|
|
CTD Chemicals (CC): Estradiol Congeners 
(show info)
Biomedical Ontology
Like Gene Ontology (GO), biomedical ontology such as phenotype ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Biomedical ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI’s thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology Based on YP which is the major contributor to the ‘Ascomycete phenotype ontology’, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- UniProtKB KeyWords (KW) Ontology Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- CTD Diseases (CD) Ontology CD is MEDIC disease vocabulary that is modified by CTD from the "Diseases" [C] branch of Medical Subject Headings (MeSH), combined with genetic disorders from the Online Mendelian Inheritance in OMIM database.
- CTD Chemicals (CC) Ontology CC is chemical vocabulary that is adapted by CTD from the "Chemicals and Drugs" category and Supplementary Concept Records of Medical Subject Headings (MeSH, a hierarchical vocabulary used to index articles for MEDLINE/PubMed).
Jump to [ Top · Hierarchy · Annotations ]
Root: CC Hierarchy (CTD chemicals from Comparative Toxicogenomics Database)
| Shortest distance to current term (+ for parents, - for children) |
CC term [CC ID] <#Children> |
#Domains (Superfamily|Family) |
#Supra-domain (Single|Duplex|Triple) |
| + + + + + + + + 8: | Chemicals [MESH:D] <13> |
| + + + + + + + 7: | Chemical Actions and Uses [MESH:D020164] <3> | (170|228) |
(175|158|72) |
| + + + + + + 6: | Pharmacologic Actions [MESH:D020228] <5> | (153|206) |
(158|137|60) |
| + + + + + 5: | Physiological Effects of Drugs [MESH:D045505] <26> | (96|127) |
(100|73|31) |
| + + + + 4: | Hormones, Hormone Substitutes, and Hormone Antagonists [MESH:D006730] <2> | (92|122) |
(96|71|31) |
| + + + 3: | Hormones [MESH:D006728] <17> | (88|121) |
(92|71|31) |
| + + 2: | Gonadal Hormones [MESH:D042341] <6> | (80|114) |
(84|68|31) |
| + 1: | Gonadal Steroid Hormones [MESH:D012739] <4> | (69|97) |
(75|56|26) |
| 0: | Estradiol Congeners [MESH:D045166] <18> | (52|71) |
(53|41|14) |
| - 1: | Estradiol [MESH:D004958] <306> | (42|62) |
(43|35|12) |
| - 1: | Estrone [MESH:D004970] <96> | (7|8) |
(7|2|0) |
| - 1: | Estriol [MESH:D004964] <40> | (3|3) |
(3|1|0) |
| - 1: | Equilenin [MESH:D004855] <11> | (1|1) |
(1|0|0) |
| - 1: | Equilin [MESH:D004857] <7> | (2|2) |
(2|0|0) |
| - 1: | Estrogens, Conjugated (USP) [MESH:D004966] <6> | (1|0) |
(1|0|0) |
| - 1: | Estrogens, Catechol [MESH:D002393] <4> | (1|1) |
(1|0|0) |
| - 1: | Estrogens, Esterified (USP) [MESH:D042724] <2> | (0|0) |
(0|0|0) |
| - 1: | Estrogenic Steroids, Alkylated [MESH:D042782] <1> | (10|12) |
(10|5|1) |
| - 1: | 17-(N,N'-diethylethylenediamine)-1,3,5(10)-estratrien-3-ol [MESH:C117721] | (0|0) |
(0|0|0) |
| - 1: | Duogestral [MESH:C031304] | (0|0) |
(0|0|0) |
| - 1: | Estratab [MESH:C084328] | (0|0) |
(0|0|0) |
| - 1: | N,N'-bis-(3-hydroxy-1,3,5(10)-estratrien-17beta-yl)-1,4-butanediamine [MESH:C574241] | (0|0) |
(0|0|0) |
| - 1: | buame [MESH:C083897] | (0|0) |
(0|0|0) |
| - 1: | estrogens, conjugated synthetic A [MESH:C509653] | (0|0) |
(0|0|0) |
| - 1: | estrogens, conjugated synthetic B [MESH:C509657] | (0|0) |
(0|0|0) |
| - 1: | pamoestrol [MESH:C026544] | (0|0) |
(0|0|0) |
| - 1: | prodiame [MESH:C038378] | (0|0) |
(0|0|0) |
Jump to [ Top · Hierarchy ]
Superfamily( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| DEK C-terminal domain | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| beta-lactamase/transpeptidase-like | 0 | DIRECT |
| MAPEG domain-like | 0 | DIRECT |
| P-domain of calnexin/calreticulin | 0 | DIRECT |
| AhpD-like | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | DIRECT |
| N-terminal domain of cbl (N-cbl) | 0 | DIRECT |
| A heparin-binding domain | 0 | DIRECT |
| Fibrinogen coiled-coil and central regions | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Arginase/deacetylase | 0.00005435 | DIRECT |
| PGBD-like | 0.00006327 | DIRECT |
| Hemopexin-like domain | 0.0001078 | DIRECT |
| Metallothionein | 0.0003674 | DIRECT |
| VHP, Villin headpiece domain | 0.001093 | INHERITED FROM: Estradiol |
| NAD(P)-linked oxidoreductase | 0.002182 | INHERITED FROM: Estrone || 16-ketoestrone || Equilenin || 4-hydroxyequilenin-o-quinone |
