CTD Chemicals (CC): Enzyme Inhibitors 

Root: CC Hierarchy (CTD chemicals from Comparative Toxicogenomics Database)

Shortest distance to current term (+ for parents, - for children)	CC term [CC ID] <#Children>	#Domains (Superfamily|Family)	#Supra-domain (Single|Duplex|Triple)
+ + + + 4:	Chemicals [MESH:D] <13>
+ + + 3:	Chemical Actions and Uses [MESH:D020164] <3>	(170|228)	(175|158|72)
+ + 2:	Pharmacologic Actions [MESH:D020228] <5>	(153|206)	(158|137|60)
+ 1:	Molecular Mechanisms of Pharmacological Action [MESH:D045504] <31>	(47|52)	(50|30|7)
0:	Enzyme Inhibitors [MESH:D004791] <33>	(43|48)	(46|28|7)
- 1:	Cytochrome P-450 Enzyme Inhibitors [MESH:D065607] <9>	(0|0)	(0|0|0)
- 1:	Protease Inhibitors [MESH:D011480] <7>	(9|10)	(9|5|1)
- 1:	Phosphodiesterase Inhibitors [MESH:D010726] <3>	(0|0)	(0|0|0)
- 1:	Steroid Synthesis Inhibitors [MESH:D065088] <3>	(0|0)	(0|0|0)
- 1:	Topoisomerase Inhibitors [MESH:D059003] <2>	(0|0)	(0|0|0)
- 1:	Cyclooxygenase Inhibitors [MESH:D016861] <1>	(0|0)	(0|0|0)
- 1:	Integrase Inhibitors [MESH:D019429] <1>	(0|0)	(0|0|0)
- 1:	Nucleic Acid Synthesis Inhibitors [MESH:D019384] <1>	(0|0)	(0|0|0)
- 1:	Protein Kinase Inhibitors [MESH:D047428] <1>	(3|3)	(3|3|0)
- 1:	Uncoupling Agents [MESH:D014475] <1>	(0|0)	(0|0|0)
- 1:	5-Lipoxygenase-Activating Protein Inhibitors [MESH:D058946]	(0|0)	(0|0|0)
- 1:	Acetaldehyde Dehydrogenase Inhibitors [MESH:D065086]	(0|0)	(0|0|0)
- 1:	Adenosine Deaminase Inhibitors [MESH:D058892]	(0|0)	(0|0|0)
- 1:	Adenylyl Cyclase Inhibitors [MESH:D000067956]	(0|0)	(0|0|0)
- 1:	Aromatic Amino Acid Decarboxylase Inhibitors [MESH:D065105]	(0|0)	(0|0|0)
- 1:	Calcineurin Inhibitors [MESH:D065095]	(0|0)	(0|0|0)
- 1:	Carbonic Anhydrase Inhibitors [MESH:D002257]	(0|0)	(0|0|0)
- 1:	Catechol O-Methyltransferase Inhibitors [MESH:D065098]	(0|0)	(0|0|0)
- 1:	Cholinesterase Inhibitors [MESH:D002800]	(0|0)	(0|0|0)
- 1:	Folic Acid Antagonists [MESH:D005493]	(0|0)	(0|0|0)
- 1:	Glycoside Hydrolase Inhibitors [MESH:D065089]	(0|0)	(0|0|0)
- 1:	Histone Deacetylase Inhibitors [MESH:D056572]	(0|0)	(0|0|0)
- 1:	Hydroxymethylglutaryl-CoA Reductase Inhibitors [MESH:D019161]	(0|0)	(0|0|0)
- 1:	Lipoxygenase Inhibitors [MESH:D016859]	(0|0)	(0|0|0)
- 1:	Monoamine Oxidase Inhibitors [MESH:D008996]	(0|0)	(0|0|0)
- 1:	Ornithine Decarboxylase Inhibitors [MESH:D065108]	(0|0)	(0|0|0)
- 1:	Phosphoinositide-3 Kinase Inhibitors [MESH:D000081082]	(0|0)	(0|0|0)
- 1:	Phospholipase A2 Inhibitors [MESH:D064801]	(3|3)	(3|1|0)
- 1:	Poly(ADP-ribose) Polymerase Inhibitors [MESH:D000067856]	(0|0)	(0|0|0)
- 1:	Prolyl-Hydroxylase Inhibitors [MESH:D064800]	(0|0)	(0|0|0)
- 1:	Protein Synthesis Inhibitors [MESH:D011500]	(0|0)	(0|0|0)
- 1:	Proton Pump Inhibitors [MESH:D054328]	(0|0)	(0|0|0)
- 1:	beta-Lactamase Inhibitors [MESH:D065093]	(0|0)	(0|0|0)

