Mammalian Phenotype (MP): abnormal nervous system physiology 

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children)	MP term [MP ID] <#Children>	#Domains (Superfamily|Family)	#Supra-domain (Single|Duplex|Triple)
+ + 2:	mammalian phenotype [MP:0000001] <29>
+ 1:	nervous system phenotype [MP:0003631] <2>	(98|128)	(113|79|50)
0:	abnormal nervous system physiology [MP:0003633] <38>	(43|60)	(52|31|18)
- 1:	abnormal neuron physiology [MP:0004811] <12>	(8|12)	(11|7|5)
- 1:	abnormal synaptic transmission [MP:0003635] <8>	(23|28)	(27|14|6)
- 1:	abnormal nervous system electrophysiology [MP:0002272] <7>	(4|8)	(7|3|0)
- 1:	seizures [MP:0002064] <6>	(10|15)	(13|3|0)
- 1:	abnormal glial cell physiology [MP:0003690] <5>	(2|2)	(3|0|0)
- 1:	intracranial hemorrhage [MP:0001915] <4>	(0|0)	(0|1|0)
- 1:	abnormal myelination [MP:0000920] <3>	(0|4)	(0|2|2)
- 1:	abnormal somatic nervous system physiology [MP:0005423] <3>	(0|0)	(0|1|0)
- 1:	increased brain apoptosis [MP:0014178] <3>	(0|0)	(0|0|0)
- 1:	abnormal autonomic nervous system physiology [MP:0006276] <2>	(1|1)	(1|0|0)
- 1:	abnormal cerebrospinal fluid production [MP:0001911] <2>	(0|0)	(0|0|0)
- 1:	abnormal dopamine level [MP:0001905] <2>	(2|1)	(2|1|0)
- 1:	abnormal embryonic neuroepithelial cell proliferation [MP:0012704] <2>	(1|1)	(1|0|0)
- 1:	abnormal ependyma motile cilium physiology [MP:0011068] <2>	(0|0)	(0|0|0)
- 1:	abnormal nervous system regeneration [MP:0004858] <2>	(2|2)	(2|0|0)
- 1:	abnormal neuroendocrine gland physiology [MP:0013570] <2>	(0|0)	(0|0|0)
- 1:	abnormal sensorimotor gating [MP:0002634] <2>	(1|1)	(1|0|0)
- 1:	altered response to CNS ischemic injury [MP:0003075] <2>	(4|4)	(6|1|0)
- 1:	CNS inflammation [MP:0006082] <1>	(0|1)	(1|0|0)
- 1:	abnormal central pattern generator function [MP:0003880] <1>	(1|2)	(2|0|0)
- 1:	abnormal endoneurial fluid pressure [MP:0011398] <1>	(0|0)	(0|0|0)
- 1:	abnormal hypothalamus physiology [MP:0005645] <1>	(0|0)	(0|0|0)
- 1:	abnormal neuronal stem cell physiology [MP:0012204] <1>	(0|0)	(0|0|0)
- 1:	abnormal somatosensory cortex physiology [MP:0001908] <1>	(0|0)	(0|0|0)
- 1:	abnormal synaptic plasticity [MP:0004859] <1>	(2|1)	(2|1|0)
- 1:	increased neural tube apoptosis [MP:0012505] <1>	(0|0)	(0|0|0)
- 1:	CNS ischemia [MP:0006080]	(0|0)	(0|0|0)
- 1:	abnormal blood-brain barrier function [MP:0005167]	(2|0)	(2|0|0)
- 1:	abnormal blood-cerebrospinal fluid barrier function [MP:0006088]	(0|0)	(0|0|0)
- 1:	abnormal blood-retinal barrier function [MP:0014179]	(0|0)	(0|0|0)
- 1:	abnormal cerebrospinal fluid flow [MP:0013907]	(0|0)	(0|0|0)
- 1:	abnormal glymphatic system physiology [MP:0020371]	(0|0)	(0|0|0)
- 1:	abnormal hippocampus physiology [MP:0012006]	(0|0)	(0|0|0)
- 1:	decreased hindbrain apoptosis [MP:0012502]	(0|0)	(0|0|0)
- 1:	encephalopathy [MP:0013806]	(0|0)	(0|0|0)
- 1:	endoneurial edema [MP:0011397]	(0|0)	(0|0|0)
- 1:	increased spinal cord apoptosis [MP:0013182]	(0|0)	(0|0|0)
- 1:	spinal hemorrhage [MP:0006054]	(0|0)	(0|0|0)

Superfamily

Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Metallothionein	0	DIRECT
Nitric oxide (NO) synthase oxygenase domain	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Synuclein	0	DIRECT
Lamin A/C globular tail domain	0	DIRECT
Voltage-gated potassium channels	0.00000006203	DIRECT
Neurotransmitter-gated ion-channel transmembrane pore	0.0003908	DIRECT
Nicotinic receptor ligand binding domain-like	0.0003908	DIRECT
Periplasmic binding protein-like I	0.003679	INHERITED FROM: abnormal synaptic plasticity || abnormal synaptic transmission || seizures || abnormal glutamate-mediated receptor currents || abnormal long term depression || absence seizures || abnormal inhibitory postsynaptic potential
