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CTD Chemicals (CC): Cycloparaffins 
(show info)
Biomedical Ontology
Like Gene Ontology (GO), biomedical ontology such as phenotype ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Biomedical ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI’s thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology Based on YP which is the major contributor to the ‘Ascomycete phenotype ontology’, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- UniProtKB KeyWords (KW) Ontology Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- CTD Diseases (CD) Ontology CD is MEDIC disease vocabulary that is modified by CTD from the "Diseases" [C] branch of Medical Subject Headings (MeSH), combined with genetic disorders from the Online Mendelian Inheritance in OMIM database.
- CTD Chemicals (CC) Ontology CC is chemical vocabulary that is adapted by CTD from the "Chemicals and Drugs" category and Supplementary Concept Records of Medical Subject Headings (MeSH, a hierarchical vocabulary used to index articles for MEDLINE/PubMed).
Jump to [ Top · Hierarchy · Annotations ]
Root: CC Hierarchy (CTD chemicals from Comparative Toxicogenomics Database)
| Shortest distance to current term (+ for parents, - for children) |
CC term [CC ID] <#Children> |
#Domains (Superfamily|Family) |
#Supra-domain (Single|Duplex|Triple) |
| + + + + 4: | Organic Chemicals [MESH:D009930] <621> | (617|829) |
(620|532|254) |
| + + + 3: | Chemicals [MESH:D] <13> |
| + + + 3: | Hydrocarbons [MESH:D006838] <35> | (468|641) |
(485|436|221) |
| + + 2: | Polycyclic Compounds [MESH:D011083] <191> | (419|579) |
(431|390|204) |
| + + 2: | Hydrocarbons, Cyclic [MESH:D006844] <11> | (425|591) |
(443|416|217) |
| + 1: | Hydrocarbons, Alicyclic [MESH:D006840] <3> | (114|125) |
(121|74|36) |
| + 1: | Macrocyclic Compounds [MESH:D047028] <111> | (186|253) |
(192|153|75) |
| 0: | Cycloparaffins [MESH:D003516] <36> | (113|125) |
(120|74|36) |
| - 1: | Cyclopentanes [MESH:D003517] <444> | (14|14) |
(15|6|2) |
| - 1: | Cyclohexanes [MESH:D003510] <320> | (90|101) |
(94|54|24) |
| - 1: | Adamantane [MESH:D000218] <304> | (12|7) |
(13|4|2) |
| - 1: | Cyclopropanes [MESH:D003521] <249> | (3|3) |
(3|0|0) |
| - 1: | Cyclobutanes [MESH:D003503] <156> | (1|1) |
(1|0|0) |
| - 1: | Cyclooctanes [MESH:D034242] <79> | (0|0) |
(0|0|0) |
| - 1: | Cycloheptanes [MESH:D003508] <76> | (15|18) |
(20|9|4) |
| - 1: | Cyclitols [MESH:D054812] <6> | (0|0) |
(0|0|0) |
| - 1: | Cyclodecanes [MESH:D043822] <5> | (19|25) |
(20|17|11) |
| - 1: | 1,2-bis(methyldioxy)cyclododecane [MESH:C452426] | (0|0) |
(0|0|0) |
| - 1: | 1,5,9-trinitrobishomopentaprismane [MESH:C073240] | (0|0) |
(0|0|0) |
| - 1: | 1,7,9-trioxadispiro(5.1.5.3)hexadecane [MESH:C516985] | (0|0) |
(0|0|0) |
| - 1: | 1893A compound [MESH:C496106] | (0|0) |
(0|0|0) |
| - 1: | 1893B compound [MESH:C515286] | (0|0) |
(0|0|0) |
| - 1: | 2,8-dibenzylcyclooctanone [MESH:C010107] | (0|0) |
(0|0|0) |
| - 1: | 2-(hydroxymethyl)-12-methylenecyclododecanone [MESH:C000588855] | (0|0) |
(0|0|0) |
| - 1: | 5,6,11,12,17,18,23,24-octahydrocyclododeca(1,2-b-4,5-b'-7,8-b'-10,11-b'')tetraindole [MESH:C000605990] | (0|0) |
(0|0|0) |
| - 1: | 5-(3-dimethylamino-2-methylpropyl)dibenzo(a,d), (1,4)cyclooctadiene.HCl [MESH:C010928] | (0|0) |
(0|0|0) |
| - 1: | 6-cycloparaphenilacetylene [MESH:C516386] | (0|0) |
(0|0|0) |
| - 1: | O,O-diphenyl-N-cyclooctyl phosphoramidate [MESH:C119921] | (0|0) |
(0|0|0) |
| - 1: | civetone [MESH:C056157] | (0|0) |
(0|0|0) |
| - 1: | cooliatin [MESH:C543296] | (0|0) |
(0|0|0) |
| - 1: | cycloundecanone [MESH:C423469] | (0|0) |
(0|0|0) |
| - 1: | dactylol [MESH:C555280] | (0|0) |
(0|0|0) |
| - 1: | dezocine glucuronide [MESH:C029336] | (0|0) |
(0|0|0) |
| - 1: | epoxyethylcyclooctane [MESH:C040532] | (0|0) |
(0|0|0) |
| - 1: | grandlure [MESH:C011834] | (0|0) |
(0|0|0) |
| - 1: | isoteucladiol [MESH:C555281] | (0|0) |
(0|0|0) |
| - 1: | kedarcidin chromophore [MESH:C080542] | (0|0) |
(0|0|0) |
| - 1: | methyl 2,7-dinitropentacyclo-(4.2.0,0(2,5).0(3,8).0(4,7))octane-1-carboxylate [MESH:C084281] | (0|0) |
(0|0|0) |
| - 1: | methylcyclopentadiene [MESH:C028692] | (0|0) |
(0|0|0) |
| - 1: | muscone [MESH:C031021] | (0|0) |
(0|0|0) |
| - 1: | periplanone C [MESH:C496155] | (0|0) |
(0|0|0) |
| - 1: | poitediol [MESH:C546806] | (0|0) |
(0|0|0) |
| - 1: | poly(1,7-bis(mercaptoacetyl)-1,4,7,10-tetraazacyclododecane) [MESH:C542857] | (0|0) |
(0|0|0) |
| - 1: | poly-para-phenylene [MESH:C509547] | (0|0) |
(0|0|0) |
Jump to [ Top · Hierarchy ]
Superfamily( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| BAG domain | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | DIRECT |
| Di-copper centre-containing domain | 0 | DIRECT |
| Alpha-L RNA-binding motif | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| MOSC N-terminal domain-like | 0 | DIRECT |
| P-domain of calnexin/calreticulin | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Nicotinate/Quinolinate PRTase C-terminal domain-like | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| Rudiment single hybrid motif | 0 | DIRECT |
| Alanine racemase C-terminal domain-like | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | DIRECT |
| PK beta-barrel domain-like | 0 | DIRECT |
| 4Fe-4S ferredoxins | 0 | DIRECT |
| A heparin-binding domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| S15/NS1 RNA-binding domain | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| Bcl-2 inhibitors of programmed cell death | 0.000009012 | DIRECT |
| DEATH domain | 0.00002419 | DIRECT |
| Nuclear receptor ligand-binding domain | 0.0002014 | DIRECT |
| EGF/Laminin | 0.0004745 | DIRECT |
| Fibronectin type III | 0.0008046 | DIRECT |
| TNF receptor-like | 0.001294 | INHERITED FROM: Paclitaxel || 4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid || Cyclohexane Monoterpenes || Cyclohexanols || Menthol || Cyclohexanes |
| ABC transporter transmembrane region | 0.001294 | INHERITED FROM: Taxoids || Cyclodecanes || Docetaxel |
| Thyroglobulin type-1 domain | 0.001771 | INHERITED FROM: Paclitaxel || Cyclohexenes || Vitamin A || Menthol || Tretinoin || Retinoids |
| Growth factor receptor domain | 0.001859 | INHERITED FROM: Paclitaxel |
| Frizzled cysteine-rich domain | 0.003704 | INHERITED FROM: Vitamin A || Tretinoin || Cyclohexanes |
| SH2 domain | 0.004163 | INHERITED FROM: 4-acetylantroquinonol B || Cyclohexanones |
| Caspase-like | 0.004452 | INHERITED FROM: Taxoids || dehydroxymethylepoxyquinomicin || Ketamine || Fenretinide || Cycloheptanes || Cyclohexane Monoterpenes || Xanthophylls || Cyclopentanes || NSC 680410 || Cyclohexanecarboxylic Acids || Cyclohexanols || Cyclodecanes || Menthol || Pyrethrins || Cyclohexanes || CD 437 || Amantadine || methyl 5-chloro-4,5-didehydrojasmonate || cypermethrin || Sesquiterpenes, Guaiane || Acitretin || Cyclohexanones |
| PGBD-like | 0.006997 | INHERITED FROM: Paclitaxel || 3-caffeoyl-4-dihydrocaffeoylquinic acid || Cyclohexanecarboxylic Acids || Chlorogenic Acid || Cyclodecanes |
| Metalloproteases ("zincins"), catalytic domain | 0.007437 | INHERITED FROM: 3-caffeoyl-4-dihydrocaffeoylquinic acid |
| E2F-DP heterodimerization region | 0.01115 | INHERITED FROM: Paclitaxel || Cyclohexane Monoterpenes || Cyclohexanols || Menthol |
| BTG domain-like | 0.01324 | INHERITED FROM: LG 100815 |
| Cytochrome P450 | 0.01429 | INHERITED FROM: 4-hydroxyretinoic acid || Limonene || 4,4'-cyclohexylidenebisphenol || cyhalothrin || Cyclopentanes || decamethrin || Eucalyptol || 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid || 4-oxoretinoic acid || fenvalerate || 2-methyl-5-isopropenylcyclohex-2-enone oxime || Permethrin || Cyclobutanes || Pyrethrins || Cyclopentane Monoterpenes || sibutramine || Alitretinoin |
| Leucine zipper domain | 0.01527 | INHERITED FROM: Cyclohexenes || Cycloheptanes || Thapsigargin || Retinoids || diphenylcyclopropenone || Sesquiterpenes, Guaiane |
| HD-domain/PDEase-like | 0.02313 | INHERITED FROM: Roflumilast || Cilomilast || Cyclohexanecarboxylic Acids || Cyclopropanes |
| ALDH-like | 0.0325 | INHERITED FROM: Retinaldehyde || apocarotenal |
| A DNA-binding domain in eukaryotic transcription factors | 0.03254 | INHERITED FROM: Vitamin A || Tretinoin |
| GST C-terminal domain-like | 0.03412 | INHERITED FROM: beta Carotene || apple polyphenol extract || apocarotenal |
| 4-helical cytokines | 0.03474 | INHERITED FROM: helenalin || Cilomilast || Cyclohexanecarboxylic Acids || apocarotenal || Alitretinoin |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.03967 | INHERITED FROM: aurin || Cyclohexanecarboxylic Acids |
| Aminoacid dehydrogenase-like, N-terminal domain | 0.03967 | INHERITED FROM: Vitamin A || Tretinoin |
| ClpP/crotonase | 0.04532 | INHERITED FROM: Isotretinoin |
| p53-like transcription factors | 0.0573 | INHERITED FROM: pevonedistat || Cyclopentanes || Cyclohexanones |
| Zn-binding ribosomal proteins | 0.06002 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane || CD 437 |
| Integrin domains | 0.06306 | INHERITED FROM: Cyclohexenes || Retinoids |
| BPTI-like | 0.06595 | INHERITED FROM: Paclitaxel || Cyclodecanes |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.07493 | INHERITED FROM: 9-cis-retinal || phenothrin || Ciclopirox || 4-hydroxyretinoic acid || diisononyl 1,2-cyclohexanedicarboxylic acid || Fenretinide || cyhalothrin || Cyclopentanes || beta Carotene || Cyclohexanecarboxylic Acids || Retinaldehyde || 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid || fenvalerate || SR 11237 || Permethrin || Pyrethrins || 1,1-bis(4-hydroxyphenyl)cyclohexane || Bexarotene || 4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid || Cyclopentane Monoterpenes || Alitretinoin |