Superfamily

Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
BAG domain	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
BSD domain-like	0	DIRECT
Proteasome activator	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
RNA-binding domain, RBD	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
ARM repeat	0.000000001626	DIRECT
Eukaryotic type KH-domain (KH-domain type I)	0.000001443	DIRECT
dsRNA-binding domain-like	0.000002867	DIRECT
beta-sandwich domain of Sec23/24	0.000005249	DIRECT
GroEL-intermediate domain like	0.000005249	DIRECT
SCOP hierarchy in SUPERFAMILY	0.00002458	DIRECT
GroEL equatorial domain-like	0.00003471	DIRECT
GroEL apical domain-like	0.00003471	DIRECT
Nucleic acid-binding proteins	0.00003776	DIRECT
Nucleotidylyl transferase	0.00005334	DIRECT
Caspase-like	0.00007405	DIRECT
GST C-terminal domain-like	0.00009663	DIRECT
S15/NS1 RNA-binding domain	0.0001208	DIRECT
SPOC domain-like	0.0001658	DIRECT
UBA-like	0.0001701	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.0001818	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0.0001818	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0.0001818	DIRECT
SAP domain	0.0001988	DIRECT
Bcl-2 inhibitors of programmed cell death	0.0003507	DIRECT
Ribosomal protein S5 domain 2-like	0.0003618	DIRECT
R3H domain	0.0004193	DIRECT
post-AAA+ oligomerization domain-like	0.0007786	DIRECT
Hemopexin-like domain	0.04482	INHERITED FROM: Phospholipase A2 Inhibitors || Matrix Metalloproteinase Inhibitors || Protease Inhibitors
PGBD-like	0.05778	INHERITED FROM: Phospholipase A2 Inhibitors || Matrix Metalloproteinase Inhibitors || Protease Inhibitors
Kringle-like	0.1746	INHERITED FROM: Protease Inhibitors
MHC antigen-recognition domain	0.4255	INHERITED FROM: Angiotensin-Converting Enzyme Inhibitors || Protease Inhibitors
DEATH domain	0.8686	INHERITED FROM: Cysteine Proteinase Inhibitors || Protease Inhibitors
Protein kinase-like (PK-like)	0.9303	INHERITED FROM: Protein Kinase Inhibitors
Metalloproteases ("zincins"), catalytic domain	0.9479	INHERITED FROM: Phospholipase A2 Inhibitors || Matrix Metalloproteinase Inhibitors || Protease Inhibitors
Trypsin-like serine proteases	1	INHERITED FROM: Protease Inhibitors
4-helical cytokines	1	INHERITED FROM: Protein Kinase Inhibitors
Immunoglobulin	1	INHERITED FROM: Protein Kinase Inhibitors

