Worm Phenotype (WP): locomotion variant 

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children)	WP term [WP ID] <#Children>	#Domains (Superfamily|Family)	#Supra-domain (Single|Duplex|Triple)
+ + + + + 5:	Variant [WBPhenotype:0000886] <2>
+ + + + 4:	physiology variant [WBPhenotype:0000519] <14>	(510|587)	(510|248|68)
+ + + 3:	behavior variant [WBPhenotype:0000517] <2>	(119|121)	(119|54|20)
+ + 2:	organism behavior variant [WBPhenotype:0000525] <20>	(119|121)	(119|54|20)
+ 1:	movement variant [WBPhenotype:0001206] <4>	(48|56)	(48|25|14)
0:	locomotion variant [WBPhenotype:0000643] <4>	(46|52)	(46|23|12)
- 1:	locomotor coordination variant [WBPhenotype:0004017] <7>	(18|21)	(18|7|1)
- 1:	activity level variant [WBPhenotype:0000641] <6>	(23|27)	(24|11|5)
- 1:	forward locomotion variant [WBPhenotype:0002345] <2>	(12|14)	(12|4|0)
- 1:	burrowing assay distance abnormal [WBPhenotype:0002516] <1>	(1|0)	(1|0|0)

Superfamily

Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Chaperone J-domain	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Subdomain of clathrin and coatomer appendage domain	0	DIRECT
Clathrin adaptor appendage domain	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
HSP20-like chaperones	0.000000000000009842	DIRECT
Insulin-like	0.0000000001404	DIRECT
Neurotransmitter-gated ion-channel transmembrane pore	0.0000000001759	DIRECT
Histone-fold	0.0000000005097	DIRECT
Nicotinic receptor ligand binding domain-like	0.000000004796	DIRECT
SNF-like	0.0000007901	DIRECT
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.00001406	DIRECT
Tubulin C-terminal domain-like	0.00002333	DIRECT
EGF/Laminin	0.00003565	DIRECT
Hedgehog/intein (Hint) domain	0.00004039	DIRECT
RNA-binding domain, RBD	0.0000895	DIRECT
Tubulin nucleotide-binding domain-like	0.00009304	DIRECT
Tropomyosin	0.000123	DIRECT
Spectrin repeat	0.000123	DIRECT
Sm-like ribonucleoproteins	0.0003548	DIRECT
Growth factor receptor domain	0.000721	DIRECT
Prefoldin	0.0009073	DIRECT
Troponin coil-coiled subunits	0.0009073	DIRECT
SMAD MH1 domain	0.001401	INHERITED FROM: amplitude of sinusoidal movement variant || directionality variant || turning frequency variant || velocity of movement variant || sinusoidal movement variant || backward locomotion variant || turning variant || roaming variant || body bend variant || backward point velocity variant || reversal variant || frequency of body bend variant
Transducin (heterotrimeric G protein), gamma chain	0.00169	INHERITED FROM: amplitude of sinusoidal movement variant || directionality variant || turning frequency variant || activity level variant || sinusoidal movement variant || backward locomotion variant || turning variant || body bend variant || reversal variant || path curvature variant || locomotor coordination variant || frequency of body bend variant