| Cystine-knot cytokines | 0.00374 | INHERITED FROM: Estradiol |
| FnI-like domain | 0.00392 | INHERITED FROM: Estrogenic Steroids, Alkylated |
| EGF/Laminin | 0.01506 | INHERITED FROM: Estrogenic Steroids, Alkylated || estradiol, norethindrone drug combination |
| Nuclear receptor ligand-binding domain | 0.02051 | INHERITED FROM: Fulvestrant || Estrone || Equilin || Estriol |
| Cyclin-like | 0.02831 | INHERITED FROM: Fulvestrant || 2-Methoxyestradiol |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.0493 | INHERITED FROM: Equilin || Estriol |
| Serpins | 0.07092 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Estrogenic Steroids, Alkylated |
| MFS general substrate transporter | 0.09621 | INHERITED FROM: estrone sulfate || Estrone || estradiol-17 beta-glucuronide |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0.09647 | INHERITED FROM: Estradiol |
| Thyroglobulin type-1 domain | 0.1347 | INHERITED FROM: Estradiol |
| Plexin repeat | 0.136 | INHERITED FROM: Estradiol |
| Cupredoxins | 0.1586 | INHERITED FROM: ethinyl estradiol-desogestrel combination |
| Caspase-like | 0.1586 | INHERITED FROM: Estradiol || 2-Methoxyestradiol |
| Kazal-type serine protease inhibitors | 0.2405 | INHERITED FROM: estrone sulfate |
| Kringle-like | 0.2416 | INHERITED FROM: ethinyl estradiol-desogestrel combination |
| Protein kinase-like (PK-like) | 0.2534 | INHERITED FROM: Fulvestrant |
| GLA-domain | 0.2552 | INHERITED FROM: estradiol valerate-dienogest || ethinyl estradiol-desogestrel combination || Estrogenic Steroids, Alkylated || norgestimate, ethinyl estradiol drug combination || estradiol, norethindrone drug combination |
| Leucine zipper domain | 0.2886 | INHERITED FROM: Estradiol |
| Fibrinogen C-terminal domain-like | 0.2966 | INHERITED FROM: estradiol valerate-dienogest || ethinyl estradiol-desogestrel combination |
| Sema domain | 0.2975 | INHERITED FROM: Estradiol |
| ABC transporter transmembrane region | 0.3086 | INHERITED FROM: estradiol-17 beta-glucuronide |
| Interleukin 8-like chemokines | 0.4006 | INHERITED FROM: Fulvestrant |
| 4-helical cytokines | 0.4344 | INHERITED FROM: Estrogens, Conjugated (USP) |
| NAD(P)-binding Rossmann-fold domains | 0.5022 | INHERITED FROM: Estrone |
| Cytochrome P450 | 0.5102 | INHERITED FROM: Estrogenic Steroids, Alkylated || Estrone || 2-hydroxyestradiol |
| Trypsin-like serine proteases | 0.5378 | INHERITED FROM: estradiol valerate-dienogest || NuvaRing || ethinyl estradiol-desogestrel combination || Estrogenic Steroids, Alkylated || estradiol, norethindrone drug combination |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.6369 | INHERITED FROM: 2-Methoxyestradiol || 4-hydroxyestrone || Estrone || Hydroxyestrones || Estrogens, Catechol || 2-hydroxyestradiol || Estriol |
| PYP-like sensor domain (PAS domain) | 1 | INHERITED FROM: Fulvestrant |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: estradiol-17 beta-glucuronide |
LINKTO: Domain2BO Download and Domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Family( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| Alkaline phosphatase | 0 | DIRECT |
| 2'-5'-oligoadenylate synthetase 1, OAS1, second domain | 0 | DIRECT |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | DIRECT |
| DEATH effector domain, DED | 0 | DIRECT |
| MAPEG domain | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | DIRECT |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | DIRECT |
| P-domain of calnexin/calreticulin | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| 2'-5'-oligoadenylate synthetase 1, OAS1, N-terminal domain | 0 | DIRECT |
| DEK C-terminal domain | 0 | DIRECT |
| Troponin T | 0 | DIRECT |
| Fibrinogen coiled-coil and central regions | 0 | DIRECT |
| Tetrahydrofolate dehydrogenase/cyclohydrolase | 0 | DIRECT |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
| SelR domain | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, C-terminal domain | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | DIRECT |
| p53 DNA-binding domain-like | 0 | DIRECT |
| Transferrin | 0 | DIRECT |
| Retinoblastoma tumor suppressor domains | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Calnexin/calreticulin | 0 | DIRECT |
