|
  
|
Mammalian Phenotype (MP): abnormal cell physiology  
(show info)
Biomedical Ontology
Like Gene Ontology (GO), biomedical ontology such as phenotype ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Biomedical ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI’s thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology Based on YP which is the major contributor to the ‘Ascomycete phenotype ontology’, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- UniProtKB KeyWords (KW) Ontology Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- CTD Diseases (CD) Ontology CD is MEDIC disease vocabulary that is modified by CTD from the "Diseases" [C] branch of Medical Subject Headings (MeSH), combined with genetic disorders from the Online Mendelian Inheritance in OMIM database.
- CTD Chemicals (CC) Ontology CC is chemical vocabulary that is adapted by CTD from the "Chemicals and Drugs" category and Supplementary Concept Records of Medical Subject Headings (MeSH, a hierarchical vocabulary used to index articles for MEDLINE/PubMed).
Jump to [ Top · Hierarchy · Annotations ]
Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)
Jump to [ Top · Hierarchy ]
Family( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Lamin A/C globular tail domain | 0 | DIRECT |
| Chromo barrel domain | 0 | DIRECT |
| Transcriptional factor tubby, C-terminal domain | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme postcatalytic domain | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| p53 DNA-binding domain-like | 0 | DIRECT |
| The spindle assembly checkpoint protein mad2 | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| SCF ubiquitin ligase complex WHB domain | 0 | DIRECT |
| SMAD4-binding domain of oncoprotein Ski | 0 | DIRECT |
| RUNT domain | 0 | DIRECT |
| Polo-box duplicated region | 0 | DIRECT |
| Cullin homology domain | 0 | DIRECT |
| Extracellular domain of cell surface receptors | 0 | DIRECT |
| Rel/Dorsal transcription factors, DNA-binding domain | 0 | DIRECT |
| Other IPT/TIG domains | 0 | DIRECT |
| Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
| ATP-dependent DNA ligase catalytic domain | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | DIRECT |
| E2F dimerization segment | 0 | DIRECT |
| Retinoblastoma tumor suppressor domains | 0 | DIRECT |
| Cullin repeat | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| Cytochrome p450 reductase N-terminal domain-like | 0 | DIRECT |
| U-box | 0 | DIRECT |
| DEATH domain, DD | 0.00001174 | DIRECT |
| Integrin domains | 0.0001072 | DIRECT |
| Caspase catalytic domain | 0.0001641 | DIRECT |
| Caspase recruitment domain, CARD | 0.0003458 | DIRECT |
| Cell cycle transcription factor e2f-dp | 0.00093 | DIRECT |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.001539 | INHERITED FROM: abnormal apoptosis |
| Integrin beta EGF-like domains | 0.002172 | INHERITED FROM: abnormal leukocyte migration |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.002172 | INHERITED FROM: decreased cell proliferation || abnormal chromosome stability || decreased fibroblast proliferation || chromosomal instability || spontaneous chromosome breakage || abnormal fibroblast proliferation |
| Erythroid transcription factor GATA-1 | 0.002172 | INHERITED FROM: abnormal fetal cardiomyocyte proliferation |
| Integrin alpha N-terminal domain | 0.002983 | INHERITED FROM: abnormal cell adhesion || abnormal cellular extravasation |
| Integrin beta tail domain | 0.004988 | INHERITED FROM: abnormal leukocyte migration |
| Single strand DNA-binding domain, SSB | 0.004988 | INHERITED FROM: abnormal chromosome stability || abnormal male germ cell apoptosis || chromosomal instability |
| Plexin repeat | 0.00582 | INHERITED FROM: abnormal cell migration || abnormal neuronal migration |
| Ran binding protein zinc finger-like | 0.009034 | INHERITED FROM: increased apoptosis || increased cell death |
| UBA domain | 0.01616 | INHERITED FROM: chromosomal instability |
