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CTD Diseases (CD): Neoplasms by Site 
(show info)
Biomedical Ontology
Like Gene Ontology (GO), biomedical ontology such as phenotype ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Biomedical ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI’s thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology Based on YP which is the major contributor to the ‘Ascomycete phenotype ontology’, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- UniProtKB KeyWords (KW) Ontology Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- CTD Diseases (CD) Ontology CD is MEDIC disease vocabulary that is modified by CTD from the "Diseases" [C] branch of Medical Subject Headings (MeSH), combined with genetic disorders from the Online Mendelian Inheritance in OMIM database.
- CTD Chemicals (CC) Ontology CC is chemical vocabulary that is adapted by CTD from the "Chemicals and Drugs" category and Supplementary Concept Records of Medical Subject Headings (MeSH, a hierarchical vocabulary used to index articles for MEDLINE/PubMed).
Jump to [ Top · Hierarchy · Annotations ]
Root: CD Hierarchy (CTD diseases from Comparative Toxicogenomics Database)
Jump to [ Top · Hierarchy ]
Family( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| PDI-like | 0 | DIRECT |
| DNA repair protein MutS, domain III | 0 | DIRECT |
| Bcl-2 inhibitors of programmed cell death | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Kinase associated domain 1, KA1 | 0 | DIRECT |
| C5 cytosine-specific DNA methylase, DCM | 0 | DIRECT |
| Multidrug efflux transporter AcrB transmembrane domain | 0 | DIRECT |
| Formate/glycerate dehydrogenases, substrate-binding domain | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | DIRECT |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | DIRECT |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | DIRECT |
| RGC domain | 0 | DIRECT |
| DEATH effector domain, DED | 0 | DIRECT |
| Hsp90 middle domain | 0 | DIRECT |
| p53 DNA-binding domain-like | 0 | DIRECT |
| ABC transporter transmembrane region | 0.0002746 | DIRECT |
| ABC transporter ATPase domain-like | 0.00143 | INHERITED FROM: Digestive System Neoplasms || Gastrointestinal Neoplasms || Intestinal Neoplasms || Colorectal Neoplasms |
| Cytochrome P450 | 0.001451 | INHERITED FROM: Prostatic Neoplasms |
| Fibronectin type II module | 0.003154 | INHERITED FROM: Mammary Neoplasms, Animal || Liver Neoplasms |
| Cell cycle transcription factor e2f-dp | 0.006496 | INHERITED FROM: Carcinoma, Non-Small-Cell Lung || Thoracic Neoplasms || Lung Neoplasms || Carcinoma, Bronchogenic || Respiratory Tract Neoplasms || Bronchial Neoplasms |
| Metallothionein | 0.00673 | INHERITED FROM: Urinary Bladder Neoplasms || Carcinoma, Hepatocellular |
| Prefoldin | 0.01414 | INHERITED FROM: Esophageal Squamous Cell Carcinoma || Esophageal Neoplasms |
| E2F dimerization segment | 0.01414 | INHERITED FROM: Carcinoma, Non-Small-Cell Lung || Thoracic Neoplasms || Lung Neoplasms || Carcinoma, Bronchogenic || Respiratory Tract Neoplasms || Bronchial Neoplasms |
| EGF-type module | 0.02863 | INHERITED FROM: Carcinoma, Pancreatic Ductal |
| Serum albumin-like | 0.02896 | INHERITED FROM: Stomach Neoplasms |
| Notch domain | 0.02896 | INHERITED FROM: Endocrine Gland Neoplasms || Breast Neoplasms || Skin Neoplasms || Pancreatic Neoplasms || Esophageal Neoplasms |
| Interleukin 8-like chemokines | 0.03734 | INHERITED FROM: Thoracic Neoplasms || Mesothelioma, Malignant |
| Lamin A/C globular tail domain | 0.05922 | INHERITED FROM: Thoracic Neoplasms || Lung Neoplasms || Respiratory Tract Neoplasms |
| Growth factor receptor domain | 0.09905 | INHERITED FROM: Biliary Tract Neoplasms || Gallbladder Neoplasms || Nasopharyngeal Neoplasms || Pharyngeal Neoplasms || Breast Neoplasms || Skin Neoplasms || Carcinoma, Pancreatic Ductal |
| Plexin repeat | 0.2152 | INHERITED FROM: Endometrial Neoplasms |
| SMAD MH1 domain | 0.2472 | INHERITED FROM: Intestinal Neoplasms || Colorectal Neoplasms |
| SMAD domain | 0.2472 | INHERITED FROM: Intestinal Neoplasms || Colorectal Neoplasms |
| Annexin | 0.283 | INHERITED FROM: Mouth Neoplasms |
