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CTD Diseases (CD): Nutritional and Metabolic Diseases 
(show info)
Biomedical Ontology
Like Gene Ontology (GO), biomedical ontology such as phenotype ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Biomedical ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI’s thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology Based on YP which is the major contributor to the ‘Ascomycete phenotype ontology’, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- UniProtKB KeyWords (KW) Ontology Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- CTD Diseases (CD) Ontology CD is MEDIC disease vocabulary that is modified by CTD from the "Diseases" [C] branch of Medical Subject Headings (MeSH), combined with genetic disorders from the Online Mendelian Inheritance in OMIM database.
- CTD Chemicals (CC) Ontology CC is chemical vocabulary that is adapted by CTD from the "Chemicals and Drugs" category and Supplementary Concept Records of Medical Subject Headings (MeSH, a hierarchical vocabulary used to index articles for MEDLINE/PubMed).
Jump to [ Top · Hierarchy · Annotations ]
Root: CD Hierarchy (CTD diseases from Comparative Toxicogenomics Database)
Jump to [ Top · Hierarchy ]
Superfamily( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| SIS domain | 0 | DIRECT |
| Aminomethyltransferase beta-barrel domain | 0 | DIRECT |
| TK C-terminal domain-like | 0 | DIRECT |
| Folate-binding domain | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Single hybrid motif | 0 | DIRECT |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
| L-aspartase-like | 0 | DIRECT |
| Apolipoprotein A-I | 0 | DIRECT |
| (Trans)glycosidases | 0.0000003596 | DIRECT |
| Acyl-CoA dehydrogenase NM domain-like | 0.00001692 | DIRECT |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0.00001692 | DIRECT |
| alpha/beta-Hydrolases | 0.0001008 | DIRECT |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.0001204 | DIRECT |
| FAD/NAD(P)-binding domain | 0.0002214 | DIRECT |
| Cytochrome P450 | 0.0004089 | DIRECT |
| Class II aaRS and biotin synthetases | 0.0004223 | DIRECT |
| Flavoproteins | 0.0004239 | DIRECT |
| Glycosyl hydrolase domain | 0.0006236 | DIRECT |
| Aldolase | 0.0006236 | DIRECT |
| NAD(P)-binding Rossmann-fold domains | 0.0006972 | DIRECT |
| Six-hairpin glycosidases | 0.001874 | INHERITED FROM: Carbohydrate Metabolism, Inborn Errors |
| Alkaline phosphatase-like | 0.003619 | INHERITED FROM: Lysosomal Storage Diseases || Metabolism, Inborn Errors || Mucopolysaccharidoses |
| FAD-binding/transporter-associated domain-like | 0.004653 | INHERITED FROM: Metabolism, Inborn Errors |
| Nuclear receptor ligand-binding domain | 0.009174 | INHERITED FROM: Glucose Metabolism Disorders || Insulin Resistance |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.009923 | INHERITED FROM: Metabolism, Inborn Errors || Carbohydrate Metabolism, Inborn Errors |
| Adenine nucleotide alpha hydrolases-like | 0.01334 | INHERITED FROM: Metabolism, Inborn Errors |
| PRTase-like | 0.01542 | INHERITED FROM: Purine-Pyrimidine Metabolism, Inborn Errors || Metabolism, Inborn Errors |
| CBS-domain pair | 0.03405 | INHERITED FROM: Renal Tubular Transport, Inborn Errors |
| Kringle-like | 0.03519 | INHERITED FROM: Diabetes Complications || Diabetic Neuropathies |
| Galactose mutarotase-like | 0.04001 | INHERITED FROM: Carbohydrate Metabolism, Inborn Errors |
| 4-helical cytokines | 0.08053 | INHERITED FROM: Celiac Disease || Insulin Resistance |
| Ribosomal protein S5 domain 2-like | 0.1007 | INHERITED FROM: Colorectal Neoplasms, Hereditary Nonpolyposis || DNA Repair-Deficiency Disorders |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0.1154 | INHERITED FROM: Colorectal Neoplasms, Hereditary Nonpolyposis || DNA Repair-Deficiency Disorders |
