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CTD Diseases (CD): Immune System Diseases 
(show info)
Biomedical Ontology
Like Gene Ontology (GO), biomedical ontology such as phenotype ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Biomedical ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI’s thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology Based on YP which is the major contributor to the ‘Ascomycete phenotype ontology’, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- UniProtKB KeyWords (KW) Ontology Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- CTD Diseases (CD) Ontology CD is MEDIC disease vocabulary that is modified by CTD from the "Diseases" [C] branch of Medical Subject Headings (MeSH), combined with genetic disorders from the Online Mendelian Inheritance in OMIM database.
- CTD Chemicals (CC) Ontology CC is chemical vocabulary that is adapted by CTD from the "Chemicals and Drugs" category and Supplementary Concept Records of Medical Subject Headings (MeSH, a hierarchical vocabulary used to index articles for MEDLINE/PubMed).
Jump to [ Top · Hierarchy · Annotations ]
Root: CD Hierarchy (CTD diseases from Comparative Toxicogenomics Database)
| Shortest distance to current term (+ for parents, - for children) |
CD term [CD ID] <#Children> |
#Domains (Superfamily|Family) |
#Supra-domain (Single|Duplex|Triple) |
| + 1: | Diseases [MESH:C] <25> |
| 0: | Immune System Diseases [MESH:D007154] <18> | (36|47) |
(41|22|8) |
| - 1: | Immunologic Deficiency Syndromes [MESH:D007153] <95> | (15|15) |
(15|5|1) |
| - 1: | Autoimmune Diseases [MESH:D001327] <52> | (6|9) |
(9|2|0) |
| - 1: | Hypersensitivity [MESH:D006967] <10> | (6|8) |
(6|2|0) |
| - 1: | Glomerulonephritis, Membranoproliferative [MESH:D015432] <7> | (0|0) |
(0|0|0) |
| - 1: | Immunoproliferative Disorders [MESH:D007160] <3> | (13|17) |
(14|9|4) |
| - 1: | Purpura, Thrombocytopenic [MESH:D011696] <3> | (0|0) |
(0|0|0) |
| - 1: | Erythroblastosis, Fetal [MESH:D004899] <2> | (0|0) |
(0|0|0) |
| - 1: | Transfusion Reaction [MESH:D065227] <1> | (0|0) |
(0|0|0) |
| - 1: | Chondroitin-6-Sulfaturia, Defective Cellular Immunity, Nephrotic Syndrome [MESH:C565852] | (0|0) |
(0|0|0) |
| - 1: | Graft vs Host Disease [MESH:D006086] | (0|0) |
(0|0|0) |
| - 1: | IMMUNE RESPONSE TO SYNTHETIC POLYPEPTIDE--IRGAT [OMIM:146820] | (0|0) |
(0|0|0) |
| - 1: | IMMUNE SUPPRESSION [OMIM:146850] | (0|0) |
(0|0|0) |
| - 1: | Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome [MESH:C580192] | (0|0) |
(0|0|0) |
| - 1: | Immune Reconstitution Inflammatory Syndrome [MESH:D054019] | (0|0) |
(0|0|0) |
| - 1: | Lymphoblastic Transformation, Inhibition of [MESH:C565433] | (0|0) |
(0|0|0) |
| - 1: | Monocyte Chemotactic Disorder [MESH:C565371] | (0|0) |
(0|0|0) |
| - 1: | Neutrophil Chemotactic Response, Abnormal [MESH:C563515] | (0|0) |
(0|0|0) |
| - 1: | Radiation Sensitivity of Natural Killer Activity [MESH:C564066] | (0|0) |
(0|0|0) |
Jump to [ Top · Hierarchy ]
Superfamily( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Anaphylotoxins (complement system) | 0 | DIRECT |
| Proteasome activator | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Interleukin 8-like chemokines | 0.000000000001077 | DIRECT |
| 4-helical cytokines | 0.000000006894 | DIRECT |
| Immunoglobulin | 0.00000001008 | DIRECT |
| SH2 domain | 0.00000002369 | DIRECT |
| TNF receptor-like | 0.00000004332 | DIRECT |
| DEATH domain | 0.0000004992 | DIRECT |
| p53-like transcription factors | 0.00004688 | DIRECT |
| Complement control module/SCR domain | 0.00007364 | DIRECT |
| STAT | 0.00007712 | DIRECT |
| Transcription factor STAT-4 N-domain | 0.00007712 | DIRECT |
| TNF-like | 0.0004201 | DIRECT |