| NADPH-cytochrome p450 reductase-like | 0.0246 | INHERITED FROM: abnormal kidney apoptosis || increased kidney apoptosis || increased apoptosis || increased cell death || abnormal apoptosis || increased renal tubule apoptosis |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.0246 | INHERITED FROM: abnormal kidney apoptosis || increased kidney apoptosis || increased apoptosis || increased cell death || abnormal apoptosis || increased renal tubule apoptosis |
| STAT DNA-binding domain | 0.03706 | INHERITED FROM: decreased cell proliferation || increased apoptosis || increased cell death || abnormal apoptosis |
| Transcription factor STAT-4 N-domain | 0.03706 | INHERITED FROM: decreased cell proliferation || increased apoptosis || increased cell death || abnormal apoptosis |
| Sir2 family of transcriptional regulators | 0.03706 | INHERITED FROM: increased sensitivity to induced cell death |
| STAT | 0.03706 | INHERITED FROM: decreased cell proliferation || increased apoptosis || increased cell death || abnormal apoptosis |
| ets domain | 0.04207 | INHERITED FROM: increased B cell apoptosis |
| Bcl-2 inhibitors of programmed cell death | 0.04389 | INHERITED FROM: decreased cell death || abnormal cell death || decreased apoptosis || abnormal T cell apoptosis || abnormal apoptosis |
| C5 cytosine-specific DNA methylase, DCM | 0.05336 | INHERITED FROM: abnormal DNA methylation || abnormal epigenetic regulation of gene expression |
| SH2 domain | 0.06676 | INHERITED FROM: abnormal cell differentiation || increased B cell apoptosis || abnormal B cell apoptosis |
| Sema domain | 0.07177 | INHERITED FROM: abnormal cell migration || abnormal neuronal migration |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.07816 | INHERITED FROM: abnormal vascular regression |
| EGF-type module | 0.07972 | INHERITED FROM: abnormal leukocyte adhesion |
| Leucine zipper domain | 0.09295 | INHERITED FROM: increased hepatocyte apoptosis |
| Histone lysine methyltransferases | 0.0951 | INHERITED FROM: abnormal epigenetic regulation of gene expression |
| HLH, helix-loop-helix DNA-binding domain | 0.1024 | INHERITED FROM: premature neuronal precursor differentiation || abnormal neuron differentiation || abnormal skeletal muscle satellite cell proliferation || abnormal cell differentiation || abnormal retinal apoptosis || abnormal neuronal precursor proliferation |
| RING finger domain, C3HC4 | 0.1193 | INHERITED FROM: chromosomal instability |
| Cell cycle control phosphatase, catalytic domain | 0.1294 | INHERITED FROM: abnormal small intestinal crypt cell proliferation || abnormal enterocyte differentiation || abnormal enterocyte apoptosis || increased enterocyte apoptosis |
| DNA polymerase beta, N-terminal domain-like | 0.1342 | INHERITED FROM: abnormal DNA repair |
| C2 set domains | 0.1349 | INHERITED FROM: abnormal cell chemotaxis |
| Homeodomain | 0.1701 | INHERITED FROM: abnormal neuron differentiation || abnormal cell differentiation |
| Mitochondrial carrier | 0.1779 | INHERITED FROM: abnormal mitochondrial physiology || abnormal cellular respiration |
| FHA domain | 0.1779 | INHERITED FROM: abnormal DNA repair || abnormal chromosome stability || chromosomal instability || increased cellular sensitivity to ionizing radiation |
| Forkhead DNA-binding domain | 0.1848 | INHERITED FROM: abnormal mesenchymal cell proliferation involved in lung development || abnormal pancreatic beta cell differentiation || decreased mesenchymal cell proliferation involved in lung development || abnormal radial glial cell morphology |
| Nuclear receptor | 0.1963 | INHERITED FROM: abnormal cellular cholesterol metabolism |
| Enabled/VASP homology 1 domain (EVH1 domain) | 0.2017 | INHERITED FROM: abnormal radial glial cell morphology |
| I set domains | 0.2089 | INHERITED FROM: increased granulosa cell apoptosis || decreased kidney cell proliferation |
| Fibroblast growth factors (FGF) | 0.223 | INHERITED FROM: abnormal cardiac neural crest cell migration |
| WW domain | 0.2826 | INHERITED FROM: increased cardiomyocyte apoptosis |
| Tudor domain | 0.3358 | INHERITED FROM: abnormal male germ cell apoptosis |
| Toll/Interleukin receptor TIR domain | 0.3532 | INHERITED FROM: abnormal splenocyte proliferation || decreased neuron apoptosis |