Periplasmic binding protein-like II	0.01572	INHERITED FROM: abnormal synaptic plasticity || abnormal synaptic transmission || seizures || abnormal glutamate-mediated receptor currents || abnormal CNS synaptic transmission || abnormal long term depression || tonic-clonic seizures
SRF-like	0.01718	INHERITED FROM: abnormal paired-pulse facilitation || abnormal CNS synaptic transmission || abnormal long term potentiation || enhanced paired-pulse facilitation || abnormal neuron physiology
Flavoproteins	0.03806	INHERITED FROM: abnormal seizure response to inducing agent
SNARE fusion complex	0.04937	INHERITED FROM: enhanced paired-pulse facilitation || abnormal neurotransmitter secretion
Family A G protein-coupled receptor-like	0.05619	INHERITED FROM: abnormal dopamine level
Cysteine-rich domain	0.06631	INHERITED FROM: reduced long term potentiation
L27 domain	0.07026	INHERITED FROM: abnormal excitatory postsynaptic currents
SH3-domain	0.08773	INHERITED FROM: abnormal synaptic vesicle recycling || decreased excitatory postsynaptic current amplitude
MFS general substrate transporter	0.09264	INHERITED FROM: abnormal neurotransmitter uptake
Riboflavin synthase domain-like	0.09981	INHERITED FROM: decreased cerebral infarction size || reduced long term potentiation || decreased susceptibility to ischemic brain injury || abnormal blood-brain barrier function
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.09981	INHERITED FROM: decreased cerebral infarction size || reduced long term potentiation || decreased susceptibility to ischemic brain injury || abnormal blood-brain barrier function
Toll/Interleukin receptor TIR domain	0.1341	INHERITED FROM: abnormal glial cell physiology
TNF receptor-like	0.1451	INHERITED FROM: abnormal nervous system regeneration
PDZ domain-like	0.1511	INHERITED FROM: abnormal synaptic transmission
Caspase-like	0.1823	INHERITED FROM: abnormal neuron apoptosis || abnormal neuron physiology
SNF-like	0.1823	INHERITED FROM: abnormal CNS synaptic transmission || abnormal sensorimotor gating
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.1955	INHERITED FROM: altered response to CNS ischemic injury
Kringle-like	0.2547	INHERITED FROM: altered response to CNS ischemic injury
PreATP-grasp domain	0.3022	INHERITED FROM: abnormal brain wave pattern || increased synaptic depression || abnormal synaptic depression || environmentally induced seizures || abnormal seizure response to inducing agent || tonic-clonic seizures || convulsive seizures
Spermadhesin, CUB domain	0.3749	INHERITED FROM: decreased excitatory postsynaptic current amplitude || short excitatory postsynaptic current rise time || biphasic excitatory postsynaptic current amplitude || abnormal excitatory postsynaptic currents
4-helical cytokines	0.4245	INHERITED FROM: abnormal glial cell physiology
BAR/IMD domain-like	0.4257	INHERITED FROM: abnormal synaptic vesicle recycling || decreased excitatory postsynaptic current amplitude || abnormal excitatory postsynaptic current amplitude
Plexin repeat	0.4324	INHERITED FROM: abnormal neuronal migration
PLP-dependent transferases	0.4818	INHERITED FROM: abnormal neurotransmitter level
Zn-dependent exopeptidases	0.4818	INHERITED FROM: decreased prepulse inhibition || abnormal prepulse inhibition
alpha/beta-Hydrolases	0.5358	INHERITED FROM: abnormal central pattern generator function || abnormal pre-Botzinger complex physiology
HLH, helix-loop-helix DNA-binding domain	0.6298	INHERITED FROM: abnormal neuronal precursor proliferation
Sema domain	0.6644	INHERITED FROM: abnormal neuronal migration
FAD/NAD(P)-binding domain	0.698	INHERITED FROM: increased dopamine level
Complement control module/SCR domain	0.7526	INHERITED FROM: decreased excitatory postsynaptic current amplitude || short excitatory postsynaptic current rise time || biphasic excitatory postsynaptic current amplitude
Glutathione synthetase ATP-binding domain-like	0.7784	INHERITED FROM: abnormal brain wave pattern || increased synaptic depression || environmentally induced seizures || tonic-clonic seizures
