|
|
Phenotypic Abnormality (PA): Abnormality of the integument 
(show info)
Biomedical Ontology
Like Gene Ontology (GO), biomedical ontology such as phenotype ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Biomedical ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI’s thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology Based on YP which is the major contributor to the ‘Ascomycete phenotype ontology’, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- UniProtKB KeyWords (KW) Ontology Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- CTD Diseases (CD) Ontology CD is MEDIC disease vocabulary that is modified by CTD from the "Diseases" [C] branch of Medical Subject Headings (MeSH), combined with genetic disorders from the Online Mendelian Inheritance in OMIM database.
- CTD Chemicals (CC) Ontology CC is chemical vocabulary that is adapted by CTD from the "Chemicals and Drugs" category and Supplementary Concept Records of Medical Subject Headings (MeSH, a hierarchical vocabulary used to index articles for MEDLINE/PubMed).
Jump to [ Top · Hierarchy · Annotations ]
Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)
Jump to [ Top · Hierarchy ]
Family( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| CCCH zinc finger | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Proteasome subunits | 0 | DIRECT |
| Gonadodropin/Follitropin | 0 | DIRECT |
| alpha-Amylases, C-terminal beta-sheet domain | 0 | DIRECT |
| Lamin A/C globular tail domain | 0 | DIRECT |
| Apolipoprotein A-I | 0 | DIRECT |
| Integrin beta EGF-like domains | 0 | DIRECT |
| SWIRM domain | 0 | DIRECT |
| beta-glycanases | 0 | DIRECT |
| ets domain | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| Caspase catalytic domain | 0 | DIRECT |
| Smc hinge domain | 0 | DIRECT |
| XPF/Rad1/Mus81 nuclease | 0 | DIRECT |
| Histone deacetylase, HDAC | 0 | DIRECT |
| Erythroid transcription factor GATA-1 | 0 | DIRECT |
| Plakin repeat | 0 | DIRECT |
| Exostosin | 0 | DIRECT |
| Ferredoxin reductase FAD-binding domain-like | 0 | DIRECT |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | DIRECT |
| JAB1/MPN domain | 0 | DIRECT |
| Integrin beta tail domain | 0 | DIRECT |
| ABC transporter ATPase domain-like | 0.002701 | INHERITED FROM: Curly eyelashes || Congenital, generalized hypertrichosis |
| Integrin A (or I) domain | 0.005335 | INHERITED FROM: Follicular hyperkeratosis || Abnormality of the skin || Abnormality of skin morphology |
| C1 set domains (antibody constant domain-like) | 0.006884 | INHERITED FROM: Alopecia || Abnormality of skin physiology || Skin ulcer |
| Actin/HSP70 | 0.01218 | INHERITED FROM: Highly arched eyebrow |
| Intermediate filament protein, coiled coil region | 0.01807 | INHERITED FROM: Abnormality of epidermal morphology || Hypohidrosis or hyperhidrosis || Abnormal blistering of the skin || Verrucae || Abnormal perifollicular morphology || Epidermal thickening || Plantar hyperkeratosis || Cutaneous cyst || Abnormality of skin adnexa physiology || Hyperkeratosis || Abnormality of the plantar skin of foot || Neoplasm of the skin || Erythema || Abnormality of the nail || Onychogryposis || Palmar hyperkeratosis || Keratosis pilaris || Congenital bullous ichthyosiform erythroderma || Nail dystrophy || Thickened skin || Reticulated skin pigmentation || Epidermoid cyst || Abnormality of hair growth || Squamous cell carcinoma of the skin || Skin plaque || Slow-growing hair |
| MHC antigen-recognition domain | 0.02801 | INHERITED FROM: Psoriasiform dermatitis || Alopecia || Abnormality of skin physiology || Skin ulcer |
| GLA-domain | 0.03431 | INHERITED FROM: Aplasia/Hypoplasia of the skin |
| SH2 domain | 0.04354 | INHERITED FROM: Recurrent skin infections |
| Histone lysine methyltransferases | 0.04375 | INHERITED FROM: Abnormality of skin adnexa morphology || Regional abnormality of skin || Congenital abnormal hair pattern || Abnormality of the frontal hairline || Abnormality of the hairline || Abnormal hair morphology |
| Spectrin repeat | 0.04411 | INHERITED FROM: Epidermal thickening |
| Globins | 0.05646 | INHERITED FROM: Pallor |
| DnaQ-like 3'-5' exonuclease | 0.05646 | INHERITED FROM: Telangiectasia |
| Integrin domains | 0.06718 | INHERITED FROM: Petechiae || Ecchymosis || Purpura || Macular purpura || Spontaneous hematomas |
| DNA gyrase/MutL, second domain | 0.09177 | INHERITED FROM: Basal cell carcinoma || Neoplasm of the skin |
| DNA gyrase/MutL, N-terminal domain | 0.09177 | INHERITED FROM: Basal cell carcinoma || Neoplasm of the skin |
