CTD Chemicals (CC): Piperazines

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Biomedical Ontology
Like Gene Ontology (GO), biomedical ontology such as phenotype ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Biomedical ontologies we have incorporated are as follows:

Disease Ontology (DO) Ontology
DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI’s thesaurus, SNOMED and OMIM.
Human Phenotype (HP) Ontology
HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
Mouse Phenotype (MP) Ontology
MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
Worm Phenotype (WP) Ontology
WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
Yeast Phenotype (YP) Ontology
Based on YP which is the major contributor to the ‘Ascomycete phenotype ontology’, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
Fly Phenotype (FP) Ontology
FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
Fly Anatomy (FA) Ontology
FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
Zebrafish Anatomy (ZA) Ontology
ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
Xenopus Anatomy (XA) Ontology
XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
Arabidopsis Plant Ontology (AP) Ontology
As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
Enzyme Commission (EC) Ontology
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
UniProtKB KeyWords (KW) Ontology
Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
CTD Diseases (CD) Ontology
CD is MEDIC disease vocabulary that is modified by CTD from the "Diseases" [C] branch of Medical Subject Headings (MeSH), combined with genetic disorders from the Online Mendelian Inheritance in OMIM database.
CTD Chemicals (CC) Ontology
CC is chemical vocabulary that is adapted by CTD from the "Chemicals and Drugs" category and Supplementary Concept Records of Medical Subject Headings (MeSH, a hierarchical vocabulary used to index articles for MEDLINE/PubMed).

Root: CC Hierarchy (CTD chemicals from Comparative Toxicogenomics Database)

Superfamily

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Superfamily

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SCOP term	FDR (all)	Annotation (direct or inherited)
Cytochrome P450	0	Direct
Interleukin 8-like chemokines	0.00000000004781	Direct
4-helical cytokines	0.00000000011	Direct
Protein kinase-like (PK-like)	0.0000000001839	Direct
Nuclear receptor ligand-binding domain	0.00000003775	Direct
DEATH domain	0.00000006492	Direct
Cyclin-like	0.000001437	Direct
Neurotransmitter-gated ion-channel transmembrane pore	0.000004231	Direct
Nicotinic receptor ligand binding domain-like	0.000004231	Direct
Leucine zipper domain	0.000005156	Direct
Bcl-2 inhibitors of programmed cell death	0.00001371	Direct
Caspase-like	0.00002384	Direct
p53-like transcription factors	0.00002697	Direct
TNF receptor-like	0.00005911	Direct
ABC transporter transmembrane region	0.0002045	Direct
Heat shock protein 70kD (HSP70), peptide-binding domain	0.0003949	Direct
TNF-like	0.0007104	Direct
Toll/Interleukin receptor TIR domain	0.0008724	Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.004077	Inherited
SH2 domain	0.01001	Inherited
L30e-like	0.02119	Inherited
Actin-like ATPase domain	0.03032	Inherited
Family A G protein-coupled receptor-like	0.1018	Inherited
UDP-Glycosyltransferase/glycogen phosphorylase	0.1367	Inherited
Immunoglobulin	0.272	Inherited
Voltage-gated potassium channels	0.8368	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

Family

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Family

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SCOP term	FDR (all)	Annotation (direct or inherited)
Cytochrome P450	0	Direct
Retinoblastoma tumor suppressor domains	0	Direct
Interleukin 8-like chemokines	0.0000000001485	Direct
Protein kinases, catalytic subunit	0.000000002558	Direct
Nuclear receptor ligand-binding domain	0.00000009515	Direct
Nuclear receptor	0.0000004138	Direct
Short-chain cytokines	0.0000004495	Direct
Nicotinic receptor ligand binding domain-like	0.000006467	Direct
Neurotransmitter-gated ion-channel transmembrane pore	0.000008362	Direct
Caspase catalytic domain	0.00001011	Direct
Leucine zipper domain	0.00001084	Direct
Bcl-2 inhibitors of programmed cell death	0.00001881	Direct
TNF receptor-like	0.00004159	Direct
Cyclin	0.00004428	Direct
ABC transporter transmembrane region	0.00008773	Direct
Long-chain cytokines	0.0001151	Direct
ABC transporter ATPase domain-like	0.0002304	Direct
Heat shock protein 70kD (HSP70), peptide-binding domain	0.0002593	Direct
Rel/Dorsal transcription factors, DNA-binding domain	0.0004758	Direct
DNA gyrase/MutL, N-terminal domain	0.0006152	Direct
DNA gyrase/MutL, second domain	0.0006152	Direct
TNF-like	0.0008717	Direct
Toll/Interleukin receptor TIR domain	0.004565	Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.004649	Inherited
Interleukin-1 (IL-1)	0.004649	Inherited
UDPGT-like	0.01057	Inherited
SH2 domain	0.01743	Inherited
Motor proteins	0.02448	Inherited
Rhodopsin-like	0.0352	Inherited
Actin/HSP70	0.04634	Inherited
Laminin-type module	0.05003	Inherited
Glutathione S-transferase (GST), C-terminal domain	0.1263	Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