Concanavalin A-like lectins/glucanases	0.8127	INHERITED FROM: abnormal paired-pulse inhibition
L domain-like	0.8206	INHERITED FROM: abnormal nervous system regeneration
Homeodomain-like	1	INHERITED FROM: decreased embryonic neuroepithelial cell proliferation

Family

Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Lamin A/C globular tail domain	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Nitric oxide (NO) synthase oxygenase domain	0	DIRECT
Synapsin C-terminal domain	0	DIRECT
Metallothionein	0	DIRECT
Retinoblastoma tumor suppressor domains	0	DIRECT
Synuclein	0	DIRECT
Cytochrome p450 reductase N-terminal domain-like	0	DIRECT
Synapsin domain	0	DIRECT
Voltage-gated potassium channels	0.0000709	DIRECT
Nicotinic receptor ligand binding domain-like	0.0002311	DIRECT
Neurotransmitter-gated ion-channel transmembrane pore	0.0002311	DIRECT
NADPH-cytochrome p450 reductase-like	0.003999	INHERITED FROM: abnormal seizure response to inducing agent
NADPH-cytochrome p450 reductase FAD-binding domain-like	0.003999	INHERITED FROM: abnormal seizure response to inducing agent
L-arabinose binding protein-like	0.00838	INHERITED FROM: absence of NMDA-mediated synaptic currents || abnormal synaptic transmission || abnormal glutamate-mediated receptor currents || abnormal nervous system electrophysiology || abnormal long term depression || abnormal inhibitory postsynaptic potential
Phosphate binding protein-like	0.01098	INHERITED FROM: abnormal synaptic plasticity || abnormal synaptic transmission || seizures || abnormal glutamate-mediated receptor currents || abnormal CNS synaptic transmission || abnormal nervous system electrophysiology || abnormal long term depression || tonic-clonic seizures
Tetramerization domain of potassium channels	0.01166	INHERITED FROM: increased susceptibility to induction of seizure by inducing agent || abnormal channel response || increased susceptibility to pharmacologically induced seizures
SRF-like	0.01295	INHERITED FROM: abnormal paired-pulse facilitation || abnormal synaptic transmission || abnormal CNS synaptic transmission || abnormal long term potentiation || enhanced paired-pulse facilitation || abnormal neuron physiology
Synaptotagmin-like (S variant)	0.01336	INHERITED FROM: abnormal miniature endplate potential
Pyridoxal-dependent decarboxylase	0.01376	INHERITED FROM: abnormal inhibitory postsynaptic currents || abnormal synaptic transmission || abnormal neurotransmitter level
Rhodopsin-like	0.01546	INHERITED FROM: abnormal dopamine level || increased susceptibility to pharmacologically induced seizures
SNARE fusion complex	0.03676	INHERITED FROM: enhanced paired-pulse facilitation || abnormal neurotransmitter secretion
PDZ domain	0.04217	INHERITED FROM: abnormal miniature endplate potential || abnormal synaptic transmission || enhanced paired-pulse facilitation
Leucine zipper domain	0.05007	INHERITED FROM: absence seizures
L27 domain	0.05394	INHERITED FROM: abnormal excitatory postsynaptic currents
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)	0.05678	INHERITED FROM: reduced long term potentiation
Acetylcholinesterase-like	0.0615	INHERITED FROM: abnormal miniature inhibitory postsynaptic currents || abnormal autonomic nervous system physiology || abnormal inhibitory postsynaptic currents || decreased excitatory postsynaptic current amplitude || abnormal central pattern generator function || abnormal excitatory postsynaptic currents || abnormal pre-Botzinger complex physiology || abnormal excitatory postsynaptic current amplitude
SH3-domain	0.07037	INHERITED FROM: abnormal synaptic vesicle recycling || decreased excitatory postsynaptic current amplitude
Cytoplasmic domain of inward rectifier potassium channel	0.08797	INHERITED FROM: tonic-clonic seizures