E2F-DP heterodimerization region	0.00169	INHERITED FROM: directionality variant || backward locomotion variant || reversal variant || locomotor coordination variant
cAMP-binding domain-like	0.007264	INHERITED FROM: amplitude of sinusoidal movement variant || directionality variant || turning frequency variant || turning variant || body bend variant || backward point velocity variant || path curvature variant || forward point velocity variant || frequency of body bend variant || roller
Intermediate filament protein, coiled coil region	0.008377	INHERITED FROM: paralyzed
Lamin A/C globular tail domain	0.008377	INHERITED FROM: paralyzed
SMAD/FHA domain	0.01368	INHERITED FROM: amplitude of sinusoidal movement variant || directionality variant || turning frequency variant || velocity of movement variant || path curvature increased || sinusoidal movement variant || backward locomotion variant || turning variant || roaming variant || body bend variant || backward point velocity variant || reversal variant || frequency of body bend variant || forward locomotion decreased || roaming reduced
Myosin rod fragments	0.01604	INHERITED FROM: sluggish
C2 domain (Calcium/lipid-binding domain, CaLB)	0.01867	INHERITED FROM: locomotor coordination variant
Voltage-gated potassium channels	0.03908	INHERITED FROM: turning frequency variant || forward locomotion variant || activity level variant || backward locomotion variant || body bend variant || backward point velocity variant || locomotor coordination variant || forward point velocity variant || roller
PLP-dependent transferases	0.1937	INHERITED FROM: path curvature decreased || forward locomotion increased
Ankyrin repeat	0.2611	INHERITED FROM: turning frequency variant || forward locomotion variant || sinusoidal movement variant || backward locomotion variant || turning variant || body bend variant || reversal variant
Homeodomain-like	0.5263	INHERITED FROM: backward locomotion variant || forward locomotion decreased || roaming reduced
LDL receptor-like module	0.6865	INHERITED FROM: paralyzed
Fibronectin type III	0.8176	INHERITED FROM: locomotion reduced || path curvature increased || reversal variant || forward locomotion decreased
PH domain-like	0.8898	INHERITED FROM: body bend variant || forward locomotion decreased
P-loop containing nucleoside triphosphate hydrolases	1	INHERITED FROM: burrowing assay distance abnormal || turning frequency variant || backward locomotion variant
Immunoglobulin	1	INHERITED FROM: locomotion reduced
Protein kinase-like (PK-like)	1	INHERITED FROM: velocity of movement increased