| MHC antigen-recognition domain | 0.001111 | INHERITED FROM: Asthma || Angioedema || Respiratory Hypersensitivity || Multiple Sclerosis || Drug Hypersensitivity || Autoimmune Diseases of the Nervous System || Hypersensitivity |
| Bcl-2 inhibitors of programmed cell death | 0.001475 | INHERITED FROM: Lymphoproliferative Disorders || Lymphoma, Non-Hodgkin |
| Protein kinase-like (PK-like) | 0.002027 | INHERITED FROM: Immunoproliferative Disorders || Lymphoma, Non-Hodgkin |
| GroEL-intermediate domain like | 0.003836 | INHERITED FROM: HIV Infections |
| Heme-dependent peroxidases | 0.01231 | INHERITED FROM: Autoimmune Diseases || Drug Hypersensitivity || Hypersensitivity, Immediate |
| GroEL equatorial domain-like | 0.01404 | INHERITED FROM: HIV Infections |
| GroEL apical domain-like | 0.01404 | INHERITED FROM: HIV Infections |
| Alpha-macroglobulin receptor domain | 0.03597 | INHERITED FROM: Immunologic Deficiency Syndromes || Primary Immunodeficiency Diseases || Hereditary Complement Deficiency Diseases |
| TIMP-like | 0.05036 | INHERITED FROM: Hereditary Complement Deficiency Diseases |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.05298 | INHERITED FROM: Lymphoma || Lymphoma, Large B-Cell, Diffuse || Lymphoma, Non-Hodgkin |
| BRCT domain | 0.06168 | INHERITED FROM: Lymphoproliferative Disorders || Immunoproliferative Disorders |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.0645 | INHERITED FROM: HIV Infections |
| Bromodomain | 0.07559 | INHERITED FROM: Lymphoma, T-Cell |
| SET domain | 0.07559 | INHERITED FROM: Lymphoproliferative Disorders || Immunoproliferative Disorders |
| Terpenoid cyclases/Protein prenyltransferases | 0.09833 | INHERITED FROM: Immunologic Deficiency Syndromes || Primary Immunodeficiency Diseases || Hereditary Complement Deficiency Diseases |
| Family A G protein-coupled receptor-like | 0.1031 | INHERITED FROM: Asthma, Aspirin-Induced || Hypersensitivity |
| TSP-1 type 1 repeat | 0.1033 | INHERITED FROM: Primary Immunodeficiency Diseases || Hereditary Complement Deficiency Diseases |
| HMG-box | 0.1374 | INHERITED FROM: Lymphoma, T-Cell, Cutaneous |
| SOCS box-like | 0.196 | INHERITED FROM: Hypersensitivity, Delayed || Dermatitis, Allergic Contact |
| Trypsin-like serine proteases | 0.2793 | INHERITED FROM: Hereditary Complement Deficiency Diseases |
| HLH, helix-loop-helix DNA-binding domain | 0.2965 | INHERITED FROM: Immunoproliferative Disorders || Burkitt Lymphoma |
| LDL receptor-like module | 0.5393 | INHERITED FROM: Hereditary Complement Deficiency Diseases |
LINKTO: Domain2BO Download and Domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Family( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| C5 cytosine-specific DNA methylase, DCM | 0 | DIRECT |
| Anaphylotoxins (complement system) | 0 | DIRECT |
| RhoGDI-like | 0 | DIRECT |
| Proteasome activator | 0 | DIRECT |
| DEATH effector domain, DED | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Interleukin 8-like chemokines | 0.00000000000182 | DIRECT |
| SH2 domain | 0.0000000466 | DIRECT |
| TNF receptor-like | 0.0000008805 | DIRECT |
| C1 set domains (antibody constant domain-like) | 0.00000351 | DIRECT |
| STAT | 0.00006624 | DIRECT |
| STAT DNA-binding domain | 0.00006624 | DIRECT |
| Transcription factor STAT-4 N-domain | 0.00006624 | DIRECT |
| Interferons/interleukin-10 (IL-10) | 0.00007528 | DIRECT |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.00008343 | DIRECT |
| Complement control module/SCR domain | 0.00009101 | DIRECT |
| Short-chain cytokines | 0.0002189 | DIRECT |
| TNF-like | 0.0004719 | DIRECT |
| V set domains (antibody variable domain-like) | 0.0005116 | DIRECT |
| Toll/Interleukin receptor TIR domain | 0.0007516 | DIRECT |
