Mammalian Phenotype (MP): abnormal skeleton morphology 

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children)	MP term [MP ID] <#Children>	#Domains (Superfamily|Family)	#Supra-domain (Single|Duplex|Triple)
+ + 2:	mammalian phenotype [MP:0000001] <29>
+ 1:	skeleton phenotype [MP:0005390] <2>	(46|63)	(50|41|26)
0:	abnormal skeleton morphology [MP:0005508] <15>	(41|59)	(47|38|25)
- 1:	abnormal bone structure [MP:0003795] <17>	(17|23)	(22|14|6)
- 1:	abnormal cartilage morphology [MP:0000163] <14>	(8|14)	(11|7|2)
- 1:	abnormal skeleton development [MP:0002113] <13>	(6|14)	(6|5|2)
- 1:	abnormal joint morphology [MP:0002932] <12>	(3|6)	(4|3|0)
- 1:	abnormal ligament morphology [MP:0005504] <5>	(2|2)	(2|1|0)
- 1:	abnormal appendicular skeleton morphology [MP:0009250] <4>	(12|17)	(17|12|13)
- 1:	abnormal axial skeleton morphology [MP:0002114] <4>	(24|40)	(25|21|14)
- 1:	abnormal tendon morphology [MP:0005503] <3>	(2|3)	(3|0|0)
- 1:	increased skeletal tumor incidence [MP:0010280] <3>	(0|0)	(0|0|0)
- 1:	abnormal clitoral bone morphology [MP:0011849] <1>	(0|0)	(0|0|0)
- 1:	abnormal perichondrium morphology [MP:0006322] <1>	(0|0)	(0|0|0)
- 1:	ectopic bone [MP:0014167] <1>	(0|0)	(0|0|0)
- 1:	abnormal enthesis morphology [MP:0013941]	(0|0)	(0|0|0)
- 1:	decreased skeletal tumor incidence [MP:0012426]	(0|0)	(0|0|0)
- 1:	synostosis [MP:0000566]	(0|0)	(0|0|0)

Superfamily

Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain	0	DIRECT
p53 tetramerization domain	0	DIRECT
BTG domain-like	0	DIRECT
p53-like transcription factors	0.0000008399	DIRECT
Growth factor receptor domain	0.000001995	DIRECT
FnI-like domain	0.0007745	DIRECT
(Trans)glycosidases	0.003315	INHERITED FROM: abnormal long bone morphology || kyphosis
Homeodomain-like	0.013	INHERITED FROM: rib fusion || abnormal Meckel's cartilage morphology || absent palatine bone horizontal plate || abnormal basicranium morphology || abnormal tarsal bone morphology || abnormal deltoid tuberosity morphology || abnormal axial skeleton morphology || abnormal stapedial artery morphology || abnormal nasal capsule morphology || abnormal pectoral girdle bone morphology || abnormal joint morphology || abnormal neurocranium morphology || absent alveolar process || vertebral transformation || abnormal rib development || abnormal hyoid bone morphology || abnormal rib joint || absent sternal manubrium || abnormal middle ear ossicle morphology || abnormal mandibular coronoid process morphology
TB module/8-cys domain	0.0159	INHERITED FROM: abnormal jaw morphology || abnormal viscerocranium morphology || abnormal appendicular skeleton morphology || abnormal incisor morphology
Hect, E3 ligase catalytic domain	0.01659	INHERITED FROM: decreased bone mineral content
SCOP hierarchy in SUPERFAMILY	0.02296	INHERITED FROM: abnormal lumbar vertebrae morphology
Bromodomain	0.02928	INHERITED FROM: short nasal bone || small nasal bone
Transducin (alpha subunit), insertion domain	0.04027	INHERITED FROM: domed cranium || abnormal sternocostal joint morphology || lumbar vertebral fusion || vertebral fusion || abnormal rib morphology
HMG-box	0.06072	INHERITED FROM: abnormal sternum morphology || absent cartilage || chondrodystrophy
Clc chloride channel	0.06683	INHERITED FROM: kyphosis
TNF receptor-like	0.07286	INHERITED FROM: abnormal bone structure
YWTD domain	0.07626	INHERITED FROM: abnormal metacarpal bone morphology
Flavoproteins	0.1378	INHERITED FROM: abnormal trabecular bone morphology || abnormal osteoclast cell number || increased bone mineral density || increased osteoclast cell number || abnormal osteoclast morphology
4-helical cytokines	0.1529	INHERITED FROM: abnormal alveolar process morphology
Riboflavin synthase domain-like	0.1838	INHERITED FROM: abnormal osteoclast cell number || increased osteoclast cell number
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.1838	INHERITED FROM: abnormal osteoclast cell number || increased osteoclast cell number
Kazal-type serine protease inhibitors	0.2005	INHERITED FROM: increased presacral vertebrae number || increased lumbar vertebrae number
PYP-like sensor domain (PAS domain)	0.2005	INHERITED FROM: increased osteoblast cell number