| N-terminal domain of cbl (N-cbl) | 0 | DIRECT |
| Hsp90 middle domain | 0 | DIRECT |
| Tissue inhibitor of metalloproteinases, TIMP | 0 | DIRECT |
| A heparin-binding domain | 0 | DIRECT |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | DIRECT |
| Histone deacetylase, HDAC | 0.00005282 | DIRECT |
| MMP N-terminal domain | 0.00007244 | DIRECT |
| Hemopexin-like domain | 0.0001285 | DIRECT |
| Caspase catalytic domain | 0.0001507 | DIRECT |
| Metallothionein | 0.0003849 | DIRECT |
| Gonadodropin/Follitropin | 0.0009646 | DIRECT |
| VHP, Villin headpiece domain | 0.001085 | INHERITED FROM: Estradiol |
| Integrin beta EGF-like domains | 0.001085 | INHERITED FROM: Estradiol |
| Aldo-keto reductases (NADP) | 0.002403 | INHERITED FROM: Estrone || 16-ketoestrone || Equilenin || 4-hydroxyequilenin-o-quinone |
| PAPS sulfotransferase | 0.005606 | INHERITED FROM: Estrone || 2-hydroxyestradiol |
| Transforming growth factor (TGF)-beta | 0.01512 | INHERITED FROM: Estradiol |
| Nuclear receptor ligand-binding domain | 0.01936 | INHERITED FROM: Fulvestrant || Estrone || Equilin || Estriol |
| Nuclear receptor | 0.02672 | INHERITED FROM: Fulvestrant || Estrone || Equilin || Estriol |
| EGF-type module | 0.05032 | INHERITED FROM: Estrogenic Steroids, Alkylated || estradiol, norethindrone drug combination |
| Matrix metalloproteases, catalytic domain | 0.06351 | INHERITED FROM: Estradiol |
| Cyclin | 0.07551 | INHERITED FROM: Fulvestrant || 2-Methoxyestradiol |
| Serpins | 0.07743 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Estrogenic Steroids, Alkylated |
| Integrin A (or I) domain | 0.1146 | INHERITED FROM: Estradiol |
| Thyroglobulin type-1 domain | 0.1251 | INHERITED FROM: Estradiol |
| Plexin repeat | 0.1293 | INHERITED FROM: Estradiol |
| Kringle modules | 0.1474 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Estradiol |
| GLA-domain | 0.2391 | INHERITED FROM: estradiol valerate-dienogest || ethinyl estradiol-desogestrel combination || Estrogenic Steroids, Alkylated || norgestimate, ethinyl estradiol drug combination || estradiol, norethindrone drug combination |
| VWC domain | 0.2502 | INHERITED FROM: Estrogenic Steroids, Alkylated |
| Leucine zipper domain | 0.2789 | INHERITED FROM: Estradiol |
| Sema domain | 0.2844 | INHERITED FROM: Estradiol |
| Fibrinogen C-terminal domain-like | 0.3129 | INHERITED FROM: estradiol valerate-dienogest || ethinyl estradiol-desogestrel combination |
| ABC transporter transmembrane region | 0.3291 | INHERITED FROM: estradiol-17 beta-glucuronide |
| UDPGT-like | 0.3291 | INHERITED FROM: 2-Methoxyestradiol || 4-hydroxyestrone || Estrone || Hydroxyestrones || Estrogens, Catechol || 2-hydroxyestradiol || Estriol |
| Ovomucoid domain III-like | 0.3474 | INHERITED FROM: estrone sulfate |
| Interleukin 8-like chemokines | 0.3866 | INHERITED FROM: Fulvestrant |
| Protein kinases, catalytic subunit | 0.3964 | INHERITED FROM: Fulvestrant |
| Myb/SANT domain | 0.4143 | INHERITED FROM: Fulvestrant |
| L domain | 0.4425 | INHERITED FROM: Fulvestrant |
| Cytochrome P450 | 0.5273 | INHERITED FROM: Estrogenic Steroids, Alkylated || Estrone || 2-hydroxyestradiol |
| Tyrosine-dependent oxidoreductases | 0.5438 | INHERITED FROM: Estrone |
| C2 set domains | 0.546 | INHERITED FROM: Estrogenic Steroids, Alkylated |
| Multidomain cupredoxins | 0.5979 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Estrogenic Steroids, Alkylated |
| Eukaryotic proteases | 0.7169 | INHERITED FROM: estradiol valerate-dienogest || NuvaRing || ethinyl estradiol-desogestrel combination || estradiol, norethindrone drug combination |
| ABC transporter ATPase domain-like | 0.73 | INHERITED FROM: estradiol-17 beta-glucuronide |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| Alkaline phosphatase | 0 | Direct |
| 2'-5'-oligoadenylate synthetase 1, OAS1, second domain | 0 | Direct |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | Direct |
| DEATH effector domain, DED | 0 | Direct |
| MAPEG domain | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | Direct |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | Direct |
