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CTD Diseases (CD): Male Urogenital Diseases 
(show info)
Biomedical Ontology
Like Gene Ontology (GO), biomedical ontology such as phenotype ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Biomedical ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI’s thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology Based on YP which is the major contributor to the ‘Ascomycete phenotype ontology’, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- UniProtKB KeyWords (KW) Ontology Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- CTD Diseases (CD) Ontology CD is MEDIC disease vocabulary that is modified by CTD from the "Diseases" [C] branch of Medical Subject Headings (MeSH), combined with genetic disorders from the Online Mendelian Inheritance in OMIM database.
- CTD Chemicals (CC) Ontology CC is chemical vocabulary that is adapted by CTD from the "Chemicals and Drugs" category and Supplementary Concept Records of Medical Subject Headings (MeSH, a hierarchical vocabulary used to index articles for MEDLINE/PubMed).
Jump to [ Top · Hierarchy · Annotations ]
Root: CD Hierarchy (CTD diseases from Comparative Toxicogenomics Database)
Jump to [ Top · Hierarchy ]
Superfamily( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Proteasome activator | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| Cytochrome P450 | 0.00000394 | DIRECT |
| 4-helical cytokines | 0.0002431 | DIRECT |
| Flavoproteins | 0.0005098 | DIRECT |
| Riboflavin synthase domain-like | 0.0008098 | DIRECT |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.0008098 | DIRECT |
| DEATH domain | 0.003007 | INHERITED FROM: Carcinoma, Renal Cell |
| Nuclear receptor ligand-binding domain | 0.005571 | INHERITED FROM: Infertility |
| Bromodomain | 0.006744 | INHERITED FROM: Urogenital Neoplasms |
| GroEL-intermediate domain like | 0.01512 | INHERITED FROM: HIV Infections || Sexually Transmitted Diseases |
| DNA repair protein MutS, domain III | 0.01595 | INHERITED FROM: Genital Neoplasms, Female |
| NAD(P)-linked oxidoreductase | 0.02224 | INHERITED FROM: Urogenital Abnormalities || Genital Neoplasms, Female || Endometrial Neoplasms || Disorders of Sex Development || Uterine Neoplasms |
| Interleukin 8-like chemokines | 0.02271 | INHERITED FROM: Glomerulonephritis || Cystitis, Interstitial || Nephritis || Cystitis |
| Cystatin/monellin | 0.02648 | INHERITED FROM: Acute Kidney Injury |
| Metallothionein | 0.03587 | INHERITED FROM: Urinary Bladder Neoplasms |
| Serum albumin-like | 0.0434 | INHERITED FROM: Acute Kidney Injury || Renal Insufficiency |
| GroEL equatorial domain-like | 0.04686 | INHERITED FROM: HIV Infections || Sexually Transmitted Diseases |
| GroEL apical domain-like | 0.04686 | INHERITED FROM: HIV Infections || Sexually Transmitted Diseases |
| Lipocalins | 0.05491 | INHERITED FROM: Kidney Diseases || Acute Kidney Injury |
| Complement control module/SCR domain | 0.06798 | INHERITED FROM: Hemolytic-Uremic Syndrome || Glomerulonephritis || Atypical Hemolytic Uremic Syndrome || Uremia |
| Orange domain-like | 0.08281 | INHERITED FROM: Ureteral Obstruction || Ureteral Diseases |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.09617 | INHERITED FROM: HIV Infections || Sexually Transmitted Diseases || Sexually Transmitted Diseases, Viral |
| PAZ domain | 0.1308 | INHERITED FROM: Infertility || Oligospermia || Infertility, Male |
| Heme-dependent peroxidases | 0.1308 | INHERITED FROM: Renal Insufficiency |
| MHC antigen-recognition domain | 0.1389 | INHERITED FROM: Proteinuria || Nephritis |
| TNF-like | 0.1662 | INHERITED FROM: Glomerulonephritis || C1q DEFICIENCY |
| Kringle-like | 0.1802 | INHERITED FROM: Glomerulonephritis |
| Clc chloride channel | 0.1851 | INHERITED FROM: Renal Tubular Transport, Inborn Errors |
| Plexin repeat | 0.2476 | INHERITED FROM: Endometrial Neoplasms |
| C-type lectin-like | 0.2679 | INHERITED FROM: Nephritis, Hereditary |
| RING/U-box | 0.3768 | INHERITED FROM: Zellweger Syndrome |
| CBS-domain pair | 0.3825 | INHERITED FROM: Renal Tubular Transport, Inborn Errors |
| Sema domain | 0.4321 | INHERITED FROM: Endometrial Neoplasms |
| dsRNA-binding domain-like | 0.4321 | INHERITED FROM: Wilms Tumor |