| Interleukin 8-like chemokines | 0.08613 | INHERITED FROM: pevonedistat || Roflumilast || roflumilast N-oxide || beta Carotene || Cyclopropanes || 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol |
| Single hybrid motif | 0.09398 | INHERITED FROM: Isotretinoin |
| Hemopexin-like domain | 0.09811 | INHERITED FROM: Paclitaxel || 3-caffeoyl-4-dihydrocaffeoylquinic acid || Chlorogenic Acid || Cyclodecanes |
| CAD & PB1 domains | 0.1151 | INHERITED FROM: Cyclohexane Monoterpenes || Cyclohexanols || Menthol |
| Intermediate filament protein, coiled coil region | 0.1298 | INHERITED FROM: ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid || beta Carotene || 4-oxoretinol || 4-oxoretinoic acid || Isotretinoin || Alitretinoin |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.1307 | INHERITED FROM: aurin || Cyclohexanecarboxylic Acids |
| NAD(P)-linked oxidoreductase | 0.1533 | INHERITED FROM: 9-cis-retinal || cyclopentanol || Retinaldehyde || cyclopentanone |
| TK C-terminal domain-like | 0.1746 | INHERITED FROM: Isotretinoin |
| Nucleoside diphosphate kinase, NDK | 0.1747 | INHERITED FROM: Cyclohexane Monoterpenes || Menthol |
| CoA-dependent acyltransferases | 0.1787 | INHERITED FROM: Isotretinoin |
| Ferritin-like | 0.1943 | INHERITED FROM: Paclitaxel || Cyclodecanes |
| Thioredoxin-like | 0.2133 | INHERITED FROM: Quinic Acid || captafol || beta Carotene || apocarotenal |
| GroES-like | 0.2159 | INHERITED FROM: apocarotenal |
| Nucleotidylyl transferase | 0.2167 | INHERITED FROM: 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol || Thapsigargin || Sesquiterpenes, Guaiane |
| Immunoglobulin | 0.2368 | INHERITED FROM: helenalin |
| PYP-like sensor domain (PAS domain) | 0.2582 | INHERITED FROM: Cyclopentanes |
| Cytochrome b5-like heme/steroid binding domain | 0.2596 | INHERITED FROM: Isotretinoin |
| Tubulin C-terminal domain-like | 0.2676 | INHERITED FROM: 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol || Thapsigargin || Sesquiterpenes, Guaiane |
| Tubulin nucleotide-binding domain-like | 0.2676 | INHERITED FROM: 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol || Thapsigargin || Sesquiterpenes, Guaiane |
| NAD(P)-binding Rossmann-fold domains | 0.271 | INHERITED FROM: Isotretinoin || Retinoids |
| TNF-like | 0.2789 | INHERITED FROM: Cyclohexane Monoterpenes || Cyclohexanols || Menthol |
| SMAD/FHA domain | 0.279 | INHERITED FROM: Iridoid Glycosides || Iridoids || Iridoid Glucosides || aucubin |
| Protein kinase-like (PK-like) | 0.2791 | INHERITED FROM: Iridoid Glycosides || beta-ionone || NSC 680410 || Cyclodecanes || Lycopene || 3-O-caffeoyl-1-methylquinic acid || aucubin || 4-acetylantroquinonol B |
| Cyclin-like | 0.3226 | INHERITED FROM: Paclitaxel || Cyclodecanes || 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid |
| TRAF domain-like | 0.3264 | INHERITED FROM: Cyclohexane Monoterpenes || Cyclohexanols || Menthol |
| Kringle-like | 0.3675 | INHERITED FROM: Iridoids || genipin |
| Toll/Interleukin receptor TIR domain | 0.3797 | INHERITED FROM: Paclitaxel || Cyclodecanes |
| Prefoldin | 0.3797 | INHERITED FROM: ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid || beta Carotene || 4-oxoretinol || 4-oxoretinoic acid || Bexarotene || Alitretinoin |
| SNF-like | 0.4252 | INHERITED FROM: Cyclohexylamines || 2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone || Cyclohexanones |
| Homeodomain-like | 0.4289 | INHERITED FROM: beta Carotene || apocarotenal |
| Nucleic acid-binding proteins | 0.4773 | INHERITED FROM: Quinic Acid || Cycloheptanes || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Thapsigargin || Adamantane || CD 437 || Sesquiterpenes, Guaiane |
| Lipocalins | 0.4925 | INHERITED FROM: 4-oxoretinoic acid |
| Inhibitor of apoptosis (IAP) repeat | 0.5108 | INHERITED FROM: Paclitaxel || Taxoids || dehydroxymethylepoxyquinomicin || Cyclohexane Monoterpenes || Cyclodecanes || Menthol || Adamantane || Cyclohexanones |
| vWA-like | 0.5115 | INHERITED FROM: Cyclodecanes |
| Actin-like ATPase domain | 0.5253 | INHERITED FROM: aurin |
| LuxS/MPP-like metallohydrolase | 0.537 | INHERITED FROM: Isotretinoin |
| Mitochondrial carrier | 0.5722 | INHERITED FROM: Cycloheptanes || Thapsigargin || CD 437 || Sesquiterpenes, Guaiane |
| GroEL-intermediate domain like | 0.5784 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane || CD 437 |
| Ribosomal protein S5 domain 2-like | 0.5851 | INHERITED FROM: CD 437 |
| Translation proteins SH3-like domain | 0.622 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane |
| RNA-binding domain, RBD | 0.6464 | INHERITED FROM: 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol |
| Thiolase-like | 0.6773 | INHERITED FROM: Isotretinoin |
| GroEL apical domain-like | 0.7218 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane || CD 437 |
| Carbon-nitrogen hydrolase | 0.7364 | INHERITED FROM: Isotretinoin |
| Sm-like ribonucleoproteins | 0.7456 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane || CD 437 |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.8059 | INHERITED FROM: menthone || Picrotoxin || carvone |
| Nicotinic receptor ligand binding domain-like | 0.8059 | INHERITED FROM: menthone || Picrotoxin || carvone |
| BRCT domain | 0.8319 | INHERITED FROM: Fenretinide |
| Class II aaRS and biotin synthetases | 0.8872 | INHERITED FROM: Cycloheptanes || Thapsigargin || Sesquiterpenes, Guaiane |
| GroEL equatorial domain-like | 0.9028 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane || CD 437 |
| CCCH zinc finger | 0.9123 | INHERITED FROM: 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.9272 | INHERITED FROM: Cyclohexanecarboxylic Acids |
| P-loop containing nucleoside triphosphate hydrolases | 0.9332 | INHERITED FROM: Docetaxel |
| Calpain large subunit, middle domain (domain III) | 0.9671 | INHERITED FROM: Cyclohexane Monoterpenes || Menthol |
| MFS general substrate transporter | 1 | INHERITED FROM: Nateglinide |
| FAD/NAD(P)-binding domain | 1 | INHERITED FROM: Xanthophylls |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| BAG domain | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | Direct |
| Di-copper centre-containing domain | 0 | Direct |
| Alpha-L RNA-binding motif | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| MOSC N-terminal domain-like | 0 | Direct |
| P-domain of calnexin/calreticulin | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Nicotinate/Quinolinate PRTase C-terminal domain-like | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| Rudiment single hybrid motif | 0 | Direct |
| Alanine racemase C-terminal domain-like | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | Direct |
| PK beta-barrel domain-like | 0 | Direct |
| 4Fe-4S ferredoxins | 0 | Direct |
| A heparin-binding domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| S15/NS1 RNA-binding domain | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| Bcl-2 inhibitors of programmed cell death | 0.000009012 | Direct |
| DEATH domain | 0.00002419 | Direct |
| Nuclear receptor ligand-binding domain | 0.0002014 | Direct |
| EGF/Laminin | 0.0004745 | Direct |
| Fibronectin type III | 0.0008046 | Direct |
| TNF receptor-like | 0.001294 | Inherited |
| ABC transporter transmembrane region | 0.001294 | Inherited |
| Thyroglobulin type-1 domain | 0.001771 | Inherited |
| Growth factor receptor domain | 0.001859 | Inherited |
| Frizzled cysteine-rich domain | 0.003704 | Inherited |
| SH2 domain | 0.004163 | Inherited |
| Caspase-like | 0.004452 | Inherited |
| PGBD-like | 0.006997 | Inherited |
| Metalloproteases ("zincins"), catalytic domain | 0.007437 | Inherited |
| E2F-DP heterodimerization region | 0.01115 | Inherited |
| BTG domain-like | 0.01324 | Inherited |
| Cytochrome P450 | 0.01429 | Inherited |
| Leucine zipper domain | 0.01527 | Inherited |
| HD-domain/PDEase-like | 0.02313 | Inherited |
| ALDH-like | 0.0325 | Inherited |
| A DNA-binding domain in eukaryotic transcription factors | 0.03254 | Inherited |
| GST C-terminal domain-like | 0.03412 | Inherited |
| 4-helical cytokines | 0.03474 | Inherited |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.03967 | Inherited |
| Aminoacid dehydrogenase-like, N-terminal domain | 0.03967 | Inherited |
| ClpP/crotonase | 0.04532 | Inherited |
| p53-like transcription factors | 0.0573 | Inherited |
| Zn-binding ribosomal proteins | 0.06002 | Inherited |
| Integrin domains | 0.06306 | Inherited |
| BPTI-like | 0.06595 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.07493 | Inherited |
| Interleukin 8-like chemokines | 0.08613 | Inherited |
| Single hybrid motif | 0.09398 | Inherited |
| Hemopexin-like domain | 0.09811 | Inherited |
| CAD & PB1 domains | 0.1151 | Inherited |
| Intermediate filament protein, coiled coil region | 0.1298 | Inherited |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.1307 | Inherited |
| NAD(P)-linked oxidoreductase | 0.1533 | Inherited |
| TK C-terminal domain-like | 0.1746 | Inherited |
| Nucleoside diphosphate kinase, NDK | 0.1747 | Inherited |
| CoA-dependent acyltransferases | 0.1787 | Inherited |
| Ferritin-like | 0.1943 | Inherited |
| Thioredoxin-like | 0.2133 | Inherited |
| GroES-like | 0.2159 | Inherited |
| Nucleotidylyl transferase | 0.2167 | Inherited |
| Immunoglobulin | 0.2368 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.2582 | Inherited |
| Cytochrome b5-like heme/steroid binding domain | 0.2596 | Inherited |
| Tubulin C-terminal domain-like | 0.2676 | Inherited |
| Tubulin nucleotide-binding domain-like | 0.2676 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 0.271 | Inherited |