| MHC antigen-recognition domain | 0.001222 | INHERITED FROM: Asthma || Angioedema || Respiratory Hypersensitivity || Multiple Sclerosis || Drug Hypersensitivity || Autoimmune Diseases of the Nervous System || Hypersensitivity |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0.001325 | INHERITED FROM: Lymphoma || Lymphoproliferative Disorders || Immunoproliferative Disorders || Lymphoma, Large B-Cell, Diffuse || Lymphoma, Non-Hodgkin || Lymphoma, B-Cell |
| Interleukin-1 (IL-1) | 0.001325 | INHERITED FROM: Arthritis, Rheumatoid || Hypersensitivity |
| Bcl-2 inhibitors of programmed cell death | 0.001351 | INHERITED FROM: Lymphoproliferative Disorders || Multiple Myeloma || Lymphoma, Non-Hodgkin || Paraproteinemias |
| PLC-like (P variant) | 0.003906 | INHERITED FROM: Lymphoma || Lymphoproliferative Disorders || Lymphoma, Large B-Cell, Diffuse || Lymphoma, Non-Hodgkin || Lymphoma, T-Cell, Cutaneous |
| Netrin-like domain (NTR/C345C module) | 0.004851 | INHERITED FROM: Immunologic Deficiency Syndromes || Primary Immunodeficiency Diseases || Hereditary Complement Deficiency Diseases |
| DEATH domain, DD | 0.007016 | INHERITED FROM: Lymphoma, Large B-Cell, Diffuse || Lymphoma, Non-Hodgkin |
| Myeloperoxidase-like | 0.01137 | INHERITED FROM: Autoimmune Diseases || Drug Hypersensitivity || Hypersensitivity, Immediate |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0.01137 | INHERITED FROM: HIV Infections |
| Link domain | 0.01344 | INHERITED FROM: Autoimmune Diseases |
| Group II chaperonin (CCT, TRIC), apical domain | 0.02132 | INHERITED FROM: HIV Infections |
| Proteasome subunits | 0.03201 | INHERITED FROM: Immunologic Deficiency Syndromes || HIV Infections |
| Complement components | 0.03423 | INHERITED FROM: Immunologic Deficiency Syndromes || Primary Immunodeficiency Diseases || Hereditary Complement Deficiency Diseases |
| Alpha-macroglobulin receptor domain | 0.03423 | INHERITED FROM: Immunologic Deficiency Syndromes || Primary Immunodeficiency Diseases || Hereditary Complement Deficiency Diseases |
| Leucine zipper domain | 0.04422 | INHERITED FROM: Arthritis, Juvenile |
| Histone lysine methyltransferases | 0.04466 | INHERITED FROM: Lymphoproliferative Disorders || Immunoproliferative Disorders |
| ets domain | 0.06506 | INHERITED FROM: Precursor Cell Lymphoblastic Leukemia-Lymphoma |
| Rhodopsin-like | 0.07666 | INHERITED FROM: Asthma, Aspirin-Induced || Hypersensitivity |
| Bromodomain | 0.07932 | INHERITED FROM: Lymphoma, T-Cell |
| Ras-binding domain, RBD | 0.1008 | INHERITED FROM: Lymphoma || Lymphoproliferative Disorders || Immunoproliferative Disorders || Lymphoma, Large B-Cell, Diffuse || Lymphoma, Non-Hodgkin |
| TSP-1 type 1 repeat | 0.1124 | INHERITED FROM: Primary Immunodeficiency Diseases || Hereditary Complement Deficiency Diseases |
| PHD domain | 0.1191 | INHERITED FROM: Lymphoma, T-Cell, Cutaneous |
| HMG-box | 0.1457 | INHERITED FROM: Lymphoma, T-Cell, Cutaneous |
| Eukaryotic proteases | 0.1863 | INHERITED FROM: Hereditary Complement Deficiency Diseases |
| SOCS box-like | 0.192 | INHERITED FROM: Hypersensitivity, Delayed || Dermatitis, Allergic Contact |
| HLH, helix-loop-helix DNA-binding domain | 0.3318 | INHERITED FROM: Immunoproliferative Disorders || Burkitt Lymphoma |
| LDL receptor-like module | 0.5603 | INHERITED FROM: Hereditary Complement Deficiency Diseases |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| C5 cytosine-specific DNA methylase, DCM | 0 | Direct |
| Anaphylotoxins (complement system) | 0 | Direct |
| RhoGDI-like | 0 | Direct |
| Proteasome activator | 0 | Direct |
| DEATH effector domain, DED | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Interleukin 8-like chemokines | 0.00000000000182 | Direct |