| Bcl-2 inhibitors of programmed cell death | 0.1225 | INHERITED FROM: Diabetes Mellitus, Experimental |
| Clc chloride channel | 0.1736 | INHERITED FROM: Renal Tubular Transport, Inborn Errors |
| Cytokine | 0.175 | INHERITED FROM: Calcinosis |
| Cysteine-rich domain | 0.1797 | INHERITED FROM: Glucose Metabolism Disorders |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0.4059 | INHERITED FROM: Lipid Metabolism, Inborn Errors |
| Intermediate filament protein, coiled coil region | 0.4149 | INHERITED FROM: Amyotrophic lateral sclerosis 1 |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.4458 | INHERITED FROM: Insulin Resistance || Metabolic Syndrome |
| Interleukin 8-like chemokines | 0.6114 | INHERITED FROM: Celiac Disease |
| Voltage-gated potassium channels | 0.7823 | INHERITED FROM: Paralyses, Familial Periodic |
| P-loop containing nucleoside triphosphate hydrolases | 0.8849 | INHERITED FROM: DNA Repair-Deficiency Disorders |
| L domain-like | 0.9557 | INHERITED FROM: Lewy Body Disease |
| EGF/Laminin | 0.9572 | INHERITED FROM: Protoporphyria, Erythropoietic |
| Nicotinic receptor ligand binding domain-like | 0.9909 | INHERITED FROM: Hepatic Encephalopathy |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.9909 | INHERITED FROM: Hepatic Encephalopathy |
| RING/U-box | 1 | INHERITED FROM: Peroxisome biogenesis disorders || Zellweger Syndrome |
| RNA-binding domain, RBD | 1 | INHERITED FROM: Frontotemporal Lobar Degeneration |
LINKTO: Domain2BO Download and Domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Family( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Bacterial dinuclear zinc exopeptidases | 0 | DIRECT |
| Apolipoprotein A-I | 0 | DIRECT |
| Cystathionine synthase-like | 0 | DIRECT |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0 | DIRECT |
| Aminomethyltransferase beta-barrel domain | 0 | DIRECT |
| alpha-Amylases, C-terminal beta-sheet domain | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | DIRECT |
| Neurolysin-like | 0 | DIRECT |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Biotin dependent carboxylase carboxyltransferase domain | 0 | DIRECT |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | DIRECT |
| L-aspartase/fumarase | 0 | DIRECT |
| Cytochrome p450 reductase N-terminal domain-like | 0 | DIRECT |
| MHCK/EF2 kinase | 0 | DIRECT |
| Biotinyl/lipoyl-carrier proteins and domains | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | DIRECT |
| NADPH-cytochrome p450 reductase-like | 0 | DIRECT |
| Bactericidal permeability-increasing protein, BPI | 0 | DIRECT |
| beta-glycanases | 0 | DIRECT |
| Aminomethyltransferase folate-binding domain | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Cytochrome P450 | 0.0007672 | DIRECT |
| Amylase, catalytic domain | 0.001133 | INHERITED FROM: Metabolic Diseases || Metabolism, Inborn Errors |
| BC C-terminal domain-like | 0.001133 | INHERITED FROM: Metabolic Diseases |
| Arylsulfatase | 0.00152 | INHERITED FROM: Lysosomal Storage Diseases || Metabolism, Inborn Errors || Carbohydrate Metabolism, Inborn Errors || Mucopolysaccharidoses |
| Class I aldolase | 0.003752 | INHERITED FROM: Metabolism, Inborn Errors || Carbohydrate Metabolism, Inborn Errors |
| Nuclear receptor ligand-binding domain | 0.008739 | INHERITED FROM: Glucose Metabolism Disorders || Insulin Resistance |
| Fibronectin type II module | 0.01123 | INHERITED FROM: Diabetes Complications |
| Nuclear receptor | 0.01164 | INHERITED FROM: Insulin Resistance |
| HCDH C-domain-like | 0.01196 | INHERITED FROM: Metabolism, Inborn Errors |