| RNA-binding domain, RBD | 0.6473 | INHERITED FROM: Spermatogenic Failure, Nonobstructive, Y-Linked |
| Family A G protein-coupled receptor-like | 0.9963 | INHERITED FROM: Sexual Dysfunction, Physiological |
LINKTO: Domain2BO Download and Domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Family( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Bacterial dinuclear zinc exopeptidases | 0 | DIRECT |
| PDI-like | 0 | DIRECT |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0 | DIRECT |
| C5 cytosine-specific DNA methylase, DCM | 0 | DIRECT |
| Glucose 6-phosphate dehydrogenase-like | 0 | DIRECT |
| Tissue inhibitor of metalloproteinases, TIMP | 0 | DIRECT |
| Cytochrome p450 reductase N-terminal domain-like | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| NADPH-cytochrome p450 reductase-like | 0 | DIRECT |
| Proteasome activator | 0 | DIRECT |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Cytochrome P450 | 0.000009668 | DIRECT |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.0006356 | DIRECT |
| Interferons/interleukin-10 (IL-10) | 0.0006974 | DIRECT |
| Noncollagenous (NC1) domain of collagen IV | 0.001378 | INHERITED FROM: Urogenital Abnormalities || Urologic Diseases || Kidney Diseases || Nephritis, Hereditary |
| Histone lysine methyltransferases | 0.003752 | INHERITED FROM: Prostatic Neoplasms || Genital Diseases, Male |
| Interleukin-1 (IL-1) | 0.004426 | INHERITED FROM: Urologic Diseases || Genital Diseases, Male || Kidney Diseases |
| Nuclear receptor ligand-binding domain | 0.005781 | INHERITED FROM: Infertility |
| Bromodomain | 0.006649 | INHERITED FROM: Urogenital Neoplasms |
| Nuclear receptor | 0.007633 | INHERITED FROM: Infertility |
| DNA repair protein MutS, domain III | 0.01361 | INHERITED FROM: Genital Neoplasms, Female |
| Formate/glycerate dehydrogenases, substrate-binding domain | 0.01361 | INHERITED FROM: Genital Neoplasms, Male || Prostatic Neoplasms || Prostatic Diseases |
| Aldo-keto reductases (NADP) | 0.02017 | INHERITED FROM: Urogenital Abnormalities || Genital Neoplasms, Female || Endometrial Neoplasms || Disorders of Sex Development || Uterine Neoplasms |
| Long-chain cytokines | 0.02017 | INHERITED FROM: Infertility, Female |
| Interleukin 8-like chemokines | 0.02267 | INHERITED FROM: Glomerulonephritis || Cystitis, Interstitial || Nephritis || Cystitis |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0.03202 | INHERITED FROM: HIV Infections |
| Metallothionein | 0.03202 | INHERITED FROM: Urinary Bladder Neoplasms |
| Proteasome subunits | 0.03235 | INHERITED FROM: HIV Infections || Sexually Transmitted Diseases || Sexually Transmitted Diseases, Viral |
| Serum albumin-like | 0.03819 | INHERITED FROM: Acute Kidney Injury || Renal Insufficiency |
| ets domain | 0.03837 | INHERITED FROM: Prostatic Neoplasms || Prostatic Diseases |
| DEATH domain, DD | 0.03943 | INHERITED FROM: Carcinoma, Renal Cell |
| C1 set domains (antibody constant domain-like) | 0.05255 | INHERITED FROM: Proteinuria |
| Fibronectin type II module | 0.05689 | INHERITED FROM: Glomerulonephritis || Nephritis |
| Group II chaperonin (CCT, TRIC), apical domain | 0.05689 | INHERITED FROM: HIV Infections |
| Complement control module/SCR domain | 0.06824 | INHERITED FROM: Hemolytic-Uremic Syndrome || Glomerulonephritis || Atypical Hemolytic Uremic Syndrome || Uremia |
| Gonadodropin/Follitropin | 0.07458 | INHERITED FROM: Infertility || Infertility, Male |
| Hairy Orange domain | 0.07458 | INHERITED FROM: Ureteral Obstruction || Ureteral Diseases |
| Myeloperoxidase-like | 0.1198 | INHERITED FROM: Renal Insufficiency |
| Galectin (animal S-lectin) | 0.1198 | INHERITED FROM: Nephritis |
| MHC antigen-recognition domain | 0.1357 | INHERITED FROM: Proteinuria || Nephritis |
| TNF-like | 0.1622 | INHERITED FROM: Glomerulonephritis || C1q DEFICIENCY |
| Clc chloride channel | 0.173 | INHERITED FROM: Renal Tubular Transport, Inborn Errors |
| Plexin repeat | 0.2449 | INHERITED FROM: Endometrial Neoplasms |
| Cyclin | 0.2472 | INHERITED FROM: Genital Neoplasms, Female |
| Tetratricopeptide repeat (TPR) | 0.308 | INHERITED FROM: Kidney Diseases, Cystic |