| Glutathione peroxidase-like | 0.3649 | INHERITED FROM: abnormal redox activity || abnormal mitochondrial physiology || increased cellular sensitivity to hydrogen peroxide || increased cellular sensitivity to oxidative stress || increased sensitivity to induced cell death |
| Calponin-homology domain, CH-domain | 0.3666 | INHERITED FROM: abnormal cell adhesion |
| Nuclear receptor ligand-binding domain | 0.3712 | INHERITED FROM: abnormal cellular cholesterol metabolism |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.3973 | INHERITED FROM: decreased cell proliferation |
| Ras GEF | 0.421 | INHERITED FROM: abnormal cell adhesion |
| Integrin A (or I) domain | 0.5092 | INHERITED FROM: abnormal cell adhesion || abnormal leukocyte migration |
| Tandem AAA-ATPase domain | 0.5328 | INHERITED FROM: chromosome breakage |
| Arylsulfatase | 0.5575 | INHERITED FROM: abnormal lysosome physiology |
| DBL homology domain (DH-domain) | 0.5981 | INHERITED FROM: abnormal vascular endothelial cell migration |
| Ephrin receptor ligand binding domain | 0.6074 | INHERITED FROM: abnormal axon pruning || abnormal axon guidance |
| Histone deacetylase, HDAC | 0.661 | INHERITED FROM: abnormal fibroblast apoptosis || increased fibroblast apoptosis |
| DNA repair protein MutS, domain III | 0.661 | INHERITED FROM: abnormal DNA repair || abnormal mismatch repair |
| Fibronectin type III | 0.6659 | INHERITED FROM: increased granulosa cell apoptosis || abnormal axon guidance |
| ABC transporter ATPase domain-like | 0.6777 | INHERITED FROM: decreased cholesterol efflux || abnormal cellular cholesterol metabolism || abnormal mismatch repair |
| MAM domain | 0.6997 | INHERITED FROM: abnormal neuronal migration |
| Long-chain cytokines | 0.6997 | INHERITED FROM: abnormal osteoclast differentiation |
| SNARE fusion complex | 0.7561 | INHERITED FROM: abnormal axon extension |
| SAM (sterile alpha motif) domain | 0.8241 | INHERITED FROM: abnormal axon pruning || abnormal axon guidance |
| Fatty acid binding protein-like | 0.9412 | INHERITED FROM: abnormal cellular glucose import || abnormal muscle cell glucose uptake |
| Canonical RBD | 0.9519 | INHERITED FROM: premature neuronal precursor differentiation |
| Transforming growth factor (TGF)-beta | 0.9959 | INHERITED FROM: abnormal anterior visceral endoderm cell migration || abnormal interdigital cell death |
| C-type lectin domain | 1 | INHERITED FROM: impaired leukocyte tethering or rolling |
| Rhodopsin-like | 1 | INHERITED FROM: abnormal leukocyte migration |
| Complement control module/SCR domain | 1 | INHERITED FROM: abnormal leukocyte tethering or rolling || impaired leukocyte tethering or rolling |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Lamin A/C globular tail domain | 0 | Direct |
| Chromo barrel domain | 0 | Direct |
| Transcriptional factor tubby, C-terminal domain | 0 | Direct |
| DNA ligase/mRNA capping enzyme postcatalytic domain | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| p53 DNA-binding domain-like | 0 | Direct |
| The spindle assembly checkpoint protein mad2 | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| SCF ubiquitin ligase complex WHB domain | 0 | Direct |
| SMAD4-binding domain of oncoprotein Ski | 0 | Direct |
| RUNT domain | 0 | Direct |
| Polo-box duplicated region | 0 | Direct |
| Cullin homology domain | 0 | Direct |
| Extracellular domain of cell surface receptors | 0 | Direct |
| Rel/Dorsal transcription factors, DNA-binding domain | 0 | Direct |
| Other IPT/TIG domains | 0 | Direct |
| Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
| ATP-dependent DNA ligase catalytic domain | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | Direct |
| E2F dimerization segment | 0 | Direct |
| Retinoblastoma tumor suppressor domains | 0 | Direct |
| Cullin repeat | 0 | Direct |
| SRF-like | 0 | Direct |
| Cytochrome p450 reductase N-terminal domain-like | 0 | Direct |
| U-box | 0 | Direct |
| DEATH domain, DD | 0.00001174 | Direct |
| Integrin domains | 0.0001072 | Direct |
| Caspase catalytic domain | 0.0001641 | Direct |
| Caspase recruitment domain, CARD | 0.0003458 | Direct |