| TNF-like | 0.2789 | Inherited |
| SMAD/FHA domain | 0.279 | Inherited |
| Protein kinase-like (PK-like) | 0.2791 | Inherited |
| Cyclin-like | 0.3226 | Inherited |
| TRAF domain-like | 0.3264 | Inherited |
| Kringle-like | 0.3675 | Inherited |
| Toll/Interleukin receptor TIR domain | 0.3797 | Inherited |
| Prefoldin | 0.3797 | Inherited |
| SNF-like | 0.4252 | Inherited |
| Homeodomain-like | 0.4289 | Inherited |
| Nucleic acid-binding proteins | 0.4773 | Inherited |
| Lipocalins | 0.4925 | Inherited |
| Inhibitor of apoptosis (IAP) repeat | 0.5108 | Inherited |
| vWA-like | 0.5115 | Inherited |
| Actin-like ATPase domain | 0.5253 | Inherited |
| LuxS/MPP-like metallohydrolase | 0.537 | Inherited |
| Mitochondrial carrier | 0.5722 | Inherited |
| GroEL-intermediate domain like | 0.5784 | Inherited |
| Ribosomal protein S5 domain 2-like | 0.5851 | Inherited |
| Translation proteins SH3-like domain | 0.622 | Inherited |
| RNA-binding domain, RBD | 0.6464 | Inherited |
| Thiolase-like | 0.6773 | Inherited |
| GroEL apical domain-like | 0.7218 | Inherited |
| Carbon-nitrogen hydrolase | 0.7364 | Inherited |
| Sm-like ribonucleoproteins | 0.7456 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.8059 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.8059 | Inherited |
| BRCT domain | 0.8319 | Inherited |
| Class II aaRS and biotin synthetases | 0.8872 | Inherited |
| GroEL equatorial domain-like | 0.9028 | Inherited |
| CCCH zinc finger | 0.9123 | Inherited |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.9272 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 0.9332 | Inherited |
| Calpain large subunit, middle domain (domain III) | 0.9671 | Inherited |
| MFS general substrate transporter | 1 | Inherited |
| FAD/NAD(P)-binding domain | 1 | Inherited |
LINKTO: Domain2BO Download and Domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Family( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | DIRECT |
| MOSC N-terminal domain-like | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| BC C-terminal domain-like | 0 | DIRECT |
| DEATH effector domain, DED | 0 | DIRECT |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | DIRECT |
| Oligoxyloglucan reducing end-specific cellobiohydrolase | 0 | DIRECT |
| P-domain of calnexin/calreticulin | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Platelet-derived growth factor-like | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| a tRNA synthase domain | 0 | DIRECT |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, C-terminal domain | 0 | DIRECT |
| p53 DNA-binding domain-like | 0 | DIRECT |
| CAT-like | 0 | DIRECT |
| Osteonectin | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| Eukaryotic ODC-like | 0 | DIRECT |
| Cystathionine synthase-like | 0 | DIRECT |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | DIRECT |
| Biotin dependent carboxylase carboxyltransferase domain | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Alanine racemase-like, N-terminal domain | 0 | DIRECT |
| Isoprenyl diphosphate synthases | 0 | DIRECT |
| 1,3-glucuronyltransferase | 0 | DIRECT |
| Calnexin/calreticulin | 0 | DIRECT |
| Hsp90 middle domain | 0 | DIRECT |
| Ferredoxin domains from multidomain proteins | 0 | DIRECT |
| Tissue inhibitor of metalloproteinases, TIMP | 0 | DIRECT |
| Malic enzyme N-domain | 0 | DIRECT |
| A heparin-binding domain | 0 | DIRECT |
| SMAD domain | 0 | DIRECT |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | DIRECT |
| BAG domain | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| Bcl-2 inhibitors of programmed cell death | 0.00001136 | DIRECT |
| Caspase catalytic domain | 0.00002851 | DIRECT |
| ABC transporter ATPase domain-like | 0.0002876 | DIRECT |
| Nuclear receptor ligand-binding domain | 0.0003916 | DIRECT |
| ABC transporter transmembrane region | 0.0005816 | DIRECT |
| Nuclear receptor | 0.0007802 | DIRECT |
| Caspase recruitment domain, CARD | 0.0009133 | DIRECT |
| Matrix metalloproteases, catalytic domain | 0.0009133 | DIRECT |
| C2 set domains | 0.001052 | INHERITED FROM: Cyclohexenes || Carotenoids || Retinoids || Cyclohexanes |
| Thyroglobulin type-1 domain | 0.002233 | INHERITED FROM: Paclitaxel || Cyclohexenes || Vitamin A || Menthol || Tretinoin || Retinoids |
| PDEase | 0.002544 | INHERITED FROM: Roflumilast || Cilomilast || Cyclohexanecarboxylic Acids || Cyclopropanes |
| Cell cycle transcription factor e2f-dp | 0.002633 | INHERITED FROM: Paclitaxel || Cyclohexane Monoterpenes || Cyclohexanols || Menthol |
| TNF receptor-like | 0.002695 | INHERITED FROM: Paclitaxel || 4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid || Cyclohexane Monoterpenes || Cyclohexanols || Menthol || Cyclohexanes |
| Glutathione S-transferase (GST), N-terminal domain | 0.003008 | INHERITED FROM: beta Carotene || Cyclohexanes || apocarotenal |
| Frizzled cysteine-rich domain | 0.004769 | INHERITED FROM: Vitamin A || Tretinoin |
| EGF-type module | 0.005667 | INHERITED FROM: Chlorogenic Acid || Retinoids |
| L domain | 0.005959 | INHERITED FROM: Paclitaxel || Cyclopentanes |
| Interferon regulatory factor 3 (IRF3), transactivation domain | 0.005959 | INHERITED FROM: Paclitaxel |
| MMP N-terminal domain | 0.008732 | INHERITED FROM: Paclitaxel || 3-caffeoyl-4-dihydrocaffeoylquinic acid || Cyclohexanecarboxylic Acids || Chlorogenic Acid || Cyclodecanes |
| SH2 domain | 0.00889 | INHERITED FROM: 4-acetylantroquinonol B || Cyclohexanones |
| Glutathione S-transferase (GST), C-terminal domain | 0.0104 | INHERITED FROM: beta Carotene || apple polyphenol extract || apocarotenal |
| E2F dimerization segment | 0.01375 | INHERITED FROM: Paclitaxel || Taxoids || Cyclohexane Monoterpenes || Cyclodecanes || Menthol |
| BTG domain-like | 0.01375 | INHERITED FROM: LG 100815 |
| Laminin G-like module | 0.01462 | INHERITED FROM: Retinoids || Cyclohexanes |
| Growth factor receptor domain | 0.01478 | INHERITED FROM: Paclitaxel || Cyclohexenes |
| Leucine zipper domain | 0.02403 | INHERITED FROM: Cyclohexenes || Cycloheptanes || Thapsigargin || Retinoids || diphenylcyclopropenone || Sesquiterpenes, Guaiane |
| Integrin A (or I) domain | 0.0248 | INHERITED FROM: Paclitaxel || Cyclodecanes |
| Cytochrome P450 | 0.02987 | INHERITED FROM: 4-hydroxyretinoic acid || Limonene || 4,4'-cyclohexylidenebisphenol || cyhalothrin || Cyclopentanes || decamethrin || Eucalyptol || 4-oxoretinoic acid || fenvalerate || 2-methyl-5-isopropenylcyclohex-2-enone oxime || Permethrin || Cyclobutanes || Pyrethrins || Cyclopentane Monoterpenes || sibutramine |
| A DNA-binding domain in eukaryotic transcription factors | 0.03781 | INHERITED FROM: Vitamin A || Tretinoin |
| ALDH-like | 0.03947 | INHERITED FROM: Retinaldehyde || apocarotenal |
| MIF4G domain-like | 0.04319 | INHERITED FROM: Vitamin A || Tretinoin |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.04319 | INHERITED FROM: aurin || Cyclohexanecarboxylic Acids |
| Small Kunitz-type inhibitors & BPTI-like toxins | 0.04585 | INHERITED FROM: Paclitaxel || Cyclodecanes |
| Cytochrome b5 | 0.06374 | INHERITED FROM: Isotretinoin |
| Short-chain cytokines | 0.07423 | INHERITED FROM: Cyclohexenes || Cyclohexanecarboxylic Acids || Retinoids || Alitretinoin |
| S100 proteins | 0.07504 | INHERITED FROM: 4-oxoretinoic acid || Alitretinoin |
| Integrin domains | 0.07741 | INHERITED FROM: Cyclohexenes || Retinoids |
| DEATH domain, DD | 0.07741 | INHERITED FROM: Paclitaxel || Cyclohexane Monoterpenes || beta Carotene || Cyclohexanols || Cyclodecanes || apocarotenal |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.09373 | INHERITED FROM: Cycloheptanes || Thapsigargin || Sesquiterpenes, Guaiane |
| Biotinyl/lipoyl-carrier proteins and domains | 0.1023 | INHERITED FROM: Isotretinoin |
| Interleukin 8-like chemokines | 0.111 | INHERITED FROM: pevonedistat || Roflumilast || roflumilast N-oxide || beta Carotene || Cyclopropanes || 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol |
| Hemopexin-like domain | 0.1133 | INHERITED FROM: Paclitaxel || 3-caffeoyl-4-dihydrocaffeoylquinic acid || Chlorogenic Acid || Cyclodecanes |
| Nucleoside diphosphate kinase, NDK | 0.1155 | INHERITED FROM: Cyclohexane Monoterpenes || Menthol |
| Integrin alpha N-terminal domain | 0.1452 | INHERITED FROM: Cyclohexenes || Retinoids |
| Aldo-keto reductases (NADP) | 0.1669 | INHERITED FROM: 9-cis-retinal || cyclopentanol || Retinaldehyde || cyclopentanone |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0.175 | INHERITED FROM: Isotretinoin |
| Intermediate filament protein, coiled coil region | 0.1761 | INHERITED FROM: ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid || beta Carotene || 4-oxoretinol || 4-oxoretinoic acid || Isotretinoin || Alitretinoin |
| Alcohol dehydrogenase-like, C-terminal domain | 0.1839 | INHERITED FROM: apocarotenal |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.1877 | INHERITED FROM: Cyclohexanecarboxylic Acids || Thapsigargin || Sesquiterpenes, Guaiane |
| CAD domain | 0.1958 | INHERITED FROM: Cyclohexane Monoterpenes || Cyclohexanols || Menthol |
| Cyclin | 0.2078 | INHERITED FROM: Paclitaxel || Taxoids || Cyclodecanes || 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.2405 | INHERITED FROM: Thapsigargin || Sesquiterpenes, Guaiane |
| Acetylcholinesterase-like | 0.2493 | INHERITED FROM: Pyrethrins || Cyclopentane Monoterpenes |
| MATH domain | 0.2624 | INHERITED FROM: Paclitaxel || Cyclohexane Monoterpenes || Cyclohexanols || Cyclodecanes || Menthol |
| Tetrahydrofolate dehydrogenase/cyclohydrolase | 0.28 | INHERITED FROM: Cycloheptanes || Thapsigargin || Sesquiterpenes, Guaiane |