| Sema domain | 0.4278 | INHERITED FROM: Genital Neoplasms, Female || Endometrial Neoplasms |
| Canonical RBD | 0.4957 | INHERITED FROM: Spermatogenic Failure, Nonobstructive, Y-Linked |
| CBS-domain pair | 0.5336 | INHERITED FROM: Renal Tubular Transport, Inborn Errors |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Bacterial dinuclear zinc exopeptidases | 0 | Direct |
| PDI-like | 0 | Direct |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0 | Direct |
| C5 cytosine-specific DNA methylase, DCM | 0 | Direct |
| Glucose 6-phosphate dehydrogenase-like | 0 | Direct |
| Tissue inhibitor of metalloproteinases, TIMP | 0 | Direct |
| Cytochrome p450 reductase N-terminal domain-like | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| NADPH-cytochrome p450 reductase-like | 0 | Direct |
| Proteasome activator | 0 | Direct |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Cytochrome P450 | 0.000009668 | Direct |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.0006356 | Direct |
| Interferons/interleukin-10 (IL-10) | 0.0006974 | Direct |
| Noncollagenous (NC1) domain of collagen IV | 0.001378 | Inherited |
| Histone lysine methyltransferases | 0.003752 | Inherited |
| Interleukin-1 (IL-1) | 0.004426 | Inherited |
| Nuclear receptor ligand-binding domain | 0.005781 | Inherited |
| Bromodomain | 0.006649 | Inherited |
| Nuclear receptor | 0.007633 | Inherited |
| DNA repair protein MutS, domain III | 0.01361 | Inherited |
| Formate/glycerate dehydrogenases, substrate-binding domain | 0.01361 | Inherited |
| Aldo-keto reductases (NADP) | 0.02017 | Inherited |
| Long-chain cytokines | 0.02017 | Inherited |
| Interleukin 8-like chemokines | 0.02267 | Inherited |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0.03202 | Inherited |
| Metallothionein | 0.03202 | Inherited |
| Proteasome subunits | 0.03235 | Inherited |
| Serum albumin-like | 0.03819 | Inherited |
| ets domain | 0.03837 | Inherited |
| DEATH domain, DD | 0.03943 | Inherited |
| C1 set domains (antibody constant domain-like) | 0.05255 | Inherited |
| Fibronectin type II module | 0.05689 | Inherited |
| Group II chaperonin (CCT, TRIC), apical domain | 0.05689 | Inherited |
| Complement control module/SCR domain | 0.06824 | Inherited |
| Gonadodropin/Follitropin | 0.07458 | Inherited |
| Hairy Orange domain | 0.07458 | Inherited |
| Myeloperoxidase-like | 0.1198 | Inherited |
| Galectin (animal S-lectin) | 0.1198 | Inherited |
| MHC antigen-recognition domain | 0.1357 | Inherited |
| TNF-like | 0.1622 | Inherited |
| Clc chloride channel | 0.173 | Inherited |
| Plexin repeat | 0.2449 | Inherited |
| Cyclin | 0.2472 | Inherited |
| Tetratricopeptide repeat (TPR) | 0.308 | Inherited |
| Sema domain | 0.4278 | Inherited |
| Canonical RBD | 0.4957 | Inherited |
| CBS-domain pair | 0.5336 | Inherited |
LINKTO: Domain2BO Download and Domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Single)( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| Proteasome activator | 0 | DIRECT |
| Cytochrome P450 | 0.00000186 | DIRECT |
| 4-helical cytokines | 0.0001433 | DIRECT |
| Flavoproteins | 0.0003142 | DIRECT |
| Riboflavin synthase domain-like | 0.000517 | DIRECT |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.000517 | DIRECT |
| DEATH domain | 0.002083 | INHERITED FROM: Carcinoma, Renal Cell |
| Nuclear receptor ligand-binding domain | 0.003994 | INHERITED FROM: Infertility |
| Bromodomain | 0.004916 | INHERITED FROM: Urogenital Neoplasms |
| GroEL-intermediate domain like | 0.01119 | INHERITED FROM: HIV Infections || Genital Diseases, Male || Sexually Transmitted Diseases |
| DNA repair protein MutS, domain III | 0.01184 | INHERITED FROM: Genital Neoplasms, Female |
| NAD(P)-linked oxidoreductase | 0.0169 | INHERITED FROM: Disorders of Sex Development || Genital Neoplasms, Female || Urogenital Abnormalities || Endometrial Neoplasms || Uterine Neoplasms |
| Interleukin 8-like chemokines | 0.01729 | INHERITED FROM: Nephritis || Glomerulonephritis || Cystitis || Cystitis, Interstitial |
| Cystatin/monellin | 0.02042 | INHERITED FROM: Acute Kidney Injury |
| Metallothionein | 0.02805 | INHERITED FROM: Urologic Neoplasms || Urinary Bladder Neoplasms |
| Serum albumin-like | 0.03443 | INHERITED FROM: Renal Insufficiency || Acute Kidney Injury |