| SH2 domain | 0.0000000466 | Direct |
| TNF receptor-like | 0.0000008805 | Direct |
| C1 set domains (antibody constant domain-like) | 0.00000351 | Direct |
| STAT | 0.00006624 | Direct |
| STAT DNA-binding domain | 0.00006624 | Direct |
| Transcription factor STAT-4 N-domain | 0.00006624 | Direct |
| Interferons/interleukin-10 (IL-10) | 0.00007528 | Direct |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.00008343 | Direct |
| Complement control module/SCR domain | 0.00009101 | Direct |
| Short-chain cytokines | 0.0002189 | Direct |
| TNF-like | 0.0004719 | Direct |
| V set domains (antibody variable domain-like) | 0.0005116 | Direct |
| Toll/Interleukin receptor TIR domain | 0.0007516 | Direct |
| MHC antigen-recognition domain | 0.001222 | Inherited |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0.001325 | Inherited |
| Interleukin-1 (IL-1) | 0.001325 | Inherited |
| Bcl-2 inhibitors of programmed cell death | 0.001351 | Inherited |
| PLC-like (P variant) | 0.003906 | Inherited |
| Netrin-like domain (NTR/C345C module) | 0.004851 | Inherited |
| DEATH domain, DD | 0.007016 | Inherited |
| Myeloperoxidase-like | 0.01137 | Inherited |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0.01137 | Inherited |
| Link domain | 0.01344 | Inherited |
| Group II chaperonin (CCT, TRIC), apical domain | 0.02132 | Inherited |
| Proteasome subunits | 0.03201 | Inherited |
| Complement components | 0.03423 | Inherited |
| Alpha-macroglobulin receptor domain | 0.03423 | Inherited |
| Leucine zipper domain | 0.04422 | Inherited |
| Histone lysine methyltransferases | 0.04466 | Inherited |
| ets domain | 0.06506 | Inherited |
| Rhodopsin-like | 0.07666 | Inherited |
| Bromodomain | 0.07932 | Inherited |
| Ras-binding domain, RBD | 0.1008 | Inherited |
| TSP-1 type 1 repeat | 0.1124 | Inherited |
| PHD domain | 0.1191 | Inherited |
| HMG-box | 0.1457 | Inherited |
| Eukaryotic proteases | 0.1863 | Inherited |
| SOCS box-like | 0.192 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.3318 | Inherited |
| LDL receptor-like module | 0.5603 | Inherited |
LINKTO: Domain2BO Download and Domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Single)( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Proteasome activator | 0 | DIRECT |
| Anaphylotoxins (complement system) | 0 | DIRECT |
| Interleukin 8-like chemokines | 0.0000000000004079 | DIRECT |
| 4-helical cytokines | 0.000000002781 | DIRECT |
| Immunoglobulin | 0.000000004069 | DIRECT |
| SH2 domain | 0.000000009946 | DIRECT |
| TNF receptor-like | 0.00000001839 | DIRECT |
| DEATH domain | 0.0000002224 | DIRECT |
| p53-like transcription factors | 0.0000249 | DIRECT |
| Complement control module/SCR domain | 0.00004036 | DIRECT |
| Transcription factor STAT-4 N-domain | 0.0000423 | DIRECT |
| STAT | 0.0000423 | DIRECT |
| TNF-like | 0.000257 | DIRECT |
| MHC antigen-recognition domain | 0.0007305 | DIRECT |
| Bcl-2 inhibitors of programmed cell death | 0.0009807 | DIRECT |
| Flavoproteins | 0.0009807 | DIRECT |
| Protein kinase-like (PK-like) | 0.001367 | INHERITED FROM: Lymphoma, Non-Hodgkin || Immunoproliferative Disorders |
| GroEL-intermediate domain like | 0.002678 | INHERITED FROM: HIV Infections |
| Caspase-like | 0.006208 | INHERITED FROM: Lymphoma, Non-Hodgkin |
| Heme-dependent peroxidases | 0.008978 | INHERITED FROM: Drug Hypersensitivity || Autoimmune Diseases || Hypersensitivity, Immediate |
| GroEL apical domain-like | 0.01035 | INHERITED FROM: HIV Infections |
| GroEL equatorial domain-like | 0.01035 | INHERITED FROM: HIV Infections |