| Cell cycle transcription factor e2f-dp | 0.00093 | Direct |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.001539 | Inherited |
| Integrin beta EGF-like domains | 0.002172 | Inherited |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.002172 | Inherited |
| Erythroid transcription factor GATA-1 | 0.002172 | Inherited |
| Integrin alpha N-terminal domain | 0.002983 | Inherited |
| Integrin beta tail domain | 0.004988 | Inherited |
| Single strand DNA-binding domain, SSB | 0.004988 | Inherited |
| Plexin repeat | 0.00582 | Inherited |
| Ran binding protein zinc finger-like | 0.009034 | Inherited |
| UBA domain | 0.01616 | Inherited |
| NADPH-cytochrome p450 reductase-like | 0.0246 | Inherited |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.0246 | Inherited |
| STAT DNA-binding domain | 0.03706 | Inherited |
| Transcription factor STAT-4 N-domain | 0.03706 | Inherited |
| Sir2 family of transcriptional regulators | 0.03706 | Inherited |
| STAT | 0.03706 | Inherited |
| ets domain | 0.04207 | Inherited |
| Bcl-2 inhibitors of programmed cell death | 0.04389 | Inherited |
| C5 cytosine-specific DNA methylase, DCM | 0.05336 | Inherited |
| SH2 domain | 0.06676 | Inherited |
| Sema domain | 0.07177 | Inherited |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.07816 | Inherited |
| EGF-type module | 0.07972 | Inherited |
| Leucine zipper domain | 0.09295 | Inherited |
| Histone lysine methyltransferases | 0.0951 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.1024 | Inherited |
| RING finger domain, C3HC4 | 0.1193 | Inherited |
| Cell cycle control phosphatase, catalytic domain | 0.1294 | Inherited |
| DNA polymerase beta, N-terminal domain-like | 0.1342 | Inherited |
| C2 set domains | 0.1349 | Inherited |
| Homeodomain | 0.1701 | Inherited |
| Mitochondrial carrier | 0.1779 | Inherited |
| FHA domain | 0.1779 | Inherited |
| Forkhead DNA-binding domain | 0.1848 | Inherited |
| Nuclear receptor | 0.1963 | Inherited |
| Enabled/VASP homology 1 domain (EVH1 domain) | 0.2017 | Inherited |
| I set domains | 0.2089 | Inherited |
| Fibroblast growth factors (FGF) | 0.223 | Inherited |
| WW domain | 0.2826 | Inherited |
| Tudor domain | 0.3358 | Inherited |
| Toll/Interleukin receptor TIR domain | 0.3532 | Inherited |
| Glutathione peroxidase-like | 0.3649 | Inherited |
| Calponin-homology domain, CH-domain | 0.3666 | Inherited |
| Nuclear receptor ligand-binding domain | 0.3712 | Inherited |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.3973 | Inherited |
| Ras GEF | 0.421 | Inherited |
| Integrin A (or I) domain | 0.5092 | Inherited |
| Tandem AAA-ATPase domain | 0.5328 | Inherited |
| Arylsulfatase | 0.5575 | Inherited |
| DBL homology domain (DH-domain) | 0.5981 | Inherited |
| Ephrin receptor ligand binding domain | 0.6074 | Inherited |
| Histone deacetylase, HDAC | 0.661 | Inherited |
| DNA repair protein MutS, domain III | 0.661 | Inherited |
| Fibronectin type III | 0.6659 | Inherited |
| ABC transporter ATPase domain-like | 0.6777 | Inherited |
| MAM domain | 0.6997 | Inherited |
| Long-chain cytokines | 0.6997 | Inherited |
| SNARE fusion complex | 0.7561 | Inherited |
| SAM (sterile alpha motif) domain | 0.8241 | Inherited |
| Fatty acid binding protein-like | 0.9412 | Inherited |
| Canonical RBD | 0.9519 | Inherited |
| Transforming growth factor (TGF)-beta | 0.9959 | Inherited |
| C-type lectin domain | 1 | Inherited |
| Rhodopsin-like | 1 | Inherited |
| Complement control module/SCR domain | 1 | Inherited |
LINKTO: Domain2BO Download and Domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Single)( show details)
Highlighted in gray are those with FDR>0.001
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Duplex) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
56091,50249 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins | 0 | DIRECT |
47576,48065 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain) | 0 | DIRECT |
64593,74853 64593 - Intermediate filament protein, coiled coil region 74853 - Lamin A/C globular tail domain | 0 | DIRECT |
49417,81296 49417 - p53-like transcription factors 81296 - E set domains | 0 | DIRECT |
74788,75632 74788 - Cullin repeat-like 75632 - Cullin homology domain | 0 | DIRECT |