| P-domain of calnexin/calreticulin | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| 2'-5'-oligoadenylate synthetase 1, OAS1, N-terminal domain | 0 | Direct |
| DEK C-terminal domain | 0 | Direct |
| Troponin T | 0 | Direct |
| Fibrinogen coiled-coil and central regions | 0 | Direct |
| Tetrahydrofolate dehydrogenase/cyclohydrolase | 0 | Direct |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
| SelR domain | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, C-terminal domain | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | Direct |
| p53 DNA-binding domain-like | 0 | Direct |
| Transferrin | 0 | Direct |
| Retinoblastoma tumor suppressor domains | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Calnexin/calreticulin | 0 | Direct |
| N-terminal domain of cbl (N-cbl) | 0 | Direct |
| Hsp90 middle domain | 0 | Direct |
| Tissue inhibitor of metalloproteinases, TIMP | 0 | Direct |
| A heparin-binding domain | 0 | Direct |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | Direct |
| Histone deacetylase, HDAC | 0.00005282 | Direct |
| MMP N-terminal domain | 0.00007244 | Direct |
| Hemopexin-like domain | 0.0001285 | Direct |
| Caspase catalytic domain | 0.0001507 | Direct |
| Metallothionein | 0.0003849 | Direct |
| Gonadodropin/Follitropin | 0.0009646 | Direct |
| VHP, Villin headpiece domain | 0.001085 | Inherited |
| Integrin beta EGF-like domains | 0.001085 | Inherited |
| Aldo-keto reductases (NADP) | 0.002403 | Inherited |
| PAPS sulfotransferase | 0.005606 | Inherited |
| Transforming growth factor (TGF)-beta | 0.01512 | Inherited |
| Nuclear receptor ligand-binding domain | 0.01936 | Inherited |
| Nuclear receptor | 0.02672 | Inherited |
| EGF-type module | 0.05032 | Inherited |
| Matrix metalloproteases, catalytic domain | 0.06351 | Inherited |
| Cyclin | 0.07551 | Inherited |
| Serpins | 0.07743 | Inherited |
| Integrin A (or I) domain | 0.1146 | Inherited |
| Thyroglobulin type-1 domain | 0.1251 | Inherited |
| Plexin repeat | 0.1293 | Inherited |
| Kringle modules | 0.1474 | Inherited |
| GLA-domain | 0.2391 | Inherited |
| VWC domain | 0.2502 | Inherited |
| Leucine zipper domain | 0.2789 | Inherited |
| Sema domain | 0.2844 | Inherited |
| Fibrinogen C-terminal domain-like | 0.3129 | Inherited |
| ABC transporter transmembrane region | 0.3291 | Inherited |
| UDPGT-like | 0.3291 | Inherited |
| Ovomucoid domain III-like | 0.3474 | Inherited |
| Interleukin 8-like chemokines | 0.3866 | Inherited |
| Protein kinases, catalytic subunit | 0.3964 | Inherited |
| Myb/SANT domain | 0.4143 | Inherited |
| L domain | 0.4425 | Inherited |
| Cytochrome P450 | 0.5273 | Inherited |
| Tyrosine-dependent oxidoreductases | 0.5438 | Inherited |
| C2 set domains | 0.546 | Inherited |
| Multidomain cupredoxins | 0.5979 | Inherited |
| Eukaryotic proteases | 0.7169 | Inherited |
| ABC transporter ATPase domain-like | 0.73 | Inherited |
LINKTO: Domain2BO Download and Domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Single)( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | DIRECT |
| beta-lactamase/transpeptidase-like | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| AhpD-like | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| N-terminal domain of cbl (N-cbl) | 0 | DIRECT |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| DEK C-terminal domain | 0 | DIRECT |
| A heparin-binding domain | 0 | DIRECT |
| P-domain of calnexin/calreticulin | 0 | DIRECT |
| Fibrinogen coiled-coil and central regions | 0 | DIRECT |
| MAPEG domain-like | 0 | DIRECT |
| Arginase/deacetylase | 0.0000284 | DIRECT |
| PGBD-like | 0.00003326 | DIRECT |
| Hemopexin-like domain | 0.00005797 | DIRECT |
| Metallothionein | 0.0002087 | DIRECT |
| VHP, Villin headpiece domain | 0.0006553 | DIRECT |
| NAD(P)-linked oxidoreductase | 0.001356 | INHERITED FROM: 4-hydroxyequilenin-o-quinone || 16-ketoestrone || Equilenin || Estrone |
| Cystine-knot cytokines | 0.002386 | INHERITED FROM: Estradiol |
| FnI-like domain | 0.00251 | INHERITED FROM: Estrogenic Steroids, Alkylated |
| EGF/Laminin | 0.0104 | INHERITED FROM: Estrogenic Steroids, Alkylated || estradiol, norethindrone drug combination |
| Nuclear receptor ligand-binding domain | 0.01443 | INHERITED FROM: Equilin || Estriol || Estrone || Fulvestrant |
