HIPIP (high potential iron protein) superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Small proteins [ 56992] (90)
• Fold: HIPIP (high potential iron protein) [ 57651]
• Superfamily: HIPIP (high potential iron protein) [ 57652]
• Families: HIPIP (high potential iron protein) [ 57653]

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Superfamily statistics

	Genomes (136)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	187	1,711	12
Proteins	187	1,706	12

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Functional annotation

• General category: Metabolism
• Detailed category: E- transfer

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InterPro annotation

• Cross references: IPR000170 SSF57652 Protein matches
• Abstract: High potential iron-sulphur proteins (HiPIP) [1917989] are a specific class of high-redox potential 4Fe-4S ferredoxins that functions in anaerobic electron transport and which occurs in photosynthetic bacteria and in Paracoccus denitrificans. The HiPIPs are small proteins which show significant variation in their sequences, their sizes (from 63 to 85 amino acids), and in their oxidation- reduction potentials. As shown in the following schematic representation the iron-sulphur cluster is bound by four conserved cysteine residues.

                             [ 4Fe-4S cluster]
                             | |       |     |
          xxxxxxxxxxxxxxxxxxxCxCxxxxxxxCxxxxxCxxxx
  
  'C': conserved cysteine involved in the binding of the iron-sulphur cluster.

InterPro database

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