Family

Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Helical domain of Sec23/24	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Canonical RBD	0	DIRECT
Proteasome activator	0	DIRECT
Trunk domain of Sec23/24	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Hsp90 middle domain	0	DIRECT
BSD domain	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
BAG domain	0	DIRECT
Eukaryotic type KH-domain (KH-domain type I)	0.0000006496	DIRECT
UBA domain	0.000001542	DIRECT
La domain	0.000002278	DIRECT
Double-stranded RNA-binding domain (dsRBD)	0.000005684	DIRECT
Group II chaperonin (CCT, TRIC), ATPase domain	0.00002841	DIRECT
Group II chaperonin (CCT, TRIC), apical domain	0.00007302	DIRECT
Class I aminoacyl-tRNA synthetases (RS), catalytic domain	0.0001012	DIRECT
a tRNA synthase domain	0.0001424	DIRECT
Cofilin-like	0.0001634	DIRECT
MIF4G domain-like	0.0001634	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.0001634	DIRECT
R3H domain	0.0001634	DIRECT
SAP domain	0.0001925	DIRECT
Ubiquitin-related	0.0002289	DIRECT
Armadillo repeat	0.000299	DIRECT
Tandem AAA-ATPase domain	0.0003054	DIRECT
Bcl-2 inhibitors of programmed cell death	0.0003243	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.0003511	DIRECT
Cold shock DNA-binding domain-like	0.0006898	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0.0008824	DIRECT
Caspase catalytic domain	0.001439	INHERITED FROM: Trypsin Inhibitors || Cysteine Proteinase Inhibitors || Protease Inhibitors
Fibronectin type II module	0.03041	INHERITED FROM: Angiotensin-Converting Enzyme Inhibitors || Protease Inhibitors
Hemopexin-like domain	0.04365	INHERITED FROM: Phospholipase A2 Inhibitors || Matrix Metalloproteinase Inhibitors || Protease Inhibitors
Interferons/interleukin-10 (IL-10)	0.05304	INHERITED FROM: Protein Kinase Inhibitors
MMP N-terminal domain	0.05559	INHERITED FROM: Phospholipase A2 Inhibitors || Matrix Metalloproteinase Inhibitors || Protease Inhibitors
Rel/Dorsal transcription factors, DNA-binding domain	0.06607	INHERITED FROM: Protein Kinase Inhibitors
Matrix metalloproteases, catalytic domain	0.1138	INHERITED FROM: Phospholipase A2 Inhibitors || Matrix Metalloproteinase Inhibitors || Protease Inhibitors
Caspase recruitment domain, CARD	0.1481	INHERITED FROM: Cysteine Proteinase Inhibitors || Protease Inhibitors
C1 set domains (antibody constant domain-like)	0.3952	INHERITED FROM: Angiotensin-Converting Enzyme Inhibitors || Protease Inhibitors
MHC antigen-recognition domain	0.4186	INHERITED FROM: Angiotensin-Converting Enzyme Inhibitors || Protease Inhibitors
Protein kinases, catalytic subunit	0.8373	INHERITED FROM: Protein Kinase Inhibitors
Eukaryotic proteases	1	INHERITED FROM: Protease Inhibitors

Supra-domain (Single|Duplex|Triple)

Supra-domain (Single)

Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
BAG domain	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Surp module (SWAP domain)	0	DIRECT
RNA-binding domain, RBD	0	DIRECT
BSD domain-like	0	DIRECT
Proteasome activator	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
ARM repeat	0.0000000006687	DIRECT
Eukaryotic type KH-domain (KH-domain type I)	0.0000006708	DIRECT
dsRNA-binding domain-like	0.000001358	DIRECT
GroEL-intermediate domain like	0.00000253	DIRECT
beta-sandwich domain of Sec23/24	0.00000253	DIRECT
GroEL equatorial domain-like	0.00001783	DIRECT
GroEL apical domain-like	0.00001783	DIRECT
Nucleic acid-binding proteins	0.00001945	DIRECT
Nucleotidylyl transferase	0.00002784	DIRECT
Caspase-like	0.00003918	DIRECT
GST C-terminal domain-like	0.00005174	DIRECT
S15/NS1 RNA-binding domain	0.00006526	DIRECT
SPOC domain-like	0.00009085	DIRECT
UBA-like	0.00009336	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0.0001001	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.0001001	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0.0001001	DIRECT
SAP domain	0.0001098	DIRECT
Bcl-2 inhibitors of programmed cell death	0.0001987	DIRECT
Ribosomal protein S5 domain 2-like	0.0002053	DIRECT
R3H domain	0.0002396	DIRECT
post-AAA+ oligomerization domain-like	0.0004589	DIRECT
G protein-binding domain	0.000733	DIRECT
Ribosomal proteins S24e, L23 and L15e	0.000733	DIRECT
Translation proteins	0.0008089	DIRECT
Class II aaRS ABD-related	0.0009431	DIRECT
Hemopexin-like domain	0.03295	INHERITED FROM: Protease Inhibitors || Matrix Metalloproteinase Inhibitors || Phospholipase A2 Inhibitors
PGBD-like	0.04309	INHERITED FROM: Protease Inhibitors || Matrix Metalloproteinase Inhibitors || Phospholipase A2 Inhibitors
Kringle-like	0.1388	INHERITED FROM: Protease Inhibitors
MHC antigen-recognition domain	0.3627	INHERITED FROM: Protease Inhibitors || Angiotensin-Converting Enzyme Inhibitors
DEATH domain	0.8034	INHERITED FROM: Protease Inhibitors || Cysteine Proteinase Inhibitors
Protein kinase-like (PK-like)	0.8698	INHERITED FROM: Protein Kinase Inhibitors
Metalloproteases ("zincins"), catalytic domain	0.8892	INHERITED FROM: Protease Inhibitors || Matrix Metalloproteinase Inhibitors || Phospholipase A2 Inhibitors
Trypsin-like serine proteases	1	INHERITED FROM: Protease Inhibitors
4-helical cytokines	1	INHERITED FROM: Protein Kinase Inhibitors
Immunoglobulin	1	INHERITED FROM: Protein Kinase Inhibitors