TNF receptor-like	0.1133	INHERITED FROM: abnormal myelination || abnormal nervous system regeneration || altered response to CNS ischemic injury
Ephrin ectodomain	0.1142	INHERITED FROM: reduced long term potentiation || abnormal CNS synaptic transmission
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	0.1178	INHERITED FROM: abnormal nervous system electrophysiology
C1 set domains (antibody constant domain-like)	0.1324	INHERITED FROM: enhanced paired-pulse facilitation
Caspase catalytic domain	0.1525	INHERITED FROM: abnormal neuron apoptosis || abnormal neuron physiology
SNF-like	0.1525	INHERITED FROM: abnormal CNS synaptic transmission || abnormal sensorimotor gating
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.1647	INHERITED FROM: altered response to CNS ischemic injury
Fibronectin type II module	0.1647	INHERITED FROM: altered response to CNS ischemic injury
L domain	0.1647	INHERITED FROM: abnormal myelination
Motor proteins	0.1874	INHERITED FROM: abnormal cochlear nerve compound action potential
Toll/Interleukin receptor TIR domain	0.1907	INHERITED FROM: decreased neuron apoptosis || abnormal glial cell physiology
Actin/HSP70	0.2459	INHERITED FROM: altered response to CNS ischemic injury
Long-chain cytokines	0.2722	INHERITED FROM: abnormal glial cell physiology
BAR domain	0.2728	INHERITED FROM: increased synaptic depression || abnormal synaptic vesicle recycling || decreased excitatory postsynaptic current amplitude || abnormal excitatory postsynaptic current amplitude
Spermadhesin, CUB domain	0.3621	INHERITED FROM: decreased excitatory postsynaptic current amplitude || short excitatory postsynaptic current rise time || biphasic excitatory postsynaptic current amplitude || abnormal excitatory postsynaptic currents
Plexin repeat	0.3961	INHERITED FROM: abnormal neuronal migration
Phosphotyrosine-binding domain (PTB)	0.4326	INHERITED FROM: abnormal NMDA-mediated synaptic currents
YWTD domain	0.5076	INHERITED FROM: reduced long term potentiation
MAM domain	0.5104	INHERITED FROM: abnormal neuronal migration
HLH, helix-loop-helix DNA-binding domain	0.5989	INHERITED FROM: abnormal neuronal precursor proliferation
Laminin-type module	0.6007	INHERITED FROM: abnormal myelination
Intermediate filament protein, coiled coil region	0.6286	INHERITED FROM: abnormal axonal transport
Sema domain	0.6323	INHERITED FROM: abnormal neuronal migration
V set domains (antibody variable domain-like)	0.6631	INHERITED FROM: demyelination || abnormal myelination || CNS inflammation || brain inflammation
SH2 domain	0.7128	INHERITED FROM: abnormal central pattern generator function
G proteins	0.7217	INHERITED FROM: abnormal neurotransmitter secretion
SAM (sterile alpha motif) domain	0.731	INHERITED FROM: reduced long term depression
Complement control module/SCR domain	0.749	INHERITED FROM: decreased excitatory postsynaptic current amplitude || short excitatory postsynaptic current rise time || biphasic excitatory postsynaptic current amplitude
Laminin G-like module	0.8599	INHERITED FROM: abnormal NMDA-mediated synaptic currents || abnormal paired-pulse inhibition || decreased neurotransmitter release || abnormal GABA-mediated receptor currents || decreased excitatory postsynaptic current amplitude || reduced NMDA-mediated synaptic currents || abnormal AMPA-mediated synaptic currents || reduced AMPA-mediated synaptic currents || abnormal excitatory postsynaptic current amplitude
Ngr ectodomain-like	0.9161	INHERITED FROM: abnormal nervous system regeneration
Homeodomain	1	INHERITED FROM: decreased embryonic neuroepithelial cell proliferation

Supra-domain (Single|Duplex|Triple)

Supra-domain (Single)

Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Lamin A/C globular tail domain	0	DIRECT
Synuclein	0	DIRECT