| GroEL apical domain-like | 0.03726 | INHERITED FROM: HIV Infections || Sexually Transmitted Diseases |
| GroEL equatorial domain-like | 0.03726 | INHERITED FROM: HIV Infections || Sexually Transmitted Diseases |
| Lipocalins | 0.04397 | INHERITED FROM: Kidney Diseases || Acute Kidney Injury || Urologic Diseases |
| Complement control module/SCR domain | 0.05524 | INHERITED FROM: Hemolytic-Uremic Syndrome || Atypical Hemolytic Uremic Syndrome || Glomerulonephritis || Uremia |
| Orange domain-like | 0.06815 | INHERITED FROM: Ureteral Obstruction || Ureteral Diseases |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.07983 | INHERITED FROM: HIV Infections || Sexually Transmitted Diseases, Viral || Sexually Transmitted Diseases |
| Heme-dependent peroxidases | 0.111 | INHERITED FROM: Renal Insufficiency |
| PAZ domain | 0.111 | INHERITED FROM: Oligospermia || Infertility || Infertility, Male |
| MHC antigen-recognition domain | 0.118 | INHERITED FROM: Urination Disorders || Nephritis || Proteinuria |
| TNF-like | 0.1426 | INHERITED FROM: Glomerulonephritis || C1q DEFICIENCY |
| Kringle-like | 0.1559 | INHERITED FROM: Glomerulonephritis |
| Clc chloride channel | 0.1606 | INHERITED FROM: Renal Tubular Transport, Inborn Errors |
| Plexin repeat | 0.2196 | INHERITED FROM: Endometrial Neoplasms |
| C-type lectin-like | 0.2384 | INHERITED FROM: Nephritis, Hereditary |
| RING/U-box | 0.3433 | INHERITED FROM: Zellweger Syndrome |
| CBS-domain pair | 0.3489 | INHERITED FROM: Renal Tubular Transport, Inborn Errors |
| dsRNA-binding domain-like | 0.3977 | INHERITED FROM: Wilms Tumor |
| Sema domain | 0.3977 | INHERITED FROM: Genital Neoplasms, Female || Endometrial Neoplasms |
| RNA-binding domain, RBD | 0.614 | INHERITED FROM: Spermatogenic Failure, Nonobstructive, Y-Linked |
| Family A G protein-coupled receptor-like | 0.9861 | INHERITED FROM: Sexual Dysfunction, Physiological |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Duplex) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
48371,-7
48371 - ARM repeat
-7 - CATH | 0 | DIRECT |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0.003738 | INHERITED FROM: Genital Neoplasms, Male || Urinary Bladder Neoplasms || Urinary Bladder Diseases || Prostatic Diseases || Genital Diseases, Male || Prostatic Neoplasms |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.004521 | INHERITED FROM: Prostatic Diseases || Prostatic Neoplasms |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.004521 | INHERITED FROM: HIV Infections || Genital Diseases, Male || Sexually Transmitted Diseases |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.009081 | INHERITED FROM: Genital Neoplasms, Male || Prostatic Diseases || Genital Diseases, Male || Prostatic Neoplasms |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0.009081 | INHERITED FROM: Prostatic Diseases || Prostatic Neoplasms |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.01119 | INHERITED FROM: HIV Infections || Genital Diseases, Male || Sexually Transmitted Diseases |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.01184 | INHERITED FROM: Genital Neoplasms, Female |
50729,49562
50729 - PH domain-like
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.01184 | INHERITED FROM: Genital Neoplasms, Male || Prostatic Diseases || Prostatic Neoplasms |
48403,48403
48403 - Ankyrin repeat
48403 - Ankyrin repeat | 0.01276 | INHERITED FROM: Urologic Diseases |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.02199 | INHERITED FROM: Kidney Diseases || Glomerulonephritis || Urologic Diseases |
52283,51735
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0.02805 | INHERITED FROM: Genital Neoplasms, Male || Prostatic Diseases || Prostatic Neoplasms |
48552,48552
48552 - Serum albumin-like