| Cyclin-like | 0.02027 | INHERITED FROM: 2-Methoxyestradiol || Fulvestrant |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.03647 | INHERITED FROM: Equilin || Estriol |
| Serpins | 0.05351 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Estrogenic Steroids, Alkylated |
| MFS general substrate transporter | 0.07381 | INHERITED FROM: estrone sulfate || Estrone || estradiol-17 beta-glucuronide |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0.07403 | INHERITED FROM: Estradiol |
| Thyroglobulin type-1 domain | 0.1053 | INHERITED FROM: Estradiol |
| Plexin repeat | 0.1064 | INHERITED FROM: Estradiol |
| Caspase-like | 0.1253 | INHERITED FROM: 2-Methoxyestradiol || Estradiol |
| Cupredoxins | 0.1253 | INHERITED FROM: ethinyl estradiol-desogestrel combination |
| Kazal-type serine protease inhibitors | 0.1957 | INHERITED FROM: estrone sulfate |
| Kringle-like | 0.1967 | INHERITED FROM: ethinyl estradiol-desogestrel combination |
| Protein kinase-like (PK-like) | 0.207 | INHERITED FROM: Fulvestrant |
| GLA-domain | 0.2086 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Estrogenic Steroids, Alkylated || norgestimate, ethinyl estradiol drug combination || estradiol valerate-dienogest || estradiol, norethindrone drug combination |
| Leucine zipper domain | 0.2378 | INHERITED FROM: Estradiol |
| DBL homology domain (DH-domain) | 0.2404 | INHERITED FROM: Estradiol |
| Fibrinogen C-terminal domain-like | 0.245 | INHERITED FROM: ethinyl estradiol-desogestrel combination || estradiol valerate-dienogest |
| Sema domain | 0.2457 | INHERITED FROM: Estradiol |
| ABC transporter transmembrane region | 0.2558 | INHERITED FROM: estradiol-17 beta-glucuronide |
| Interleukin 8-like chemokines | 0.3394 | INHERITED FROM: Fulvestrant |
| 4-helical cytokines | 0.3708 | INHERITED FROM: Estrogens, Conjugated (USP) |
| NAD(P)-binding Rossmann-fold domains | 0.4351 | INHERITED FROM: Estrone |
| Cytochrome P450 | 0.4425 | INHERITED FROM: 2-hydroxyestradiol || Estrogenic Steroids, Alkylated || Estrone |
| Trypsin-like serine proteases | 0.4688 | INHERITED FROM: NuvaRing || ethinyl estradiol-desogestrel combination || Estrogenic Steroids, Alkylated || estradiol valerate-dienogest || estradiol, norethindrone drug combination |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.5653 | INHERITED FROM: 2-Methoxyestradiol || 4-hydroxyestrone || 2-hydroxyestradiol || Estriol || Estrone || Estrogens, Catechol || Hydroxyestrones |
| P-loop containing nucleoside triphosphate hydrolases | 0.9953 | INHERITED FROM: estradiol-17 beta-glucuronide |
| PYP-like sensor domain (PAS domain) | 1 | INHERITED FROM: Fulvestrant |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Duplex) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47473,57610
47473 - EF-hand
57610 - Thyroglobulin type-1 domain | 0 | DIRECT |
47862,47862
47862 - Saposin
47862 - Saposin | 0 | DIRECT |
53300,49899
53300 - vWA-like
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0 | DIRECT |
47473,55550
47473 - EF-hand
55550 - SH2 domain | 0 | DIRECT |
55486,49854
55486 - Metalloproteases ("zincins"), catalytic domain
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
47668,47473
47668 - N-terminal domain of cbl (N-cbl)
47473 - EF-hand | 0 | DIRECT |
48403,47986
48403 - Ankyrin repeat
47986 - DEATH domain | 0 | DIRECT |
69012,55874
69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
57184,57610
57184 - Growth factor receptor domain
57610 - Thyroglobulin type-1 domain | 0 | DIRECT |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | DIRECT |
55550,57850
55550 - SH2 domain
57850 - RING/U-box | 0 | DIRECT |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | DIRECT |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | DIRECT |
53300,57184
53300 - vWA-like
57184 - Growth factor receptor domain | 0 | DIRECT |
53850,53850
53850 - Periplasmic binding protein-like II
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
49899,63887
49899 - Concanavalin A-like lectins/glucanases
63887 - P-domain of calnexin/calreticulin | 0 | DIRECT |
100934,100934
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
56491,89811
56491 - A heparin-binding domain