| Interferons/interleukin-10 (IL-10) | 0.283 | INHERITED FROM: Endocrine Gland Neoplasms || Intestinal Neoplasms || Pancreatic Neoplasms |
| Aldo-keto reductases (NADP) | 0.3202 | INHERITED FROM: Genital Neoplasms, Female || Uterine Neoplasms || Endometrial Neoplasms |
| ets domain | 0.3227 | INHERITED FROM: Prostatic Neoplasms |
| p120GAP domain-like | 0.3325 | INHERITED FROM: Nervous System Neoplasms |
| Frizzled cysteine-rich domain | 0.3325 | INHERITED FROM: Colorectal Neoplasms |
| Cyclin | 0.3629 | INHERITED FROM: Genital Neoplasms, Female || Head and Neck Neoplasms || Squamous Cell Carcinoma of Head and Neck |
| DNA gyrase/MutL, second domain | 0.3902 | INHERITED FROM: Digestive System Neoplasms || Colorectal Neoplasms, Hereditary Nonpolyposis || Intestinal Neoplasms || Colorectal Neoplasms |
| DNA gyrase/MutL, N-terminal domain | 0.3902 | INHERITED FROM: Digestive System Neoplasms || Colorectal Neoplasms, Hereditary Nonpolyposis || Intestinal Neoplasms || Colorectal Neoplasms |
| L domain | 0.3902 | INHERITED FROM: Biliary Tract Neoplasms || Gallbladder Neoplasms || Nasopharyngeal Neoplasms || Otorhinolaryngologic Neoplasms || Pharyngeal Neoplasms |
| Hairy Orange domain | 0.3902 | INHERITED FROM: Pancreatic Neoplasms || Carcinoma, Pancreatic Ductal |
| Classic zinc finger, C2H2 | 0.4193 | INHERITED FROM: Thyroid Cancer, Papillary |
| C1 set domains (antibody constant domain-like) | 0.4542 | INHERITED FROM: Oropharyngeal Neoplasms || Otorhinolaryngologic Neoplasms || Pharyngeal Neoplasms |
| MHC antigen-recognition domain | 0.4907 | INHERITED FROM: Oropharyngeal Neoplasms || Otorhinolaryngologic Neoplasms || Pharyngeal Neoplasms |
| Sema domain | 0.5289 | INHERITED FROM: Genital Neoplasms, Female || Endometrial Neoplasms |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.5629 | INHERITED FROM: Prostatic Neoplasms || Urogenital Neoplasms |
| RecA protein-like (ATPase-domain) | 0.6245 | INHERITED FROM: Breast Neoplasms |
| Histone lysine methyltransferases | 0.6259 | INHERITED FROM: Prostatic Neoplasms |
| DEATH domain, DD | 0.7946 | INHERITED FROM: Carcinoma, Renal Cell |
| Bromodomain | 0.8102 | INHERITED FROM: Small Cell Lung Carcinoma || Urogenital Neoplasms |
| Protein kinases, catalytic subunit | 0.8177 | INHERITED FROM: Biliary Tract Neoplasms |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| PDI-like | 0 | Direct |
| DNA repair protein MutS, domain III | 0 | Direct |
| Bcl-2 inhibitors of programmed cell death | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Kinase associated domain 1, KA1 | 0 | Direct |
| C5 cytosine-specific DNA methylase, DCM | 0 | Direct |
| Multidrug efflux transporter AcrB transmembrane domain | 0 | Direct |
| Formate/glycerate dehydrogenases, substrate-binding domain | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | Direct |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | Direct |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | Direct |
| RGC domain | 0 | Direct |
| DEATH effector domain, DED | 0 | Direct |
| Hsp90 middle domain | 0 | Direct |
| p53 DNA-binding domain-like | 0 | Direct |
| ABC transporter transmembrane region | 0.0002746 | Direct |
| ABC transporter ATPase domain-like | 0.00143 | Inherited |
| Cytochrome P450 | 0.001451 | Inherited |
| Fibronectin type II module | 0.003154 | Inherited |
| Cell cycle transcription factor e2f-dp | 0.006496 | Inherited |
| Metallothionein | 0.00673 | Inherited |
| Prefoldin | 0.01414 | Inherited |
| E2F dimerization segment | 0.01414 | Inherited |
| EGF-type module | 0.02863 | Inherited |
| Serum albumin-like | 0.02896 | Inherited |
| Notch domain | 0.02896 | Inherited |
| Interleukin 8-like chemokines | 0.03734 | Inherited |
| Lamin A/C globular tail domain | 0.05922 | Inherited |
| Growth factor receptor domain | 0.09905 | Inherited |
| Plexin repeat | 0.2152 | Inherited |
| SMAD MH1 domain | 0.2472 | Inherited |
| SMAD domain | 0.2472 | Inherited |
| Annexin | 0.283 | Inherited |
| Interferons/interleukin-10 (IL-10) | 0.283 | Inherited |
| Aldo-keto reductases (NADP) | 0.3202 | Inherited |
| ets domain | 0.3227 | Inherited |
| p120GAP domain-like | 0.3325 | Inherited |
