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CTD Chemicals (CC): Eicosanoids 

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Root: CC Hierarchy (CTD chemicals from Comparative Toxicogenomics Database)

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CC term [CC ID] <#Children> #Domains
(Superfamily|Family)
#Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Chemicals [MESH:D] <13>
+ + + 3:   Biological Factors [MESH:D001685] <39>(253|342) (261|248|150)
+ + + 3:   Lipids [MESH:D008055] <125>(304|430) (309|270|137)
+ + 2:   Inflammation Mediators [MESH:D018836] <3>(39|39) (41|20|10)
+ + 2:   Fatty Acids [MESH:D005227] <230>(246|355) (248|222|117)
+ 1:   Fatty Acids, Unsaturated [MESH:D005231] <444>(60|64) (61|33|11)
+ 1:   Autacoids [MESH:D012898] <6>(37|37) (38|17|7)
0:   Eicosanoids [MESH:D015777] <14>(30|33) (31|16|7)
- 1:   Arachidonic Acids [MESH:D001095] <94>(16|18) (16|8|3)
- 1:   8,11,14-Eicosatrienoic Acid [MESH:D015126] <50>(1|1) (1|0|0)
- 1:   Eicosapentaenoic Acid [MESH:D015118] <37>(1|0) (1|0|0)
- 1:   Prostaglandins [MESH:D011453] <31>(18|20) (20|5|2)
- 1:   Leukotrienes [MESH:D015289] <15>(2|2) (2|1|0)
- 1:   Lipoxins [MESH:D044045] <14>(0|0) (0|1|1)
- 1:   5,8,11,14-Eicosatetraynoic Acid [MESH:D015117] <3>(0|0) (0|0|0)
- 1:   (8-hydroxymethylen)trieicosanyl acetate [MESH:C534089](0|0) (0|0|0)
- 1:   14-ethyl-2,5,11-trimethyl-4,13,19,20-tetraoxa-tricyclo(14.2.1.1(7,10))eicosane-3,12-dione [MESH:C526293](0|0) (0|0|0)
- 1:   N1-(4-isothiocyanatobenzyl)-3,6,10,13,16,19-hexaaza bicyclo(6.6.6)icosane-1,8-diamine [MESH:C584874](0|0) (0|0|0)
- 1:   U 49619 [MESH:C062714](0|0) (0|0|0)
- 1:   lipoxin C4 [MESH:C073550](0|0) (0|0|0)
- 1:   methyl 6-eicosanyl-2-hydroxy-4-methoxybenzoate [MESH:C503470](0|0) (0|0|0)
- 1:   solandelactone F [MESH:C523382](0|0) (0|0|0)

Superfamily

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Superfamily

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SCOP term FDR (all) Annotation (direct or inherited)
Lipoxigenase0.000001846Direct
GST C-terminal domain-like0.000002268Direct
Cytochrome P4500.00002221Direct
MAPEG domain-like0.0001164Direct
Integrin domains0.000684Direct
Calcium-dependent phosphotriesterase0.000762Direct
Heme-dependent peroxidases0.001182Inherited
4-helical cytokines0.001322Inherited
Cystine-knot cytokines0.002505Inherited
ABC transporter transmembrane region0.002597Inherited
Interleukin 8-like chemokines0.005782Inherited
Metalloproteases ("zincins"), catalytic domain0.0354Inherited
Hemopexin-like domain0.04537Inherited
PGBD-like0.04537Inherited
Kringle-like0.08221Inherited
Arginase/deacetylase0.09945Inherited
Cytokine0.1034Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.1034Inherited
Nuclear receptor ligand-binding domain0.1042Inherited
p53-like transcription factors0.1274Inherited
Thioredoxin-like0.1415Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.1435Inherited
Bcl-2 inhibitors of programmed cell death0.1676Inherited
Cyclin-like0.1897Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.2253Inherited
Inhibitor of apoptosis (IAP) repeat0.2397Inherited
DEATH domain0.2631Inherited
Caspase-like0.3859Inherited
alpha/beta-Hydrolases0.6501Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