Glycosyl hydrolase domain	0.248	INHERITED FROM: kyphosis
HLH, helix-loop-helix DNA-binding domain	0.2702	INHERITED FROM: small clavicle || clavicle hypoplasia
lambda repressor-like DNA-binding domains	0.2752	INHERITED FROM: abnormal temporal bone morphology
L domain-like	0.458	INHERITED FROM: osteophytes || abnormal tendon morphology || decreased compact bone mass
Cyclin-like	0.5002	INHERITED FROM: abnormal scapula morphology
Glucocorticoid receptor-like (DNA-binding domain)	0.5224	INHERITED FROM: split cervical axis || decreased compact bone area || increased trabecular bone volume || abnormal cricoid cartilage morphology || osteoporosis || split cervical atlas
Nuclear receptor ligand-binding domain	0.5268	INHERITED FROM: abnormal basioccipital bone morphology || abnormal incus morphology || abnormal stapes morphology || split cervical axis || fusion of atlas and occipital bones || decreased compact bone area || increased trabecular bone volume || abnormal stapedial artery morphology || abnormal cricoid cartilage morphology || osteoporosis || fusion of vertebral arches || fusion of atlas and odontoid process || abnormal odontoid process morphology || abnormal laryngeal cartilage morphology || increased bone volume || split cervical atlas
EGF/Laminin	0.5444	INHERITED FROM: abnormal compact bone thickness || abnormal cranium morphology
TSP-1 type 1 repeat	0.634	INHERITED FROM: increased compact bone thickness
Spermadhesin, CUB domain	0.6577	INHERITED FROM: abnormal tendon morphology || abnormal bone volume || abnormal osteoblast morphology || abnormal osteoblast cell number
TIMP-like	0.6822	INHERITED FROM: decreased thoracic vertebrae number || abnormal vertebrae number || abnormal thoracic vertebrae morphology || abnormal limb long bone morphology
Neurotransmitter-gated ion-channel transmembrane pore	0.6845	INHERITED FROM: abnormal ligament morphology || abnormal spiral ligament fibrocyte morphology || abnormal spiral ligament morphology || abnormal type IV spiral ligament fibrocytes
Nicotinic receptor ligand binding domain-like	0.6845	INHERITED FROM: abnormal ligament morphology || abnormal spiral ligament fibrocyte morphology || abnormal spiral ligament morphology || abnormal type IV spiral ligament fibrocytes
Hemopexin-like domain	0.7342	INHERITED FROM: abnormal trabecular bone morphology || small maxilla
Cystine-knot cytokines	0.7431	INHERITED FROM: abnormal vertebral arch morphology || absent alisphenoid bone || abnormal alisphenoid bone morphology || absent zygomatic bone || absent squamosal bone || absent maxilla || absent mandibular angle || large anterior fontanelle || small zygomatic bone || small nasal bone || abnormal mandibular condyloid process morphology || abnormal incisor morphology || abnormal mandibular coronoid process morphology
PGBD-like	0.7621	INHERITED FROM: abnormal trabecular bone morphology || abnormal femur morphology || abnormal long bone hypertrophic chondrocyte zone || decreased length of long bones || small maxilla
Metalloproteases ("zincins"), catalytic domain	0.7754	INHERITED FROM: abnormal femur morphology || short femur || abnormal long bone hypertrophic chondrocyte zone || small cranium
GLA-domain	0.8206	INHERITED FROM: abnormal trabecular bone thickness

Family

Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
p53 DNA-binding domain-like	0	DIRECT
Nitric oxide (NO) synthase oxygenase domain	0	DIRECT
Homeodomain	0	DIRECT
RUNT domain	0	DIRECT
Clathrin adaptor appendage, alpha and beta chain-specific domain	0	DIRECT
BTG domain-like	0	DIRECT
Alpha-adaptin ear subdomain-like	0	DIRECT
p53 tetramerization domain	0	DIRECT
Retinoblastoma tumor suppressor domains	0	DIRECT
Growth factor receptor domain	0.00004274	DIRECT
VWC domain	0.0004812	DIRECT
Paired domain	0.0004868	DIRECT
Transforming growth factor (TGF)-beta	0.0009347	DIRECT
DIX domain	0.001149	INHERITED FROM: rib fusion || abnormal axial skeleton morphology
Rel/Dorsal transcription factors, DNA-binding domain	0.001531	INHERITED FROM: osteopetrosis || abnormal epiphyseal plate morphology || abnormal craniofacial bone morphology || abnormal jaw morphology || abnormal viscerocranium morphology || abnormal osteoclast cell number || abnormal long bone epiphyseal plate morphology || abnormal cranium morphology