| Frizzled cysteine-rich domain | 0.3325 | Inherited |
| Cyclin | 0.3629 | Inherited |
| DNA gyrase/MutL, second domain | 0.3902 | Inherited |
| DNA gyrase/MutL, N-terminal domain | 0.3902 | Inherited |
| L domain | 0.3902 | Inherited |
| Hairy Orange domain | 0.3902 | Inherited |
| Classic zinc finger, C2H2 | 0.4193 | Inherited |
| C1 set domains (antibody constant domain-like) | 0.4542 | Inherited |
| MHC antigen-recognition domain | 0.4907 | Inherited |
| Sema domain | 0.5289 | Inherited |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.5629 | Inherited |
| RecA protein-like (ATPase-domain) | 0.6245 | Inherited |
| Histone lysine methyltransferases | 0.6259 | Inherited |
| DEATH domain, DD | 0.7946 | Inherited |
| Bromodomain | 0.8102 | Inherited |
| Protein kinases, catalytic subunit | 0.8177 | Inherited |
LINKTO: Domain2BO Download and Domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Single)( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| p53 tetramerization domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| RGC domain-like | 0 | DIRECT |
| DNA repair protein MutS, domain III | 0 | DIRECT |
| Bcl-2 inhibitors of programmed cell death | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| Glutamine synthetase/guanido kinase | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| ABC transporter transmembrane region | 0.00005676 | DIRECT |
| Cytochrome P450 | 0.0004797 | DIRECT |
| Prefoldin | 0.000956 | DIRECT |
| Multidrug efflux transporter AcrB transmembrane domain | 0.005448 | INHERITED FROM: Gastrointestinal Stromal Tumors || Digestive System Neoplasms |
| Metallothionein | 0.005448 | INHERITED FROM: Urologic Neoplasms || Urinary Bladder Neoplasms || Carcinoma, Hepatocellular |
| Kringle-like | 0.00745 | INHERITED FROM: Bone Neoplasms |
| E2F-DP heterodimerization region | 0.01994 | INHERITED FROM: Thoracic Neoplasms || Respiratory Tract Neoplasms || Carcinoma, Non-Small-Cell Lung || Lung Neoplasms |
| Notch domain | 0.02519 | INHERITED FROM: Breast Neoplasms || Pancreatic Neoplasms || Esophageal Neoplasms || Endocrine Gland Neoplasms || Skin Neoplasms |
| Serum albumin-like | 0.02519 | INHERITED FROM: Stomach Neoplasms |
| Interleukin 8-like chemokines | 0.02723 | INHERITED FROM: Thoracic Neoplasms || Mesothelioma, Malignant |
| Lamin A/C globular tail domain | 0.05298 | INHERITED FROM: Thoracic Neoplasms || Respiratory Tract Neoplasms || Lung Neoplasms |
| Growth factor receptor domain | 0.08421 | INHERITED FROM: Gallbladder Neoplasms || Biliary Tract Neoplasms || Skin Neoplasms |
| Ribosomal protein S5 domain 2-like | 0.08811 | INHERITED FROM: Colorectal Neoplasms, Hereditary Nonpolyposis |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0.1692 | INHERITED FROM: Colorectal Neoplasms, Hereditary Nonpolyposis |
| Plexin repeat | 0.1838 | INHERITED FROM: Endometrial Neoplasms |
| dsRNA-binding domain-like | 0.1992 | INHERITED FROM: Wilms Tumor |
| 4-helical cytokines | 0.2112 | INHERITED FROM: Endocrine Gland Neoplasms |
| SMAD MH1 domain | 0.2265 | INHERITED FROM: Intestinal Neoplasms || Colorectal Neoplasms |
| Cyclin-like | 0.2447 | INHERITED FROM: Head and Neck Neoplasms || Squamous Cell Carcinoma of Head and Neck |
| Annexin | 0.2765 | INHERITED FROM: Mouth Neoplasms |
| NAD(P)-linked oxidoreductase | 0.2914 | INHERITED FROM: Genital Neoplasms, Female || Endometrial Neoplasms || Uterine Neoplasms |
| "Winged helix" DNA-binding domain | 0.3086 | INHERITED FROM: Carcinoma, Non-Small-Cell Lung |
| Frizzled cysteine-rich domain | 0.3253 | INHERITED FROM: Colorectal Neoplasms |
| DEATH domain | 0.3506 | INHERITED FROM: Carcinoma, Renal Cell |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0.3816 | INHERITED FROM: Colonic Neoplasms |
| Orange domain-like | 0.3816 | INHERITED FROM: Pancreatic Neoplasms || Carcinoma, Pancreatic Ductal |
| MHC antigen-recognition domain | 0.4439 | INHERITED FROM: Oropharyngeal Neoplasms || Pharyngeal Neoplasms || Otorhinolaryngologic Neoplasms |
| Sema domain | 0.4883 | INHERITED FROM: Genital Neoplasms, Female || Endometrial Neoplasms |
| ARM repeat | 0.549 | INHERITED FROM: Adenocarcinoma Of Esophagus |
| PYP-like sensor domain (PAS domain) | 0.5627 | INHERITED FROM: Breast Neoplasms |
