Xenopus ANatomical entity (XAN): brain 

Root: XA Hierarchy (Xenopus anatomy and development from Xenbase frog anatomy ontology)

Shortest distance to current term (+ for parents, - for children)	XA term [XA ID] <#Children>	#Domains (Superfamily|Family)	#Supra-domain (Single|Duplex|Triple)
+ + + + 4:	anatomical group [XAO:0003001] <2>	(414|530)	(418|309|134)
+ + + + 4:	Xenopus anatomical entity [XAO:0000000] <9>
+ + + + 4:	whole organism [XAO:0003004] <12>	(461|598)	(465|335|145)
+ + + + 4:	anatomical structure [XAO:0003000] <11>	(577|733)	(577|400|163)
+ + + 3:	anatomical region [XAO:0003186] <51>	(370|484)	(374|284|123)
+ + + 3:	anatomical system [XAO:0003002] <19>	(283|382)	(289|204|93)
+ + + 3:	multicellular anatomical structure [XAO:0005002] <4>	(436|565)	(440|325|142)
+ + 2:	compound organ [XAO:0003041] <8>	(332|444)	(336|275|125)
+ + 2:	nervous system [XAO:0000177] <11>	(134|201)	(141|114|53)
+ + 2:	head region [XAO:0000040] <4>	(178|245)	(183|137|58)
+ + 2:	organism subdivision [XAO:0003013] <11>	(375|498)	(381|292|126)
+ 1:	central nervous system [XAO:0000215] <7>	(129|191)	(135|108|49)
+ 1:	head [XAO:0003024] <22>	(178|244)	(183|137|58)
+ 1:	cavitated compound organ [XAO:0003165] <21>	(287|395)	(292|247|114)
0:	brain [XAO:0000010] <14>	(79|120)	(80|65|28)
- 1:	midbrain [XAO:0000014] <9>	(9|10)	(9|3|0)
- 1:	hindbrain [XAO:0000015] <7>	(10|11)	(11|2|1)
- 1:	forebrain [XAO:0000011] <5>	(12|12)	(13|3|3)
- 1:	brain ventricle [XAO:0004602] <3>	(0|0)	(0|0|0)
- 1:	astrocyte [XAO:0005131] <1>	(0|0)	(0|0|0)
- 1:	midbrain-hindbrain boundary [XAO:0000016] <1>	(4|5)	(4|1|1)
- 1:	pia mater [XAO:0005289] <1>	(0|0)	(0|0|0)
- 1:	forebrain-midbrain boundary [XAO:0005027]	(0|0)	(0|0|0)
- 1:	metencephalic artery [XAO:0004167]	(0|0)	(0|0|0)
- 1:	metencephalic vein [XAO:0004168]	(0|0)	(0|0|0)
- 1:	neural stem cell [XAO:0005032]	(0|0)	(0|0|0)
- 1:	oligodendrocyte [XAO:0005133]	(0|0)	(0|0|0)
- 1:	stria terminalis [XAO:0005057]	(0|0)	(0|0|0)
- 1:	ventricular zone [XAO:0000021]	(4|3)	(4|0|0)

