Enzyme Commission (EC): RING-type E3 ubiquitin transferase 

Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children)	EC term [EC ID] <#Children>	#Domains (Superfamily|Family)	#Supra-domain (Single|Duplex|Triple)
+ + + + 4:	root [root] <7>
+ + + 3:	Transferases [2] <10>	(445|680)	(444|535|275)
+ + 2:	Acyltransferases [2.3] <3>	(128|157)	(128|116|43)
+ 1:	Aminoacyltransferases [2.3.2] <32>	(61|69)	(61|65|22)
0:	RING-type E3 ubiquitin transferase [2.3.2.27]	(37|41)	(37|45|14)

Superfamily

Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
SAP domain	0	DIRECT
PA domain	0	DIRECT
Concanavalin A-like lectins/glucanases	0	DIRECT
ClpS-like	0	DIRECT
B-box zinc-binding domain	0	DIRECT
Trimerization domain of TRAF	0	DIRECT
SMAD/FHA domain	0	DIRECT
TRAF domain-like	0	DIRECT
beta-beta-alpha zinc fingers	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
NRDP1 C-terminal domain-like	0	DIRECT
Zinc hairpin stack	0	DIRECT
NHL repeat	0	DIRECT
N-terminal domain of cbl (N-cbl)	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
RING/U-box	0	DIRECT
CCCH zinc finger	0	DIRECT
CHY zinc finger-like	0	DIRECT
vWA-like	0.000000000001957	DIRECT
SH3-domain	0.0000000000245	DIRECT
L domain-like	0.0000000007957	DIRECT
Fibronectin type III	0.0000000009625	DIRECT
SH2 domain	0.000000001114	DIRECT
Cyclophilin-like	0.0000000167	DIRECT
Bromodomain	0.0000000288	DIRECT
FYVE/PHD zinc finger	0.00000004925	DIRECT
Formin homology 2 domain (FH2 domain)	0.00000009911	DIRECT
WD40 repeat-like	0.0000001316	DIRECT
EF-hand	0.0000002822	DIRECT
Second domain of FERM	0.0000003078	DIRECT
DEATH domain	0.00000212	DIRECT
TPR-like	0.000004521	DIRECT
PDZ domain-like	0.0000152	DIRECT
ARM repeat	0.0000317	DIRECT
BRCT domain	0.0006102	DIRECT
RNA-binding domain, RBD	0.0006119	DIRECT
PUA domain-like	0.0006178	DIRECT

Family

Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Trimerization domain of TRAF	0	DIRECT
FYVE, a phosphatidylinositol-3-phosphate binding domain	0	DIRECT
SPRY domain	0	DIRECT
FHA domain	0	DIRECT
Filamin repeat (rod domain)	0	DIRECT
BRCT domain	0	DIRECT
CCCH zinc finger	0	DIRECT
Classic zinc finger, C2H2	0	DIRECT
SAP domain	0	DIRECT
Variant RING domain	0	DIRECT
Zinc hairpin stack	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
CHY zinc finger	0	DIRECT
U-box	0	DIRECT
NHL repeat	0	DIRECT
N-terminal domain of cbl (N-cbl)	0	DIRECT
ZZ domain	0	DIRECT
SIAH, seven in absentia homolog	0	DIRECT
SRA domain-like	0	DIRECT
B-box zinc-binding domain	0	DIRECT
MATH domain	0	DIRECT
USP8 interacting domain	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
RING finger domain, C3HC4	0	DIRECT
Leucine rich effector protein YopM	5.532e-16	DIRECT
EF-hand modules in multidomain proteins	0.000000000000001101	DIRECT
PA domain	0.0000000000006633	DIRECT
SH3-domain	0.000000000001107	DIRECT
PDZ domain	0.00000000004584	DIRECT
Fibronectin type III	0.00000000004736	DIRECT
SH2 domain	0.00000000006084	DIRECT
Cyclophilin (peptidylprolyl isomerase)	0.0000000005308	DIRECT
First domain of FERM	0.000000003343	DIRECT
Bromodomain	0.00000000522	DIRECT
Third domain of FERM	0.000000005763	DIRECT
Tetratricopeptide repeat (TPR)	0.00000003347	DIRECT
Second domain of FERM	0.00000005883	DIRECT
RWD domain	0.0000003729	DIRECT
WD40-repeat	0.000004799	DIRECT
Caspase recruitment domain, CARD	0.00001755	DIRECT
PHD domain	0.00004541	DIRECT