89811 - Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
57414,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like | 0 | DIRECT |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.00003326 | DIRECT |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.00008268 | DIRECT |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0.0002282 | DIRECT |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.003675 | INHERITED FROM: ethinyl estradiol-desogestrel combination |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.00504 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Estrogenic Steroids, Alkylated |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.02507 | INHERITED FROM: Fulvestrant |
103473,100895
103473 - MFS general substrate transporter
100895 - Kazal-type serine protease inhibitors | 0.02634 | INHERITED FROM: estrone sulfate || Estrone |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.02956 | INHERITED FROM: Estriol || Estrone || Fulvestrant |
81296,81296
81296 - E set domains
81296 - E set domains | 0.08841 | INHERITED FROM: Estradiol |
49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0.1721 | INHERITED FROM: Estrogenic Steroids, Alkylated |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.174 | INHERITED FROM: 2-Methoxyestradiol || Fulvestrant |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.1786 | INHERITED FROM: Estradiol |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.1967 | INHERITED FROM: Estradiol |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0.2457 | INHERITED FROM: Estradiol |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.2558 | INHERITED FROM: estradiol-17 beta-glucuronide |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.4003 | INHERITED FROM: Fulvestrant |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.4003 | INHERITED FROM: Fulvestrant |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.4154 | INHERITED FROM: Fulvestrant |
57630,57196
57630 - GLA-domain
57196 - EGF/Laminin | 0.4703 | INHERITED FROM: Estrogenic Steroids, Alkylated || estradiol, norethindrone drug combination |
49503,49503
49503 - Cupredoxins
49503 - Cupredoxins | 0.5519 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Estrogenic Steroids, Alkylated |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47473,57610
47473 - EF-hand
57610 - Thyroglobulin type-1 domain | 0 | Direct |
47862,47862
47862 - Saposin
47862 - Saposin | 0 | Direct |
53300,49899
53300 - vWA-like
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0 | Direct |
47473,55550
47473 - EF-hand
55550 - SH2 domain | 0 | Direct |
55486,49854
55486 - Metalloproteases ("zincins"), catalytic domain
49854 - Spermadhesin, CUB domain | 0 | Direct |
47668,47473
47668 - N-terminal domain of cbl (N-cbl)
47473 - EF-hand | 0 | Direct |
48403,47986
48403 - Ankyrin repeat
47986 - DEATH domain | 0 | Direct |
69012,55874
69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
57184,57610
57184 - Growth factor receptor domain
57610 - Thyroglobulin type-1 domain | 0 | Direct |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | Direct |
55550,57850
55550 - SH2 domain
57850 - RING/U-box | 0 | Direct |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | Direct |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | Direct |
53300,57184
53300 - vWA-like
57184 - Growth factor receptor domain | 0 | Direct |
53850,53850
53850 - Periplasmic binding protein-like II
53850 - Periplasmic binding protein-like II | 0 | Direct |
49899,63887
49899 - Concanavalin A-like lectins/glucanases
63887 - P-domain of calnexin/calreticulin | 0 | Direct |
100934,100934
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
56491,89811
56491 - A heparin-binding domain
89811 - Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
57414,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like | 0 | Direct |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.00003326 | Direct |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.00008268 | Direct |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0.0002282 | Direct |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.003675 | Inherited |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.00504 | Inherited |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.02507 | Inherited |