Superfamily

Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
ClpS-like	0	DIRECT
alpha-ketoacid dehydrogenase kinase, N-terminal domain	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
Amyloid beta a4 protein copper binding domain (domain 2)	0	DIRECT
PAH2 domain	0	DIRECT
Oligoxyloglucan reducing end-specific cellobiohydrolase	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Sialidases	0	DIRECT
USP8 N-terminal domain-like	0	DIRECT
Synuclein	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
Dimeric alpha+beta barrel	0	DIRECT
Stathmin	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
4Fe-4S ferredoxins	0	DIRECT
Subdomain of clathrin and coatomer appendage domain	0	DIRECT
BRK domain-like	0	DIRECT
Clathrin adaptor appendage domain	0	DIRECT
Pentein	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Families 57/38 glycoside transferase middle domain	0	DIRECT
RNase III domain-like	0	DIRECT
Moesin tail domain	0	DIRECT
BEACH domain	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
Nuclear receptor coactivator interlocking domain	0	DIRECT
NAP-like	0	DIRECT
Isocitrate/Isopropylmalate dehydrogenase-like	0	DIRECT
GINS helical bundle-like	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0	DIRECT
PriA/YqbF domain	0	DIRECT
alpha-catenin/vinculin-like	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
Ribulose-phoshate binding barrel	0	DIRECT
Glycoside hydrolase/deacetylase	0	DIRECT
Subunits of heterodimeric actin filament capping protein Capz	0	DIRECT
ACP-like	0	DIRECT
Mss4-like	0	DIRECT
I/LWEQ domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
A heparin-binding domain	0	DIRECT
MAST3 pre-PK domain-like	0	DIRECT
PLP-binding barrel	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
Glutamine synthetase/guanido kinase	0	DIRECT
CAPPD, an extracellular domain of amyloid beta A4 protein	0	DIRECT
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	0	DIRECT
CCHHC domain	0	DIRECT
AraD/HMP-PK domain-like	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
SMAD MH1 domain	0	DIRECT
Myosin phosphatase inhibitor 17kDa protein, CPI-17	0	DIRECT
GYF domain	0	DIRECT
Hedgehog/DD-peptidase	0	DIRECT
TAFH domain-like	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Hook domain	0	DIRECT
Alanine racemase C-terminal domain-like	0	DIRECT
Transcription factor STAT-4 N-domain	0	DIRECT
DLC	0	DIRECT
Nop domain	0	DIRECT
SRF-like	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
Delta-sleep-inducing peptide immunoreactive peptide	0	DIRECT
14-3-3 protein	0	DIRECT
PH domain-like	0.0002482	DIRECT
Ubiquitin-like	0.0002655	DIRECT
HMG-box	0.004618	INHERITED FROM: forebrain || midbrain-hindbrain boundary || hindbrain
RNA-binding domain, RBD	0.01095	INHERITED FROM: hindbrain
Frizzled cysteine-rich domain	0.02091	INHERITED FROM: forebrain || midbrain-hindbrain boundary || hindbrain || midbrain
HLH, helix-loop-helix DNA-binding domain	0.02292	INHERITED FROM: forebrain || hindbrain || ventricular zone || midbrain
Orange domain-like	0.05031	INHERITED FROM: midbrain
Cytokine	0.08471	INHERITED FROM: forebrain
Homeodomain-like	0.09021	INHERITED FROM: pallidum || forebrain || pallium || prosomere || infundibulum || ventral pallium || septum || anterior hypothalamus || preoptic area || subpallium || amygdala || optic stalk || lateral ganglionic eminence || pretectum || prethalamus || diencephalon || optic tract || ventral septum || posterior hypothalamus || midbrain-hindbrain boundary || basal forebrain || medial ganglionic eminence || zona limitans intrathalamica || olfactory bulb || rhombomere || telencephalon || hindbrain || basal ganglion || hypothalamus || medial septum || dorsal thalamus || lateral septum || ventricular zone || lateral pallium || thalamus || midbrain
Intermediate filament protein, coiled coil region	0.6694	INHERITED FROM: medulla oblongata || ventricular zone || midbrain tegmentum
Glucocorticoid receptor-like (DNA-binding domain)	0.8527	INHERITED FROM: forebrain || prosomere || ventrolateral thalamic nucleus || ventral pallium || septum || anterior hypothalamus || preoptic area || subpallium || amygdala || pretectum || diencephalon || striatum || ventral septum || basal forebrain || zona limitans intrathalamica || hindbrain || basal ganglion || hypothalamus || medial septum || optic tectum || lateral septum || thalamus || midbrain
Family A G protein-coupled receptor-like	1	INHERITED FROM: pallium || septum || anterior hypothalamus || granule cell layer of the olfactory bulb || preoptic area || amygdala || diencephalon || striatum || basal forebrain || medial pallium || basal ganglion || hypothalamus

