SUPERFAMILY 2 can be accessed from supfam.org. Please contact us if you experience any problems.
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Iron-dependent repressor protein, dimerization domain superfamily
SCOP classification
Superfamily statistics
Functional annotation
| General category | Regulation |
| Detailed category | DNA-binding |
Document: Function annotation of SCOP domain superfamilies
InterPro annotation
| Cross references | IPR001367 SSF47979 Protein matches |
| Abstract | The diphtheria toxin repressor protein (DTXR) is a member of this group [ 7568230]. In
Corynebacterium diphtheriae where it has been studied in some detail this protein acts
as an iron-binding repressor of dipheteria toxin gene expression and may serve as a
global regulator of gene expression. The N-terminus may be involved in iron binding and
may associate with the Tox operator. Binding of DTXR to Tox operator requires a divalent
metal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak
activation [7743135]. |
InterPro database
PDBeMotif information about ligands, sequence and structure motifs
PDBeMotif resource
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]
Internal database links
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Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
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Alignments of sequences to 3 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
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Browse and view proteins in genomes which have
different domain combinations including a Iron-dependent repressor protein, dimerization domain domain.
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Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
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Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
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There are 3 hidden Markov models representing the Iron-dependent repressor protein, dimerization domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
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Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]
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