T-box	0.001759	INHERITED FROM: abnormal vertebral arch morphology || rib fusion || abnormal intervertebral disk morphology || abnormal presacral vertebrae morphology || abnormal cervical atlas morphology || abnormal occipital bone morphology
Notch domain	0.003937	INHERITED FROM: abnormal axial skeleton morphology
Arylsulfatase	0.00437	INHERITED FROM: abnormal epiphyseal plate morphology || abnormal craniofacial bone morphology || abnormal long bone epiphyseal plate morphology || abnormal cranium morphology
Hect, E3 ligase catalytic domain	0.009061	INHERITED FROM: decreased bone mineral content
TB module/8-cys domain	0.01178	INHERITED FROM: abnormal jaw morphology || abnormal viscerocranium morphology || abnormal appendicular skeleton morphology || abnormal presacral vertebrae morphology || abnormal incisor morphology
beta-glycanases	0.0128	INHERITED FROM: abnormal bone structure || abnormal skeleton development
Cytochrome p450 reductase N-terminal domain-like	0.0128	INHERITED FROM: abnormal bone structure || abnormal bone mineral density || abnormal trabecular bone morphology || abnormal osteoclast cell number || increased bone mineral density || increased osteoclast cell number || abnormal osteoclast morphology || abnormal skeleton development
MBT repeat	0.01355	INHERITED FROM: abnormal vertebral column morphology || abnormal presacral vertebrae morphology || abnormal vertebrae morphology
TNF receptor-like	0.01553	INHERITED FROM: abnormal bone structure || abnormal jaw morphology
Fibroblast growth factors (FGF)	0.0178	INHERITED FROM: abnormal limb long bone morphology
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	0.02122	INHERITED FROM: osteopetrosis || abnormal jaw morphology || abnormal viscerocranium morphology || abnormal osteoclast cell number
Laminin G-like module	0.02289	INHERITED FROM: abnormal spine curvature
Bromodomain	0.02371	INHERITED FROM: short nasal bone || decreased vertebrae number || small nasal bone
Transducin (alpha subunit), insertion domain	0.03191	INHERITED FROM: domed cranium || abnormal sternocostal joint morphology || lumbar vertebral fusion || vertebral fusion || abnormal rib morphology
Laminin-type module	0.03325	INHERITED FROM: abnormal jaw morphology || abnormal cranium morphology
NADPH-cytochrome p450 reductase-like	0.0371	INHERITED FROM: abnormal bone mineral density || abnormal trabecular bone morphology || abnormal osteoclast cell number || increased bone mineral density || increased osteoclast cell number || abnormal osteoclast morphology || abnormal skeleton development
NADPH-cytochrome p450 reductase FAD-binding domain-like	0.0371	INHERITED FROM: abnormal bone mineral density || abnormal trabecular bone morphology || abnormal osteoclast cell number || increased bone mineral density || increased osteoclast cell number || abnormal osteoclast morphology || abnormal skeleton development
HMG-box	0.05161	INHERITED FROM: abnormal sternum morphology || absent cartilage || chondrodystrophy
Clc chloride channel	0.05368	INHERITED FROM: kyphosis
Forkhead DNA-binding domain	0.05561	INHERITED FROM: abnormal jaw morphology || abnormal cranium morphology
YWTD domain	0.06295	INHERITED FROM: abnormal metacarpal bone morphology
Classic zinc finger, C2H2	0.06867	INHERITED FROM: small clavicle || clavicle hypoplasia
Neutral endopeptidase (neprilysin)	0.1168	INHERITED FROM: small mandible || abnormal mandible morphology
HLH, helix-loop-helix DNA-binding domain	0.2114	INHERITED FROM: rib bifurcation || small clavicle || clavicle hypoplasia
Long-chain cytokines	0.3011	INHERITED FROM: abnormal osteoclast differentiation
Ngr ectodomain-like	0.3377	INHERITED FROM: osteophytes || decreased trabecular bone mass || abnormal articular cartilage morphology || abnormal tendon morphology || decreased compact bone mass
EF-hand modules in multidomain proteins	0.4497	INHERITED FROM: kyphosis
SAM (sterile alpha motif) domain	0.4558	INHERITED FROM: cervical vertebral fusion || cervical vertebral transformation