Family

Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Stathmin	0	DIRECT
Hedgehog (development protein), N-terminal signaling domain	0	DIRECT
PreBEACH PH-like domain	0	DIRECT
PAS domain of steroid receptor coactivator 1A, NCo-A1	0	DIRECT
Group II chaperonin (CCT, TRIC), apical domain	0	DIRECT
Pumilio repeat	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
Hook domain	0	DIRECT
Amyloid beta a4 protein copper binding domain (domain 2)	0	DIRECT
I/LWEQ domain	0	DIRECT
Cofactor-dependent phosphoglycerate mutase	0	DIRECT
SMAD MH1 domain	0	DIRECT
Glyoxalase II (hydroxyacylglutathione hydrolase)	0	DIRECT
Linker histone H1/H5	0	DIRECT
alpha-mannosidase	0	DIRECT
Nuclear receptor coactivator interlocking domain	0	DIRECT
TAFH domain-like	0	DIRECT
Protein-L-isoaspartyl O-methyltransferase	0	DIRECT
GS domain	0	DIRECT
HCDH C-domain-like	0	DIRECT
14-3-3 protein	0	DIRECT
HAT/Suf repeat	0	DIRECT
DNA gyrase/MutL, second domain	0	DIRECT
CUE domain	0	DIRECT
gamma-adaptin C-terminal appendage domain-like	0	DIRECT
Guanido kinase catalytic domain	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
Gonadodropin/Follitropin	0	DIRECT
Transcription factor STAT-4 N-domain	0	DIRECT
TRASH domain	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
NIPSNAP	0	DIRECT
DNA ligase	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Glycosyl transferases group 1	0	DIRECT
Autophagin-like	0	DIRECT
Alpha-adaptin ear subdomain-like	0	DIRECT
CCHHC domain	0	DIRECT
Phoshoinositide 3-kinase (PI3K) helical domain	0	DIRECT
SRF-like	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
Sedlin (SEDL)	0	DIRECT
CAPPD, an extracellular domain of amyloid beta A4 protein	0	DIRECT
Phoshatidylinositol transfer protein, PITP	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
MSP-like	0	DIRECT
DLC	0	DIRECT
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	0	DIRECT
Delta-sleep-inducing peptide immunoreactive peptide	0	DIRECT
alpha-mannosidase, domain 2	0	DIRECT
Alanine racemase-like, N-terminal domain	0	DIRECT
RPR domain (SMART 00582 )	0	DIRECT
Ephrin receptor ligand binding domain	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
alpha-ketoacid dehydrogenase kinase, N-terminal domain	0	DIRECT
USP8 N-terminal domain-like	0	DIRECT
SMAD domain	0	DIRECT
Dimeric isocitrate & isopropylmalate dehydrogenases	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase PP module	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
DIX domain	0	DIRECT
BRK domain-like	0	DIRECT
Moesin tail domain	0	DIRECT
MAST3 pre-PK domain-like	0	DIRECT
Noggin	0	DIRECT
Eukaryotic ODC-like	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
NAP-like	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
Cyclin A/CDK2-associated p19, Skp2	0	DIRECT
4HBT-like	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
alpha-mannosidase, C-terminal domain	0	DIRECT
A heparin-binding domain	0	DIRECT
PAH2 domain	0	DIRECT
alpha-catenin/vinculin	0	DIRECT
A20-like zinc finger	0	DIRECT
Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	0	DIRECT
alpha-ketoacid dehydrogenase kinase, C-terminal domain	0	DIRECT