| Pancreatic lipase, N-terminal domain | 0.01196 | INHERITED FROM: Lipid Metabolism, Inborn Errors || Metabolism, Inborn Errors || Lipid Metabolism Disorders |
| DNA gyrase/MutL, second domain | 0.01283 | INHERITED FROM: Colorectal Neoplasms, Hereditary Nonpolyposis || DNA Repair-Deficiency Disorders |
| DNA gyrase/MutL, N-terminal domain | 0.01283 | INHERITED FROM: Colorectal Neoplasms, Hereditary Nonpolyposis || DNA Repair-Deficiency Disorders |
| RecA protein-like (ATPase-domain) | 0.02747 | INHERITED FROM: Fanconi Anemia || DNA Repair-Deficiency Disorders |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.04648 | INHERITED FROM: Glucose Metabolism Disorders |
| Interferons/interleukin-10 (IL-10) | 0.05689 | INHERITED FROM: Diabetes Mellitus, Type 1 |
| Phosphotyrosine-binding domain (PTB) | 0.05768 | INHERITED FROM: Diabetes Mellitus, Type 2 |
| CBS-domain pair | 0.05922 | INHERITED FROM: Renal Tubular Transport, Inborn Errors |
| Rel/Dorsal transcription factors, DNA-binding domain | 0.06699 | INHERITED FROM: Diabetes Mellitus || Diabetes Mellitus, Type 2 |
| ABC transporter ATPase domain-like | 0.09377 | INHERITED FROM: Hypercholesterolemia |
| Bcl-2 inhibitors of programmed cell death | 0.1096 | INHERITED FROM: Diabetes Mellitus, Experimental |
| Tyrosine-dependent oxidoreductases | 0.1149 | INHERITED FROM: Steroid Metabolism, Inborn Errors |
| FHA domain | 0.1439 | INHERITED FROM: DNA Repair-Deficiency Disorders |
| Long-chain cytokines | 0.1521 | INHERITED FROM: Hyperinsulinism || Insulin Resistance |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.1577 | INHERITED FROM: Diabetes Mellitus, Type 2 |
| Clc chloride channel | 0.1577 | INHERITED FROM: Renal Tubular Transport, Inborn Errors |
| Intermediate filament protein, coiled coil region | 0.4137 | INHERITED FROM: Amyotrophic lateral sclerosis 1 |
| Interleukin 8-like chemokines | 0.6103 | INHERITED FROM: Celiac Disease |
| EGF-type module | 0.614 | INHERITED FROM: Porphyrias || Protoporphyria, Erythropoietic || Porphyrias, Hepatic |
| Tandem AAA-ATPase domain | 0.96 | INHERITED FROM: DNA Repair-Deficiency Disorders |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.9859 | INHERITED FROM: Hepatic Encephalopathy |
| Nicotinic receptor ligand binding domain-like | 0.9859 | INHERITED FROM: Hepatic Encephalopathy |
| Canonical RBD | 0.9982 | INHERITED FROM: Frontotemporal Lobar Degeneration |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Bacterial dinuclear zinc exopeptidases | 0 | Direct |
| Apolipoprotein A-I | 0 | Direct |
| Cystathionine synthase-like | 0 | Direct |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0 | Direct |
| Aminomethyltransferase beta-barrel domain | 0 | Direct |
| alpha-Amylases, C-terminal beta-sheet domain | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | Direct |
| Neurolysin-like | 0 | Direct |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | Direct |
| Biotin dependent carboxylase carboxyltransferase domain | 0 | Direct |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | Direct |
| L-aspartase/fumarase | 0 | Direct |
| Cytochrome p450 reductase N-terminal domain-like | 0 | Direct |
| MHCK/EF2 kinase | 0 | Direct |
| Biotinyl/lipoyl-carrier proteins and domains | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase PP module | 0 | Direct |
| NADPH-cytochrome p450 reductase-like | 0 | Direct |
| Bactericidal permeability-increasing protein, BPI | 0 | Direct |
| beta-glycanases | 0 | Direct |
| Aminomethyltransferase folate-binding domain | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Cytochrome P450 | 0.0007672 | Direct |
| Amylase, catalytic domain | 0.001133 | Inherited |
| BC C-terminal domain-like | 0.001133 | Inherited |
| Arylsulfatase | 0.00152 | Inherited |