48726,82895 48726 - Immunoglobulin 82895 - TSP-1 type 1 repeat | 0 | DIRECT |
49417,47719 49417 - p53-like transcription factors 47719 - p53 tetramerization domain | 0 | DIRECT |
117018,56091 117018 - ATP-dependent DNA ligase DNA-binding domain 56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
47986,52129 47986 - DEATH domain 52129 - Caspase-like | 0 | DIRECT |
82615,82615 82615 - Polo-box domain 82615 - Polo-box domain | 0 | DIRECT |
75632,46785 75632 - Cullin homology domain 46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
46579,64593 46579 - Prefoldin 64593 - Intermediate filament protein, coiled coil region | 0 | DIRECT |
57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
46955,63763 46955 - Putative DNA-binding domain 63763 - SAND domain-like | 0 | DIRECT |
57196,57424 57196 - EGF/Laminin 57424 - LDL receptor-like module | 0 | DIRECT |
50249,50249 50249 - Nucleic acid-binding proteins 50249 - Nucleic acid-binding proteins | 0 | DIRECT |
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain | 0.00002404 | DIRECT |
63825,57196 63825 - YWTD domain 57196 - EGF/Laminin | 0.0007288 | DIRECT |
69318,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains | 0.001911 | INHERITED FROM: abnormal cellular extravasation || abnormal cell adhesion |
69179,69179 69179 - Integrin domains 69179 - Integrin domains | 0.001911 | INHERITED FROM: abnormal cellular extravasation || abnormal cell adhesion |
52113,52113 52113 - BRCT domain 52113 - BRCT domain | 0.004106 | INHERITED FROM: increased cellular sensitivity to ionizing radiation || abnormal chromosome stability || increased sensitivity to induced cell death || abnormal cell cycle || abnormal DNA repair || chromosome breakage || chromosomal instability |
53300,69179 53300 - vWA-like 69179 - Integrin domains | 0.004106 | INHERITED FROM: abnormal leukocyte migration |
46785,144074 46785 - "Winged helix" DNA-binding domain 144074 - E2F-DP heterodimerization region | 0.004106 | INHERITED FROM: abnormal cell cycle || decreased cell proliferation |
57196,69687 57196 - EGF/Laminin 69687 - Integrin beta tail domain | 0.004106 | INHERITED FROM: abnormal leukocyte migration |
57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like | 0.005024 | INHERITED FROM: decreased neuron apoptosis |
55550,55550 55550 - SH2 domain 55550 - SH2 domain | 0.0095 | INHERITED FROM: abnormal cell death || abnormal apoptosis |
49417,55550 49417 - p53-like transcription factors 55550 - SH2 domain | 0.03222 | INHERITED FROM: increased cell death || increased apoptosis || abnormal apoptosis || decreased cell proliferation |
48092,47655 48092 - Transcription factor STAT-4 N-domain 47655 - STAT | 0.03222 | INHERITED FROM: increased cell death || increased apoptosis || abnormal apoptosis || decreased cell proliferation |
47655,49417 47655 - STAT 49417 - p53-like transcription factors | 0.03222 | INHERITED FROM: increased cell death || increased apoptosis || abnormal apoptosis || decreased cell proliferation |
101912,103575 101912 - Sema domain 103575 - Plexin repeat | 0.05787 | INHERITED FROM: abnormal neuronal migration || abnormal cell migration |
50729,55550 50729 - PH domain-like 55550 - SH2 domain | 0.06396 | INHERITED FROM: abnormal cell differentiation |
53300,69318 53300 - vWA-like 69318 - Integrin alpha N-terminal domain | 0.06978 | INHERITED FROM: abnormal cell adhesion |
103575,48726 103575 - Plexin repeat 48726 - Immunoglobulin | 0.1146 | INHERITED FROM: abnormal neuronal migration || abnormal cell migration |
49785,49899 49785 - Galactose-binding domain-like 49899 - Concanavalin A-like lectins/glucanases | 0.1226 | INHERITED FROM: abnormal neuronal migration || abnormal cell migration |
57196,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases | 0.1247 | INHERITED FROM: abnormal axon guidance |
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.1323 | INHERITED FROM: abnormal cell adhesion |
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.2612 | INHERITED FROM: abnormal cell differentiation || increased granulosa cell apoptosis || decreased kidney cell proliferation || abnormal cell migration |