Family

Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
Laminin-type module	0	DIRECT
RhoGDI-like	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Hsp90 middle domain	0	DIRECT
Chaperone J-domain	0	DIRECT
HSP20	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Phoshatidylinositol transfer protein, PITP	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Integrin domains	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Transducin (alpha subunit), insertion domain	6.263e-16	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0.000000000000001252	DIRECT
Nucleosome core histones	0.000000001538	DIRECT
Insulin-like	0.000000003394	DIRECT
Neurotransmitter-gated ion-channel transmembrane pore	0.000000006183	DIRECT
Nicotinic receptor ligand binding domain-like	0.0000001075	DIRECT
Proteasome subunits	0.0000003979	DIRECT
SNF-like	0.000001604	DIRECT
Canonical RBD	0.000102	DIRECT
Tubulin, C-terminal domain	0.0001171	DIRECT
Spectrin repeat	0.0001315	DIRECT
Hedgehog C-terminal (Hog) autoprocessing domain	0.0001315	DIRECT
Tubulin, GTPase domain	0.0003839	DIRECT
Tropomyosin	0.0003858	DIRECT
Ubiquitin activating enzymes (UBA)	0.0005719	DIRECT
Smc hinge domain	0.0005719	DIRECT
Clathrin coat assembly domain	0.0006385	DIRECT
SMAD MH1 domain	0.0027	INHERITED FROM: amplitude of sinusoidal movement variant || directionality variant || turning frequency variant || velocity of movement variant || sinusoidal movement variant || backward locomotion variant || turning variant || roaming variant || body bend variant || backward point velocity variant || reversal variant || frequency of body bend variant
Transducin (heterotrimeric G protein), gamma chain	0.002784	INHERITED FROM: amplitude of sinusoidal movement variant || directionality variant || turning frequency variant || activity level variant || sinusoidal movement variant || backward locomotion variant || turning variant || body bend variant || reversal variant || path curvature variant || locomotor coordination variant || frequency of body bend variant
Cell cycle transcription factor e2f-dp	0.002784	INHERITED FROM: directionality variant || backward locomotion variant || reversal variant || locomotor coordination variant
cAMP-binding domain	0.01052	INHERITED FROM: amplitude of sinusoidal movement variant || directionality variant || turning frequency variant || turning variant || backward point velocity variant || path curvature variant || forward point velocity variant || frequency of body bend variant || roller
SMAD domain	0.01612	INHERITED FROM: amplitude of sinusoidal movement variant || directionality variant || turning frequency variant || velocity of movement variant || sinusoidal movement variant || backward locomotion variant || turning variant || roaming variant || body bend variant || backward point velocity variant || reversal variant || frequency of body bend variant
Intermediate filament protein, coiled coil region	0.01752	INHERITED FROM: paralyzed
EGF-type module	0.02606	INHERITED FROM: activity level variant
Myosin rod fragments	0.02942	INHERITED FROM: sluggish
Pyridoxal-dependent decarboxylase	0.02942	INHERITED FROM: amplitude of sinusoidal movement variant || path curvature decreased || directionality variant || turning frequency variant || forward locomotion variant || activity level variant || sinusoidal movement variant || backward locomotion variant || body bend variant || backward point velocity variant || reversal variant || backward point velocity increased || locomotor coordination variant || forward point velocity variant || roaming increased || forward point velocity increased || forward locomotion increased
Lamin A/C globular tail domain	0.02942	INHERITED FROM: paralyzed
PLC-like (P variant)	0.07156	INHERITED FROM: body bend variant || locomotor coordination variant || frequency of body bend variant
Synaptotagmin-like (S variant)	0.1103	INHERITED FROM: roller
Rhodopsin-like	0.2761	INHERITED FROM: directionality variant || turning frequency variant || pausing variant || amplitude of sinusoidal movement decreased || forward locomotion variant || velocity of movement variant || sinusoidal movement variant || backward locomotion variant || body bend variant || locomotor coordination variant
Voltage-gated potassium channels	0.2851	INHERITED FROM: turning frequency variant || forward locomotion variant || body bend variant || backward point velocity variant || locomotor coordination variant || forward point velocity variant || roller
Integrin A (or I) domain	0.3737	INHERITED FROM: paralyzed
G proteins	0.4528	INHERITED FROM: turning frequency variant || pausing variant || forward locomotion variant || activity level variant || velocity of movement variant || backward locomotion variant || roaming variant || body bend variant || locomotor coordination variant || roaming increased
Ankyrin repeat	0.544	INHERITED FROM: turning frequency variant || forward locomotion variant || sinusoidal movement variant || backward locomotion variant || turning variant || body bend variant || reversal variant
Homeodomain	0.5973	INHERITED FROM: backward locomotion variant || forward locomotion decreased || roaming reduced
Pleckstrin-homology domain (PH domain)	0.7577	INHERITED FROM: body bend variant || locomotor coordination variant || forward locomotion decreased
Fibronectin type III	0.8024	INHERITED FROM: locomotion reduced || path curvature increased || forward locomotion decreased
LDL receptor-like module	0.8215	INHERITED FROM: paralyzed
Protein kinases, catalytic subunit	0.9658	INHERITED FROM: velocity of movement increased
I set domains	1	INHERITED FROM: locomotion reduced || path curvature increased || forward locomotion decreased || pausing increased

Supra-domain (Single|Duplex|Triple)

Supra-domain (Single)

Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
Clathrin adaptor appendage domain	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Chaperone J-domain	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Subdomain of clathrin and coatomer appendage domain	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
HSP20-like chaperones	0.000000000000007718	DIRECT
Insulin-like	0.0000000001112	DIRECT
Neurotransmitter-gated ion-channel transmembrane pore	0.0000000001393	DIRECT
Histone-fold	0.0000000004042	DIRECT
Nicotinic receptor ligand binding domain-like	0.00000000382	DIRECT
SNF-like	0.0000006378	DIRECT
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.00001145	DIRECT
Tubulin C-terminal domain-like	0.00001902	DIRECT
EGF/Laminin	0.00002911	DIRECT
Hedgehog/intein (Hint) domain	0.00003301	DIRECT
RNA-binding domain, RBD	0.00007331	DIRECT
Tubulin nucleotide-binding domain-like	0.00007622	DIRECT
Tropomyosin	0.0001008	DIRECT
Spectrin repeat	0.0001008	DIRECT
Sm-like ribonucleoproteins	0.0002925	DIRECT
Growth factor receptor domain	0.0005986	DIRECT
Troponin coil-coiled subunits	0.000755	DIRECT
Prefoldin	0.000755	DIRECT
SMAD MH1 domain	0.001169	INHERITED FROM: sinusoidal movement variant || frequency of body bend variant || backward locomotion variant || roaming variant || amplitude of sinusoidal movement variant || directionality variant || body bend variant || turning frequency variant || reversal variant || velocity of movement variant || turning variant || backward point velocity variant
Transducin (heterotrimeric G protein), gamma chain	0.001414	INHERITED FROM: activity level variant || path curvature variant || sinusoidal movement variant || frequency of body bend variant || backward locomotion variant || amplitude of sinusoidal movement variant || directionality variant || body bend variant || locomotor coordination variant || turning frequency variant || reversal variant || turning variant
E2F-DP heterodimerization region	0.001414	INHERITED FROM: backward locomotion variant || directionality variant || locomotor coordination variant || reversal variant
cAMP-binding domain-like	0.006202	INHERITED FROM: path curvature variant || sinusoidal movement variant || forward point velocity variant || frequency of body bend variant || amplitude of sinusoidal movement variant || directionality variant || body bend variant || turning frequency variant || roller || turning variant || backward point velocity variant
Intermediate filament protein, coiled coil region	0.007176	INHERITED FROM: paralyzed
Lamin A/C globular tail domain	0.007176	INHERITED FROM: paralyzed
SMAD/FHA domain	0.01184	INHERITED FROM: sinusoidal movement variant || path curvature increased || frequency of body bend variant || backward locomotion variant || roaming variant || amplitude of sinusoidal movement variant || directionality variant || pausing variant || body bend variant || turning frequency variant || reversal variant || velocity of movement variant || forward locomotion decreased || turning variant || backward point velocity variant || roaming reduced
Myosin rod fragments	0.01391	INHERITED FROM: sluggish
C2 domain (Calcium/lipid-binding domain, CaLB)	0.01622	INHERITED FROM: locomotor coordination variant
Voltage-gated potassium channels	0.03443	INHERITED FROM: activity level variant || forward point velocity variant || backward locomotion variant || body bend variant || locomotor coordination variant || turning frequency variant || roller || forward locomotion variant || backward point velocity variant
PLP-dependent transferases	0.1783	INHERITED FROM: backward point velocity increased || path curvature decreased || forward point velocity increased || forward locomotion increased
Ankyrin repeat	0.2431	INHERITED FROM: sinusoidal movement variant || backward locomotion variant || body bend variant || turning frequency variant || reversal variant || turning variant || forward locomotion variant
Homeodomain-like	0.5044	INHERITED FROM: backward locomotion variant || forward locomotion decreased || roaming reduced
LDL receptor-like module	0.6654	INHERITED FROM: paralyzed
Fibronectin type III	0.7996	INHERITED FROM: path curvature increased || locomotion reduced || reversal variant || forward locomotion decreased
PH domain-like	0.8744	INHERITED FROM: body bend variant || forward locomotion decreased
P-loop containing nucleoside triphosphate hydrolases	1	INHERITED FROM: backward locomotion variant || turning frequency variant || burrowing assay distance abnormal
Immunoglobulin	1	INHERITED FROM: locomotion reduced
Protein kinase-like (PK-like)	1	INHERITED FROM: velocity of movement increased