| Class I aldolase | 0.003752 | Inherited |
| Nuclear receptor ligand-binding domain | 0.008739 | Inherited |
| Fibronectin type II module | 0.01123 | Inherited |
| Nuclear receptor | 0.01164 | Inherited |
| HCDH C-domain-like | 0.01196 | Inherited |
| Pancreatic lipase, N-terminal domain | 0.01196 | Inherited |
| DNA gyrase/MutL, second domain | 0.01283 | Inherited |
| DNA gyrase/MutL, N-terminal domain | 0.01283 | Inherited |
| RecA protein-like (ATPase-domain) | 0.02747 | Inherited |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.04648 | Inherited |
| Interferons/interleukin-10 (IL-10) | 0.05689 | Inherited |
| Phosphotyrosine-binding domain (PTB) | 0.05768 | Inherited |
| CBS-domain pair | 0.05922 | Inherited |
| Rel/Dorsal transcription factors, DNA-binding domain | 0.06699 | Inherited |
| ABC transporter ATPase domain-like | 0.09377 | Inherited |
| Bcl-2 inhibitors of programmed cell death | 0.1096 | Inherited |
| Tyrosine-dependent oxidoreductases | 0.1149 | Inherited |
| FHA domain | 0.1439 | Inherited |
| Long-chain cytokines | 0.1521 | Inherited |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.1577 | Inherited |
| Clc chloride channel | 0.1577 | Inherited |
| Intermediate filament protein, coiled coil region | 0.4137 | Inherited |
| Interleukin 8-like chemokines | 0.6103 | Inherited |
| EGF-type module | 0.614 | Inherited |
| Tandem AAA-ATPase domain | 0.96 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.9859 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.9859 | Inherited |
| Canonical RBD | 0.9982 | Inherited |
LINKTO: Domain2BO Download and Domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Single)( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| L-aspartase-like | 0 | DIRECT |
| Single hybrid motif | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| TK C-terminal domain-like | 0 | DIRECT |
| Apolipoprotein A-I | 0 | DIRECT |
| Folate-binding domain | 0 | DIRECT |
| SIS domain | 0 | DIRECT |
| Aminomethyltransferase beta-barrel domain | 0 | DIRECT |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
| (Trans)glycosidases | 0.000000158 | DIRECT |
| Acyl-CoA dehydrogenase NM domain-like | 0.000008595 | DIRECT |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0.000008595 | DIRECT |
| alpha/beta-Hydrolases | 0.00005638 | DIRECT |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.00006836 | DIRECT |
| FAD/NAD(P)-binding domain | 0.0001297 | DIRECT |
| Cytochrome P450 | 0.0002498 | DIRECT |
| Class II aaRS and biotin synthetases | 0.0002589 | DIRECT |
| Flavoproteins | 0.0002601 | DIRECT |
| Aldolase | 0.0003894 | DIRECT |
| Glycosyl hydrolase domain | 0.0003894 | DIRECT |
| NAD(P)-binding Rossmann-fold domains | 0.0004384 | DIRECT |
| Rudiment single hybrid motif | 0.0009568 | DIRECT |
| Mitochondrial carrier | 0.0009857 | DIRECT |
| Six-hairpin glycosidases | 0.001264 | INHERITED FROM: Metabolism, Inborn Errors || Metabolic Diseases || Carbohydrate Metabolism, Inborn Errors |
| Glutathione synthetase ATP-binding domain-like | 0.001406 | INHERITED FROM: Overnutrition |
| Alkaline phosphatase-like | 0.00252 | INHERITED FROM: Metabolism, Inborn Errors || Lysosomal Storage Diseases || Mucopolysaccharidoses |
| FAD-binding/transporter-associated domain-like | 0.003297 | INHERITED FROM: Metabolism, Inborn Errors |
| CoA-dependent acyltransferases | 0.003619 | INHERITED FROM: Brain Diseases, Metabolic |
| Nuclear receptor ligand-binding domain | 0.00667 | INHERITED FROM: Insulin Resistance || Glucose Metabolism Disorders |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.007234 | INHERITED FROM: Metabolism, Inborn Errors || Carbohydrate Metabolism, Inborn Errors |
| Adenine nucleotide alpha hydrolases-like | 0.009798 | INHERITED FROM: Metabolism, Inborn Errors |
