Resistin superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Small proteins [ 56992] (90)
• Fold: Resistin [ 111422]
• Superfamily: Resistin [ 111423]
• Families: Resistin [ 111424] (2)

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Superfamily statistics

	Genomes (46)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	86	161	3
Proteins	86	159	3

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Functional annotation

• General category: General
• Detailed category: Small molecule binding

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal immune system physiology	0	0.737	--	DIRECT
Mammalian Phenotype (MP)	increased inflammatory response	0	1.146	--	DIRECT
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0	0.3617	--	DIRECT
Mammalian Phenotype (MP)	immune system phenotype	0	0.627	Least Informative	DIRECT
Mammalian Phenotype (MP)	abnormal inflammatory response	0	1.076	Moderately Informative	DIRECT

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InterPro annotation

• Cross references: IPR009714 SSF111423 Protein matches
• Abstract:

  This family consists of several mammalian resistin proteins. Resistin is a 12.5 kDa cysteine-rich secreted polypeptide first reported from rodent adipocytes. It belongs to a multigene family termed RELMs or FIZZ proteins. Plasma resistin levels are significantly increased in both genetically susceptible and high-fat-diet-induced obese mice. Immunoneutralisation of resistin improves hyperglycemia and insulin resistance in high-fat-diet-induced obese mice, while administration of recombinant resistin impairs glucose tolerance and insulin action in normal mice. It has been demonstrated that increases in circulating resistin levels markedly stimulate glucose production in the presence of fixed physiological insulin levels, whereas insulin suppressed resistin expression. It has been suggested that resistin could be a link between obesity and type 2 diabetes [12885401].

InterPro database

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