RNA-directed RNA polymerase

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children)	EC term [EC ID] <#Children>	(#SF|#FA)	#Supra-domain (Single|Duplex|Triple)
+ + + + 4:	root [root] <6>
+ + + 3:	Transferases [2] <10>	(363|551)	(398|460|240)
+ + 2:	Transferring phosphorous-containing groups [2.7] <13>	(220|294)	(251|300|176)
+ 1:	Nucleotidyltransferases [2.7.7] <86>	(89|111)	(98|96|59)
0:	RNA-directed RNA polymerase [2.7.7.48]	(18|21)	(21|23|17)

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Superfamily

Superfamily domains annotated to this EC term (SDEO level: Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
E set domains	0	DIRECT
DNA/RNA polymerases	0	DIRECT
P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
Macro domain-like	0	DIRECT
Flavivirus capsid protein C	0	DIRECT
S-adenosyl-L-methionine-dependent methyltransferases	0	DIRECT
Coronavirus NSP8-like	0	DIRECT
Coronavirus NSP7-like	0	DIRECT
Positive stranded ssRNA viruses	0	DIRECT
EndoU-like	0	DIRECT
Viral glycoprotein, central and dimerisation domains	0	DIRECT
Soluble domain of poliovirus core protein 3a	0	DIRECT
Replicase NSP9	0	DIRECT
Coronavirus NSP10-like	0	DIRECT
NSP3A-like	0	DIRECT
Trypsin-like serine proteases	0	DIRECT
Clavaminate synthase-like	0.00000000001846	DIRECT
Ribonuclease Rh-like	0.00000001353	DIRECT

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Family

Family domains annotated to this (SDEO level: Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Coronavirus NSP8-like	0	DIRECT
Nsp15 C-terminal domain-like	0	DIRECT
Class II viral fusion proteins C-terminal domain	0	DIRECT
Replicase NSP9	0	DIRECT
Viral proteases	0	DIRECT
RNA helicase	0	DIRECT
Nsp15 N-terminal domain-like	0	DIRECT
AlkB-like	0	DIRECT
RNA-dependent RNA-polymerase	0	DIRECT
Picornaviridae-like VP (VP1, VP2, VP3 and VP4)	0	DIRECT
Flavivirus capsid protein C	0	DIRECT
Viral glycoprotein, central and dimerisation domains	0	DIRECT
Soluble domain of poliovirus core protein 3a	0	DIRECT
NSP3A-like	0	DIRECT
Macro domain	0	DIRECT
Coronavirus NSP7-like	0	DIRECT
Caliciviridae-like VP	0	DIRECT
Coronavirus NSP10-like	0	DIRECT
Viral cysteine protease of trypsin fold	0	DIRECT
mRNA cap methylase	0	DIRECT
Ribonuclease Rh-like	0.000000001922	DIRECT

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Supra-domain (including individual superfamily)

Supra-domains annotated to this EC term (SPEO level: Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Coronavirus NSP8-like	0	DIRECT
Soluble domain of poliovirus core protein 3a	0	DIRECT
S-adenosyl-L-methionine-dependent methyltransferases	0	DIRECT
Trypsin-like serine proteases	0	DIRECT
Positive stranded ssRNA viruses	0	DIRECT
Replicase NSP9	0	DIRECT
E set domains	0	DIRECT
Flavivirus capsid protein C	0	DIRECT
P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
NSP3A-like	0	DIRECT
EndoU-like	0	DIRECT
Macro domain-like	0	DIRECT
Viral leader polypeptide zinc finger	0	DIRECT
Coronavirus NSP10-like	0	DIRECT
Coronavirus NSP7-like	0	DIRECT
DNA/RNA polymerases	0	DIRECT
Viral glycoprotein, central and dimerisation domains	0	DIRECT
Clavaminate synthase-like	0.0000000000192	DIRECT
SARS Nsp1-like	0.00000000003386	DIRECT
Ribonuclease Rh-like	0.00000001061	DIRECT
Cysteine proteinases	0.0009767	DIRECT