| PGBD-like | 0.6635 | INHERITED FROM: Colorectal Neoplasms |
| Bromodomain | 0.799 | INHERITED FROM: Small Cell Lung Carcinoma || Urogenital Neoplasms |
| Protein kinase-like (PK-like) | 0.8154 | INHERITED FROM: Biliary Tract Neoplasms || Pharyngeal Neoplasms |
| L domain-like | 0.8965 | INHERITED FROM: Gallbladder Neoplasms || Biliary Tract Neoplasms |
| p53-like transcription factors | 0.9715 | INHERITED FROM: Pancreatic Neoplasms |
| Immunoglobulin | 0.9759 | INHERITED FROM: Oropharyngeal Neoplasms |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Duplex) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
103473,100895
103473 - MFS general substrate transporter
100895 - Kazal-type serine protease inhibitors | 0 | DIRECT |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | DIRECT |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
52058,52047
52058 - L domain-like
52047 - RNI-like | 0 | DIRECT |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
117839,117839
117839 - WWE domain
117839 - WWE domain | 0 | DIRECT |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | DIRECT |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | DIRECT |
48371,-7
48371 - ARM repeat
-7 - CATH | 0 | DIRECT |
46579,64593
46579 - Prefoldin
64593 - Intermediate filament protein, coiled coil region | 0 | DIRECT |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
-7,56112
-7 - CATH
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.00005676 | DIRECT |
52540,90123
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0.001099 | INHERITED FROM: Gastrointestinal Neoplasms || Intestinal Neoplasms || Colorectal Neoplasms |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0.005086 | INHERITED FROM: Prostatic Neoplasms |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.005448 | INHERITED FROM: Breast Neoplasms || Prostatic Neoplasms |
52283,51735
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0.005448 | INHERITED FROM: Genital Neoplasms, Male || Prostatic Neoplasms |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.01016 | INHERITED FROM: Carcinoma, Hepatocellular |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0.01994 | INHERITED FROM: Thoracic Neoplasms || Respiratory Tract Neoplasms || Carcinoma, Non-Small-Cell Lung || Lung Neoplasms |
51735,50129
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0.02519 | INHERITED FROM: Mouth Neoplasms |
63501,50242
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like | 0.02519 | INHERITED FROM: Gastrointestinal Neoplasms || Intestinal Neoplasms || Colorectal Neoplasms |
48552,48552
48552 - Serum albumin-like
48552 - Serum albumin-like | 0.02519 | INHERITED FROM: Stomach Neoplasms |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.02566 | INHERITED FROM: Genital Neoplasms, Male || Prostatic Neoplasms |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0.03843 | INHERITED FROM: Stomach Neoplasms |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.04341 | INHERITED FROM: Carcinoma, Pancreatic Ductal |
50729,49562
50729 - PH domain-like
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.05298 | INHERITED FROM: Genital Neoplasms, Male || Prostatic Neoplasms |
49899,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0.236 | INHERITED FROM: Esophageal Neoplasms || Esophageal Squamous Cell Carcinoma |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.236 | INHERITED FROM: Breast Neoplasms |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.2447 | INHERITED FROM: Pancreatic Neoplasms || Carcinoma, Pancreatic Ductal || Endocrine Gland Neoplasms || Skin Neoplasms |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0.3253 | INHERITED FROM: Colorectal Neoplasms || Digestive System Neoplasms || Colorectal Neoplasms, Hereditary Nonpolyposis |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.3524 | INHERITED FROM: Carcinoma, Pancreatic Ductal |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.3528 | INHERITED FROM: Genital Neoplasms, Female || Head and Neck Neoplasms || Squamous Cell Carcinoma of Head and Neck |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.3816 | INHERITED FROM: Nasopharyngeal Neoplasms || Gallbladder Neoplasms || Biliary Tract Neoplasms || Pharyngeal Neoplasms || Otorhinolaryngologic Neoplasms |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.3816 | INHERITED FROM: Head and Neck Neoplasms |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.3816 | INHERITED FROM: Nasopharyngeal Neoplasms || Gallbladder Neoplasms || Biliary Tract Neoplasms || Pharyngeal Neoplasms || Otorhinolaryngologic Neoplasms |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0.3816 | INHERITED FROM: Pancreatic Neoplasms || Carcinoma, Pancreatic Ductal |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.4504 | INHERITED FROM: Thyroid Cancer, Papillary |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0.4883 | INHERITED FROM: Genital Neoplasms, Female || Endometrial Neoplasms |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.496 | INHERITED FROM: Oropharyngeal Neoplasms || Pharyngeal Neoplasms || Otorhinolaryngologic Neoplasms |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.6635 | INHERITED FROM: Colorectal Neoplasms |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
103473,100895
103473 - MFS general substrate transporter
100895 - Kazal-type serine protease inhibitors | 0 | Direct |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | Direct |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
52058,52047
52058 - L domain-like
52047 - RNI-like | 0 | Direct |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
117839,117839
117839 - WWE domain
117839 - WWE domain | 0 | Direct |
48334,52540
48334 - DNA repair protein MutS, domain III
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | Direct |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | Direct |
48371,-7
48371 - ARM repeat
-7 - CATH | 0 | Direct |
46579,64593
46579 - Prefoldin
64593 - Intermediate filament protein, coiled coil region | 0 | Direct |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0 | Direct |
-7,56112
-7 - CATH
56112 - Protein kinase-like (PK-like) | 0 | Direct |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.00005676 | Direct |
52540,90123
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0.001099 | Inherited |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0.005086 | Inherited |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.005448 | Inherited |
52283,51735
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0.005448 | Inherited |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.01016 | Inherited |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0.01994 | Inherited |
51735,50129
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0.02519 | Inherited |
63501,50242
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like | 0.02519 | Inherited |
48552,48552
48552 - Serum albumin-like
48552 - Serum albumin-like | 0.02519 | Inherited |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.02566 | Inherited |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0.03843 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.04341 | Inherited |
50729,49562
50729 - PH domain-like
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.05298 | Inherited |
49899,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0.236 | Inherited |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.236 | Inherited |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.2447 | Inherited |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0.3253 | Inherited |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.3524 | Inherited |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.3528 | Inherited |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.3816 | Inherited |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.3816 | Inherited |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.3816 | Inherited |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0.3816 | Inherited |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.4504 | Inherited |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0.4883 | Inherited |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.496 | Inherited |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.6635 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Triple) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
