SUPERFAMILY 1.75 HMM library and genome assignments server

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Synapsin C-terminal domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ATP-grasp [ 56058] (2)
Superfamily:   Glutathione synthetase ATP-binding domain-like [ 56059] (9)
Family:   Synapsin C-terminal domain [ 56078] (2)

Family statistics
Genomes (135) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 323 802 3
Proteins 321 801 3

Disease Ontology (DO)

show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of mental health0Moderately InformativeDirect
Disease Ontology (DO)schizophrenia0InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal synaptic transmission0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal neuron morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system electrophysiology0InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0InformativeDirect
Mammalian Phenotype (MP)abnormal emotion/affect behavior0InformativeDirect
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0InformativeDirect
Mammalian Phenotype (MP)seizures0InformativeDirect
Mammalian Phenotype (MP)increased synaptic depression0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal social/conspecific interaction0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal aggression-related behavior0Highly InformativeDirect
Mammalian Phenotype (MP)tonic-clonic seizures0Highly InformativeDirect

Document: MP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 60 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Glutathione synthetase ATP-binding domain-like domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Internal database links ]