| Alpha-macroglobulin receptor domain | 0.02813 | INHERITED FROM: Primary Immunodeficiency Diseases || Hereditary Complement Deficiency Diseases || Immunologic Deficiency Syndromes |
| Leucine zipper domain | 0.03223 | INHERITED FROM: Arthritis, Juvenile |
| TIMP-like | 0.04012 | INHERITED FROM: Primary Immunodeficiency Diseases || Hereditary Complement Deficiency Diseases |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.04238 | INHERITED FROM: Lymphoma, Large B-Cell, Diffuse || Lymphoma || Lymphoma, Non-Hodgkin || Immunoproliferative Disorders |
| BRCT domain | 0.04997 | INHERITED FROM: Lymphoproliferative Disorders || Immunoproliferative Disorders |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.05243 | INHERITED FROM: HIV Infections |
| SET domain | 0.06177 | INHERITED FROM: Lymphoproliferative Disorders || Immunoproliferative Disorders |
| Bromodomain | 0.06177 | INHERITED FROM: Lymphoma, T-Cell |
| Terpenoid cyclases/Protein prenyltransferases | 0.08175 | INHERITED FROM: Primary Immunodeficiency Diseases || Hereditary Complement Deficiency Diseases || Immunologic Deficiency Syndromes |
| Family A G protein-coupled receptor-like | 0.08616 | INHERITED FROM: Hypersensitivity || Asthma, Aspirin-Induced |
| TSP-1 type 1 repeat | 0.08641 | INHERITED FROM: Primary Immunodeficiency Diseases || Hereditary Complement Deficiency Diseases |
| HMG-box | 0.1168 | INHERITED FROM: Lymphoma, T-Cell, Cutaneous |
| Ribonuclease H-like | 0.1387 | INHERITED FROM: Autoimmune Diseases of the Nervous System |
| SOCS box-like | 0.1705 | INHERITED FROM: Dermatitis, Allergic Contact || Hypersensitivity, Delayed |
| Trypsin-like serine proteases | 0.2487 | INHERITED FROM: Hereditary Complement Deficiency Diseases |
| HLH, helix-loop-helix DNA-binding domain | 0.2648 | INHERITED FROM: Burkitt Lymphoma || Immunoproliferative Disorders |
| Rhodanese/Cell cycle control phosphatase | 0.29 | INHERITED FROM: Arthritis, Juvenile |
| LDL receptor-like module | 0.5059 | INHERITED FROM: Hereditary Complement Deficiency Diseases |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Duplex) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
82895,57424
82895 - TSP-1 type 1 repeat
57424 - LDL receptor-like module | 0 | DIRECT |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
63763,57903
63763 - SAND domain-like
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
49410,50242
49410 - Alpha-macroglobulin receptor domain
50242 - TIMP-like | 0 | DIRECT |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.0000004168 | DIRECT |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.0000343 | DIRECT |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0.0000423 | DIRECT |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0.0000423 | DIRECT |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0.0000423 | DIRECT |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.00007306 | DIRECT |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.000219 | DIRECT |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.000449 | DIRECT |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.0009807 | DIRECT |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0.0009807 | DIRECT |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0.0009976 | DIRECT |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.0009976 | DIRECT |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.002678 | INHERITED FROM: HIV Infections |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0.01361 | INHERITED FROM: Lymphoproliferative Disorders || Leukemia, Lymphoid || Immunoproliferative Disorders |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0.01361 | INHERITED FROM: Lymphoproliferative Disorders || Immunoproliferative Disorders |
55550,158235
55550 - SH2 domain