| Pyrin domain, PYD | 0.09177 | INHERITED FROM: Skin rash |
| Tyrosine-dependent oxidoreductases | 0.09588 | INHERITED FROM: Palmoplantar hyperkeratosis |
| TNF receptor-like | 0.09639 | INHERITED FROM: Subcutaneous nodule |
| PHD domain | 0.09697 | INHERITED FROM: Abnormal dermatoglyphics || Periauricular skin pits || Preauricular pit |
| G proteins | 0.09936 | INHERITED FROM: Nevus sebaceous |
| Bromodomain | 0.1086 | INHERITED FROM: Abnormal dermatoglyphics || Long eyelashes || Sacral dimple || Thick eyebrow || Single transverse palmar crease || Low anterior hairline || Abnormal hair quantity |
| HMG-box | 0.1113 | INHERITED FROM: Hypoplastic fifth toenail || Cutis marmorata || Hypoplastic fingernail || Hypoplastic fifth fingernail || Slow-growing hair |
| Hect, E3 ligase catalytic domain | 0.1371 | INHERITED FROM: Sparse eyebrow |
| C-terminal, gelsolin-like domain of Sec23/24 | 0.1477 | INHERITED FROM: Abnormality of skin pigmentation |
| DNA repair protein MutS, domain III | 0.1477 | INHERITED FROM: Neoplasm of the skin |
| Helical domain of Sec23/24 | 0.1477 | INHERITED FROM: Abnormality of skin pigmentation |
| BRK domain-like | 0.1477 | INHERITED FROM: Abnormality of hair density || Sparse hair |
| beta-sandwich domain of Sec23/24 | 0.1477 | INHERITED FROM: Abnormality of skin pigmentation |
| Trunk domain of Sec23/24 | 0.1477 | INHERITED FROM: Abnormality of skin pigmentation |
| VWC domain | 0.1489 | INHERITED FROM: Thin skin || Dermal atrophy || Subcutaneous nodule || Atrophic scars || Abnormally lax or hyperextensible skin || Bruising susceptibility |
| DEATH domain, DD | 0.194 | INHERITED FROM: Subcutaneous hemorrhage || Abnormality of skin physiology |
| Complement control module/SCR domain | 0.2025 | INHERITED FROM: Poor wound healing |
| EGF-type module | 0.214 | INHERITED FROM: Abnormally lax or hyperextensible skin |
| ARID domain | 0.2184 | INHERITED FROM: Small nail || Abnormal dermatoglyphics || Abnormal fingernail morphology || Hypoplastic fifth toenail || Generalized hirsutism || Cutis marmorata || Long eyelashes || Aplastic/hypoplastic toenail || Hypoplastic toenails || Abnormal toenail morphology || Aplasia/Hypoplasia of the nails || Hypoplastic fingernail || Thick eyebrow || Abnormality of the palmar creases || Single transverse palmar crease || Bilateral single transverse palmar creases || Abnormal palmar dermatoglyphics || Abnormality of hair growth || Hypoplastic fifth fingernail || Slow-growing hair |
| Ras-binding domain, RBD | 0.2184 | INHERITED FROM: Nevus || Melanocytic nevus || Palmoplantar keratoderma || Cafe-au-lait spot || Skin nodule || Subcutaneous nodule || Irregular hyperpigmentation || Hyperpigmentation of the skin || Macule || Hypermelanotic macule |
| Laminin-type module | 0.2533 | INHERITED FROM: Palmar hyperhidrosis || Squamous cell carcinoma || Milia || Abnormality of the periungual region || Oral mucosal blisters || Palmoplantar keratoderma || Fragile nails || Dermal atrophy || Paronychia || Onycholysis || Anonychia || Congenital localized absence of skin || Aplasia cutis congenita || Sparse body hair || Scarring alopecia of scalp || Alopecia of scalp || Junctional split || Skin erosion || Atypical scarring of skin || Squamous cell carcinoma of the skin |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.2655 | INHERITED FROM: Cafe-au-lait spot || Telangiectasia |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.3126 | INHERITED FROM: Pterygium || Multiple pterygia |
| Nicotinic receptor ligand binding domain-like | 0.3126 | INHERITED FROM: Pterygium || Multiple pterygia |
| TBP-associated factors, TAFs | 0.3159 | INHERITED FROM: Congenital abnormal hair pattern || Abnormality of the scalp hair || Abnormality of the hairline || Abnormal hair pattern |
| Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) | 0.362 | INHERITED FROM: Bruising susceptibility |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.481 | INHERITED FROM: Alopecia |
| RecA protein-like (ATPase-domain) | 0.5142 | INHERITED FROM: Multiple cafe-au-lait spots || Hyperpigmentation of the skin |
| Ngr ectodomain-like | 0.6303 | INHERITED FROM: Spontaneous hematomas |
| Extended AAA-ATPase domain | 0.8882 | INHERITED FROM: Abnormal hair laboratory examination || Pili torti |
| V set domains (antibody variable domain-like) | 0.9558 | INHERITED FROM: Skin plaque |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| CCCH zinc finger | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Proteasome subunits | 0 | Direct |