Supra-domain (Duplex) in N- to C-terminal order

Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
53300,81995 53300 - vWA-like 81995 - beta-sandwich domain of Sec23/24	0	DIRECT
100934,100934 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
54928,54928 54928 - RNA-binding domain, RBD 54928 - RNA-binding domain, RBD	0	DIRECT
47060,55681 47060 - S15/NS1 RNA-binding domain 55681 - Class II aaRS and biotin synthetases	0	DIRECT
81811,82754 81811 - Helical domain of Sec23/24 82754 - C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
81995,81811 81995 - beta-sandwich domain of Sec23/24 81811 - Helical domain of Sec23/24	0	DIRECT
82919,53300 82919 - Zn-finger domain of Sec23/24 53300 - vWA-like	0	DIRECT
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
54768,54768 54768 - dsRNA-binding domain-like 54768 - dsRNA-binding domain-like	0.0000001488	DIRECT
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like	0.0000007196	DIRECT
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0.00000253	DIRECT
54791,54791 54791 - Eukaryotic type KH-domain (KH-domain type I) 54791 - Eukaryotic type KH-domain (KH-domain type I)	0.00000887	DIRECT
47095,47095 47095 - HMG-box 47095 - HMG-box	0.00001088	DIRECT
48371,48371 48371 - ARM repeat 48371 - ARM repeat	0.00001485	DIRECT
64268,103657 64268 - PX domain 103657 - BAR/IMD domain-like	0.00009085	DIRECT
49899,52540 49899 - Concanavalin A-like lectins/glucanases 52540 - P-loop containing nucleoside triphosphate hydrolases	0.00009085	DIRECT
46785,54928 46785 - "Winged helix" DNA-binding domain 54928 - RNA-binding domain, RBD	0.00009085	DIRECT
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0.0001001	DIRECT
52540,48019 52540 - P-loop containing nucleoside triphosphate hydrolases 48019 - post-AAA+ oligomerization domain-like	0.0004589	DIRECT
47986,52129 47986 - DEATH domain 52129 - Caspase-like	0.0005803	DIRECT
52540,-7 52540 - P-loop containing nucleoside triphosphate hydrolases -7 - CATH	0.000733	DIRECT
55550,158235 55550 - SH2 domain 158235 - SOCS box-like	0.02465	INHERITED FROM: Protein Kinase Inhibitors
47090,55486 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain	0.04309	INHERITED FROM: Protease Inhibitors || Matrix Metalloproteinase Inhibitors || Phospholipase A2 Inhibitors
49417,81296 49417 - p53-like transcription factors 81296 - E set domains	0.05299	INHERITED FROM: Protein Kinase Inhibitors
57440,57440 57440 - Kringle-like 57440 - Kringle-like	0.07103	INHERITED FROM: Protease Inhibitors
55486,50923 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain	0.2452	INHERITED FROM: Protease Inhibitors || Matrix Metalloproteinase Inhibitors
54452,48726 54452 - MHC antigen-recognition domain 48726 - Immunoglobulin	0.3756	INHERITED FROM: Protease Inhibitors || Angiotensin-Converting Enzyme Inhibitors
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin	1	INHERITED FROM: Protein Kinase Inhibitors

Supra-domain (Triple) in N- to C-terminal order

Highlighted in gray are those with FDR>0.001

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
81995,81811,82754 81995 - beta-sandwich domain of Sec23/24 81811 - Helical domain of Sec23/24 82754 - C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
53300,81995,81811 53300 - vWA-like 81995 - beta-sandwich domain of Sec23/24 81811 - Helical domain of Sec23/24	0	DIRECT
48592,54849,52029 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0.0000007196	DIRECT
54791,54791,54791 54791 - Eukaryotic type KH-domain (KH-domain type I) 54791 - Eukaryotic type KH-domain (KH-domain type I) 54791 - Eukaryotic type KH-domain (KH-domain type I)	0.000001275	DIRECT
48371,48371,48371 48371 - ARM repeat 48371 - ARM repeat 48371 - ARM repeat	0.00003462	DIRECT
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0.0001001	DIRECT
47090,55486,50923 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain	0.1894	INHERITED FROM: Protease Inhibitors || Matrix Metalloproteinase Inhibitors