Supra-domains annotated to this EC term (SPEO level: Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
56672,52540 56672 - DNA/RNA polymerases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
56983,81296 56983 - Viral glycoprotein, central and dimerisation domains 81296 - E set domains	0	DIRECT
53335,52949 53335 - S-adenosyl-L-methionine-dependent methyltransferases 52949 - Macro domain-like	0	DIRECT
50494,56672 50494 - Trypsin-like serine proteases 56672 - DNA/RNA polymerases	0	DIRECT
88633,88633 88633 - Positive stranded ssRNA viruses 88633 - Positive stranded ssRNA viruses	0	DIRECT
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
56672,88633 56672 - DNA/RNA polymerases 88633 - Positive stranded ssRNA viruses	0	DIRECT
52540,142877 52540 - P-loop containing nucleoside triphosphate hydrolases 142877 - EndoU-like	0	DIRECT
52540,89043 52540 - P-loop containing nucleoside triphosphate hydrolases 89043 - Soluble domain of poliovirus core protein 3a	0	DIRECT
53335,56672 53335 - S-adenosyl-L-methionine-dependent methyltransferases 56672 - DNA/RNA polymerases	0	DIRECT
140367,143076 140367 - Coronavirus NSP7-like 143076 - Coronavirus NSP8-like	0	DIRECT
89043,50494 89043 - Soluble domain of poliovirus core protein 3a 50494 - Trypsin-like serine proteases	0	DIRECT
50494,52540 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
88633,50494 88633 - Positive stranded ssRNA viruses 50494 - Trypsin-like serine proteases	0	DIRECT
53335,142877 53335 - S-adenosyl-L-methionine-dependent methyltransferases 142877 - EndoU-like	0	DIRECT
52540,56672 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases	0	DIRECT
51197,52540 51197 - Clavaminate synthase-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
101816,144246 101816 - Replicase NSP9 144246 - Coronavirus NSP10-like	0	DIRECT
143076,101816 143076 - Coronavirus NSP8-like 101816 - Replicase NSP9	0	DIRECT
52949,52540 52949 - Macro domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
54001,88633 54001 - Cysteine proteinases 88633 - Positive stranded ssRNA viruses	0.0000000000006279	DIRECT
159936,52949 159936 - NSP3A-like 52949 - Macro domain-like	0.00000000003386	DIRECT
159936,53335 159936 - NSP3A-like 53335 - S-adenosyl-L-methionine-dependent methyltransferases	0.000000002622	DIRECT

Supra-domains annotated to this EC term (SPEO level: Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
89043,50494,56672 89043 - Soluble domain of poliovirus core protein 3a 50494 - Trypsin-like serine proteases 56672 - DNA/RNA polymerases	0	DIRECT
50494,52540,52540 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
52949,52540,52540 52949 - Macro domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
50494,52540,89043 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases 89043 - Soluble domain of poliovirus core protein 3a	0	DIRECT
51197,52540,56672 51197 - Clavaminate synthase-like 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases	0	DIRECT
140367,143076,101816 140367 - Coronavirus NSP7-like 143076 - Coronavirus NSP8-like 101816 - Replicase NSP9	0	DIRECT
52540,52540,56672 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases	0	DIRECT
56672,52540,52540 56672 - DNA/RNA polymerases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
50494,56672,88633 50494 - Trypsin-like serine proteases 56672 - DNA/RNA polymerases 88633 - Positive stranded ssRNA viruses	0	DIRECT
88633,88633,88633 88633 - Positive stranded ssRNA viruses 88633 - Positive stranded ssRNA viruses 88633 - Positive stranded ssRNA viruses	0	DIRECT
52540,52540,142877 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 142877 - EndoU-like	0	DIRECT
52540,89043,50494 52540 - P-loop containing nucleoside triphosphate hydrolases 89043 - Soluble domain of poliovirus core protein 3a 50494 - Trypsin-like serine proteases	0	DIRECT
50494,52540,56672 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases	0	DIRECT
52949,52540,56672 52949 - Macro domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases	0	DIRECT
143076,101816,144246 143076 - Coronavirus NSP8-like 101816 - Replicase NSP9 144246 - Coronavirus NSP10-like	0	DIRECT
88633,50494,52540 88633 - Positive stranded ssRNA viruses 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
54001,88633,88633 54001 - Cysteine proteinases 88633 - Positive stranded ssRNA viruses 88633 - Positive stranded ssRNA viruses	0.0000000000006279	DIRECT