| Gonadodropin/Follitropin | 0 | Direct |
| alpha-Amylases, C-terminal beta-sheet domain | 0 | Direct |
| Lamin A/C globular tail domain | 0 | Direct |
| Apolipoprotein A-I | 0 | Direct |
| Integrin beta EGF-like domains | 0 | Direct |
| SWIRM domain | 0 | Direct |
| beta-glycanases | 0 | Direct |
| ets domain | 0 | Direct |
| Notch domain | 0 | Direct |
| Caspase catalytic domain | 0 | Direct |
| Smc hinge domain | 0 | Direct |
| XPF/Rad1/Mus81 nuclease | 0 | Direct |
| Histone deacetylase, HDAC | 0 | Direct |
| Erythroid transcription factor GATA-1 | 0 | Direct |
| Plakin repeat | 0 | Direct |
| Exostosin | 0 | Direct |
| Ferredoxin reductase FAD-binding domain-like | 0 | Direct |
| Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | Direct |
| JAB1/MPN domain | 0 | Direct |
| Integrin beta tail domain | 0 | Direct |
| ABC transporter ATPase domain-like | 0.002701 | Inherited |
| Integrin A (or I) domain | 0.005335 | Inherited |
| C1 set domains (antibody constant domain-like) | 0.006884 | Inherited |
| Actin/HSP70 | 0.01218 | Inherited |
| Intermediate filament protein, coiled coil region | 0.01807 | Inherited |
| MHC antigen-recognition domain | 0.02801 | Inherited |
| GLA-domain | 0.03431 | Inherited |
| SH2 domain | 0.04354 | Inherited |
| Histone lysine methyltransferases | 0.04375 | Inherited |
| Spectrin repeat | 0.04411 | Inherited |
| Globins | 0.05646 | Inherited |
| DnaQ-like 3'-5' exonuclease | 0.05646 | Inherited |
| Integrin domains | 0.06718 | Inherited |
| DNA gyrase/MutL, second domain | 0.09177 | Inherited |
| DNA gyrase/MutL, N-terminal domain | 0.09177 | Inherited |
| Pyrin domain, PYD | 0.09177 | Inherited |
| Tyrosine-dependent oxidoreductases | 0.09588 | Inherited |
| TNF receptor-like | 0.09639 | Inherited |
| PHD domain | 0.09697 | Inherited |
| G proteins | 0.09936 | Inherited |
| Bromodomain | 0.1086 | Inherited |
| HMG-box | 0.1113 | Inherited |
| Hect, E3 ligase catalytic domain | 0.1371 | Inherited |
| C-terminal, gelsolin-like domain of Sec23/24 | 0.1477 | Inherited |
| DNA repair protein MutS, domain III | 0.1477 | Inherited |
| Helical domain of Sec23/24 | 0.1477 | Inherited |
| BRK domain-like | 0.1477 | Inherited |
| beta-sandwich domain of Sec23/24 | 0.1477 | Inherited |
| Trunk domain of Sec23/24 | 0.1477 | Inherited |
| VWC domain | 0.1489 | Inherited |
| DEATH domain, DD | 0.194 | Inherited |
| Complement control module/SCR domain | 0.2025 | Inherited |
| EGF-type module | 0.214 | Inherited |
| ARID domain | 0.2184 | Inherited |
| Ras-binding domain, RBD | 0.2184 | Inherited |
| Laminin-type module | 0.2533 | Inherited |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.2655 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.3126 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.3126 | Inherited |
| TBP-associated factors, TAFs | 0.3159 | Inherited |
| Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) | 0.362 | Inherited |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.481 | Inherited |
| RecA protein-like (ATPase-domain) | 0.5142 | Inherited |
| Ngr ectodomain-like | 0.6303 | Inherited |
| Extended AAA-ATPase domain | 0.8882 | Inherited |
| V set domains (antibody variable domain-like) | 0.9558 | Inherited |
LINKTO: Domain2BO Download and Domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Single)( show details)
Highlighted in gray are those with FDR>0.001
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Duplex) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
63380,52343
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0 | DIRECT |
49562,48350
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48350 - GTPase activation domain, GAP | 0 | DIRECT |
103473,100895
103473 - MFS general substrate transporter
100895 - Kazal-type serine protease inhibitors | 0 | DIRECT |
52096,52096
52096 - ClpP/crotonase
52096 - ClpP/crotonase | 0 | DIRECT |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | DIRECT |
46579,64593
46579 - Prefoldin
64593 - Intermediate filament protein, coiled coil region | 0 | DIRECT |
64268,50044
64268 - PX domain
50044 - SH3-domain | 0 | DIRECT |
52980,47781
52980 - Restriction endonuclease-like
47781 - RuvA domain 2-like | 0 | DIRECT |
57184,49899
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | DIRECT |
57424,50494
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | DIRECT |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | DIRECT |
75399,75399
75399 - Plakin repeat