Metallothionein	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Nitric oxide (NO) synthase oxygenase domain	0	DIRECT
Voltage-gated potassium channels	0.00000002417	DIRECT
Neurotransmitter-gated ion-channel transmembrane pore	0.000204	DIRECT
Nicotinic receptor ligand binding domain-like	0.000204	DIRECT
Periplasmic binding protein-like I	0.00216	INHERITED FROM: abnormal synaptic transmission || absence seizures || abnormal synaptic plasticity || abnormal inhibitory postsynaptic potential || abnormal long term depression || abnormal glutamate-mediated receptor currents || seizures || abnormal nervous system electrophysiology
Periplasmic binding protein-like II	0.01013	INHERITED FROM: abnormal synaptic transmission || abnormal synaptic plasticity || abnormal long term depression || abnormal glutamate-mediated receptor currents || seizures || abnormal CNS synaptic transmission || tonic-clonic seizures || abnormal nervous system electrophysiology
SRF-like	0.01117	INHERITED FROM: enhanced paired-pulse facilitation || abnormal synaptic transmission || abnormal paired-pulse facilitation || abnormal long term potentiation || abnormal CNS synaptic transmission || abnormal neuron physiology
Flavoproteins	0.02631	INHERITED FROM: abnormal seizure response to inducing agent
SNARE fusion complex	0.03485	INHERITED FROM: enhanced paired-pulse facilitation || abnormal neurotransmitter secretion
Leucine zipper domain	0.03799	INHERITED FROM: decreased neuron apoptosis || absence seizures
Family A G protein-coupled receptor-like	0.04016	INHERITED FROM: abnormal dopamine level
Cysteine-rich domain	0.04822	INHERITED FROM: reduced long term potentiation
L27 domain	0.05137	INHERITED FROM: abnormal excitatory postsynaptic currents
SH3-domain	0.06542	INHERITED FROM: decreased excitatory postsynaptic current amplitude || abnormal synaptic vesicle recycling
MFS general substrate transporter	0.06941	INHERITED FROM: abnormal neurotransmitter uptake
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.07527	INHERITED FROM: reduced long term potentiation || decreased susceptibility to ischemic brain injury || abnormal blood-brain barrier function || abnormal seizure response to inducing agent || decreased cerebral infarction size || altered response to CNS ischemic injury
Riboflavin synthase domain-like	0.07527	INHERITED FROM: reduced long term potentiation || decreased susceptibility to ischemic brain injury || abnormal blood-brain barrier function || abnormal seizure response to inducing agent || decreased cerebral infarction size || altered response to CNS ischemic injury
Toll/Interleukin receptor TIR domain	0.1048	INHERITED FROM: abnormal glial cell physiology
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	0.1062	INHERITED FROM: abnormal nervous system electrophysiology
TNF receptor-like	0.1144	INHERITED FROM: abnormal nervous system regeneration || altered response to CNS ischemic injury
PDZ domain-like	0.1198	INHERITED FROM: abnormal miniature endplate potential || abnormal synaptic transmission
SNF-like	0.1473	INHERITED FROM: abnormal sensorimotor gating || abnormal CNS synaptic transmission
Caspase-like	0.1473	INHERITED FROM: abnormal neuron apoptosis || abnormal neuron physiology
Cupredoxins	0.1473	INHERITED FROM: reduced long term potentiation
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.1592	INHERITED FROM: altered response to CNS ischemic injury
Kringle-like	0.214	INHERITED FROM: altered response to CNS ischemic injury
PreATP-grasp domain	0.2589	INHERITED FROM: abnormal brain wave pattern || environmentally induced seizures || abnormal seizure response to inducing agent || increased synaptic depression || abnormal synaptic depression || convulsive seizures || tonic-clonic seizures
Spermadhesin, CUB domain	0.3289	INHERITED FROM: abnormal excitatory postsynaptic currents || decreased excitatory postsynaptic current amplitude || short excitatory postsynaptic current rise time || biphasic excitatory postsynaptic current amplitude