50729,50729 50729 - PH domain-like 50729 - PH domain-like | 0.3726 | INHERITED FROM: abnormal cellular glucose import |
47459,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) | 0.451 | INHERITED FROM: abnormal vascular regression |
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like | 0.4678 | INHERITED FROM: abnormal vascular endothelial cell migration |
56112,47769 56112 - Protein kinase-like (PK-like) 47769 - SAM/Pointed domain | 0.5903 | INHERITED FROM: abnormal axon guidance || abnormal axon pruning |
52058,57184 52058 - L domain-like 57184 - Growth factor receptor domain | 0.5903 | INHERITED FROM: abnormal neural crest cell migration |
57184,52058 57184 - Growth factor receptor domain 52058 - L domain-like | 0.5903 | INHERITED FROM: abnormal neural crest cell migration |
48334,52540 48334 - DNA repair protein MutS, domain III 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.6452 | INHERITED FROM: abnormal mismatch repair || abnormal DNA repair |
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.9687 | INHERITED FROM: increased cellular sensitivity to ionizing radiation |
57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain | 0.9976 | INHERITED FROM: abnormal leukocyte adhesion || impaired leukocyte tethering or rolling || abnormal leukocyte tethering or rolling || abnormal cellular extravasation |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
56091,50249 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins | 0 | Direct |
47576,48065 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain) | 0 | Direct |
64593,74853 64593 - Intermediate filament protein, coiled coil region 74853 - Lamin A/C globular tail domain | 0 | Direct |
49417,81296 49417 - p53-like transcription factors 81296 - E set domains | 0 | Direct |
74788,75632 74788 - Cullin repeat-like 75632 - Cullin homology domain | 0 | Direct |
48726,82895 48726 - Immunoglobulin 82895 - TSP-1 type 1 repeat | 0 | Direct |
49417,47719 49417 - p53-like transcription factors 47719 - p53 tetramerization domain | 0 | Direct |
117018,56091 117018 - ATP-dependent DNA ligase DNA-binding domain 56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
47986,52129 47986 - DEATH domain 52129 - Caspase-like | 0 | Direct |
82615,82615 82615 - Polo-box domain 82615 - Polo-box domain | 0 | Direct |
75632,46785 75632 - Cullin homology domain 46785 - "Winged helix" DNA-binding domain | 0 | Direct |
46579,64593 46579 - Prefoldin 64593 - Intermediate filament protein, coiled coil region | 0 | Direct |
57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
46955,63763 46955 - Putative DNA-binding domain 63763 - SAND domain-like | 0 | Direct |
57196,57424 57196 - EGF/Laminin 57424 - LDL receptor-like module | 0 | Direct |
50249,50249 50249 - Nucleic acid-binding proteins 50249 - Nucleic acid-binding proteins | 0 | Direct |
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain | 0.00002404 | Direct |
63825,57196 63825 - YWTD domain 57196 - EGF/Laminin | 0.0007288 | Direct |
69318,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains | 0.001911 | Inherited |
69179,69179 69179 - Integrin domains 69179 - Integrin domains | 0.001911 | Inherited |
52113,52113 52113 - BRCT domain 52113 - BRCT domain | 0.004106 | Inherited |
53300,69179 53300 - vWA-like 69179 - Integrin domains | 0.004106 | Inherited |
46785,144074 46785 - "Winged helix" DNA-binding domain 144074 - E2F-DP heterodimerization region | 0.004106 | Inherited |
57196,69687 57196 - EGF/Laminin 69687 - Integrin beta tail domain | 0.004106 | Inherited |
57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like | 0.005024 | Inherited |
55550,55550 55550 - SH2 domain 55550 - SH2 domain | 0.0095 | Inherited |
49417,55550 49417 - p53-like transcription factors 55550 - SH2 domain | 0.03222 | Inherited |
48092,47655 48092 - Transcription factor STAT-4 N-domain 47655 - STAT | 0.03222 | Inherited |
47655,49417 47655 - STAT 49417 - p53-like transcription factors | 0.03222 | Inherited |
101912,103575 101912 - Sema domain 103575 - Plexin repeat | 0.05787 | Inherited |
50729,55550 50729 - PH domain-like 55550 - SH2 domain | 0.06396 | Inherited |