Supra-domain (Duplex) in N- to C-terminal order

Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
49493,49493 49493 - HSP40/DnaJ peptide-binding domain 49493 - HSP40/DnaJ peptide-binding domain	0	DIRECT
81383,50978 81383 - F-box domain 50978 - WD40 repeat-like	0	DIRECT
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
49348,55711 49348 - Clathrin adaptor appendage domain 55711 - Subdomain of clathrin and coatomer appendage domain	0	DIRECT
46785,144074 46785 - "Winged helix" DNA-binding domain 144074 - E2F-DP heterodimerization region	0	DIRECT
54585,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
57938,49493 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain	0	DIRECT
50692,54585 50692 - ADC-like 54585 - Cdc48 domain 2-like	0	DIRECT
49265,48726 49265 - Fibronectin type III 48726 - Immunoglobulin	0	DIRECT
55973,55973 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase	0	DIRECT
50729,56112 50729 - PH domain-like 56112 - Protein kinase-like (PK-like)	0	DIRECT
63712,90112 63712 - Nicotinic receptor ligand binding domain-like 90112 - Neurotransmitter-gated ion-channel transmembrane pore	0.0000000001393	DIRECT
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin	0.00000005998	DIRECT
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat	0.000006556	DIRECT
52490,55307 52490 - Tubulin nucleotide-binding domain-like 55307 - Tubulin C-terminal domain-like	0.00007622	DIRECT
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0.0005182	DIRECT
48371,48371 48371 - ARM repeat 48371 - ARM repeat	0.0005593	DIRECT
64593,74853 64593 - Intermediate filament protein, coiled coil region 74853 - Lamin A/C globular tail domain	0.003374	INHERITED FROM: locomotion reduced || paralyzed
47473,47473 47473 - EF-hand 47473 - EF-hand	0.01199	INHERITED FROM: sinusoidal movement variant || body bend variant
48403,48403 48403 - Ankyrin repeat 48403 - Ankyrin repeat	0.01391	INHERITED FROM: path curvature variant || sinusoidal movement variant || forward point velocity variant || frequency of body bend variant || backward locomotion variant || amplitude of sinusoidal movement variant || directionality variant || pausing variant || backing decreased || body bend variant || turning frequency variant || reversal variant || velocity of movement variant || turning variant || forward locomotion variant || backward point velocity variant
57424,57424 57424 - LDL receptor-like module 57424 - LDL receptor-like module	0.2505	INHERITED FROM: paralyzed
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III	0.9153	INHERITED FROM: forward point velocity variant || backward locomotion variant || amplitude of sinusoidal movement variant || locomotion reduced || locomotor coordination variant || turning frequency variant || reversal variant || forward locomotion decreased || turning variant || backward point velocity variant
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin	1	INHERITED FROM: path curvature increased || forward point velocity variant || backward locomotion variant || amplitude of sinusoidal movement variant || locomotion reduced || body bend variant || locomotor coordination variant || turning frequency variant || reversal variant || turning variant || backward point velocity variant

Supra-domain (Triple) in N- to C-terminal order

Highlighted in gray are those with FDR>0.001

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
55973,55973,55973 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase	0	DIRECT
57362,57362,57362 57362 - BPTI-like 57362 - BPTI-like 57362 - BPTI-like	0	DIRECT
54585,52540,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
50692,54585,52540 50692 - ADC-like 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
57938,49493,49493 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain 49493 - HSP40/DnaJ peptide-binding domain	0	DIRECT
48726,49265,48726 48726 - Immunoglobulin 49265 - Fibronectin type III 48726 - Immunoglobulin	0	DIRECT
46966,46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat 46966 - Spectrin repeat	0	DIRECT
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin	0.000002984	DIRECT
57716,57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0.000161	DIRECT
57424,57424,57424 57424 - LDL receptor-like module 57424 - LDL receptor-like module 57424 - LDL receptor-like module	0.1316	INHERITED FROM: paralyzed
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III	0.9658	INHERITED FROM: locomotion reduced
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin	1	INHERITED FROM: forward point velocity variant || backward locomotion variant || amplitude of sinusoidal movement variant || locomotion reduced || body bend variant || turning frequency variant || reversal variant || turning variant || backward point velocity variant