4-helical cytokines	0.3777	INHERITED FROM: CNS inflammation || abnormal glial cell physiology
BAR/IMD domain-like	0.379	INHERITED FROM: abnormal excitatory postsynaptic current amplitude || decreased excitatory postsynaptic current amplitude || abnormal synaptic vesicle recycling
Plexin repeat	0.3854	INHERITED FROM: abnormal neuronal migration
PLP-dependent transferases	0.4341	INHERITED FROM: abnormal inhibitory postsynaptic currents || abnormal neurotransmitter level
Zn-dependent exopeptidases	0.4341	INHERITED FROM: decreased prepulse inhibition || abnormal prepulse inhibition
Nuclear receptor ligand-binding domain	0.4836	INHERITED FROM: absent long term depression
alpha/beta-Hydrolases	0.4888	INHERITED FROM: abnormal autonomic nervous system physiology || abnormal central pattern generator function || decreased excitatory postsynaptic current amplitude || abnormal pre-Botzinger complex physiology
YWTD domain	0.4977	INHERITED FROM: reduced long term potentiation
GTPase activation domain, GAP	0.5065	INHERITED FROM: abnormal astrocyte physiology
HLH, helix-loop-helix DNA-binding domain	0.5853	INHERITED FROM: abnormal neuronal precursor proliferation
Intermediate filament protein, coiled coil region	0.5855	INHERITED FROM: abnormal axonal transport
Sema domain	0.622	INHERITED FROM: abnormal neuronal migration
SH2 domain	0.6548	INHERITED FROM: abnormal central pattern generator function
FAD/NAD(P)-binding domain	0.6569	INHERITED FROM: increased dopamine level
Complement control module/SCR domain	0.7146	INHERITED FROM: decreased excitatory postsynaptic current amplitude || short excitatory postsynaptic current rise time || biphasic excitatory postsynaptic current amplitude
Glutathione synthetase ATP-binding domain-like	0.7419	INHERITED FROM: abnormal brain wave pattern || environmentally induced seizures || increased synaptic depression || tonic-clonic seizures
Concanavalin A-like lectins/glucanases	0.7786	INHERITED FROM: abnormal paired-pulse inhibition || reduced AMPA-mediated synaptic currents || abnormal NMDA-mediated synaptic currents
L domain-like	0.7872	INHERITED FROM: abnormal nervous system regeneration
EGF/Laminin	0.9444	INHERITED FROM: decreased cerebral infarction size
Homeodomain-like	1	INHERITED FROM: decreased embryonic neuroepithelial cell proliferation || abnormal neuron proliferation

Supra-domain (Duplex) in N- to C-terminal order

Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
50729,50156 50729 - PH domain-like 50156 - PDZ domain-like	0	DIRECT
50044,50156 50044 - SH3-domain 50156 - PDZ domain-like	0	DIRECT
50729,57889 50729 - PH domain-like 57889 - Cysteine-rich domain	0	DIRECT
64593,74853 64593 - Intermediate filament protein, coiled coil region 74853 - Lamin A/C globular tail domain	0	DIRECT
81324,53850 81324 - Voltage-gated potassium channels 53850 - Periplasmic binding protein-like II	0	DIRECT
57196,56496 57196 - EGF/Laminin 56496 - Fibrinogen C-terminal domain-like	0	DIRECT
49785,49899 49785 - Galactose-binding domain-like 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
56496,49899 56496 - Fibrinogen C-terminal domain-like 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
63712,90112 63712 - Nicotinic receptor ligand binding domain-like 90112 - Neurotransmitter-gated ion-channel transmembrane pore	0.000204	DIRECT
53822,53850 53822 - Periplasmic binding protein-like I 53850 - Periplasmic binding protein-like II	0.000944	DIRECT
57440,57440 57440 - Kringle-like 57440 - Kringle-like	0.001241	INHERITED FROM: altered response to CNS ischemic injury
81324,81324 81324 - Voltage-gated potassium channels 81324 - Voltage-gated potassium channels	0.009935	INHERITED FROM: abnormal action potential