Supra-domain (Single|Duplex|Triple)

Supra-domain (Single)

Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
N-terminal domain of cbl (N-cbl)	0	DIRECT
Trimerization domain of TRAF	0	DIRECT
TRAF domain-like	0	DIRECT
CHY zinc finger-like	0	DIRECT
SAP domain	0	DIRECT
RING/U-box	0	DIRECT
Zinc hairpin stack	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
NHL repeat	0	DIRECT
CCCH zinc finger	0	DIRECT
NRDP1 C-terminal domain-like	0	DIRECT
SMAD/FHA domain	0	DIRECT
Concanavalin A-like lectins/glucanases	0	DIRECT
SWIB/MDM2 domain	0	DIRECT
beta-beta-alpha zinc fingers	0	DIRECT
ClpS-like	0	DIRECT
B-box zinc-binding domain	0	DIRECT
PA domain	0	DIRECT
vWA-like	0.000000000001408	DIRECT
SH3-domain	0.00000000001783	DIRECT
L domain-like	0.0000000005913	DIRECT
Fibronectin type III	0.0000000007161	DIRECT
SH2 domain	0.0000000008299	DIRECT
Cyclophilin-like	0.00000001263	DIRECT
Bromodomain	0.00000002187	DIRECT
FYVE/PHD zinc finger	0.0000000375	DIRECT
Formin homology 2 domain (FH2 domain)	0.0000000757	DIRECT
WD40 repeat-like	0.0000001008	DIRECT
EF-hand	0.0000002172	DIRECT
Second domain of FERM	0.0000002372	DIRECT
DEATH domain	0.000001662	DIRECT
TPR-like	0.000003553	DIRECT
PDZ domain-like	0.00001207	DIRECT
ARM repeat	0.00002529	DIRECT
BRCT domain	0.0005002	DIRECT
RNA-binding domain, RBD	0.0005017	DIRECT
PUA domain-like	0.0005066	DIRECT