| Tubulin, GTPase domain | 0.2923 | INHERITED FROM: 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol || Thapsigargin || Sesquiterpenes, Guaiane |
| Alcohol dehydrogenase-like, N-terminal domain | 0.2923 | INHERITED FROM: apocarotenal |
| Tubulin, C-terminal domain | 0.2923 | INHERITED FROM: 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol || Thapsigargin || Sesquiterpenes, Guaiane |
| Toll/Interleukin receptor TIR domain | 0.2923 | INHERITED FROM: Paclitaxel || Cyclodecanes |
| Protein kinases, catalytic subunit | 0.3337 | INHERITED FROM: Iridoid Glycosides || beta-ionone || NSC 680410 || Cyclodecanes || Lycopene || 3-O-caffeoyl-1-methylquinic acid || aucubin |
| Actin/HSP70 | 0.334 | INHERITED FROM: aurin || Cyclohexanecarboxylic Acids |
| TNF-like | 0.3489 | INHERITED FROM: Cyclohexane Monoterpenes || Cyclohexanols || Menthol |
| Homeodomain | 0.37 | INHERITED FROM: beta Carotene || apocarotenal |
| Translational machinery components | 0.424 | INHERITED FROM: CD 437 |
| SNF-like | 0.4484 | INHERITED FROM: Cyclohexylamines || 2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone || Cyclohexanones |
| Interferons/interleukin-10 (IL-10) | 0.4597 | INHERITED FROM: beta Carotene || apocarotenal |
| Inhibitor of apoptosis (IAP) repeat | 0.5212 | INHERITED FROM: Paclitaxel || Taxoids || dehydroxymethylepoxyquinomicin || Cycloheptanes || Cyclohexane Monoterpenes || Cyclodecanes || Menthol || Adamantane || Cyclohexanones |
| Tyrosine-dependent oxidoreductases | 0.5301 | INHERITED FROM: Isotretinoin || bifenthrin |
| MPP-like | 0.5382 | INHERITED FROM: Isotretinoin |
| UDPGT-like | 0.5476 | INHERITED FROM: Cyclohexanecarboxylic Acids |
| PDI-like | 0.5949 | INHERITED FROM: Cycloheptanes || Thapsigargin || Sesquiterpenes, Guaiane |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.6277 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane || CD 437 |
| Mitochondrial carrier | 0.6366 | INHERITED FROM: Cycloheptanes || Thapsigargin || CD 437 || Sesquiterpenes, Guaiane |
| Penta-EF-hand proteins | 0.6523 | INHERITED FROM: Cyclohexane Monoterpenes || Cyclohexanols || Menthol |
| Group II chaperonin (CCT, TRIC), apical domain | 0.6901 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane || CD 437 |
| Prefoldin | 0.7139 | INHERITED FROM: 4-oxoretinoic acid || Alitretinoin |
| Thiolase-related | 0.7407 | INHERITED FROM: Isotretinoin |
| Canonical RBD | 0.758 | INHERITED FROM: 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol |
| Nicotinic receptor ligand binding domain-like | 0.8126 | INHERITED FROM: menthone || Picrotoxin || carvone |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.846 | INHERITED FROM: menthone || Picrotoxin || carvone |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0.8978 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane || CD 437 |
| CCCH zinc finger | 0.9342 | INHERITED FROM: 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol |
| Calpain large subunit, middle domain (domain III) | 0.9755 | INHERITED FROM: Cyclohexane Monoterpenes || Menthol |
| Calpain large subunit, catalytic domain (domain II) | 1 | INHERITED FROM: Cyclohexane Monoterpenes || Menthol |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | Direct |
| MOSC N-terminal domain-like | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| BC C-terminal domain-like | 0 | Direct |
| DEATH effector domain, DED | 0 | Direct |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | Direct |
| Oligoxyloglucan reducing end-specific cellobiohydrolase | 0 | Direct |
| P-domain of calnexin/calreticulin | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Platelet-derived growth factor-like | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| a tRNA synthase domain | 0 | Direct |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, C-terminal domain | 0 | Direct |
| p53 DNA-binding domain-like | 0 | Direct |
| CAT-like | 0 | Direct |
| Osteonectin | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| Eukaryotic ODC-like | 0 | Direct |
| Cystathionine synthase-like | 0 | Direct |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | Direct |
| Biotin dependent carboxylase carboxyltransferase domain | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Alanine racemase-like, N-terminal domain | 0 | Direct |
| Isoprenyl diphosphate synthases | 0 | Direct |
| 1,3-glucuronyltransferase | 0 | Direct |
| Calnexin/calreticulin | 0 | Direct |
| Hsp90 middle domain | 0 | Direct |
| Ferredoxin domains from multidomain proteins | 0 | Direct |
| Tissue inhibitor of metalloproteinases, TIMP | 0 | Direct |
| Malic enzyme N-domain | 0 | Direct |
| A heparin-binding domain | 0 | Direct |
| SMAD domain | 0 | Direct |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | Direct |
| BAG domain | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| Bcl-2 inhibitors of programmed cell death | 0.00001136 | Direct |
| Caspase catalytic domain | 0.00002851 | Direct |
| ABC transporter ATPase domain-like | 0.0002876 | Direct |
| Nuclear receptor ligand-binding domain | 0.0003916 | Direct |
| ABC transporter transmembrane region | 0.0005816 | Direct |
| Nuclear receptor | 0.0007802 | Direct |
| Caspase recruitment domain, CARD | 0.0009133 | Direct |
| Matrix metalloproteases, catalytic domain | 0.0009133 | Direct |
| C2 set domains | 0.001052 | Inherited |
| Thyroglobulin type-1 domain | 0.002233 | Inherited |
| PDEase | 0.002544 | Inherited |
| Cell cycle transcription factor e2f-dp | 0.002633 | Inherited |
| TNF receptor-like | 0.002695 | Inherited |
| Glutathione S-transferase (GST), N-terminal domain | 0.003008 | Inherited |
| Frizzled cysteine-rich domain | 0.004769 | Inherited |
| EGF-type module | 0.005667 | Inherited |
| L domain | 0.005959 | Inherited |
| Interferon regulatory factor 3 (IRF3), transactivation domain | 0.005959 | Inherited |
| MMP N-terminal domain | 0.008732 | Inherited |
| SH2 domain | 0.00889 | Inherited |
| Glutathione S-transferase (GST), C-terminal domain | 0.0104 | Inherited |
| E2F dimerization segment | 0.01375 | Inherited |
| BTG domain-like | 0.01375 | Inherited |
| Laminin G-like module | 0.01462 | Inherited |
| Growth factor receptor domain | 0.01478 | Inherited |
| Leucine zipper domain | 0.02403 | Inherited |
| Integrin A (or I) domain | 0.0248 | Inherited |
| Cytochrome P450 | 0.02987 | Inherited |
| A DNA-binding domain in eukaryotic transcription factors | 0.03781 | Inherited |
| ALDH-like | 0.03947 | Inherited |
| MIF4G domain-like | 0.04319 | Inherited |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.04319 | Inherited |
| Small Kunitz-type inhibitors & BPTI-like toxins | 0.04585 | Inherited |
| Cytochrome b5 | 0.06374 | Inherited |
| Short-chain cytokines | 0.07423 | Inherited |
| S100 proteins | 0.07504 | Inherited |
| Integrin domains | 0.07741 | Inherited |
| DEATH domain, DD | 0.07741 | Inherited |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.09373 | Inherited |
| Biotinyl/lipoyl-carrier proteins and domains | 0.1023 | Inherited |
| Interleukin 8-like chemokines | 0.111 | Inherited |
| Hemopexin-like domain | 0.1133 | Inherited |
| Nucleoside diphosphate kinase, NDK | 0.1155 | Inherited |
| Integrin alpha N-terminal domain | 0.1452 | Inherited |
| Aldo-keto reductases (NADP) | 0.1669 | Inherited |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0.175 | Inherited |
| Intermediate filament protein, coiled coil region | 0.1761 | Inherited |
| Alcohol dehydrogenase-like, C-terminal domain | 0.1839 | Inherited |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.1877 | Inherited |
| CAD domain | 0.1958 | Inherited |
| Cyclin | 0.2078 | Inherited |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.2405 | Inherited |
| Acetylcholinesterase-like | 0.2493 | Inherited |
| MATH domain | 0.2624 | Inherited |
| Tetrahydrofolate dehydrogenase/cyclohydrolase | 0.28 | Inherited |
| Tubulin, GTPase domain | 0.2923 | Inherited |
| Alcohol dehydrogenase-like, N-terminal domain | 0.2923 | Inherited |
| Tubulin, C-terminal domain | 0.2923 | Inherited |
| Toll/Interleukin receptor TIR domain | 0.2923 | Inherited |
| Protein kinases, catalytic subunit | 0.3337 | Inherited |
| Actin/HSP70 | 0.334 | Inherited |
| TNF-like | 0.3489 | Inherited |
| Homeodomain | 0.37 | Inherited |
| Translational machinery components | 0.424 | Inherited |
| SNF-like | 0.4484 | Inherited |
| Interferons/interleukin-10 (IL-10) | 0.4597 | Inherited |
| Inhibitor of apoptosis (IAP) repeat | 0.5212 | Inherited |
| Tyrosine-dependent oxidoreductases | 0.5301 | Inherited |
| MPP-like | 0.5382 | Inherited |
| UDPGT-like | 0.5476 | Inherited |
| PDI-like | 0.5949 | Inherited |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.6277 | Inherited |
| Mitochondrial carrier | 0.6366 | Inherited |
| Penta-EF-hand proteins | 0.6523 | Inherited |
| Group II chaperonin (CCT, TRIC), apical domain | 0.6901 | Inherited |
| Prefoldin | 0.7139 | Inherited |
| Thiolase-related | 0.7407 | Inherited |
| Canonical RBD | 0.758 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.8126 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.846 | Inherited |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0.8978 | Inherited |
| CCCH zinc finger | 0.9342 | Inherited |
| Calpain large subunit, middle domain (domain III) | 0.9755 | Inherited |
| Calpain large subunit, catalytic domain (domain II) | 1 | Inherited |
LINKTO: Domain2BO Download and Domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Single)( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Di-copper centre-containing domain | 0 | DIRECT |