57535,49854 57535 - Complement control module/SCR domain 49854 - Spermadhesin, CUB domain	0.01117	INHERITED FROM: abnormal excitatory postsynaptic currents || abnormal synaptic transmission || abnormal excitatory postsynaptic current amplitude || decreased excitatory postsynaptic current amplitude || short excitatory postsynaptic current rise time || biphasic excitatory postsynaptic current amplitude || abnormal CNS synaptic transmission
101288,50156 101288 - L27 domain 50156 - PDZ domain-like	0.07527	INHERITED FROM: abnormal excitatory postsynaptic currents
81324,81296 81324 - Voltage-gated potassium channels 81296 - E set domains	0.07665	INHERITED FROM: tonic-clonic seizures
57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like	0.07665	INHERITED FROM: decreased neuron apoptosis
49854,57535 49854 - Spermadhesin, CUB domain 57535 - Complement control module/SCR domain	0.1062	INHERITED FROM: abnormal excitatory postsynaptic currents || abnormal excitatory postsynaptic current amplitude || decreased excitatory postsynaptic current amplitude || short excitatory postsynaptic current rise time || biphasic excitatory postsynaptic current amplitude
49562,49562 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)	0.1509	INHERITED FROM: abnormal miniature excitatory postsynaptic currents
47986,52129 47986 - DEATH domain 52129 - Caspase-like	0.1592	INHERITED FROM: abnormal neuron physiology
52058,57184 52058 - L domain-like 57184 - Growth factor receptor domain	0.1592	INHERITED FROM: abnormal myelination
57184,52058 57184 - Growth factor receptor domain 52058 - L domain-like	0.1592	INHERITED FROM: abnormal myelination
50044,55550 50044 - SH3-domain 55550 - SH2 domain	0.1652	INHERITED FROM: increased dopamine level
52440,56059 52440 - PreATP-grasp domain 56059 - Glutathione synthetase ATP-binding domain-like	0.2047	INHERITED FROM: abnormal brain wave pattern || environmentally induced seizures || abnormal seizure response to inducing agent || increased synaptic depression || abnormal synaptic depression || convulsive seizures || tonic-clonic seizures
48726,82895 48726 - Immunoglobulin 82895 - TSP-1 type 1 repeat	0.2304	INHERITED FROM: abnormal neuron physiology
103575,48726 103575 - Plexin repeat 48726 - Immunoglobulin	0.2647	INHERITED FROM: abnormal neuronal migration
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain	0.403	INHERITED FROM: absent long term depression
50156,50156 50156 - PDZ domain-like 50156 - PDZ domain-like	0.4618	INHERITED FROM: enhanced paired-pulse facilitation || abnormal sensory neuron physiology || abnormal hair cell physiology || abnormal CNS synaptic transmission
49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases	0.5251	INHERITED FROM: decreased nerve conduction velocity || decreased neurotransmitter release || abnormal paired-pulse inhibition || abnormal excitatory postsynaptic current amplitude || decreased excitatory postsynaptic current amplitude || reduced AMPA-mediated synaptic currents || reduced NMDA-mediated synaptic currents || abnormal AMPA-mediated synaptic currents || abnormal NMDA-mediated synaptic currents || abnormal GABA-mediated receptor currents
101912,103575 101912 - Sema domain 103575 - Plexin repeat	0.622	INHERITED FROM: abnormal neuronal migration
57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain	0.7406	INHERITED FROM: abnormal excitatory postsynaptic currents || decreased excitatory postsynaptic current amplitude || short excitatory postsynaptic current rise time || biphasic excitatory postsynaptic current amplitude
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin	0.9952	INHERITED FROM: intracranial hemorrhage

Supra-domain (Triple) in N- to C-terminal order

Highlighted in gray are those with FDR>0.001

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
75399,75399,75399 75399 - Plakin repeat 75399 - Plakin repeat 75399 - Plakin repeat	0	DIRECT