| PRTase-like | 0.0114 | INHERITED FROM: Purine-Pyrimidine Metabolism, Inborn Errors || Metabolism, Inborn Errors |
| CBS-domain pair | 0.02658 | INHERITED FROM: Renal Tubular Transport, Inborn Errors |
| Kringle-like | 0.02751 | INHERITED FROM: Diabetic Neuropathies || Diabetes Complications |
| Galactose mutarotase-like | 0.03152 | INHERITED FROM: Carbohydrate Metabolism, Inborn Errors |
| 4-helical cytokines | 0.06618 | INHERITED FROM: Insulin Resistance || Celiac Disease |
| Hormone receptor domain | 0.07445 | INHERITED FROM: Diabetes Mellitus, Type 2 |
| Ribosomal protein S5 domain 2-like | 0.08398 | INHERITED FROM: DNA Repair-Deficiency Disorders || Colorectal Neoplasms, Hereditary Nonpolyposis |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0.09731 | INHERITED FROM: DNA Repair-Deficiency Disorders || Colorectal Neoplasms, Hereditary Nonpolyposis |
| Bcl-2 inhibitors of programmed cell death | 0.1035 | INHERITED FROM: Diabetes Mellitus, Experimental |
| Clc chloride channel | 0.1496 | INHERITED FROM: Renal Tubular Transport, Inborn Errors |
| Cytokine | 0.1509 | INHERITED FROM: Calcinosis |
| Cysteine-rich domain | 0.1554 | INHERITED FROM: Glucose Metabolism Disorders |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0.3718 | INHERITED FROM: Lipid Metabolism, Inborn Errors |
| Intermediate filament protein, coiled coil region | 0.3804 | INHERITED FROM: Amyotrophic lateral sclerosis 1 |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.4112 | INHERITED FROM: Metabolic Syndrome || Insulin Resistance |
| Interleukin 8-like chemokines | 0.5775 | INHERITED FROM: Celiac Disease |
| Metalloproteases ("zincins"), catalytic domain | 0.586 | INHERITED FROM: Diabetic Neuropathies |
| Voltage-gated potassium channels | 0.7536 | INHERITED FROM: Paralyses, Familial Periodic |
| P-loop containing nucleoside triphosphate hydrolases | 0.8616 | INHERITED FROM: DNA Repair-Deficiency Disorders |
| L domain-like | 0.9392 | INHERITED FROM: Lewy Body Disease |
| EGF/Laminin | 0.9411 | INHERITED FROM: Protoporphyria, Erythropoietic |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.9793 | INHERITED FROM: Hepatic Encephalopathy |
| Nicotinic receptor ligand binding domain-like | 0.9793 | INHERITED FROM: Hepatic Encephalopathy |
| RING/U-box | 0.9923 | INHERITED FROM: Peroxisome biogenesis disorders || Zellweger Syndrome |
| RNA-binding domain, RBD | 1 | INHERITED FROM: Frontotemporal Lobar Degeneration |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Duplex) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47005,52777
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | DIRECT |
54826,51604
54826 - Enolase N-terminal domain-like
51604 - Enolase C-terminal domain-like | 0 | DIRECT |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | DIRECT |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | DIRECT |
53474,49723
53474 - alpha/beta-Hydrolases
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | DIRECT |
51230,47005
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
55394,55394
55394 - Bactericidal permeability-increasing protein, BPI
55394 - Bactericidal permeability-increasing protein, BPI | 0 | DIRECT |
56059,52210
56059 - Glutathione synthetase ATP-binding domain-like
52210 - Succinyl-CoA synthetase domains | 0 | DIRECT |
103025,101790
103025 - Folate-binding domain
101790 - Aminomethyltransferase beta-barrel domain | 0 | DIRECT |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0 | DIRECT |
52799,49562
52799 - (Phosphotyrosine protein) phosphatases II
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0.000008595 | DIRECT |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.0003894 | DIRECT |