Hsp90 middle domain	0	DIRECT
P4 origin-binding domain-like	0	DIRECT
1,3-glucuronyltransferase	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
BEACH domain	0	DIRECT
Cell cycle control phosphatase, catalytic domain	0	DIRECT
Chromo barrel domain	0	DIRECT
Ran-binding domain	0	DIRECT
S-adenosylhomocystein hydrolase	0	DIRECT
Transferrin	0	DIRECT
Nop domain	0	DIRECT
DNA gyrase/MutL, N-terminal domain	0	DIRECT
SH3BGR (SH3-binding, glutamic acid-rich protein-like)	0	DIRECT
Synuclein	0	DIRECT
Cytidylyltransferase	0	DIRECT
Anticodon-binding domain of Class II aaRS	0	DIRECT
a tRNA synthase domain	0	DIRECT
Myosin phosphatase inhibitor 17kDa protein, CPI-17	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
AraD-like aldolase/epimerase	0	DIRECT
GDI-like N domain	0	DIRECT
Clathrin adaptor appendage, alpha and beta chain-specific domain	0	DIRECT
B56-like	0	DIRECT
Canonical RBD	0.00353	INHERITED FROM: hindbrain
HMG-box	0.004581	INHERITED FROM: forebrain || midbrain-hindbrain boundary || hindbrain
Frizzled cysteine-rich domain	0.01915	INHERITED FROM: forebrain || midbrain-hindbrain boundary || hindbrain || midbrain
HLH, helix-loop-helix DNA-binding domain	0.02434	INHERITED FROM: forebrain || hindbrain || ventricular zone || midbrain
Hairy Orange domain	0.04409	INHERITED FROM: midbrain
Histone lysine methyltransferases	0.05956	INHERITED FROM: hindbrain
Homeodomain	0.1335	INHERITED FROM: pallidum || forebrain || pallium || prosomere || pineal gland || infundibulum || ventral pallium || septum || anterior hypothalamus || preoptic area || subpallium || amygdala || optic stalk || lateral ganglionic eminence || pretectum || prethalamus || diencephalon || striatum || ventral septum || posterior hypothalamus || bed nucleus of the stria terminalis || midbrain-hindbrain boundary || basal forebrain || medial ganglionic eminence || zona limitans intrathalamica || olfactory bulb || rhombomere || telencephalon || hindbrain || basal ganglion || hypothalamus || medial septum || dorsal thalamus || lateral septum || ventricular zone || lateral pallium || thalamus || midbrain
Sema domain	0.3175	INHERITED FROM: midbrain-hindbrain boundary
Paired domain	0.4039	INHERITED FROM: forebrain || midbrain-hindbrain boundary || midbrain
LIM domain	0.4554	INHERITED FROM: prosomere || ventrolateral thalamic nucleus || septum || anterior thalamic nucleus || prosomere 4 || amygdala || pretectum || ventral septum || medial amygdala || bed nucleus of the stria terminalis || basal forebrain || central nucleus of the thalamus || thalamus
Intermediate filament protein, coiled coil region	0.6564	INHERITED FROM: medulla oblongata || nucleus reticularis inferior || ventricular zone || midbrain tegmentum
Classic zinc finger, C2H2	0.6646	INHERITED FROM: hindbrain || midbrain
Tandem AAA-ATPase domain	0.8028	INHERITED FROM: forebrain || hindbrain || midbrain
Rhodopsin-like	1	INHERITED FROM: pallium || septum || anterior hypothalamus || granule cell layer of the olfactory bulb || preoptic area || amygdala || diencephalon || striatum || basal forebrain || medial pallium || basal ganglion || hypothalamus