| P-domain of calnexin/calreticulin | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| Rudiment single hybrid motif | 0 | DIRECT |
| Alpha-L RNA-binding motif | 0 | DIRECT |
| Alanine racemase C-terminal domain-like | 0 | DIRECT |
| PK beta-barrel domain-like | 0 | DIRECT |
| A heparin-binding domain | 0 | DIRECT |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| BAG domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| Nicotinate/Quinolinate PRTase C-terminal domain-like | 0 | DIRECT |
| 4Fe-4S ferredoxins | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| MOSC N-terminal domain-like | 0 | DIRECT |
| S15/NS1 RNA-binding domain | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Bcl-2 inhibitors of programmed cell death | 0.000004414 | DIRECT |
| DEATH domain | 0.00001226 | DIRECT |
| Nuclear receptor ligand-binding domain | 0.0001114 | DIRECT |
| EGF/Laminin | 0.0002727 | DIRECT |
| Fibronectin type III | 0.0004751 | DIRECT |
| ABC transporter transmembrane region | 0.0007831 | DIRECT |
| TNF receptor-like | 0.0007831 | DIRECT |
| Thyroglobulin type-1 domain | 0.001089 | INHERITED FROM: Tretinoin || Menthol || Paclitaxel || Retinoids || Cyclohexenes || Vitamin A |
| Growth factor receptor domain | 0.001146 | INHERITED FROM: Paclitaxel || Cyclodecanes |
| Frizzled cysteine-rich domain | 0.002362 | INHERITED FROM: Tretinoin || Retinoids || Cyclohexanes || Vitamin A |
| SH2 domain | 0.002675 | INHERITED FROM: Cyclohexanones || 4-acetylantroquinonol B |
| Caspase-like | 0.002868 | INHERITED FROM: Menthol || Fenretinide || Amantadine || Cyclohexanones || Xanthophylls || methyl 5-chloro-4,5-didehydrojasmonate || Ketamine || Cyclohexane Monoterpenes || CD 437 || dehydroxymethylepoxyquinomicin || Cycloheptanes || Sesquiterpenes, Guaiane || NSC 680410 || Cyclohexanols || cypermethrin || Taxoids || Cyclohexanecarboxylic Acids || Cyclopentanes || Cyclohexanes || Pyrethrins || Adamantane || Acitretin || Cyclodecanes |
| PGBD-like | 0.00462 | INHERITED FROM: 3-caffeoyl-4-dihydrocaffeoylquinic acid || Paclitaxel || Chlorogenic Acid || Cyclohexanecarboxylic Acids || Cyclodecanes |
| Metalloproteases ("zincins"), catalytic domain | 0.00493 | INHERITED FROM: 3-caffeoyl-4-dihydrocaffeoylquinic acid |
| E2F-DP heterodimerization region | 0.007558 | INHERITED FROM: Menthol || Cyclohexane Monoterpenes || Paclitaxel || Cyclohexanols |
| BTG domain-like | 0.009066 | INHERITED FROM: LG 100815 |
| Cytochrome P450 | 0.009827 | INHERITED FROM: 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid || sibutramine || Cyclopentane Monoterpenes || Eucalyptol || 4,4'-cyclohexylidenebisphenol || fenvalerate || cyhalothrin || 2-methyl-5-isopropenylcyclohex-2-enone oxime || 4-oxoretinoic acid || Cyclobutanes || 4-hydroxyretinoic acid || Permethrin || Cyclopentanes || Pyrethrins || decamethrin || Limonene || Alitretinoin |
| Leucine zipper domain | 0.01055 | INHERITED FROM: Thapsigargin || diphenylcyclopropenone || LG 100815 || Cyclopropanes || Cycloheptanes || Sesquiterpenes, Guaiane || Retinoids || Cyclohexenes |
| HD-domain/PDEase-like | 0.01637 | INHERITED FROM: Cilomilast || Cyclopropanes || Cyclohexanecarboxylic Acids || Roflumilast |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0.02349 | INHERITED FROM: Thapsigargin || Sesquiterpenes, Guaiane |
| ALDH-like | 0.02349 | INHERITED FROM: apocarotenal || Retinaldehyde |
| A DNA-binding domain in eukaryotic transcription factors | 0.02351 | INHERITED FROM: Tretinoin || Retinoids || Vitamin A |
| GST C-terminal domain-like | 0.02471 | INHERITED FROM: apple polyphenol extract || apocarotenal || beta Carotene |
| 4-helical cytokines | 0.02519 | INHERITED FROM: apocarotenal || Cilomilast || helenalin || Cyclohexanecarboxylic Acids || Alitretinoin |
| Cystine-knot cytokines | 0.02793 | INHERITED FROM: Alitretinoin |
| Aminoacid dehydrogenase-like, N-terminal domain | 0.02896 | INHERITED FROM: Tretinoin || Vitamin A |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.02896 | INHERITED FROM: aurin || Thapsigargin || Sesquiterpenes, Guaiane || Cyclohexanecarboxylic Acids |
| ClpP/crotonase | 0.03336 | INHERITED FROM: Isotretinoin |
| p53-like transcription factors | 0.04271 | INHERITED FROM: Cyclohexanones || Cyclopentanes || pevonedistat |
| Zn-binding ribosomal proteins | 0.04484 | INHERITED FROM: CD 437 || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane |
| Integrin domains | 0.04721 | INHERITED FROM: Retinoids || Cyclohexenes |
| BPTI-like | 0.04951 | INHERITED FROM: Paclitaxel || Taxoids || Cyclodecanes |
| Serpins | 0.05184 | INHERITED FROM: Alitretinoin |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.05671 | INHERITED FROM: 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid || Fenretinide || Cyclopentane Monoterpenes || SR 11237 || 1,1-bis(4-hydroxyphenyl)cyclohexane || ethofenprox || 4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid || beta Carotene || fenvalerate || cyhalothrin || 4-hydroxyretinoic acid || 9-cis-retinal || diisononyl 1,2-cyclohexanedicarboxylic acid || Ciclopirox || Cyclohexanecarboxylic Acids || Permethrin || Cyclopentanes || Pyrethrins || phenothrin || Bexarotene || Alitretinoin || Retinaldehyde |
| Interleukin 8-like chemokines | 0.06561 | INHERITED FROM: Cyclopropanes || beta Carotene || 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol || roflumilast N-oxide || Roflumilast || pevonedistat |
| MHC antigen-recognition domain | 0.06761 | INHERITED FROM: Isotretinoin |
| Single hybrid motif | 0.07199 | INHERITED FROM: Isotretinoin |
| Hemopexin-like domain | 0.07534 | INHERITED FROM: 3-caffeoyl-4-dihydrocaffeoylquinic acid || Paclitaxel || Chlorogenic Acid || Cyclodecanes |
| CAD & PB1 domains | 0.08912 | INHERITED FROM: Menthol || Cyclohexane Monoterpenes || Cyclohexanols |
| Intermediate filament protein, coiled coil region | 0.1012 | INHERITED FROM: ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid || beta Carotene || 4-oxoretinoic acid || Isotretinoin || Alitretinoin || 4-oxoretinol |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.1019 | INHERITED FROM: aurin || Thapsigargin || Sesquiterpenes, Guaiane || Cyclohexanecarboxylic Acids |
| NAD(P)-linked oxidoreductase | 0.1208 | INHERITED FROM: cyclopentanone || 9-cis-retinal || cyclopentanol || Retinaldehyde |
| Nucleoside diphosphate kinase, NDK | 0.1389 | INHERITED FROM: Menthol || Cyclohexane Monoterpenes |
| TK C-terminal domain-like | 0.1389 | INHERITED FROM: Isotretinoin |
| CoA-dependent acyltransferases | 0.1423 | INHERITED FROM: Isotretinoin |
| Ferritin-like | 0.1557 | INHERITED FROM: Paclitaxel || Cyclodecanes |
| TSP-1 type 1 repeat | 0.165 | INHERITED FROM: Paclitaxel |
| Thioredoxin-like | 0.172 | INHERITED FROM: apple polyphenol extract || apocarotenal || captafol || beta Carotene || Quinic Acid |
| GroES-like | 0.1743 | INHERITED FROM: apocarotenal |
| Nucleotidylyl transferase | 0.175 | INHERITED FROM: Thapsigargin || Sesquiterpenes, Guaiane || 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol |
| Immunoglobulin | 0.1925 | INHERITED FROM: helenalin |
| PYP-like sensor domain (PAS domain) | 0.2112 | INHERITED FROM: Cyclopentanes |
| Cytochrome b5-like heme/steroid binding domain | 0.2125 | INHERITED FROM: Isotretinoin |
| Orange domain-like | 0.2191 | INHERITED FROM: Thapsigargin || Cycloheptanes || Sesquiterpenes, Guaiane |
| Tubulin nucleotide-binding domain-like | 0.2195 | INHERITED FROM: Thapsigargin || Cycloheptanes || Sesquiterpenes, Guaiane || 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol |
| Tubulin C-terminal domain-like | 0.2195 | INHERITED FROM: Thapsigargin || Cycloheptanes || Sesquiterpenes, Guaiane || 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol |
| NAD(P)-binding Rossmann-fold domains | 0.2225 | INHERITED FROM: bifenthrin || Isotretinoin || Retinoids |
| TNF-like | 0.2294 | INHERITED FROM: Menthol || Cyclohexane Monoterpenes || Cyclohexanols |
| SMAD/FHA domain | 0.2295 | INHERITED FROM: Iridoids || aucubin || Iridoid Glucosides || Iridoid Glycosides |
| Protein kinase-like (PK-like) | 0.2296 | INHERITED FROM: Lycopene || Iridoids || aucubin || Cyclohexane Monoterpenes || NSC 680410 || Iridoid Glycosides || 3-O-caffeoyl-1-methylquinic acid || 4-acetylantroquinonol B || beta-ionone || Cyclodecanes |
| Cyclin-like | 0.2687 | INHERITED FROM: 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid || Fenretinide || Paclitaxel || Taxoids || Cyclodecanes |
| TRAF domain-like | 0.2722 | INHERITED FROM: Menthol || Cyclohexane Monoterpenes || Cyclohexanols |
| Kringle-like | 0.3094 | INHERITED FROM: Iridoids || genipin |
| Toll/Interleukin receptor TIR domain | 0.3204 | INHERITED FROM: Paclitaxel || Cyclodecanes |
| Prefoldin | 0.3204 | INHERITED FROM: ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid || beta Carotene || 4-oxoretinoic acid || Bexarotene || Alitretinoin || 4-oxoretinol |
| SNF-like | 0.3624 | INHERITED FROM: 2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone || Cyclohexanones || Cyclohexylamines |
| Homeodomain-like | 0.3658 | INHERITED FROM: apocarotenal || beta Carotene |
| Nucleic acid-binding proteins | 0.4112 | INHERITED FROM: Thapsigargin || CD 437 || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Cycloheptanes || Sesquiterpenes, Guaiane || Adamantane || Quinic Acid |
| Lipocalins | 0.4258 | INHERITED FROM: 4-oxoretinoic acid |
| Inhibitor of apoptosis (IAP) repeat | 0.443 | INHERITED FROM: Menthol || Cyclohexanones || Cyclohexane Monoterpenes || Paclitaxel || dehydroxymethylepoxyquinomicin || Cycloheptanes || Taxoids || Adamantane || Cyclodecanes |
| vWA-like | 0.4437 | INHERITED FROM: Cyclodecanes |
| Actin-like ATPase domain | 0.4569 | INHERITED FROM: aurin |