Nuclear receptor ligand-binding domain	0.4625	INHERITED FROM: abnormal basioccipital bone morphology || abnormal incus morphology || abnormal stapes morphology || split cervical axis || fusion of atlas and occipital bones || abnormal squamosal bone morphology || decreased compact bone area || increased trabecular bone volume || abnormal stapedial artery morphology || abnormal cricoid cartilage morphology || osteoporosis || fusion of vertebral arches || cervical vertebral transformation || fusion of atlas and odontoid process || abnormal odontoid process morphology || abnormal laryngeal cartilage morphology || increased bone volume || split cervical atlas
Nuclear receptor	0.4625	INHERITED FROM: abnormal basioccipital bone morphology || abnormal incus morphology || abnormal stapes morphology || split cervical axis || fusion of atlas and occipital bones || abnormal squamosal bone morphology || decreased compact bone area || abnormal cervical axis morphology || increased trabecular bone volume || abnormal stapedial artery morphology || abnormal cricoid cartilage morphology || osteoporosis || fusion of vertebral arches || cervical vertebral transformation || fusion of atlas and odontoid process || abnormal odontoid process morphology || abnormal laryngeal cartilage morphology || increased bone volume || split cervical atlas
TSP-1 type 1 repeat	0.5743	INHERITED FROM: increased compact bone thickness
EGF-type module	0.5816	INHERITED FROM: increased trabecular bone mass || abnormal tendon morphology || ectopic cartilage
Spermadhesin, CUB domain	0.6001	INHERITED FROM: abnormal tendon morphology || abnormal bone volume || abnormal osteoblast morphology || abnormal osteoblast cell number
DEATH domain, DD	0.6543	INHERITED FROM: abnormal tooth morphology
Nicotinic receptor ligand binding domain-like	0.6693	INHERITED FROM: abnormal ligament morphology || abnormal spiral ligament fibrocyte morphology || abnormal spiral ligament morphology || abnormal type IV spiral ligament fibrocytes
Neurotransmitter-gated ion-channel transmembrane pore	0.6693	INHERITED FROM: abnormal ligament morphology || abnormal spiral ligament fibrocyte morphology || abnormal spiral ligament morphology || abnormal type IV spiral ligament fibrocytes
Hemopexin-like domain	0.6835	INHERITED FROM: abnormal trabecular bone morphology || abnormal femur morphology || small maxilla
MMP N-terminal domain	0.7134	INHERITED FROM: abnormal trabecular bone morphology || abnormal femur morphology || abnormal long bone hypertrophic chondrocyte zone || decreased length of long bones || small maxilla
Matrix metalloproteases, catalytic domain	0.7134	INHERITED FROM: abnormal trabecular bone morphology || abnormal femur morphology || abnormal long bone hypertrophic chondrocyte zone || decreased length of long bones || small maxilla
Extracellular domain of cell surface receptors	0.7452	INHERITED FROM: abnormal tooth morphology || abnormal vertebral column morphology
G proteins	0.7782	INHERITED FROM: domed cranium
GLA-domain	0.7784	INHERITED FROM: abnormal trabecular bone thickness
Kringle modules	0.9709	INHERITED FROM: abnormal bone volume
I set domains	1	INHERITED FROM: axial skeleton hypoplasia

Supra-domain (Single|Duplex|Triple)

Supra-domain (Single)

Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
BTG domain-like	0	DIRECT
p53 tetramerization domain	0	DIRECT
Nitric oxide (NO) synthase oxygenase domain	0	DIRECT
p53-like transcription factors	0.0000003421	DIRECT
Growth factor receptor domain	0.0000008258	DIRECT
FnI-like domain	0.0004172	DIRECT
(Trans)glycosidases	0.001934	INHERITED FROM: kyphosis || abnormal long bone morphology
Notch domain	0.003423	INHERITED FROM: abnormal axial skeleton morphology
Homeodomain-like	0.008264	INHERITED FROM: vertebral transformation || abnormal temporal bone morphology || abnormal neurocranium morphology || abnormal pectoral girdle bone morphology || abnormal middle ear ossicle morphology || absent sternal manubrium || abnormal cartilage morphology || abnormal pterygoid process morphology || abnormal basicranium morphology || absent femur || abnormal stapedial artery morphology || abnormal tarsal bone morphology || abnormal deltoid tuberosity morphology || abnormal joint morphology || abnormal nasal capsule morphology || absent palatine bone horizontal plate || absent alveolar process || abnormal Meckel's cartilage morphology || rib fusion || abnormal hyoid bone morphology || abnormal rib development || abnormal mandibular coronoid process morphology || abnormal axial skeleton morphology || abnormal rib joint