50729,50156,50156 50729 - PH domain-like 50156 - PDZ domain-like 50156 - PDZ domain-like	0	DIRECT
56496,49899,49899 56496 - Fibrinogen C-terminal domain-like 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
49785,49899,49899 49785 - Galactose-binding domain-like 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
49899,57196,56496 49899 - Concanavalin A-like lectins/glucanases 57196 - EGF/Laminin 56496 - Fibrinogen C-terminal domain-like	0	DIRECT
57196,56496,49899 57196 - EGF/Laminin 56496 - Fibrinogen C-terminal domain-like 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
49854,57535,49854 49854 - Spermadhesin, CUB domain 57535 - Complement control module/SCR domain 49854 - Spermadhesin, CUB domain	0.01117	INHERITED FROM: abnormal excitatory postsynaptic currents || abnormal synaptic transmission || abnormal excitatory postsynaptic current amplitude || decreased excitatory postsynaptic current amplitude || short excitatory postsynaptic current rise time || biphasic excitatory postsynaptic current amplitude || abnormal CNS synaptic transmission
57535,49854,57535 57535 - Complement control module/SCR domain 49854 - Spermadhesin, CUB domain 57535 - Complement control module/SCR domain	0.01117	INHERITED FROM: abnormal excitatory postsynaptic currents || abnormal synaptic transmission || abnormal excitatory postsynaptic current amplitude || decreased excitatory postsynaptic current amplitude || short excitatory postsynaptic current rise time || biphasic excitatory postsynaptic current amplitude || abnormal CNS synaptic transmission
49854,57535,57535 49854 - Spermadhesin, CUB domain 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain	0.06542	INHERITED FROM: abnormal excitatory postsynaptic currents || abnormal excitatory postsynaptic current amplitude || decreased excitatory postsynaptic current amplitude || short excitatory postsynaptic current rise time || biphasic excitatory postsynaptic current amplitude
52058,57184,52058 52058 - L domain-like 57184 - Growth factor receptor domain 52058 - L domain-like	0.1592	INHERITED FROM: abnormal myelination
48726,48726,82895 48726 - Immunoglobulin 48726 - Immunoglobulin 82895 - TSP-1 type 1 repeat	0.2304	INHERITED FROM: abnormal neuron physiology
48726,82895,82895 48726 - Immunoglobulin 82895 - TSP-1 type 1 repeat 82895 - TSP-1 type 1 repeat	0.2304	INHERITED FROM: abnormal neuron physiology
101288,50156,50044 101288 - L27 domain 50156 - PDZ domain-like 50044 - SH3-domain	0.2304	INHERITED FROM: abnormal neuron physiology
57184,52058,57184 57184 - Growth factor receptor domain 52058 - L domain-like 57184 - Growth factor receptor domain	0.2304	INHERITED FROM: abnormal myelination
101912,103575,48726 101912 - Sema domain 103575 - Plexin repeat 48726 - Immunoglobulin	0.2647	INHERITED FROM: abnormal neuronal migration
49899,49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases	0.5903	INHERITED FROM: decreased neurotransmitter release || abnormal paired-pulse inhibition || abnormal excitatory postsynaptic current amplitude || decreased excitatory postsynaptic current amplitude || reduced AMPA-mediated synaptic currents || reduced NMDA-mediated synaptic currents || abnormal glutamate-mediated receptor currents || abnormal synaptic depression || abnormal AMPA-mediated synaptic currents || abnormal NMDA-mediated synaptic currents || abnormal GABA-mediated receptor currents
57535,57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain	0.6678	INHERITED FROM: abnormal excitatory postsynaptic current amplitude || decreased excitatory postsynaptic current amplitude || short excitatory postsynaptic current rise time || biphasic excitatory postsynaptic current amplitude
57667,57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers	0.9664	INHERITED FROM: abnormal neuron proliferation