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Mammalian Phenotype (MP): abnormal hematopoietic cell number 

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term
(+ for parents, - for children)		 MP term [MP ID] <#Children> #Domains
(Superfamily|Family)		 #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + 2:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(58|86) (66|47|21)
+ 1:   abnormal hematopoietic cell morphology [MP:0013656] <9>(49|77) (60|43|18)
0:   abnormal hematopoietic cell number [MP:0011180] <7>(34|57) (43|29|13)
- 1:   abnormal leukocyte cell number [MP:0000217] <8>(29|49) (37|25|12)
- 1:   abnormal granulocyte number [MP:0020201] <6>(3|7) (5|6|2)
- 1:   abnormal myeloid cell number [MP:0013661] <6>(4|7) (4|2|0)
- 1:   decreased hematopoietic cell number [MP:0011182] <5>(21|34) (27|21|11)
- 1:   increased hematopoietic cell number [MP:0011181] <4>(12|26) (19|11|7)
- 1:   abnormal macrophage cell number [MP:0020202] <2>(5|7) (5|1|0)
- 1:   abnormal platelet cell number [MP:0011898] <2>(1|2) (1|1|0)

Superfamily

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Superfamily

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SCOP term FDR (all) Annotation (direct or inherited)
SPOC domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
PsbU/PolX domain-like0Direct
L30e-like0.002529Inherited
DNA polymerase beta, N-terminal domain-like0.006142Inherited
Flavoproteins0.007266Inherited
Toll/Interleukin receptor TIR domain0.0136Inherited
Triple coiled coil domain of C-type lectins0.01863Inherited
AraD/HMP-PK domain-like0.01863Inherited
DEATH domain0.02007Inherited
Ran binding protein zinc finger-like0.02255Inherited
p53-like transcription factors0.03041Inherited
Bcl-2 inhibitors of programmed cell death0.03273Inherited
SH2 domain0.03449Inherited
WWE domain0.04161Inherited
E2F-DP heterodimerization region0.04161Inherited
TNF receptor-like0.07066Inherited
4-helical cytokines0.1672Inherited
Integrin alpha N-terminal domain0.185Inherited
Integrin domains0.2501Inherited
TIMP-like0.2525Inherited
MHC antigen-recognition domain0.3188Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.3449Inherited
Riboflavin synthase domain-like0.3789Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.3789Inherited
Calponin-homology domain, CH-domain0.3973Inherited
DBL homology domain (DH-domain)0.4709Inherited
Cysteine-rich domain0.5195Inherited
A DNA-binding domain in eukaryotic transcription factors0.6223Inherited
Nuclear receptor ligand-binding domain0.6314Inherited
Terpenoid cyclases/Protein prenyltransferases0.7514Inherited
Cyclin-like0.762Inherited
SMAD/FHA domain0.7721Inherited
Nucleic acid-binding proteins0.9123Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

Family

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Family

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SCOP term FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Proteasome subunits0Direct
RUNT domain0Direct
DNA polymerase beta-like0Direct
BAFF receptor-like0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
Interleukin 17F, IL-17F0Direct
DNA polymerase beta-like, second domain0Direct
Short-chain cytokines0.0000001159Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0001729Direct
Pyrin domain, PYD0.0003721Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.001317Inherited
ets domain0.003364Inherited
Notch domain0.004272Inherited
Interleukin-1 (IL-1)0.004272Inherited
DNA polymerase beta, N-terminal domain-like0.004272Inherited
Pointed domain0.005157Inherited
Erythroid transcription factor GATA-10.01288Inherited
AraD-like aldolase/epimerase0.01362Inherited
Tissue inhibitor of metalloproteinases, TIMP0.01362Inherited
Triple coiled coil domain of C-type lectins0.01362Inherited
Cytochrome p450 reductase N-terminal domain-like0.01362Inherited
WWE domain0.01464Inherited
E2F dimerization segment0.01464Inherited
Ran binding protein zinc finger-like0.01747Inherited
Toll/Interleukin receptor TIR domain0.02031Inherited
Bcl-2 inhibitors of programmed cell death0.02513Inherited
Interferon regulatory factor0.02513Inherited
SH2 domain0.02539Inherited
NADPH-cytochrome p450 reductase-like0.03943Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.03943Inherited
Nuclear receptor coactivator interlocking domain0.03943Inherited
V set domains (antibody variable domain-like)0.07302Inherited
Cell cycle transcription factor e2f-dp0.0894Inherited
TNF receptor-like0.09235Inherited
DEATH domain, DD0.09235Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.1227Inherited
MATH domain0.1697Inherited
C1 set domains (antibody constant domain-like)0.1888Inherited
Integrin domains0.2165Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.2182Inherited
MHC antigen-recognition domain0.2821Inherited
CCCH zinc finger0.364Inherited
Calponin-homology domain, CH-domain0.3801Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.4316Inherited
DBL homology domain (DH-domain)0.4326Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.4774Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.4874Inherited
Noncollagenous (NC1) domain of collagen IV0.5118Inherited
Pleckstrin-homology domain (PH domain)0.5294Inherited
SH3-domain0.5439Inherited
A DNA-binding domain in eukaryotic transcription factors0.5855Inherited
Cyclin0.5855Inherited
Nuclear receptor ligand-binding domain0.5969Inherited
Nuclear receptor0.5969Inherited
PLC-like (P variant)0.7528Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.9293Inherited