TB module/8-cys domain	0.01026	INHERITED FROM: abnormal appendicular skeleton morphology || abnormal presacral vertebrae morphology || abnormal incisor morphology || abnormal viscerocranium morphology || abnormal jaw morphology || abnormal cranium morphology
Hect, E3 ligase catalytic domain	0.01074	INHERITED FROM: decreased bone mineral content
Frizzled cysteine-rich domain	0.01436	INHERITED FROM: abnormal compact bone thickness
Bromodomain	0.01987	INHERITED FROM: short nasal bone || small nasal bone || decreased vertebrae number
Alkaline phosphatase-like	0.02014	INHERITED FROM: abnormal cartilage morphology
Transducin (alpha subunit), insertion domain	0.02798	INHERITED FROM: abnormal rib morphology || lumbar vertebral fusion || abnormal sternocostal joint morphology || vertebral fusion || domed cranium || abnormal joint morphology
HMG-box	0.04376	INHERITED FROM: abnormal sternum morphology || chondrodystrophy || absent cartilage
Clc chloride channel	0.04862	INHERITED FROM: abnormal spine curvature || kyphosis
TNF receptor-like	0.05349	INHERITED FROM: abnormal bone structure
YWTD domain	0.05615	INHERITED FROM: abnormal metacarpal bone morphology
Flavoproteins	0.108	INHERITED FROM: increased bone mineral density || increased osteoclast cell number || abnormal trabecular bone morphology || abnormal osteoclast cell number || abnormal osteoclast morphology
beta-beta-alpha zinc fingers	0.1163	INHERITED FROM: clavicle hypoplasia
4-helical cytokines	0.1213	INHERITED FROM: abnormal alveolar process morphology || osteopetrosis
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.1486	INHERITED FROM: abnormal bone mineral density || increased osteoclast cell number || abnormal osteoclast cell number
Riboflavin synthase domain-like	0.1486	INHERITED FROM: abnormal bone mineral density || increased osteoclast cell number || abnormal osteoclast cell number
PYP-like sensor domain (PAS domain)	0.1637	INHERITED FROM: increased osteoblast cell number
Kazal-type serine protease inhibitors	0.1637	INHERITED FROM: abnormal rib morphology || abnormal sternocostal joint morphology || increased presacral vertebrae number || increased lumbar vertebrae number
LDL receptor-like module	0.1704	INHERITED FROM: abnormal metacarpal bone morphology
Glycosyl hydrolase domain	0.2079	INHERITED FROM: kyphosis
HLH, helix-loop-helix DNA-binding domain	0.2286	INHERITED FROM: small clavicle || clavicle hypoplasia || rib bifurcation
lambda repressor-like DNA-binding domains	0.2335	INHERITED FROM: abnormal temporal bone morphology
L domain-like	0.4102	INHERITED FROM: decreased compact bone mass || osteophytes || abnormal tendon morphology || abnormal articular cartilage morphology
Cyclin-like	0.4525	INHERITED FROM: abnormal scapula morphology
Glucocorticoid receptor-like (DNA-binding domain)	0.475	INHERITED FROM: increased trabecular bone volume || osteoporosis || abnormal cricoid cartilage morphology || split cervical atlas || split cervical axis || abnormal osteoclast morphology || decreased compact bone area
Nuclear receptor ligand-binding domain	0.4796	INHERITED FROM: fusion of atlas and odontoid process || fusion of atlas and occipital bones || abnormal stapes morphology || abnormal odontoid process morphology || increased trabecular bone volume || abnormal incus morphology || abnormal cervical axis morphology || abnormal basioccipital bone morphology || abnormal stapedial artery morphology || abnormal laryngeal cartilage morphology || abnormal squamosal bone morphology || fusion of vertebral arches || cricoid and tracheal cartilage fusion || increased bone volume || osteoporosis || abnormal cricoid cartilage morphology || split cervical atlas || cervical vertebral transformation || split cervical axis || decreased compact bone area
EGF/Laminin	0.4976	INHERITED FROM: abnormal tendon morphology || abnormal cranium morphology || abnormal compact bone thickness
TSP-1 type 1 repeat	0.5897	INHERITED FROM: increased compact bone thickness