| LuxS/MPP-like metallohydrolase | 0.4679 | INHERITED FROM: Isotretinoin |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.4703 | INHERITED FROM: Isotretinoin |
| Mitochondrial carrier | 0.5016 | INHERITED FROM: Thapsigargin || CD 437 || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Cycloheptanes || Sesquiterpenes, Guaiane |
| GroEL-intermediate domain like | 0.5076 | INHERITED FROM: CD 437 || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane |
| Ribosomal protein S5 domain 2-like | 0.5143 | INHERITED FROM: CD 437 |
| Translation proteins SH3-like domain | 0.5505 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane |
| RNA-binding domain, RBD | 0.5748 | INHERITED FROM: 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol |
| Thiolase-like | 0.6054 | INHERITED FROM: Isotretinoin |
| GroEL apical domain-like | 0.6505 | INHERITED FROM: CD 437 || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane |
| Carbon-nitrogen hydrolase | 0.6649 | INHERITED FROM: Isotretinoin |
| Sm-like ribonucleoproteins | 0.6743 | INHERITED FROM: CD 437 || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane |
| Nicotinic receptor ligand binding domain-like | 0.7371 | INHERITED FROM: carvone || menthone || Picrotoxin |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.7371 | INHERITED FROM: carvone || menthone || Picrotoxin |
| BRCT domain | 0.7643 | INHERITED FROM: Fenretinide |
| Class II aaRS and biotin synthetases | 0.8234 | INHERITED FROM: Thapsigargin || Cycloheptanes || Sesquiterpenes, Guaiane |
| GroEL equatorial domain-like | 0.84 | INHERITED FROM: CD 437 || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane |
| CCCH zinc finger | 0.8504 | INHERITED FROM: 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.8665 | INHERITED FROM: Cyclohexanecarboxylic Acids |
| P-loop containing nucleoside triphosphate hydrolases | 0.8731 | INHERITED FROM: taxane || Docetaxel || Taxoids || Cyclodecanes |
| Calpain large subunit, middle domain (domain III) | 0.911 | INHERITED FROM: Menthol || Cyclohexane Monoterpenes || Cyclohexanols |
| FAD/NAD(P)-binding domain | 0.9995 | INHERITED FROM: Xanthophylls |
| MFS general substrate transporter | 1 | INHERITED FROM: Nateglinide |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Di-copper centre-containing domain | 0 | Direct |
| P-domain of calnexin/calreticulin | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| Rudiment single hybrid motif | 0 | Direct |
| Alpha-L RNA-binding motif | 0 | Direct |
| Alanine racemase C-terminal domain-like | 0 | Direct |
| PK beta-barrel domain-like | 0 | Direct |
| A heparin-binding domain | 0 | Direct |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| BAG domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| Nicotinate/Quinolinate PRTase C-terminal domain-like | 0 | Direct |
| 4Fe-4S ferredoxins | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| MOSC N-terminal domain-like | 0 | Direct |
| S15/NS1 RNA-binding domain | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Bcl-2 inhibitors of programmed cell death | 0.000004414 | Direct |
| DEATH domain | 0.00001226 | Direct |
| Nuclear receptor ligand-binding domain | 0.0001114 | Direct |
| EGF/Laminin | 0.0002727 | Direct |
| Fibronectin type III | 0.0004751 | Direct |
| ABC transporter transmembrane region | 0.0007831 | Direct |
| TNF receptor-like | 0.0007831 | Direct |
| Thyroglobulin type-1 domain | 0.001089 | Inherited |
| Growth factor receptor domain | 0.001146 | Inherited |
| Frizzled cysteine-rich domain | 0.002362 | Inherited |
| SH2 domain | 0.002675 | Inherited |
| Caspase-like | 0.002868 | Inherited |
| PGBD-like | 0.00462 | Inherited |
| Metalloproteases ("zincins"), catalytic domain | 0.00493 | Inherited |
| E2F-DP heterodimerization region | 0.007558 | Inherited |
| BTG domain-like | 0.009066 | Inherited |
| Cytochrome P450 | 0.009827 | Inherited |
| Leucine zipper domain | 0.01055 | Inherited |
| HD-domain/PDEase-like | 0.01637 | Inherited |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0.02349 | Inherited |
| ALDH-like | 0.02349 | Inherited |
| A DNA-binding domain in eukaryotic transcription factors | 0.02351 | Inherited |
| GST C-terminal domain-like | 0.02471 | Inherited |
| 4-helical cytokines | 0.02519 | Inherited |
| Cystine-knot cytokines | 0.02793 | Inherited |
| Aminoacid dehydrogenase-like, N-terminal domain | 0.02896 | Inherited |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.02896 | Inherited |
| ClpP/crotonase | 0.03336 | Inherited |
| p53-like transcription factors | 0.04271 | Inherited |
| Zn-binding ribosomal proteins | 0.04484 | Inherited |
| Integrin domains | 0.04721 | Inherited |
| BPTI-like | 0.04951 | Inherited |
| Serpins | 0.05184 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.05671 | Inherited |
| Interleukin 8-like chemokines | 0.06561 | Inherited |
| MHC antigen-recognition domain | 0.06761 | Inherited |
| Single hybrid motif | 0.07199 | Inherited |
| Hemopexin-like domain | 0.07534 | Inherited |
| CAD & PB1 domains | 0.08912 | Inherited |
| Intermediate filament protein, coiled coil region | 0.1012 | Inherited |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.1019 | Inherited |
| NAD(P)-linked oxidoreductase | 0.1208 | Inherited |
| Nucleoside diphosphate kinase, NDK | 0.1389 | Inherited |
| TK C-terminal domain-like | 0.1389 | Inherited |
| CoA-dependent acyltransferases | 0.1423 | Inherited |
| Ferritin-like | 0.1557 | Inherited |
| TSP-1 type 1 repeat | 0.165 | Inherited |
| Thioredoxin-like | 0.172 | Inherited |
| GroES-like | 0.1743 | Inherited |
| Nucleotidylyl transferase | 0.175 | Inherited |
| Immunoglobulin | 0.1925 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.2112 | Inherited |
| Cytochrome b5-like heme/steroid binding domain | 0.2125 | Inherited |
| Orange domain-like | 0.2191 | Inherited |
| Tubulin nucleotide-binding domain-like | 0.2195 | Inherited |
| Tubulin C-terminal domain-like | 0.2195 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 0.2225 | Inherited |
| TNF-like | 0.2294 | Inherited |
| SMAD/FHA domain | 0.2295 | Inherited |
| Protein kinase-like (PK-like) | 0.2296 | Inherited |
| Cyclin-like | 0.2687 | Inherited |
| TRAF domain-like | 0.2722 | Inherited |
| Kringle-like | 0.3094 | Inherited |
| Toll/Interleukin receptor TIR domain | 0.3204 | Inherited |
| Prefoldin | 0.3204 | Inherited |
| SNF-like | 0.3624 | Inherited |
| Homeodomain-like | 0.3658 | Inherited |
| Nucleic acid-binding proteins | 0.4112 | Inherited |
| Lipocalins | 0.4258 | Inherited |
| Inhibitor of apoptosis (IAP) repeat | 0.443 | Inherited |
| vWA-like | 0.4437 | Inherited |
| Actin-like ATPase domain | 0.4569 | Inherited |
| LuxS/MPP-like metallohydrolase | 0.4679 | Inherited |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.4703 | Inherited |
| Mitochondrial carrier | 0.5016 | Inherited |
| GroEL-intermediate domain like | 0.5076 | Inherited |
| Ribosomal protein S5 domain 2-like | 0.5143 | Inherited |
| Translation proteins SH3-like domain | 0.5505 | Inherited |
| RNA-binding domain, RBD | 0.5748 | Inherited |
| Thiolase-like | 0.6054 | Inherited |
| GroEL apical domain-like | 0.6505 | Inherited |
| Carbon-nitrogen hydrolase | 0.6649 | Inherited |
| Sm-like ribonucleoproteins | 0.6743 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.7371 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.7371 | Inherited |
| BRCT domain | 0.7643 | Inherited |
| Class II aaRS and biotin synthetases | 0.8234 | Inherited |
| GroEL equatorial domain-like | 0.84 | Inherited |
| CCCH zinc finger | 0.8504 | Inherited |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.8665 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 0.8731 | Inherited |
| Calpain large subunit, middle domain (domain III) | 0.911 | Inherited |
| FAD/NAD(P)-binding domain | 0.9995 | Inherited |
| MFS general substrate transporter | 1 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
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Supra-domain (Duplex) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
57196,57535
57196 - EGF/Laminin
57535 - Complement control module/SCR domain | 0 | DIRECT |
69012,55874
69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
56491,89811
56491 - A heparin-binding domain
89811 - Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
51045,47473
51045 - WW domain
47473 - EF-hand | 0 | DIRECT |
53738,55957
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
49899,63887
49899 - Concanavalin A-like lectins/glucanases
63887 - P-domain of calnexin/calreticulin | 0 | DIRECT |
47473,57610
47473 - EF-hand
57610 - Thyroglobulin type-1 domain | 0 | DIRECT |
49899,48726
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin | 0 | DIRECT |
69572,69572
69572 - Activating enzymes of the ubiquitin-like proteins
69572 - Activating enzymes of the ubiquitin-like proteins | 0 | DIRECT |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | DIRECT |
51419,50621
51419 - PLP-binding barrel
50621 - Alanine racemase C-terminal domain-like | 0 | DIRECT |
53300,49899
53300 - vWA-like
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
49265,53300
49265 - Fibronectin type III
53300 - vWA-like | 0 | DIRECT |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | DIRECT |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0 | DIRECT |
49695,50370
49695 - gamma-Crystallin-like
50370 - Ricin B-like lectins | 0 | DIRECT |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0 | DIRECT |
46966,51045
46966 - Spectrin repeat
51045 - WW domain | 0 | DIRECT |
74924,74924
74924 - Cap-Gly domain
74924 - Cap-Gly domain | 0 | DIRECT |