75399 - Plakin repeat | 0 | DIRECT |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0 | DIRECT |
53098,56672
53098 - Ribonuclease H-like
56672 - DNA/RNA polymerases | 0 | DIRECT |
53300,49265
53300 - vWA-like
49265 - Fibronectin type III | 0 | DIRECT |
49265,53300
49265 - Fibronectin type III
53300 - vWA-like | 0 | DIRECT |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.01807 | INHERITED FROM: Jaundice |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.02555 | INHERITED FROM: Psoriasiform dermatitis || Alopecia || Abnormality of skin physiology || Skin ulcer |
64593,64593
64593 - Intermediate filament protein, coiled coil region
64593 - Intermediate filament protein, coiled coil region | 0.02555 | INHERITED FROM: Abnormal blistering of the skin || Epidermal thickening || Abnormality of the plantar skin of foot || Palmoplantar keratoderma || Hypohidrosis or hyperhidrosis || Hyperkeratosis || Nail dystrophy || Hyperhidrosis || Onychogryposis |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.03985 | INHERITED FROM: Subcutaneous nodule |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0.05264 | INHERITED FROM: Abnormal dermatoglyphics || Hirsutism || Long eyelashes |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.07597 | INHERITED FROM: Periauricular skin pits || Preauricular pit |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0.08642 | INHERITED FROM: Basal cell carcinoma || Neoplasm of the skin |
53300,53300
53300 - vWA-like
53300 - vWA-like | 0.08642 | INHERITED FROM: Follicular hyperkeratosis || Hypohidrosis or hyperhidrosis || Hyperkeratosis || Hyperhidrosis || Abnormality of skin adnexa physiology |
47986,52540
47986 - DEATH domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.08642 | INHERITED FROM: Skin rash || Papule || Abnormality of skin physiology || Vascular skin abnormality || Inflammatory abnormality of the skin |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.1271 | INHERITED FROM: Skin nodule |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1417 | INHERITED FROM: Neoplasm of the skin |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0.1417 | INHERITED FROM: Abnormality of skin pigmentation |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.1814 | INHERITED FROM: Localized skin lesion |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.2206 | INHERITED FROM: Vascular skin abnormality || Poor wound healing |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.2534 | INHERITED FROM: Plantar hyperkeratosis || Squamous cell carcinoma of the skin || Aplasia cutis congenita || Skin erosion || Milia || Scarring alopecia of scalp || Paronychia || Abnormality of the periungual region || Palmar hyperhidrosis || Junctional split || Oral mucosal blisters || Congenital localized absence of skin |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.295 | INHERITED FROM: Pterygium || Multiple pterygia |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.3118 | INHERITED FROM: Cutis laxa |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
63380,52343
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0 | Direct |
49562,48350
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48350 - GTPase activation domain, GAP | 0 | Direct |
103473,100895
103473 - MFS general substrate transporter
100895 - Kazal-type serine protease inhibitors | 0 | Direct |
52096,52096
52096 - ClpP/crotonase
52096 - ClpP/crotonase | 0 | Direct |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | Direct |
46579,64593
46579 - Prefoldin
64593 - Intermediate filament protein, coiled coil region | 0 | Direct |
64268,50044
64268 - PX domain
50044 - SH3-domain | 0 | Direct |
52980,47781
52980 - Restriction endonuclease-like
47781 - RuvA domain 2-like | 0 | Direct |
57184,49899
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | Direct |
57424,50494
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | Direct |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0 | Direct |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | Direct |
75399,75399
75399 - Plakin repeat
75399 - Plakin repeat | 0 | Direct |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0 | Direct |
53098,56672
53098 - Ribonuclease H-like
56672 - DNA/RNA polymerases | 0 | Direct |
53300,49265
53300 - vWA-like
49265 - Fibronectin type III | 0 | Direct |
49265,53300
49265 - Fibronectin type III
53300 - vWA-like | 0 | Direct |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.01807 | Inherited |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.02555 | Inherited |