Supra-domain (Single|Duplex|Triple)

Supra-domain (Single)

Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
F1F0 ATP synthase subunit C	0	DIRECT
TAFH domain-like	0	DIRECT
Synuclein	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
Myosin phosphatase inhibitor 17kDa protein, CPI-17	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
GINS helical bundle-like	0	DIRECT
SMAD MH1 domain	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
GYF domain	0	DIRECT
DLC	0	DIRECT
CAPPD, an extracellular domain of amyloid beta A4 protein	0	DIRECT
Oligoxyloglucan reducing end-specific cellobiohydrolase	0	DIRECT
Mss4-like	0	DIRECT
Acyl-CoA binding protein	0	DIRECT
alpha-catenin/vinculin-like	0	DIRECT
RNase III domain-like	0	DIRECT
Sialidases	0	DIRECT
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	0	DIRECT
A heparin-binding domain	0	DIRECT
SRF-like	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
Hedgehog/DD-peptidase	0	DIRECT
ClpS-like	0	DIRECT
PriA/YqbF domain	0	DIRECT
PAH2 domain	0	DIRECT
alpha-ketoacid dehydrogenase kinase, N-terminal domain	0	DIRECT
Alanine racemase C-terminal domain-like	0	DIRECT
Pentein	0	DIRECT
Glutamine synthetase/guanido kinase	0	DIRECT
BRK domain-like	0	DIRECT
Stathmin	0	DIRECT
MAST3 pre-PK domain-like	0	DIRECT
Ribulose-phoshate binding barrel	0	DIRECT
Moesin tail domain	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
PLP-binding barrel	0	DIRECT
Subunits of heterodimeric actin filament capping protein Capz	0	DIRECT
AraD/HMP-PK domain-like	0	DIRECT
BEACH domain	0	DIRECT
CCHHC domain	0	DIRECT
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
4Fe-4S ferredoxins	0	DIRECT
NAP-like	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Glycoside hydrolase/deacetylase	0	DIRECT
Nuclear receptor coactivator interlocking domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
14-3-3 protein	0	DIRECT
Amyloid beta a4 protein copper binding domain (domain 2)	0	DIRECT
Delta-sleep-inducing peptide immunoreactive peptide	0	DIRECT
Subdomain of clathrin and coatomer appendage domain	0	DIRECT
Isocitrate/Isopropylmalate dehydrogenase-like	0	DIRECT
Dimeric alpha+beta barrel	0	DIRECT
USP8 N-terminal domain-like	0	DIRECT
Families 57/38 glycoside transferase middle domain	0	DIRECT
I/LWEQ domain	0	DIRECT
Hook domain	0	DIRECT
Transcription factor STAT-4 N-domain	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
ACP-like	0	DIRECT
Bacterial exopeptidase dimerisation domain	0	DIRECT
Nop domain	0	DIRECT
Clathrin adaptor appendage domain	0	DIRECT
PH domain-like	0.000185	DIRECT
Ubiquitin-like	0.0001981	DIRECT
HMG-box	0.003573	INHERITED FROM: midbrain-hindbrain boundary || hindbrain || forebrain
RNA-binding domain, RBD	0.00859	INHERITED FROM: hindbrain || forebrain
Frizzled cysteine-rich domain	0.01659	INHERITED FROM: midbrain || midbrain-hindbrain boundary || hindbrain || forebrain
HLH, helix-loop-helix DNA-binding domain	0.01825	INHERITED FROM: midbrain || hindbrain || ventricular zone || forebrain
Orange domain-like	0.04134	INHERITED FROM: midbrain
Cytokine	0.07088	INHERITED FROM: forebrain
Homeodomain-like	0.07576	INHERITED FROM: zona limitans intrathalamica || lateral ganglionic eminence || pallium || medial ganglionic eminence || thalamus || hypothalamus || olfactory bulb || basal ganglion || midbrain || basal forebrain || infundibulum || amygdala || preoptic area || septum || medial septum || optic stalk || pretectum || midbrain-hindbrain boundary || striatum || subpallium || hindbrain || dorsal thalamus || prosomere || telencephalon || rhombomere || ventricular zone || pallidum || diencephalon || ventral pallium || lateral septum || prethalamus || ventral septum || anterior hypothalamus || forebrain || optic tract || lateral pallium || posterior hypothalamus
SET domain	0.2733	INHERITED FROM: hindbrain
Intermediate filament protein, coiled coil region	0.6341	INHERITED FROM: nucleus reticularis inferior || medulla oblongata || midbrain tegmentum || ventricular zone
Glucocorticoid receptor-like (DNA-binding domain)	0.8224	INHERITED FROM: optic tectum || zona limitans intrathalamica || ventrolateral thalamic nucleus || thalamus || hypothalamus || basal ganglion || midbrain || basal forebrain || amygdala || preoptic area || septum || medial septum || central nucleus of the thalamus || pretectum || striatum || prosomere 4 || subpallium || hindbrain || prosomere || diencephalon || ventral pallium || lateral septum || ventral septum || anterior hypothalamus || forebrain || lateral pallium
Family A G protein-coupled receptor-like	1	INHERITED FROM: pallium || medial pallium || hypothalamus || granule cell layer of the olfactory bulb || basal ganglion || basal forebrain || amygdala || preoptic area || septum || striatum || diencephalon || anterior hypothalamus

