases (NADP) | 0.0007964 | Direct |
| Long-chain cytokines | 0.0008283 | Direct |
| Platelet-derived growth factor-like | 0.000838 | Direct |
| Cytochrome p450 reductase N-terminal domain-like | 0.000838 | Direct |
| Transforming growth factor (TGF)-beta | 0.0009353 | Direct |
| Bcl-2 inhibitors of programmed cell death | 0.002263 | Inherited |
| Hemopexin-like domain | 0.003287 | Inherited |
| Interferon regulatory factor | 0.003675 | Inherited |
| Caspase recruitment domain, CARD | 0.004407 | Inherited |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.005245 | Inherited |
| Interleukin 17F, IL-17F | 0.005245 | Inherited |
| A DNA-binding domain in eukaryotic transcription factors | 0.005587 | Inherited |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.006145 | Inherited |
| Pyrin domain, PYD | 0.006725 | Inherited |
| C2 set domains | 0.02682 | Inherited |
| Papain-like | 0.02839 | Inherited |
| FAD/NAD-linked reductases, N-terminal and central domains | 0.03788 | Inherited |
| Cytochrome P450 | 0.08533 | Inherited |
LINKTO: Domain2BO Download and Domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Single)( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Ribosomal protein S18 | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| Mitochondrial cytochrome c oxidase subunit VIIa | 0 | DIRECT |
| Toll/Interleukin receptor TIR domain | 0 | DIRECT |
| STAT | 0 | DIRECT |
| Interleukin 8-like chemokines | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Indolic compounds 2,3-dioxygenase-like | 0 | DIRECT |
| DEATH domain | 0.000000000000002116 | DIRECT |
| 4-helical cytokines | 0.00000000000000423 | DIRECT |
| Caspase-like | 0.000000001098 | DIRECT |
| TNF-like | 0.000001009 | DIRECT |
| Cytokine | 0.000001264 | DIRECT |
| Cystine-knot cytokines | 0.000001382 | DIRECT |
| p53-like transcription factors | 0.00000202 | DIRECT |
| Leucine zipper domain | 0.000002142 | DIRECT |
| Thioredoxin-like | 0.000004599 | DIRECT |
| 4Fe-4S ferredoxins | 0.00002946 | DIRECT |
| GST C-terminal domain-like | 0.0000365 | DIRECT |
| PGBD-like | 0.00004172 | DIRECT |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.00006652 | DIRECT |
| Class II aaRS and biotin synthetases | 0.00008536 | DIRECT |
| TNF receptor-like | 0.0001175 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.0001627 | DIRECT |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.0002222 | DIRECT |
| Riboflavin synthase domain-like | 0.0002222 | DIRECT |
| HIN-2000 domain-like | 0.0003027 | DIRECT |
| Flavoproteins | 0.0003618 | DIRECT |
| NAD(P)-linked oxidoreductase | 0.0004073 | DIRECT |
| Bcl-2 inhibitors of programmed cell death | 0.001266 | INHERITED FROM: Polysaccharides, Bacterial || Antigens, Bacterial || Lipopolysaccharides |
| Hemopexin-like domain | 0.001728 | INHERITED FROM: Antigens, Bacterial || Lipopolysaccharides |
| A DNA-binding domain in eukaryotic transcription factors | 0.003269 | INHERITED FROM: Epitopes || Dinitrochlorobenzene |
| 2Fe-2S ferredoxin-like | 0.003347 | INHERITED FROM: Polysaccharides, Bacterial || Antigens, Bacterial |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.003347 | INHERITED FROM: Epitopes || Dinitrochlorobenzene |
| TIMP-like | 0.01325 | INHERITED FROM: lipopolysaccharide, E. coli O26-B6 |
| Cytochrome P450 | 0.02632 | INHERITED FROM: HIV Envelope Protein gp41 || HIV Antigens || Antigens, Viral |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Duplex) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0 | DIRECT |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | DIRECT |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0 | DIRECT |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0.00000002332 | DIRECT |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0.0000002557 | DIRECT |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.0000007443 | DIRECT |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.000012 | DIRECT |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.00002205 | DIRECT |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.00002946 | DIRECT |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.00004172 | DIRECT |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.0001627 | DIRECT |
159141,159141
159141 - HIN-2000 domain-like
159141 - HIN-2000 domain-like | 0.0003027 | DIRECT |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0.002093 | INHERITED FROM: Epitopes || Dinitrochlorobenzene |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.002202 | INHERITED FROM: Antigens, Bacterial || Lipopolysaccharides |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.003347 | INHERITED FROM: Epitopes || Dinitrochlorobenzene |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.01022 | INHERITED FROM: Antigens, Bacterial || Lipopolysaccharides |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0 | Direct |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | Direct |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0 | Direct |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0.00000002332 | Direct |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0.0000002557 | Direct |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.0000007443 | Direct |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.000012 | Direct |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.00002205 | Direct |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.00002946 | Direct |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.00004172 | Direct |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.0001627 | Direct |
159141,159141
159141 - HIN-2000 domain-like
159141 - HIN-2000 domain-like | 0.0003027 | Direct |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0.002093 | Inherited |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.002202 | Inherited |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.003347 | Inherited |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.01022 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Triple) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | DIRECT |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | DIRECT |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0 | DIRECT |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.00002946 | DIRECT |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.0001627 | DIRECT |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.004857 | INHERITED FROM: Antigens, Bacterial || Lipopolysaccharides |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.006773 | INHERITED FROM: lipopolysaccharide, E. coli O26-B6 |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | Direct |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | Direct |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0 | Direct |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.00002946 | Direct |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.0001627 | Direct |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.004857 | Inherited |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.006773 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Plot distribution on species Tree Of Life (sTOL) for Superfamily and/or Family domains annotated by this CC term
 |
Plot tree as:
| |
Download Newick format tree:
|
( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Plot distribution on species Tree Of Life (sTOL) for single supra-domains annotated by this CC term
|
Plot tree as:
| |
Download Newick format tree:
| |
Browsing in TREE OF LIFE:
|
( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|
|
> BO Hierarchy > Antigens
