Viral DNA-binding domain superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: Ferredoxin-like [ 54861] (59)
• Superfamily: Viral DNA-binding domain [ 54957]
• Families: Viral DNA-binding domain [ 54958] (2)

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Superfamily statistics

	Genomes (0)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	0	1,800	12
Proteins	0	1,800	12

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Functional annotation

• General category: Regulation
• Detailed category: DNA-binding

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UniProtKB KeyWords (KW)

Highlighted in gray are those with FDR_all>0.001

	KW term	FDR (all)	IC level	SDKW level	Annotation (direct or inherited)
Cellular component	Host nucleus	0	1.23	Moderately Informative	DIRECT

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InterPro annotation

• Cross references: IPR009021 SSF54957 Protein matches
• Abstract:

  The Epstein barr virus is a human herpes virus that is associated with several malignancies and diseases. Papillomaviruses infect epithelial cells, and certain strains are associated with tumour formation. The EBNA-1 protein of Epstein barr virus and the E2 protein of papillomavirus both function to activate viral DNA replication. Despite a lack of sequence similarity between these two proteins, the core DNA-binding domain of the EBNA-1 protein shows structural homology to the entire DNA binding and dimerisation domain of the E2 protein. X-ray crystallography reveals the E2 and EBNA1 core DNA-binding domains to be comprised of an eight-stranded beta-barrel, flanked on two sides by two alpha helices [7553871, 10587434]. The differences between the E2 and EBNA1 structures occur in the loops and connections between the beta strands.

InterPro database

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