Supra-domain (Duplex) in N- to C-terminal order

Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
48403,50044 48403 - Ankyrin repeat 50044 - SH3-domain	0	DIRECT
52821,52799 52821 - Rhodanese/Cell cycle control phosphatase 52799 - (Phosphotyrosine protein) phosphatases II	0	DIRECT
57938,49493 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain	0	DIRECT
57903,47370 57903 - FYVE/PHD zinc finger 47370 - Bromodomain	0	DIRECT
51419,50621 51419 - PLP-binding barrel 50621 - Alanine racemase C-terminal domain-like	0	DIRECT
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like	0	DIRECT
52540,51045 52540 - P-loop containing nucleoside triphosphate hydrolases 51045 - WW domain	0	DIRECT
100895,47473 100895 - Kazal-type serine protease inhibitors 47473 - EF-hand	0	DIRECT
88713,88688 88713 - Glycoside hydrolase/deacetylase 88688 - Families 57/38 glycoside transferase middle domain	0	DIRECT
49562,53300 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 53300 - vWA-like	0	DIRECT
47220,47220 47220 - alpha-catenin/vinculin-like 47220 - alpha-catenin/vinculin-like	0	DIRECT
53187,55031 53187 - Zn-dependent exopeptidases 55031 - Bacterial exopeptidase dimerisation domain	0	DIRECT
48350,50729 48350 - GTPase activation domain, GAP 50729 - PH domain-like	0	DIRECT
57440,57440 57440 - Kringle-like 57440 - Kringle-like	0	DIRECT
54637,54637 54637 - Thioesterase/thiol ester dehydrase-isomerase 54637 - Thioesterase/thiol ester dehydrase-isomerase	0	DIRECT
51045,50156 51045 - WW domain 50156 - PDZ domain-like	0	DIRECT
117281,50965 117281 - Kelch motif 50965 - Galactose oxidase, central domain	0	DIRECT
57196,100895 57196 - EGF/Laminin 100895 - Kazal-type serine protease inhibitors	0	DIRECT
47473,103506 47473 - EF-hand 103506 - Mitochondrial carrier	0	DIRECT
46565,57938 46565 - Chaperone J-domain 57938 - DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
57535,49854 57535 - Complement control module/SCR domain 49854 - Spermadhesin, CUB domain	0	DIRECT
81324,53850 81324 - Voltage-gated potassium channels 53850 - Periplasmic binding protein-like II	0	DIRECT
57903,51197 57903 - FYVE/PHD zinc finger 51197 - Clavaminate synthase-like	0	DIRECT
57184,49899 57184 - Growth factor receptor domain 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
56491,89811 56491 - A heparin-binding domain 89811 - Amyloid beta a4 protein copper binding domain (domain 2)	0	DIRECT
52540,46785 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain	0	DIRECT
49348,55711 49348 - Clathrin adaptor appendage domain 55711 - Subdomain of clathrin and coatomer appendage domain	0	DIRECT
50729,81837 50729 - PH domain-like 81837 - BEACH domain	0	DIRECT
56059,52210 56059 - Glutathione synthetase ATP-binding domain-like 52210 - Succinyl-CoA synthetase domains	0	DIRECT
55874,54211 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 54211 - Ribosomal protein S5 domain 2-like	0	DIRECT
47095,47095 47095 - HMG-box 47095 - HMG-box	0	DIRECT
48034,55931 48034 - Guanido kinase N-terminal domain 55931 - Glutamine synthetase/guanido kinase	0	DIRECT
57184,49265 57184 - Growth factor receptor domain 49265 - Fibronectin type III	0	DIRECT
56112,47769 56112 - Protein kinase-like (PK-like) 47769 - SAM/Pointed domain	0	DIRECT
50447,50465 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
47473,57850 47473 - EF-hand 57850 - RING/U-box	0	DIRECT
54160,57850 54160 - Chromo domain-like 57850 - RING/U-box	0	DIRECT
48065,103657 48065 - DBL homology domain (DH-domain) 103657 - BAR/IMD domain-like	0	DIRECT
50998,50978 50998 - Quinoprotein alcohol dehydrogenase-like 50978 - WD40 repeat-like	0	DIRECT
53850,53850 53850 - Periplasmic binding protein-like II 53850 - Periplasmic binding protein-like II	0	DIRECT
48371,46785 48371 - ARM repeat 46785 - "Winged helix" DNA-binding domain	0	DIRECT
56436,57535 56436 - C-type lectin-like 57535 - Complement control module/SCR domain	0	DIRECT
69012,55874 69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0	DIRECT
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0	DIRECT
47370,47370 47370 - Bromodomain 47370 - Bromodomain	0	DIRECT
69065,54768 69065 - RNase III domain-like 54768 - dsRNA-binding domain-like	0	DIRECT
57889,50729 57889 - Cysteine-rich domain 50729 - PH domain-like	0	DIRECT
48092,47655 48092 - Transcription factor STAT-4 N-domain 47655 - STAT	0	DIRECT
47473,57889 47473 - EF-hand 57889 - Cysteine-rich domain	0	DIRECT
57196,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
49313,49899 49313 - Cadherin-like 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
50044,50156 50044 - SH3-domain 50156 - PDZ domain-like	0	DIRECT
82919,53300 82919 - Zn-finger domain of Sec23/24 53300 - vWA-like	0	DIRECT
49493,49493 49493 - HSP40/DnaJ peptide-binding domain 49493 - HSP40/DnaJ peptide-binding domain	0	DIRECT
103637,103637 103637 - CCHHC domain 103637 - CCHHC domain	0	DIRECT
57863,48403 57863 - ArfGap/RecO-like zinc finger 48403 - Ankyrin repeat	0	DIRECT
57440,50494 57440 - Kringle-like 50494 - Trypsin-like serine proteases	0	DIRECT
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat	0	DIRECT
52518,52518 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52518 - Thiamin diphosphate-binding fold (THDP-binding)	0	DIRECT
47459,158457 47459 - HLH, helix-loop-helix DNA-binding domain 158457 - Orange domain-like	0.04134	INHERITED FROM: midbrain
103575,48726 103575 - Plexin repeat 48726 - Immunoglobulin	0.478	INHERITED FROM: midbrain-hindbrain boundary
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0.5935	INHERITED FROM: optic tectum || zona limitans intrathalamica || ventrolateral thalamic nucleus || pallium || thalamus || hypothalamus || basal ganglion || basal forebrain || amygdala || preoptic area || septum || medial septum || central nucleus of the thalamus || pretectum || striatum || prosomere 4 || subpallium || hindbrain || prosomere || ventral pallium || lateral septum || ventral septum || anterior hypothalamus || bed nucleus of the stria terminalis || forebrain || anterior thalamic nucleus || medial amygdala || lateral pallium
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers	0.6615	INHERITED FROM: hindbrain
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain	0.7114	INHERITED FROM: hypothalamus