103473,100895
103473 - MFS general substrate transporter
100895 - Kazal-type serine protease inhibitors | 0.02634 | Inherited |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.02956 | Inherited |
81296,81296
81296 - E set domains
81296 - E set domains | 0.08841 | Inherited |
49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0.1721 | Inherited |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.174 | Inherited |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.1786 | Inherited |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.1967 | Inherited |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0.2457 | Inherited |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.2558 | Inherited |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.4003 | Inherited |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.4003 | Inherited |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.4154 | Inherited |
57630,57196
57630 - GLA-domain
57196 - EGF/Laminin | 0.4703 | Inherited |
49503,49503
49503 - Cupredoxins
49503 - Cupredoxins | 0.5519 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Triple) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47668,47473,55550
47668 - N-terminal domain of cbl (N-cbl)
47473 - EF-hand
55550 - SH2 domain | 0 | DIRECT |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | DIRECT |
55486,49854,49854
55486 - Metalloproteases ("zincins"), catalytic domain
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | DIRECT |
57196,57535,57535
57196 - EGF/Laminin
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
100895,47473,57610
100895 - Kazal-type serine protease inhibitors
47473 - EF-hand
57610 - Thyroglobulin type-1 domain | 0 | DIRECT |
49265,49265,53300
49265 - Fibronectin type III
49265 - Fibronectin type III
53300 - vWA-like | 0 | DIRECT |
57414,57440,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
47473,55550,57850
47473 - EF-hand
55550 - SH2 domain
57850 - RING/U-box | 0 | DIRECT |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.0004876 | DIRECT |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.005143 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Estrogenic Steroids, Alkylated |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.009052 | INHERITED FROM: Fulvestrant |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.4003 | INHERITED FROM: Fulvestrant |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47668,47473,55550
47668 - N-terminal domain of cbl (N-cbl)
47473 - EF-hand
55550 - SH2 domain | 0 | Direct |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | Direct |
55486,49854,49854
55486 - Metalloproteases ("zincins"), catalytic domain
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | Direct |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | Direct |
57196,57535,57535
57196 - EGF/Laminin
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | Direct |
100895,47473,57610
100895 - Kazal-type serine protease inhibitors
47473 - EF-hand
57610 - Thyroglobulin type-1 domain | 0 | Direct |
49265,49265,53300
49265 - Fibronectin type III
49265 - Fibronectin type III
53300 - vWA-like | 0 | Direct |
57414,57440,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
47473,55550,57850
47473 - EF-hand
55550 - SH2 domain
57850 - RING/U-box | 0 | Direct |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.0004876 | Direct |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.005143 | Inherited |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.009052 | Inherited |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.4003 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Plot distribution on species Tree Of Life (sTOL) for Superfamily and/or Family domains annotated by this CC term
 |
Plot tree as:
| |
Download Newick format tree:
|
( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Plot distribution on species Tree Of Life (sTOL) for single supra-domains annotated by this CC term
|
Plot tree as:
| |
Download Newick format tree:
| |
Browsing in TREE OF LIFE:
|
( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|
|
> BO Hierarchy > Estradiol Congeners