Family

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Family

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SCOP term FDR (all) Annotation (direct or inherited)
Serum paraoxonase/arylesterase 1, PON10Direct
Glutathione S-transferase (GST), C-terminal domain0.0000001725Direct
Animal lipoxigenases0.000002491Direct
Glutathione S-transferase (GST), N-terminal domain0.00000537Direct
Cytochrome P4500.0000785Direct
Lipoxigenase N-terminal domain0.0003122Direct
Integrin domains0.001064Inherited
Myeloperoxidase-like0.001514Inherited
Histone deacetylase, HDAC0.002224Inherited
Gonadodropin/Follitropin0.002224Inherited
Fibronectin type II module0.003115Inherited
ABC transporter transmembrane region0.006434Inherited
Interleukin 8-like chemokines0.007421Inherited
ABC transporter ATPase domain-like0.01916Inherited
Hemopexin-like domain0.05033Inherited
Short-chain cytokines0.05033Inherited
MMP N-terminal domain0.05033Inherited
Platelet-derived growth factor-like0.05286Inherited
Interferons/interleukin-10 (IL-10)0.05286Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.05286Inherited
Long-chain cytokines0.05286Inherited
Nuclear receptor0.0928Inherited
Acetylcholinesterase-like0.1015Inherited
Interleukin-1 (IL-1)0.1015Inherited
UDPGT-like0.1128Inherited
Matrix metalloproteases, catalytic domain0.1128Inherited
Nuclear receptor ligand-binding domain0.1306Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.1493Inherited
Bcl-2 inhibitors of programmed cell death0.1779Inherited
Cyclin0.1957Inherited
Inhibitor of apoptosis (IAP) repeat0.2456Inherited
Caspase catalytic domain0.2714Inherited
EGF-type module0.2976Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

Supra-domain (Single|Duplex|Triple)

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Supra-domain (Single)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Lipoxigenase0.0000008633Direct
GST C-terminal domain-like0.000001067Direct
Cytochrome P4500.00001123Direct
MAPEG domain-like0.00006273Direct
Integrin domains0.0004006Direct
Calcium-dependent phosphotriesterase0.0004488Direct
Heme-dependent peroxidases0.0007118Direct
4-helical cytokines0.0008011Direct
Cystine-knot cytokines0.001565Inherited
ABC transporter transmembrane region0.001626Inherited
Interleukin 8-like chemokines0.003775Inherited
Metalloproteases ("zincins"), catalytic domain0.02569Inherited
Hemopexin-like domain0.0334Inherited
PGBD-like0.0334Inherited
Kringle-like0.06255Inherited
Arginase/deacetylase0.07644Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.07961Inherited
Cytokine0.07961Inherited
Nuclear receptor ligand-binding domain0.0803Inherited
p53-like transcription factors0.09924Inherited
Thioredoxin-like0.111Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.1126Inherited
Bcl-2 inhibitors of programmed cell death0.1328Inherited
Cyclin-like0.1517Inherited
Leucine zipper domain0.1573Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.1826Inherited
Inhibitor of apoptosis (IAP) repeat0.195Inherited
DEATH domain0.2155Inherited
Caspase-like0.3258Inherited
alpha/beta-Hydrolases0.5785Inherited
P-loop containing nucleoside triphosphate hydrolases0.9556Inherited

LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

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Supra-domain (Duplex) in N- to C-terminal order

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 0.0000000313Direct
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0.0000008633Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0001384Direct
    52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0.0004488Direct
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.001626Inherited
    81324,81324
  • 81324 - Voltage-gated potassium channels
  • 81324 - Voltage-gated potassium channels
  • 0.002793Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.007084Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.007084Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.01763Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.0334Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.0334Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.03721Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.07576Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.07644Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.195Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.7939Inherited

    LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

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    Supra-domain (Triple) in N- to C-terminal order

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.00000472Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0001384Direct
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0004488Direct
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0.0004488Direct
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.004627Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.007084Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.5624Inherited

    LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

    Distribution on sTOL

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