Supra-domain (Triple) in N- to C-terminal order

Highlighted in gray are those with FDR>0.001

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
50249,50249,50249 50249 - Nucleic acid-binding proteins 50249 - Nucleic acid-binding proteins 50249 - Nucleic acid-binding proteins	0	DIRECT
57440,57440,50494 57440 - Kringle-like 57440 - Kringle-like 50494 - Trypsin-like serine proteases	0	DIRECT
48092,47655,49417 48092 - Transcription factor STAT-4 N-domain 47655 - STAT 49417 - p53-like transcription factors	0	DIRECT
49313,49313,49899 49313 - Cadherin-like 49313 - Cadherin-like 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
48065,103657,50044 48065 - DBL homology domain (DH-domain) 103657 - BAR/IMD domain-like 50044 - SH3-domain	0	DIRECT
57184,57184,57196 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain 57196 - EGF/Laminin	0	DIRECT
49899,57196,49899 49899 - Concanavalin A-like lectins/glucanases 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like)	0	DIRECT
52540,50447,50465 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
57535,49854,57535 57535 - Complement control module/SCR domain 49854 - Spermadhesin, CUB domain 57535 - Complement control module/SCR domain	0	DIRECT
47220,47220,47220 47220 - alpha-catenin/vinculin-like 47220 - alpha-catenin/vinculin-like 47220 - alpha-catenin/vinculin-like	0	DIRECT
49854,57535,57535 49854 - Spermadhesin, CUB domain 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain	0	DIRECT
49899,57196,57196 49899 - Concanavalin A-like lectins/glucanases 57196 - EGF/Laminin 57196 - EGF/Laminin	0	DIRECT
48592,54849,52029 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0	DIRECT
57938,49493,49493 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain 49493 - HSP40/DnaJ peptide-binding domain	0	DIRECT
46565,57938,49493 46565 - Chaperone J-domain 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain	0	DIRECT
57196,49899,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
57196,57196,49899 57196 - EGF/Laminin 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
52540,51045,51045 52540 - P-loop containing nucleoside triphosphate hydrolases 51045 - WW domain 51045 - WW domain	0	DIRECT
54160,57850,57845 54160 - Chromo domain-like 57850 - RING/U-box 57845 - B-box zinc-binding domain	0	DIRECT
103637,103637,103637 103637 - CCHHC domain 103637 - CCHHC domain 103637 - CCHHC domain	0	DIRECT
57440,57440,57440 57440 - Kringle-like 57440 - Kringle-like 57440 - Kringle-like	0	DIRECT
49562,49562,53300 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 53300 - vWA-like	0	DIRECT
57196,49899,57196 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases 57196 - EGF/Laminin	0	DIRECT
57184,52058,57184 57184 - Growth factor receptor domain 52058 - L domain-like 57184 - Growth factor receptor domain	0	DIRECT
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III	0.2116	INHERITED FROM: hindbrain
50044,55550,56112 50044 - SH3-domain 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.3654	INHERITED FROM: forebrain
101912,103575,48726 101912 - Sema domain 103575 - Plexin repeat 48726 - Immunoglobulin	0.478	INHERITED FROM: midbrain-hindbrain boundary