49503,49503,49503
49503 - Cupredoxins
49503 - Cupredoxins
49503 - Cupredoxins | 0 | DIRECT |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | DIRECT |
90123,52540,90123
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0.001099 | INHERITED FROM: Gastrointestinal Neoplasms || Intestinal Neoplasms || Colorectal Neoplasms |
52540,90123,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.001099 | INHERITED FROM: Gastrointestinal Neoplasms || Intestinal Neoplasms || Colorectal Neoplasms |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.005448 | INHERITED FROM: Breast Neoplasms || Prostatic Neoplasms |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.01016 | INHERITED FROM: Pancreatic Neoplasms || Intestinal Neoplasms || Skin Neoplasms |
57184,57196,57184
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.01177 | INHERITED FROM: Skin Neoplasms |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0.01177 | INHERITED FROM: Carcinoma, Hepatocellular |
50129,51735,50129
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0.02519 | INHERITED FROM: Mouth Neoplasms |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.04641 | INHERITED FROM: Genital Neoplasms, Male || Prostatic Neoplasms |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.05318 | INHERITED FROM: Pancreatic Neoplasms || Carcinoma, Pancreatic Ductal || Skin Neoplasms |
49899,57196,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.2265 | INHERITED FROM: Esophageal Neoplasms || Esophageal Squamous Cell Carcinoma |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.2765 | INHERITED FROM: Breast Neoplasms || Pancreatic Neoplasms || Carcinoma, Pancreatic Ductal || Esophageal Squamous Cell Carcinoma || Endocrine Gland Neoplasms || Skin Neoplasms |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.3816 | INHERITED FROM: Nasopharyngeal Neoplasms || Gallbladder Neoplasms || Biliary Tract Neoplasms || Pharyngeal Neoplasms || Otorhinolaryngologic Neoplasms |
57196,57184,57196
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.3816 | INHERITED FROM: Carcinoma, Pancreatic Ductal |
57667,57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.6474 | INHERITED FROM: Gastrointestinal Stromal Tumors |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
49503,49503,49503
49503 - Cupredoxins
49503 - Cupredoxins
49503 - Cupredoxins | 0 | Direct |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | Direct |
90123,52540,90123
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0.001099 | Inherited |
52540,90123,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.001099 | Inherited |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.005448 | Inherited |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.01016 | Inherited |
57184,57196,57184
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.01177 | Inherited |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0.01177 | Inherited |
50129,51735,50129
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0.02519 | Inherited |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.04641 | Inherited |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.05318 | Inherited |
49899,57196,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.2265 | Inherited |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.2765 | Inherited |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.3816 | Inherited |
57196,57184,57196
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.3816 | Inherited |
57667,57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.6474 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Plot distribution on species Tree Of Life (sTOL) for Superfamily and/or Family domains annotated by this CD term
 |
Plot tree as:
| |
Download Newick format tree:
|
( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Plot distribution on species Tree Of Life (sTOL) for single supra-domains annotated by this CD term
|
Plot tree as:
| |
Download Newick format tree:
| |
Browsing in TREE OF LIFE:
|
( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|
|
> BO Hierarchy > Neoplasms by Site