48552 - Serum albumin-like | 0.03443 | INHERITED FROM: Renal Insufficiency || Acute Kidney Injury |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.04428 | INHERITED FROM: Urination Disorders || Nephritis || Proteinuria |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0.06023 | INHERITED FROM: Nephritis, Hereditary |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.06362 | INHERITED FROM: Hemolytic-Uremic Syndrome || Atypical Hemolytic Uremic Syndrome || Glomerulonephritis || Uremia |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0.06815 | INHERITED FROM: Ureteral Obstruction || Ureteral Diseases |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.1082 | INHERITED FROM: Genital Neoplasms, Female |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0.3977 | INHERITED FROM: Genital Neoplasms, Female || Endometrial Neoplasms |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
48371,-7
48371 - ARM repeat
-7 - CATH | 0 | Direct |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0.003738 | Inherited |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.004521 | Inherited |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.004521 | Inherited |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.009081 | Inherited |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0.009081 | Inherited |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.01119 | Inherited |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.01184 | Inherited |
50729,49562
50729 - PH domain-like
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.01184 | Inherited |
48403,48403
48403 - Ankyrin repeat
48403 - Ankyrin repeat | 0.01276 | Inherited |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.02199 | Inherited |
52283,51735
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0.02805 | Inherited |
48552,48552
48552 - Serum albumin-like
48552 - Serum albumin-like | 0.03443 | Inherited |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.04428 | Inherited |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0.06023 | Inherited |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.06362 | Inherited |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0.06815 | Inherited |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.1082 | Inherited |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0.3977 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Triple) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.004521 | INHERITED FROM: Prostatic Diseases || Prostatic Neoplasms |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.004521 | INHERITED FROM: HIV Infections || Genital Diseases, Male || Sexually Transmitted Diseases |
48552,48552,48552
48552 - Serum albumin-like
48552 - Serum albumin-like
48552 - Serum albumin-like | 0.01184 | INHERITED FROM: Kidney Diseases || Renal Insufficiency || Acute Kidney Injury |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0.01184 | INHERITED FROM: Genital Neoplasms, Male || Prostatic Diseases || Prostatic Neoplasms |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.01681 | INHERITED FROM: Kidney Diseases || Hemolytic-Uremic Syndrome || Atypical Hemolytic Uremic Syndrome || Glomerulonephritis || Uremia |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.02199 | INHERITED FROM: Genital Neoplasms, Male || Prostatic Diseases || Prostatic Neoplasms |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.3332 | INHERITED FROM: Uremia |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.004521 | Inherited |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.004521 | Inherited |
48552,48552,48552
48552 - Serum albumin-like
48552 - Serum albumin-like
48552 - Serum albumin-like | 0.01184 | Inherited |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0.01184 | Inherited |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.01681 | Inherited |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.02199 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.3332 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Plot distribution on species Tree Of Life (sTOL) for Superfamily and/or Family domains annotated by this CD term
 |
Plot tree as:
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Download Newick format tree:
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( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Plot distribution on species Tree Of Life (sTOL) for single supra-domains annotated by this CD term
|
Plot tree as:
| |
Download Newick format tree:
| |
Browsing in TREE OF LIFE:
|
( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|
|
> BO Hierarchy > Male Urogenital Diseases