53300,69318 53300 - vWA-like 69318 - Integrin alpha N-terminal domain | 0.06978 | Inherited |
103575,48726 103575 - Plexin repeat 48726 - Immunoglobulin | 0.1146 | Inherited |
49785,49899 49785 - Galactose-binding domain-like 49899 - Concanavalin A-like lectins/glucanases | 0.1226 | Inherited |
57196,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases | 0.1247 | Inherited |
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.1323 | Inherited |
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.2612 | Inherited |
50729,50729 50729 - PH domain-like 50729 - PH domain-like | 0.3726 | Inherited |
47459,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) | 0.451 | Inherited |
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like | 0.4678 | Inherited |
56112,47769 56112 - Protein kinase-like (PK-like) 47769 - SAM/Pointed domain | 0.5903 | Inherited |
52058,57184 52058 - L domain-like 57184 - Growth factor receptor domain | 0.5903 | Inherited |
57184,52058 57184 - Growth factor receptor domain 52058 - L domain-like | 0.5903 | Inherited |
48334,52540 48334 - DNA repair protein MutS, domain III 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.6452 | Inherited |
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.9687 | Inherited |
57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain | 0.9976 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Triple) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
117018,56091,50249 117018 - ATP-dependent DNA ligase DNA-binding domain 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins | 0 | DIRECT |
75399,75399,75399 75399 - Plakin repeat 75399 - Plakin repeat 75399 - Plakin repeat | 0 | DIRECT |
63825,57196,57424 63825 - YWTD domain 57196 - EGF/Laminin 57424 - LDL receptor-like module | 0 | DIRECT |
48726,48726,82895 48726 - Immunoglobulin 48726 - Immunoglobulin 82895 - TSP-1 type 1 repeat | 0 | DIRECT |
47576,48065,50729 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like | 0 | DIRECT |
57924,57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
57850,49599,49599 57850 - RING/U-box 49599 - TRAF domain-like 49599 - TRAF domain-like | 0 | DIRECT |
74788,75632,46785 74788 - Cullin repeat-like 75632 - Cullin homology domain 46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
57184,52058,57184 57184 - Growth factor receptor domain 52058 - L domain-like 57184 - Growth factor receptor domain | 0 | DIRECT |
57196,57424,57424 57196 - EGF/Laminin 57424 - LDL receptor-like module 57424 - LDL receptor-like module | 0 | DIRECT |
48726,82895,82895 48726 - Immunoglobulin 82895 - TSP-1 type 1 repeat 82895 - TSP-1 type 1 repeat | 0 | DIRECT |
69179,69179,69179 69179 - Integrin domains 69179 - Integrin domains 69179 - Integrin domains | 0.001559 | INHERITED FROM: abnormal cellular extravasation || abnormal cell adhesion |
69318,69179,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains 69179 - Integrin domains | 0.001911 | INHERITED FROM: abnormal cellular extravasation || abnormal cell adhesion |
57196,57196,69687 57196 - EGF/Laminin 57196 - EGF/Laminin 69687 - Integrin beta tail domain | 0.004106 | INHERITED FROM: abnormal leukocyte migration |
48092,47655,49417 48092 - Transcription factor STAT-4 N-domain 47655 - STAT 49417 - p53-like transcription factors | 0.03222 | INHERITED FROM: increased cell death || increased apoptosis || abnormal apoptosis || decreased cell proliferation |
47655,49417,55550 47655 - STAT 49417 - p53-like transcription factors 55550 - SH2 domain | 0.03222 | INHERITED FROM: increased cell death || increased apoptosis || abnormal apoptosis || decreased cell proliferation |
55550,56112,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) 56112 - Protein kinase-like (PK-like) | 0.04793 | INHERITED FROM: abnormal cell differentiation |
50729,55550,56112 50729 - PH domain-like 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) | 0.04793 | INHERITED FROM: abnormal cell differentiation |
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.04913 | INHERITED FROM: abnormal neuron differentiation |