141673,50800
141673 - MOSC N-terminal domain-like
50800 - PK beta-barrel domain-like | 0 | DIRECT |
54826,51604
54826 - Enolase N-terminal domain-like
51604 - Enolase C-terminal domain-like | 0 | DIRECT |
47060,55681
47060 - S15/NS1 RNA-binding domain
55681 - Class II aaRS and biotin synthetases | 0 | DIRECT |
53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | DIRECT |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0 | DIRECT |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.00000003136 | DIRECT |
52799,52799
52799 - (Phosphotyrosine protein) phosphatases II
52799 - (Phosphotyrosine protein) phosphatases II | 0.000004414 | DIRECT |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.00004304 | DIRECT |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.00007846 | DIRECT |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.0004067 | DIRECT |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0007831 | DIRECT |
100895,47473
100895 - Kazal-type serine protease inhibitors
47473 - EF-hand | 0.001447 | INHERITED FROM: Paclitaxel || Taxoids |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.003662 | INHERITED FROM: Paclitaxel || Cyclopentanes || Cyclodecanes |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.003662 | INHERITED FROM: Paclitaxel || Cyclopentanes || Cyclodecanes |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.00462 | INHERITED FROM: 3-caffeoyl-4-dihydrocaffeoylquinic acid || Paclitaxel || Chlorogenic Acid || Cyclohexanecarboxylic Acids || Cyclodecanes |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0.00463 | INHERITED FROM: Tretinoin || Retinoids || Cyclohexenes || Vitamin A |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0.007558 | INHERITED FROM: Menthol || Cyclohexane Monoterpenes || Paclitaxel || Cyclohexanols |
52540,90123
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0.007558 | INHERITED FROM: Docetaxel || Taxoids || Cyclodecanes |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.008772 | INHERITED FROM: Paclitaxel |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.02156 | INHERITED FROM: apple polyphenol extract || apocarotenal || beta Carotene || Cyclohexanes |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.02156 | INHERITED FROM: Isotretinoin |
53300,53300
53300 - vWA-like
53300 - vWA-like | 0.02203 | INHERITED FROM: Paclitaxel || Taxoids |
46579,64593
46579 - Prefoldin
64593 - Intermediate filament protein, coiled coil region | 0.02203 | INHERITED FROM: ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid || beta Carotene || 4-oxoretinoic acid || Isotretinoin || Bexarotene || Alitretinoin || 4-oxoretinol |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.04119 | INHERITED FROM: Cyclohexanones || 4-acetylantroquinonol B |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.04316 | INHERITED FROM: Cyclopentanes |
56112,56112
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0.0474 | INHERITED FROM: Lycopene |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.0474 | INHERITED FROM: Paclitaxel || Isotretinoin || Cyclohexanecarboxylic Acids || Alitretinoin |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.06856 | INHERITED FROM: Menthol || Cyclohexane Monoterpenes || Cyclopentanes || Cyclodecanes |
49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0.06856 | INHERITED FROM: Menthol |
57850,49599
57850 - RING/U-box
49599 - TRAF domain-like | 0.07199 | INHERITED FROM: Menthol || Cyclohexane Monoterpenes |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.1 | INHERITED FROM: Retinoids || Cyclohexanes || Cyclohexenes |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0.1 | INHERITED FROM: Retinoids || Cyclohexanes || Cyclohexenes |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.1019 | INHERITED FROM: aurin || Thapsigargin || Sesquiterpenes, Guaiane || Cyclohexanecarboxylic Acids |
57184,57610
57184 - Growth factor receptor domain
57610 - Thyroglobulin type-1 domain | 0.104 | INHERITED FROM: Menthol || Cyclohexane Monoterpenes || Cyclohexanols |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.1071 | INHERITED FROM: 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid || Paclitaxel || Cyclodecanes |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0.1389 | INHERITED FROM: Isotretinoin |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0.2191 | INHERITED FROM: Thapsigargin || Cycloheptanes || Sesquiterpenes, Guaiane |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 0.2195 | INHERITED FROM: apocarotenal |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.2195 | INHERITED FROM: Thapsigargin || Cycloheptanes || Sesquiterpenes, Guaiane || 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.2758 | INHERITED FROM: Cyclopentanes |
64593,64593
64593 - Intermediate filament protein, coiled coil region
64593 - Intermediate filament protein, coiled coil region | 0.3624 | INHERITED FROM: ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid || beta Carotene || 4-oxoretinoic acid || Alitretinoin |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.3847 | INHERITED FROM: 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.4005 | INHERITED FROM: Thapsigargin || Cycloheptanes || Sesquiterpenes, Guaiane |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.449 | INHERITED FROM: aurin |
63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0.4679 | INHERITED FROM: Isotretinoin |
57184,63825
57184 - Growth factor receptor domain
63825 - YWTD domain | 0.4679 | INHERITED FROM: Thapsigargin || Cycloheptanes || Sesquiterpenes, Guaiane |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.5076 | INHERITED FROM: CD 437 || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.6054 | INHERITED FROM: CD 437 || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane |
53901,53901
53901 - Thiolase-like
53901 - Thiolase-like | 0.7067 | INHERITED FROM: Isotretinoin |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.7371 | INHERITED FROM: carvone || menthone || Picrotoxin |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0.84 | INHERITED FROM: Menthol || Cyclohexane Monoterpenes || Cyclohexanols |
49758,47473
49758 - Calpain large subunit, middle domain (domain III)
47473 - EF-hand | 0.9005 | INHERITED FROM: Menthol || Cyclohexane Monoterpenes |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
57196,57535
57196 - EGF/Laminin
57535 - Complement control module/SCR domain | 0 | Direct |
69012,55874
69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
56491,89811
56491 - A heparin-binding domain
89811 - Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
51045,47473
51045 - WW domain
47473 - EF-hand | 0 | Direct |
53738,55957
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | Direct |
49899,63887
49899 - Concanavalin A-like lectins/glucanases
63887 - P-domain of calnexin/calreticulin | 0 | Direct |
47473,57610
47473 - EF-hand
57610 - Thyroglobulin type-1 domain | 0 | Direct |
49899,48726
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin | 0 | Direct |
69572,69572
69572 - Activating enzymes of the ubiquitin-like proteins
69572 - Activating enzymes of the ubiquitin-like proteins | 0 | Direct |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | Direct |
51419,50621
51419 - PLP-binding barrel
50621 - Alanine racemase C-terminal domain-like | 0 | Direct |
53300,49899
53300 - vWA-like
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
49265,53300
49265 - Fibronectin type III
53300 - vWA-like | 0 | Direct |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | Direct |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0 | Direct |
49695,50370
49695 - gamma-Crystallin-like
50370 - Ricin B-like lectins | 0 | Direct |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0 | Direct |
46966,51045
46966 - Spectrin repeat
51045 - WW domain | 0 | Direct |
74924,74924
74924 - Cap-Gly domain
74924 - Cap-Gly domain | 0 | Direct |
141673,50800
141673 - MOSC N-terminal domain-like
50800 - PK beta-barrel domain-like | 0 | Direct |
54826,51604
54826 - Enolase N-terminal domain-like
51604 - Enolase C-terminal domain-like | 0 | Direct |
47060,55681
47060 - S15/NS1 RNA-binding domain
55681 - Class II aaRS and biotin synthetases | 0 | Direct |
53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | Direct |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0 | Direct |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.00000003136 | Direct |
52799,52799
52799 - (Phosphotyrosine protein) phosphatases II
52799 - (Phosphotyrosine protein) phosphatases II | 0.000004414 | Direct |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.00004304 | Direct |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.00007846 | Direct |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.0004067 | Direct |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0007831 | Direct |
100895,47473
100895 - Kazal-type serine protease inhibitors
47473 - EF-hand | 0.001447 | Inherited |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.003662 | Inherited |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.003662 | Inherited |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.00462 | Inherited |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0.00463 | Inherited |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0.007558 | Inherited |
52540,90123
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0.007558 | Inherited |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.008772 | Inherited |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.02156 | Inherited |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.02156 | Inherited |
53300,53300