158235 - SOCS box-like | 0.02795 | INHERITED FROM: Dermatitis, Allergic Contact || Hypersensitivity, Delayed || Hypersensitivity |
52821,52799
52821 - Rhodanese/Cell cycle control phosphatase
52799 - (Phosphotyrosine protein) phosphatases II | 0.04807 | INHERITED FROM: Arthritis, Juvenile |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.5356 | INHERITED FROM: Leukemia, T-Cell |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
82895,57424
82895 - TSP-1 type 1 repeat
57424 - LDL receptor-like module | 0 | Direct |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
63763,57903
63763 - SAND domain-like
57903 - FYVE/PHD zinc finger | 0 | Direct |
49410,50242
49410 - Alpha-macroglobulin receptor domain
50242 - TIMP-like | 0 | Direct |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.0000004168 | Direct |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.0000343 | Direct |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0.0000423 | Direct |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0.0000423 | Direct |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0.0000423 | Direct |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.00007306 | Direct |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.000219 | Direct |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.000449 | Direct |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.0009807 | Direct |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0.0009807 | Direct |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0.0009976 | Direct |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.0009976 | Direct |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.002678 | Inherited |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0.01361 | Inherited |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0.01361 | Inherited |
55550,158235
55550 - SH2 domain
158235 - SOCS box-like | 0.02795 | Inherited |
52821,52799
52821 - Rhodanese/Cell cycle control phosphatase
52799 - (Phosphotyrosine protein) phosphatases II | 0.04807 | Inherited |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.5356 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Triple) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | DIRECT |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0.0000423 | DIRECT |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0.0000423 | DIRECT |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.00008737 | DIRECT |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.0009807 | DIRECT |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.0009807 | DIRECT |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.0009976 | DIRECT |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | Direct |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0.0000423 | Direct |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0.0000423 | Direct |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.00008737 | Direct |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.0009807 | Direct |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.0009807 | Direct |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.0009976 | Direct |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Plot distribution on species Tree Of Life (sTOL) for Superfamily and/or Family domains annotated by this CD term
 |
Plot tree as:
| |
Download Newick format tree:
|
( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Plot distribution on species Tree Of Life (sTOL) for single supra-domains annotated by this CD term
|
Plot tree as:
| |
Download Newick format tree:
| |
Browsing in TREE OF LIFE:
|
( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|
|
> BO Hierarchy > Immune System Diseases