Supra-domain (Duplex) in N- to C-terminal order

Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
117839,117839 117839 - WWE domain 117839 - WWE domain	0	DIRECT
55550,57850 55550 - SH2 domain 57850 - RING/U-box	0	DIRECT
57850,57667 57850 - RING/U-box 57667 - beta-beta-alpha zinc fingers	0	DIRECT
81296,101898 81296 - E set domains 101898 - NHL repeat	0	DIRECT
90229,90229 90229 - CCCH zinc finger 90229 - CCCH zinc finger	0	DIRECT
49265,49899 49265 - Fibronectin type III 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
161219,161245 161219 - CHY zinc finger-like 161245 - Zinc hairpin stack	0	DIRECT
50044,50044 50044 - SH3-domain 50044 - SH3-domain	0	DIRECT
57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat	0	DIRECT
52025,57850 52025 - PA domain 57850 - RING/U-box	0	DIRECT
48403,52113 48403 - Ankyrin repeat 52113 - BRCT domain	0	DIRECT
57850,159034 57850 - RING/U-box 159034 - Mib/herc2 domain-like	0	DIRECT
57850,52540 57850 - RING/U-box 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
53300,57850 53300 - vWA-like 57850 - RING/U-box	0	DIRECT
47473,55550 47473 - EF-hand 55550 - SH2 domain	0	DIRECT
49599,57953 49599 - TRAF domain-like 57953 - Trimerization domain of TRAF	0	DIRECT
48452,57850 48452 - TPR-like 57850 - RING/U-box	0	DIRECT
90229,57850 90229 - CCCH zinc finger 57850 - RING/U-box	0	DIRECT
57903,57850 57903 - FYVE/PHD zinc finger 57850 - RING/U-box	0	DIRECT
49879,57850 49879 - SMAD/FHA domain 57850 - RING/U-box	0	DIRECT
49599,49599 49599 - TRAF domain-like 49599 - TRAF domain-like	0	DIRECT
52113,52113 52113 - BRCT domain 52113 - BRCT domain	0	DIRECT
57850,48371 57850 - RING/U-box 48371 - ARM repeat	0	DIRECT
56112,57850 56112 - Protein kinase-like (PK-like) 57850 - RING/U-box	0	DIRECT
49599,50156 49599 - TRAF domain-like 50156 - PDZ domain-like	0	DIRECT
47592,90209 47592 - SWIB/MDM2 domain 90209 - Ran binding protein zinc finger-like	0	DIRECT
49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
49599,160088 49599 - TRAF domain-like 160088 - NRDP1 C-terminal domain-like	0	DIRECT
57850,49599 57850 - RING/U-box 49599 - TRAF domain-like	0	DIRECT
161245,57850 161245 - Zinc hairpin stack 57850 - RING/U-box	0	DIRECT
57850,101898 57850 - RING/U-box 101898 - NHL repeat	0	DIRECT
57850,57845 57850 - RING/U-box 57845 - B-box zinc-binding domain	0	DIRECT
57850,117839 57850 - RING/U-box 117839 - WWE domain	0	DIRECT
57850,50978 57850 - RING/U-box 50978 - WD40 repeat-like	0	DIRECT
48403,57850 48403 - Ankyrin repeat 57850 - RING/U-box	0	DIRECT
68906,57850 68906 - SAP domain 57850 - RING/U-box	0	DIRECT
57953,49599 57953 - Trimerization domain of TRAF 49599 - TRAF domain-like	0	DIRECT
159034,57850 159034 - Mib/herc2 domain-like 57850 - RING/U-box	0	DIRECT
47668,47473 47668 - N-terminal domain of cbl (N-cbl) 47473 - EF-hand	0	DIRECT
57903,47370 57903 - FYVE/PHD zinc finger 47370 - Bromodomain	0.000000000000007509	DIRECT
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers	0.0000000000001388	DIRECT
48371,48371 48371 - ARM repeat 48371 - ARM repeat	0.0000000009059	DIRECT
54236,47031 54236 - Ubiquitin-like 47031 - Second domain of FERM	0.0000000199	DIRECT
47031,50729 47031 - Second domain of FERM 50729 - PH domain-like	0.00000007867	DIRECT
48452,48452 48452 - TPR-like 48452 - TPR-like	0.00000105	DIRECT

Supra-domain (Triple) in N- to C-terminal order

Highlighted in gray are those with FDR>0.001

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
49599,49599,49599 49599 - TRAF domain-like 49599 - TRAF domain-like 49599 - TRAF domain-like	0	DIRECT
57850,49599,49599 57850 - RING/U-box 49599 - TRAF domain-like 49599 - TRAF domain-like	0	DIRECT
49599,57953,49599 49599 - TRAF domain-like 57953 - Trimerization domain of TRAF 49599 - TRAF domain-like	0	DIRECT
47473,55550,57850 47473 - EF-hand 55550 - SH2 domain 57850 - RING/U-box	0	DIRECT
161219,161245,57850 161219 - CHY zinc finger-like 161245 - Zinc hairpin stack 57850 - RING/U-box	0	DIRECT
48403,52113,52113 48403 - Ankyrin repeat 52113 - BRCT domain 52113 - BRCT domain	0	DIRECT
57850,49599,50156 57850 - RING/U-box 49599 - TRAF domain-like 50156 - PDZ domain-like	0	DIRECT
159034,57850,159034 159034 - Mib/herc2 domain-like 57850 - RING/U-box 159034 - Mib/herc2 domain-like	0	DIRECT
57924,57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat	0	DIRECT
57667,57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers	0	DIRECT
47668,47473,55550 47668 - N-terminal domain of cbl (N-cbl) 47473 - EF-hand 55550 - SH2 domain	0	DIRECT
57850,49599,160088 57850 - RING/U-box 49599 - TRAF domain-like 160088 - NRDP1 C-terminal domain-like	0	DIRECT
57850,48371,48371 57850 - RING/U-box 48371 - ARM repeat 48371 - ARM repeat	0	DIRECT
54236,47031,50729 54236 - Ubiquitin-like 47031 - Second domain of FERM 50729 - PH domain-like	0.0000000199	DIRECT