51445,51011
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0.0003894 | DIRECT |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0.0009568 | DIRECT |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0.002378 | INHERITED FROM: Glucose Metabolism Disorders || Diabetes Mellitus |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.01055 | INHERITED FROM: Insulin Resistance || Glucose Metabolism Disorders |
53901,53901
53901 - Thiolase-like
53901 - Thiolase-like | 0.0114 | INHERITED FROM: Metabolism, Inborn Errors |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0.02542 | INHERITED FROM: DNA Repair-Deficiency Disorders || Colorectal Neoplasms, Hereditary Nonpolyposis |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.06263 | INHERITED FROM: Diabetes Mellitus, Type 2 || Diabetes Mellitus |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.8005 | INHERITED FROM: Lewy Body Disease |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.8375 | INHERITED FROM: Frontotemporal Lobar Degeneration |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.9793 | INHERITED FROM: Hepatic Encephalopathy |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47005,52777
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | Direct |
54826,51604
54826 - Enolase N-terminal domain-like
51604 - Enolase C-terminal domain-like | 0 | Direct |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | Direct |
52518,52518
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52518 - Thiamin diphosphate-binding fold (THDP-binding) | 0 | Direct |
53474,49723
53474 - alpha/beta-Hydrolases
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | Direct |
51230,47005
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
55394,55394
55394 - Bactericidal permeability-increasing protein, BPI
55394 - Bactericidal permeability-increasing protein, BPI | 0 | Direct |
56059,52210
56059 - Glutathione synthetase ATP-binding domain-like
52210 - Succinyl-CoA synthetase domains | 0 | Direct |
103025,101790
103025 - Folate-binding domain
101790 - Aminomethyltransferase beta-barrel domain | 0 | Direct |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0 | Direct |
52799,49562
52799 - (Phosphotyrosine protein) phosphatases II
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0.000008595 | Direct |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.0003894 | Direct |
51445,51011
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0.0003894 | Direct |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0.0009568 | Direct |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0.002378 | Inherited |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.01055 | Inherited |
53901,53901
53901 - Thiolase-like
53901 - Thiolase-like | 0.0114 | Inherited |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0.02542 | Inherited |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.06263 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.8005 | Inherited |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.8375 | Inherited |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.9793 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Triple) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Plot distribution on species Tree Of Life (sTOL) for Superfamily and/or Family domains annotated by this CD term
 |
Plot tree as:
| |
Download Newick format tree:
|
( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Plot distribution on species Tree Of Life (sTOL) for single supra-domains annotated by this CD term
|
Plot tree as:
| |
Download Newick format tree:
| |
Browsing in TREE OF LIFE:
|
( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|
|
> BO Hierarchy > Nutritional and Metabolic Diseases