53300 - vWA-like
53300 - vWA-like | 0.02203 | Inherited |
46579,64593
46579 - Prefoldin
64593 - Intermediate filament protein, coiled coil region | 0.02203 | Inherited |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.04119 | Inherited |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.04316 | Inherited |
56112,56112
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0.0474 | Inherited |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.0474 | Inherited |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.06856 | Inherited |
49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0.06856 | Inherited |
57850,49599
57850 - RING/U-box
49599 - TRAF domain-like | 0.07199 | Inherited |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.1 | Inherited |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0.1 | Inherited |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.1019 | Inherited |
57184,57610
57184 - Growth factor receptor domain
57610 - Thyroglobulin type-1 domain | 0.104 | Inherited |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.1071 | Inherited |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0.1389 | Inherited |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0.2191 | Inherited |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 0.2195 | Inherited |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.2195 | Inherited |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.2758 | Inherited |
64593,64593
64593 - Intermediate filament protein, coiled coil region
64593 - Intermediate filament protein, coiled coil region | 0.3624 | Inherited |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.3847 | Inherited |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.4005 | Inherited |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.449 | Inherited |
63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0.4679 | Inherited |
57184,63825
57184 - Growth factor receptor domain
63825 - YWTD domain | 0.4679 | Inherited |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.5076 | Inherited |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.6054 | Inherited |
53901,53901
53901 - Thiolase-like
53901 - Thiolase-like | 0.7067 | Inherited |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.7371 | Inherited |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0.84 | Inherited |
49758,47473
49758 - Calpain large subunit, middle domain (domain III)
47473 - EF-hand | 0.9005 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Triple) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
100895,47473,57610
100895 - Kazal-type serine protease inhibitors
47473 - EF-hand
57610 - Thyroglobulin type-1 domain | 0 | DIRECT |
57196,57535,57535
57196 - EGF/Laminin
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | DIRECT |
49265,49265,53300
49265 - Fibronectin type III
49265 - Fibronectin type III
53300 - vWA-like | 0 | DIRECT |
57184,100895,48726
57184 - Growth factor receptor domain
100895 - Kazal-type serine protease inhibitors
48726 - Immunoglobulin | 0 | DIRECT |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
57196,57581,57196
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | DIRECT |
53738,53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | DIRECT |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | DIRECT |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
49899,48726,49265
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin
49265 - Fibronectin type III | 0 | DIRECT |
51045,47473,47473
51045 - WW domain
47473 - EF-hand
47473 - EF-hand | 0 | DIRECT |
46966,51045,47473
46966 - Spectrin repeat
51045 - WW domain
47473 - EF-hand | 0 | DIRECT |
46966,46966,51045
46966 - Spectrin repeat
46966 - Spectrin repeat
51045 - WW domain | 0 | DIRECT |
53738,53738,55957
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | DIRECT |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | DIRECT |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.0009565 | DIRECT |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.00322 | INHERITED FROM: Retinoids || Cyclohexanes || Cyclohexenes |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.003662 | INHERITED FROM: Paclitaxel || Cyclopentanes || Cyclodecanes |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.003662 | INHERITED FROM: Paclitaxel || Cyclodecanes |
90123,52540,90123
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0.007558 | INHERITED FROM: Docetaxel || Taxoids || Cyclodecanes |
52540,90123,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.007558 | INHERITED FROM: Docetaxel || Taxoids || Cyclodecanes |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0.01505 | INHERITED FROM: Tretinoin || Vitamin A |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.01584 | INHERITED FROM: Tretinoin || Vitamin A |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.01667 | INHERITED FROM: Paclitaxel || Cyclopentanes |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.02894 | INHERITED FROM: Paclitaxel |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0.06508 | INHERITED FROM: Retinoids || Cyclohexanes || Cyclohexenes |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0.1 | INHERITED FROM: Retinoids || Cyclohexanes || Cyclohexenes |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.1019 | INHERITED FROM: aurin || Thapsigargin || Sesquiterpenes, Guaiane || Cyclohexanecarboxylic Acids |
57850,49599,49599
57850 - RING/U-box
49599 - TRAF domain-like
49599 - TRAF domain-like | 0.1557 | INHERITED FROM: Menthol || Cyclohexane Monoterpenes || Paclitaxel || Cyclohexanols || Taxoids || Cyclodecanes |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0.1557 | INHERITED FROM: Isotretinoin |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.5618 | INHERITED FROM: Thapsigargin || Cycloheptanes || Sesquiterpenes, Guaiane |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.6054 | INHERITED FROM: CD 437 || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane |
54001,49758,47473
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III)
47473 - EF-hand | 0.8069 | INHERITED FROM: Menthol || Cyclohexane Monoterpenes || Cyclohexanols |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
100895,47473,57610
100895 - Kazal-type serine protease inhibitors
47473 - EF-hand
57610 - Thyroglobulin type-1 domain | 0 | Direct |
57196,57535,57535
57196 - EGF/Laminin
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | Direct |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | Direct |
49265,49265,53300
49265 - Fibronectin type III
49265 - Fibronectin type III
53300 - vWA-like | 0 | Direct |
57184,100895,48726
57184 - Growth factor receptor domain
100895 - Kazal-type serine protease inhibitors
48726 - Immunoglobulin | 0 | Direct |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
57196,57581,57196
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | Direct |
53738,53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | Direct |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | Direct |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
49899,48726,49265
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin
49265 - Fibronectin type III | 0 | Direct |
51045,47473,47473
51045 - WW domain
47473 - EF-hand
47473 - EF-hand | 0 | Direct |
46966,51045,47473
46966 - Spectrin repeat
51045 - WW domain
47473 - EF-hand | 0 | Direct |
46966,46966,51045
46966 - Spectrin repeat
46966 - Spectrin repeat
51045 - WW domain | 0 | Direct |
53738,53738,55957
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | Direct |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | Direct |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | Direct |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.0009565 | Direct |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.00322 | Inherited |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.003662 | Inherited |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.003662 | Inherited |
90123,52540,90123
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0.007558 | Inherited |
52540,90123,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.007558 | Inherited |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0.01505 | Inherited |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.01584 | Inherited |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.01667 | Inherited |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.02894 | Inherited |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0.06508 | Inherited |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0.1 | Inherited |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.1019 | Inherited |
57850,49599,49599
57850 - RING/U-box
49599 - TRAF domain-like
49599 - TRAF domain-like | 0.1557 | Inherited |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0.1557 | Inherited |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.5618 | Inherited |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.6054 | Inherited |
54001,49758,47473
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III)
47473 - EF-hand | 0.8069 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Plot distribution on species Tree Of Life (sTOL) for Superfamily and/or Family domains annotated by this CC term
 |
Plot tree as:
| |
Download Newick format tree:
|
( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Plot distribution on species Tree Of Life (sTOL) for single supra-domains annotated by this CC term
|
Plot tree as:
| |
Download Newick format tree:
| |
Browsing in TREE OF LIFE:
|
( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|
|
> BO Hierarchy > Cycloparaffins