53300,69318,69179 53300 - vWA-like 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains | 0.06978 | INHERITED FROM: abnormal cell adhesion |
101912,103575,48726 101912 - Sema domain 103575 - Plexin repeat 48726 - Immunoglobulin | 0.1146 | INHERITED FROM: abnormal neuronal migration || abnormal cell migration |
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.1511 | INHERITED FROM: abnormal kidney cell proliferation || abnormal cell differentiation || decreased kidney cell proliferation |
57667,57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.5439 | INHERITED FROM: abnormal neuron proliferation |
52058,57184,52058 52058 - L domain-like 57184 - Growth factor receptor domain 52058 - L domain-like | 0.5903 | INHERITED FROM: abnormal neural crest cell migration |
47459,55785,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain) | 0.7048 | INHERITED FROM: decreased cell death || decreased apoptosis |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
117018,56091,50249 117018 - ATP-dependent DNA ligase DNA-binding domain 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins | 0 | Direct |
75399,75399,75399 75399 - Plakin repeat 75399 - Plakin repeat 75399 - Plakin repeat | 0 | Direct |
63825,57196,57424 63825 - YWTD domain 57196 - EGF/Laminin 57424 - LDL receptor-like module | 0 | Direct |
48726,48726,82895 48726 - Immunoglobulin 48726 - Immunoglobulin 82895 - TSP-1 type 1 repeat | 0 | Direct |
47576,48065,50729 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like | 0 | Direct |
57924,57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
57850,49599,49599 57850 - RING/U-box 49599 - TRAF domain-like 49599 - TRAF domain-like | 0 | Direct |
74788,75632,46785 74788 - Cullin repeat-like 75632 - Cullin homology domain 46785 - "Winged helix" DNA-binding domain | 0 | Direct |
57184,52058,57184 57184 - Growth factor receptor domain 52058 - L domain-like 57184 - Growth factor receptor domain | 0 | Direct |
57196,57424,57424 57196 - EGF/Laminin 57424 - LDL receptor-like module 57424 - LDL receptor-like module | 0 | Direct |
48726,82895,82895 48726 - Immunoglobulin 82895 - TSP-1 type 1 repeat 82895 - TSP-1 type 1 repeat | 0 | Direct |
69179,69179,69179 69179 - Integrin domains 69179 - Integrin domains 69179 - Integrin domains | 0.001559 | Inherited |
69318,69179,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains 69179 - Integrin domains | 0.001911 | Inherited |
57196,57196,69687 57196 - EGF/Laminin 57196 - EGF/Laminin 69687 - Integrin beta tail domain | 0.004106 | Inherited |
48092,47655,49417 48092 - Transcription factor STAT-4 N-domain 47655 - STAT 49417 - p53-like transcription factors | 0.03222 | Inherited |
47655,49417,55550 47655 - STAT 49417 - p53-like transcription factors 55550 - SH2 domain | 0.03222 | Inherited |
55550,56112,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) 56112 - Protein kinase-like (PK-like) | 0.04793 | Inherited |
50729,55550,56112 50729 - PH domain-like 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) | 0.04793 | Inherited |
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.04913 | Inherited |
53300,69318,69179 53300 - vWA-like 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains | 0.06978 | Inherited |
101912,103575,48726 101912 - Sema domain 103575 - Plexin repeat 48726 - Immunoglobulin | 0.1146 | Inherited |
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.1511 | Inherited |
57667,57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.5439 | Inherited |
52058,57184,52058 52058 - L domain-like 57184 - Growth factor receptor domain 52058 - L domain-like | 0.5903 | Inherited |
47459,55785,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain) | 0.7048 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Plot distribution on species Tree Of Life (sTOL) for Superfamily and/or Family domains annotated by this MP term
 |
Plot tree as:
| |
Download Newick format tree:
|
( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Plot distribution on species Tree Of Life (sTOL) for single supra-domains annotated by this MP term
 |
Plot tree as:
| |
Download Newick format tree:
| |
Browsing in TREE OF LIFE:
|
( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|
  
|