LINKTO: Domain2BO Download and Domain2BO Algorithm

Supra-domain (Single|Duplex|Triple)

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Supra-domain (Single)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
SPOC domain-like0Direct
PsbU/PolX domain-like0Direct
L30e-like0.001455Inherited
DNA polymerase beta, N-terminal domain-like0.003724Inherited
Notch domain0.003724Inherited
Flavoproteins0.00446Inherited
Toll/Interleukin receptor TIR domain0.008685Inherited
Triple coiled coil domain of C-type lectins0.01215Inherited
AraD/HMP-PK domain-like0.01215Inherited
DEATH domain0.01317Inherited
Ran binding protein zinc finger-like0.01494Inherited
NAD kinase/diacylglycerol kinase-like0.01685Inherited
p53-like transcription factors0.02071Inherited
Bcl-2 inhibitors of programmed cell death0.0224Inherited
SH2 domain0.02369Inherited
WWE domain0.02898Inherited
E2F-DP heterodimerization region0.02898Inherited
Nuclear receptor coactivator interlocking domain0.03597Inherited
TNF receptor-like0.05168Inherited
4-helical cytokines0.1337Inherited
C-type lectin-like0.1427Inherited
Integrin alpha N-terminal domain0.1498Inherited
Integrin domains0.2098Inherited
Protein kinase-like (PK-like)0.2115Inherited
TIMP-like0.2121Inherited
MHC antigen-recognition domain0.2747Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.2995Inherited
Riboflavin synthase domain-like0.3328Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.3328Inherited
Calponin-homology domain, CH-domain0.3508Inherited
CCCH zinc finger0.3557Inherited
DBL homology domain (DH-domain)0.4232Inherited
Cysteine-rich domain0.472Inherited
SH3-domain0.5323Inherited
A DNA-binding domain in eukaryotic transcription factors0.5774Inherited
Nuclear receptor ligand-binding domain0.587Inherited
beta-beta-alpha zinc fingers0.591Inherited
Terpenoid cyclases/Protein prenyltransferases0.7133Inherited
Cyclin-like0.7244Inherited
SMAD/FHA domain0.7351Inherited
Acyl-CoA N-acyltransferases (Nat)0.7633Inherited
Nucleic acid-binding proteins0.8867Inherited

LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

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Supra-domain (Duplex) in N- to C-terminal order

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
    		• 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
    		• 0Direct
    57424,50494
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
    		• 0Direct
    49562,51045
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 51045 - WW domain
    		• 0Direct
    81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
    		• 0Direct
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
    		• 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
    		• 0.000139Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
    		• 0.00109Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
    		• 0.001455Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
    		• 0.004155Inherited
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
    		• 0.01215Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
    		• 0.02898Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
    		• 0.08899Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
    		• 0.1193Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
    		• 0.1319Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
    		• 0.1498Inherited
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
    		• 0.1634Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
    		• 0.1781Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
    		• 0.1781Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
    		• 0.2098Inherited
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
    		• 0.2995Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
    		• 0.3132Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
    		• 0.4232Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
    		• 0.4235Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
    		• 0.4235Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
    		• 0.4235Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
    		• 0.4235Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
    		• 0.4395Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
    		• 0.5774Inherited

    LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

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    Supra-domain (Triple) in N- to C-terminal order

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
    		• 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
    		• 0Direct
    57424,57424,50494
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
    		• 0Direct
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
    		• 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
    		• 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
    		• 0.00282Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
    		• 0.07392Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
    		• 0.1112Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
    		• 0.1781Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
    		• 0.4235Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
    		• 0.4235Inherited
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
    		• 0.5036Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
    		• 0.5036Inherited

    LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm

    Distribution on sTOL

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    Locations of visitors to this page Using dcGO in your work, please cite Nucleic Acids Research 2013, 41(Database issue):D536-44.
    On questions and detailed information, please contact Dr. Hai Fang or Prof. Julian Gough