Supra-domain (Single|Duplex|Triple)

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Supra-domain (Single)

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Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Cytochrome P450	0	Direct
Interleukin 8-like chemokines	0.00000000001906	Direct
4-helical cytokines	0.00000000004406	Direct
Protein kinase-like (PK-like)	0.00000000007407	Direct
Nuclear receptor ligand-binding domain	0.00000001625	Direct
DEATH domain	0.00000002818	Direct
Cyclin-like	0.0000006676	Direct
Neurotransmitter-gated ion-channel transmembrane pore	0.000002025	Direct
Nicotinic receptor ligand binding domain-like	0.000002025	Direct
Leucine zipper domain	0.000002484	Direct
Bcl-2 inhibitors of programmed cell death	0.000006811	Direct
Caspase-like	0.00001208	Direct
p53-like transcription factors	0.00001372	Direct
TNF receptor-like	0.00003098	Direct
ABC transporter transmembrane region	0.0001132	Direct
Heat shock protein 70kD (HSP70), peptide-binding domain	0.000225	Direct
TNF-like	0.000417	Direct
Toll/Interleukin receptor TIR domain	0.0005172	Direct
Transcription factor STAT-4 N-domain	0.0006876	Direct
STAT	0.0006876	Direct
Ferritin-like	0.0006876	Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.002617	Inherited
SH2 domain	0.006746	Inherited
L30e-like	0.01493	Inherited
Actin-like ATPase domain	0.02181	Inherited
Family A G protein-coupled receptor-like	0.07837	Inherited
UDP-Glycosyltransferase/glycogen phosphorylase	0.107	Inherited
E set domains	0.1828	Inherited
Immunoglobulin	0.2232	Inherited
Voltage-gated potassium channels	0.7698	Inherited
Ubiquitin-like	0.817	Inherited

LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

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Supra-domain (Duplex) in N- to C-terminal order

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Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
47954,47954 47954 - Cyclin-like 47954 - Cyclin-like	0.0000003046	Direct
47986,47986 47986 - DEATH domain 47986 - DEATH domain	0.0000004028	Direct
63712,90112 63712 - Nicotinic receptor ligand binding domain-like 90112 - Neurotransmitter-gated ion-channel transmembrane pore	0.000002025	Direct
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain	0.00000346	Direct
57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like	0.00007577	Direct
90123,52540 90123 - ABC transporter transmembrane region 52540 - P-loop containing nucleoside triphosphate hydrolases	0.0001132	Direct
57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat	0.0001155	Direct
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0.0001155	Direct
47986,52129 47986 - DEATH domain 52129 - Caspase-like	0.0001201	Direct
49417,81296 49417 - p53-like transcription factors 81296 - E set domains	0.000225	Direct
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0.000225	Direct
52058,57184 52058 - L domain-like 57184 - Growth factor receptor domain	0.0005399	Direct
57184,52058 57184 - Growth factor receptor domain 52058 - L domain-like	0.0005399	Direct
55874,54211 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 54211 - Ribosomal protein S5 domain 2-like	0.0006876	Direct
48092,47655 48092 - Transcription factor STAT-4 N-domain 47655 - STAT	0.0006876	Direct
47655,49417 47655 - STAT 49417 - p53-like transcription factors	0.0006876	Direct
49417,55550 49417 - p53-like transcription factors 55550 - SH2 domain	0.0006876	Direct
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain	0.01057	Inherited
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.07911	Inherited
52833,47616 52833 - Thioredoxin-like 47616 - GST C-terminal domain-like	0.08725	Inherited
50044,55550 50044 - SH3-domain 55550 - SH2 domain	0.1046	Inherited
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin	0.1479	Inherited

LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

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Supra-domain (Triple) in N- to C-terminal order

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Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
53067,100920,100934 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0.0001155	Direct
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0.000225	Direct
52058,57184,52058 52058 - L domain-like 57184 - Growth factor receptor domain 52058 - L domain-like	0.0005399	Direct
47655,49417,55550 47655 - STAT 49417 - p53-like transcription factors 55550 - SH2 domain	0.0006876	Direct
48092,47655,49417 48092 - Transcription factor STAT-4 N-domain 47655 - STAT 49417 - p53-like transcription factors	0.0006876	Direct
50044,55550,56112 50044 - SH3-domain 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.0322	Inherited