Spermadhesin, CUB domain	0.6148	INHERITED FROM: abnormal osteoblast morphology || abnormal tendon morphology || abnormal osteoblast cell number || abnormal bone volume || abnormal long bone metaphysis morphology
TIMP-like	0.6404	INHERITED FROM: abnormal vertebrae number || abnormal thoracic vertebrae morphology || decreased thoracic vertebrae number || abnormal limb long bone morphology
Nicotinic receptor ligand binding domain-like	0.6428	INHERITED FROM: abnormal spiral ligament morphology || abnormal ligament morphology || abnormal type IV spiral ligament fibrocytes || abnormal spiral ligament fibrocyte morphology
Neurotransmitter-gated ion-channel transmembrane pore	0.6428	INHERITED FROM: abnormal spiral ligament morphology || abnormal ligament morphology || abnormal type IV spiral ligament fibrocytes || abnormal spiral ligament fibrocyte morphology
Hemopexin-like domain	0.6953	INHERITED FROM: abnormal cartilage morphology || abnormal femur morphology || abnormal trabecular bone morphology || small maxilla
Cystine-knot cytokines	0.7047	INHERITED FROM: abnormal mandibular condyloid process morphology || small zygomatic bone || abnormal mandibular angle morphology || abnormal alisphenoid bone morphology || absent zygomatic bone || absent mandibular angle || abnormal incisor morphology || absent alisphenoid bone || absent maxilla || absent squamosal bone || large anterior fontanelle || abnormal vertebral arch morphology || small nasal bone || abnormal mandibular coronoid process morphology
PGBD-like	0.7245	INHERITED FROM: abnormal femur morphology || decreased length of long bones || abnormal trabecular bone morphology || small maxilla || abnormal long bone hypertrophic chondrocyte zone
Metalloproteases ("zincins"), catalytic domain	0.7387	INHERITED FROM: short femur || abnormal cartilage morphology || abnormal femur morphology || decreased length of long bones || abnormal long bone hypertrophic chondrocyte zone || small cranium
GLA-domain	0.7872	INHERITED FROM: abnormal trabecular bone thickness
Kringle-like	0.9192	INHERITED FROM: abnormal osteoblast cell number
TNF-like	1	INHERITED FROM: abnormal osteoclast morphology

Supra-domain (Duplex) in N- to C-terminal order

Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
49417,47719 49417 - p53-like transcription factors 47719 - p53 tetramerization domain	0	DIRECT
57184,82895 57184 - Growth factor receptor domain 82895 - TSP-1 type 1 repeat	0	DIRECT
57184,57581 57184 - Growth factor receptor domain 57581 - TB module/8-cys domain	0	DIRECT
49265,53300 49265 - Fibronectin type III 53300 - vWA-like	0	DIRECT
57196,57424 57196 - EGF/Laminin 57424 - LDL receptor-like module	0	DIRECT
57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0.00003642	DIRECT
55550,55550 55550 - SH2 domain 55550 - SH2 domain	0.00098	DIRECT
57184,57196 57184 - Growth factor receptor domain 57196 - EGF/Laminin	0.0009828	DIRECT
57196,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.001059	INHERITED FROM: abnormal phalanx morphology
49417,81296 49417 - p53-like transcription factors 81296 - E set domains	0.001269	INHERITED FROM: abnormal epiphyseal plate morphology || osteopetrosis || abnormal craniofacial bone morphology || abnormal viscerocranium morphology || abnormal long bone epiphyseal plate morphology || abnormal jaw morphology || abnormal osteoclast cell number || abnormal cranium morphology
63501,50242 63501 - Frizzled cysteine-rich domain 50242 - TIMP-like	0.003423	INHERITED FROM: abnormal long bone morphology || abnormal limb long bone morphology
57603,57603 57603 - FnI-like domain 57603 - FnI-like domain	0.004036	INHERITED FROM: abnormal rib morphology || abnormal presacral vertebrae morphology || abnormal craniofacial bone morphology || abnormal cranium morphology || abnormal vertebrae development || abnormal intervertebral disk morphology