64593,64593
64593 - Intermediate filament protein, coiled coil region
64593 - Intermediate filament protein, coiled coil region | 0.02555 | Inherited |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.03985 | Inherited |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0.05264 | Inherited |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.07597 | Inherited |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0.08642 | Inherited |
53300,53300
53300 - vWA-like
53300 - vWA-like | 0.08642 | Inherited |
47986,52540
47986 - DEATH domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.08642 | Inherited |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.1271 | Inherited |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1417 | Inherited |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0.1417 | Inherited |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.1814 | Inherited |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.2206 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.2534 | Inherited |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.295 | Inherited |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.3118 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Triple) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
49265,49265,53300
49265 - Fibronectin type III
49265 - Fibronectin type III
53300 - vWA-like | 0 | DIRECT |
57424,57424,57184
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0 | DIRECT |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | DIRECT |
49899,57196,49899
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0 | DIRECT |
57184,49899,49899
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57424,57184,63825
57424 - LDL receptor-like module
57184 - Growth factor receptor domain
63825 - YWTD domain | 0 | DIRECT |
57424,57424,50494
57424 - LDL receptor-like module
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | DIRECT |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | DIRECT |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.02555 | INHERITED FROM: Localized skin lesion |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.1289 | INHERITED FROM: Purpura || Generalized abnormality of skin || Poor wound healing |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0.2537 | INHERITED FROM: Atypical scarring of skin |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.2537 | INHERITED FROM: Palmoplantar keratoderma |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.4534 | INHERITED FROM: Squamous cell carcinoma of the skin || Aplasia cutis congenita || Skin erosion || Milia || Paronychia || Abnormality of the periungual region || Palmar hyperhidrosis || Junctional split || Oral mucosal blisters || Congenital localized absence of skin || Onycholysis |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
49265,49265,53300
49265 - Fibronectin type III
49265 - Fibronectin type III
53300 - vWA-like | 0 | Direct |
57424,57424,57184
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0 | Direct |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | Direct |
49899,57196,49899
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0 | Direct |
57184,49899,49899
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57424,57184,63825
57424 - LDL receptor-like module
57184 - Growth factor receptor domain
63825 - YWTD domain | 0 | Direct |
57424,57424,50494
57424 - LDL receptor-like module
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | Direct |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | Direct |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.02555 | Inherited |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.1289 | Inherited |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0.2537 | Inherited |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.2537 | Inherited |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.4534 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Plot distribution on species Tree Of Life (sTOL) for Superfamily and/or Family domains annotated by this HP term
 |
Plot tree as:
| |
Download Newick format tree:
|
( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Plot distribution on species Tree Of Life (sTOL) for single supra-domains annotated by this HP term
|
Plot tree as:
| |
Download Newick format tree:
| |
Browsing in TREE OF LIFE:
|
( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|
|
> BO Hierarchy > Abnormality of the integument