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain	0.005621	INHERITED FROM: abnormal cervical atlas morphology || fusion of atlas and odontoid process || fusion of atlas and occipital bones || abnormal stapes morphology || abnormal odontoid process morphology || thoracic vertebral transformation || increased trabecular bone volume || abnormal incus morphology || abnormal cervical axis morphology || abnormal basioccipital bone morphology || abnormal stapedial artery morphology || abnormal laryngeal cartilage morphology || abnormal squamosal bone morphology || cervical vertebral fusion || fusion of vertebral arches || cricoid and tracheal cartilage fusion || osteoporosis || abnormal cricoid cartilage morphology || split cervical atlas || cervical vertebral transformation || split cervical axis || decreased compact bone area
57603,82895 57603 - FnI-like domain 82895 - TSP-1 type 1 repeat	0.0114	INHERITED FROM: abnormal bone structure || abnormal vertebral column morphology
53300,49265 53300 - vWA-like 49265 - Fibronectin type III	0.0114	INHERITED FROM: abnormal bone structure
57196,57581 57196 - EGF/Laminin 57581 - TB module/8-cys domain	0.01192	INHERITED FROM: abnormal appendicular skeleton morphology || abnormal jaw morphology || abnormal bone structure || abnormal long bone morphology
57581,57196 57581 - TB module/8-cys domain 57196 - EGF/Laminin	0.01192	INHERITED FROM: abnormal appendicular skeleton morphology || abnormal jaw morphology || abnormal bone structure || abnormal long bone morphology
57196,63825 57196 - EGF/Laminin 63825 - YWTD domain	0.01192	INHERITED FROM: abnormal limb bone morphology || abnormal metacarpal bone morphology || abnormal craniofacial bone morphology || abnormal jaw morphology || abnormal cranium morphology || abnormal limb long bone morphology
55785,55785 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain)	0.02053	INHERITED FROM: abnormal bone volume || decreased bone volume
63825,57196 63825 - YWTD domain 57196 - EGF/Laminin	0.02053	INHERITED FROM: abnormal metacarpal bone morphology
57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like	0.02551	INHERITED FROM: abnormal bone structure
47473,57850 47473 - EF-hand 57850 - RING/U-box	0.03379	INHERITED FROM: abnormal spine curvature || kyphosis
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0.05615	INHERITED FROM: vertebral fusion || domed cranium
49899,57196 49899 - Concanavalin A-like lectins/glucanases 57196 - EGF/Laminin	0.05615	INHERITED FROM: abnormal spine curvature
48726,56436 48726 - Immunoglobulin 56436 - C-type lectin-like	0.0666	INHERITED FROM: abnormal limb bone morphology
57424,57424 57424 - LDL receptor-like module 57424 - LDL receptor-like module	0.1011	INHERITED FROM: abnormal metacarpal bone morphology || abnormal long bone hypertrophic chondrocyte zone
63748,63748 63748 - Tudor/PWWP/MBT 63748 - Tudor/PWWP/MBT	0.1103	INHERITED FROM: abnormal presacral vertebrae morphology
47459,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain)	0.1283	INHERITED FROM: decreased bone volume
51445,51011 51445 - (Trans)glycosidases 51011 - Glycosyl hydrolase domain	0.2079	INHERITED FROM: kyphosis
47413,46689 47413 - lambda repressor-like DNA-binding domains 46689 - Homeodomain-like	0.2249	INHERITED FROM: abnormal temporal bone morphology
57903,57903 57903 - FYVE/PHD zinc finger 57903 - FYVE/PHD zinc finger	0.2629	INHERITED FROM: vertebral transformation || thoracic vertebral transformation || abnormal thoracic vertebrae morphology || abnormal cervical vertebrae morphology
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin	0.3447	INHERITED FROM: abnormal jaw morphology || abnormal cranium morphology
63712,90112 63712 - Nicotinic receptor ligand binding domain-like 90112 - Neurotransmitter-gated ion-channel transmembrane pore	0.6428	INHERITED FROM: abnormal spiral ligament morphology || abnormal ligament morphology || abnormal type IV spiral ligament fibrocytes || abnormal spiral ligament fibrocyte morphology
47090,55486 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain	0.7245	INHERITED FROM: abnormal femur morphology || decreased length of long bones || abnormal trabecular bone morphology || small maxilla || abnormal long bone hypertrophic chondrocyte zone
55486,50923 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain	0.7872	INHERITED FROM: short femur || abnormal long bone hypertrophic chondrocyte zone
57440,57440 57440 - Kringle-like 57440 - Kringle-like	0.8548	INHERITED FROM: abnormal joint morphology
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.958	INHERITED FROM: abnormal bone marrow cavity morphology
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin	1	INHERITED FROM: axial skeleton hypoplasia

Supra-domain (Triple) in N- to C-terminal order

Highlighted in gray are those with FDR>0.001

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
63825,57196,57424 63825 - YWTD domain 57196 - EGF/Laminin 57424 - LDL receptor-like module	0	DIRECT
49265,49265,53300 49265 - Fibronectin type III 49265 - Fibronectin type III 53300 - vWA-like	0	DIRECT
57196,57424,57424 57196 - EGF/Laminin 57424 - LDL receptor-like module 57424 - LDL receptor-like module	0	DIRECT
57184,57184,57581 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain 57581 - TB module/8-cys domain	0	DIRECT
57196,57184,57196 57196 - EGF/Laminin 57184 - Growth factor receptor domain 57196 - EGF/Laminin	0.0004216	DIRECT
63825,57196,63825 63825 - YWTD domain 57196 - EGF/Laminin 63825 - YWTD domain	0.00098	DIRECT
57184,57196,57196 57184 - Growth factor receptor domain 57196 - EGF/Laminin 57196 - EGF/Laminin	0.002445	INHERITED FROM: abnormal viscerocranium morphology
57196,57196,57184 57196 - EGF/Laminin 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.002445	INHERITED FROM: abnormal lumbar vertebrae morphology
57196,57196,57581 57196 - EGF/Laminin 57196 - EGF/Laminin 57581 - TB module/8-cys domain	0.003423	INHERITED FROM: abnormal appendicular skeleton morphology || abnormal viscerocranium morphology || abnormal jaw morphology || abnormal bone structure || abnormal long bone morphology
57581,57196,57196 57581 - TB module/8-cys domain 57196 - EGF/Laminin 57196 - EGF/Laminin	0.003423	INHERITED FROM: abnormal appendicular skeleton morphology || abnormal viscerocranium morphology || abnormal jaw morphology || abnormal bone structure || abnormal long bone morphology
57184,57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0.004036	INHERITED FROM: abnormal appendicular skeleton morphology
47459,55785,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain)	0.01026	INHERITED FROM: abnormal bone volume || decreased bone volume
57196,57581,57184 57196 - EGF/Laminin 57581 - TB module/8-cys domain 57184 - Growth factor receptor domain	0.0114	INHERITED FROM: abnormal appendicular skeleton morphology || abnormal limb bone morphology || abnormal bone structure || abnormal long bone morphology || abnormal limb long bone morphology
57196,63825,57196 57196 - EGF/Laminin 63825 - YWTD domain 57196 - EGF/Laminin	0.01192	INHERITED FROM: abnormal metacarpal bone morphology || abnormal vertebral column morphology || abnormal limb long bone morphology
57603,57603,57603 57603 - FnI-like domain 57603 - FnI-like domain 57603 - FnI-like domain	0.01192	INHERITED FROM: abnormal rib morphology || abnormal thoracic cage morphology
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin	0.0259	INHERITED FROM: abnormal axial skeleton morphology
47473,47473,57850 47473 - EF-hand 47473 - EF-hand 57850 - RING/U-box	0.03379	INHERITED FROM: abnormal spine curvature || kyphosis
57581,57196,57581 57581 - TB module/8-cys domain 57196 - EGF/Laminin 57581 - TB module/8-cys domain	0.03379	INHERITED FROM: abnormal long bone morphology
52540,52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0.04862	INHERITED FROM: micrognathia
48726,56436,56436 48726 - Immunoglobulin 56436 - C-type lectin-like 56436 - C-type lectin-like	0.0666	INHERITED FROM: abnormal limb bone morphology
57424,57424,57424 57424 - LDL receptor-like module 57424 - LDL receptor-like module 57424 - LDL receptor-like module	0.07696	INHERITED FROM: abnormal metacarpal bone morphology || abnormal long bone hypertrophic chondrocyte zone
57667,57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers	0.7694	INHERITED FROM: polyphalangy
47090,55486,50923 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain	0.7872	INHERITED FROM: short femur || abnormal long bone hypertrophic chondrocyte zone
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin	0.921	INHERITED FROM: axial skeleton hypoplasia || abnormal jaw morphology || abnormal cranium morphology || short nasal bone
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III	0.9328	INHERITED FROM: micrognathia