RNA helicase

---

Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children)	EC term [EC ID] <#Children>	(#SF|#FA)	#Supra-domain (Single|Duplex|Triple)
+ + + + 4:	root [root] <6>
+ + + 3:	Hydrolases [3] <13>	(329|528)	(368|389|207)
+ + 2:	Acting on acid anhydrides [3.6] <5>	(83|103)	(94|93|62)
+ 1:	Acting on acid anhydrides; involved in cellular an [3.6.4] <13>	(46|55)	(51|47|29)
0:	RNA helicase [3.6.4.13]	(22|25)	(25|20|9)

---

Superfamily

Superfamily domains annotated to this EC term (Not in SDEO)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
DNA/RNA polymerases	0	DIRECT
P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
Macro domain-like	0	DIRECT
Flavivirus capsid protein C	0	DIRECT
Coronavirus NSP8-like	0	DIRECT
Coronavirus NSP7-like	0	DIRECT
EndoU-like	0	DIRECT
Viral glycoprotein, central and dimerisation domains	0	DIRECT
Tudor/PWWP/MBT	0	DIRECT
Replicase NSP9	0	DIRECT
Coronavirus NSP10-like	0	DIRECT
NSP3A-like	0	DIRECT
Trypsin-like serine proteases	0	DIRECT
E set domains	0.00000000000000646	DIRECT
RNA-binding domain, RBD	0.000000000001136	DIRECT
R3H domain	0.000000000007295	DIRECT
WW domain	0.00000002367	DIRECT
Ribonuclease Rh-like	0.00000403	DIRECT
S-adenosyl-L-methionine-dependent methyltransferases	0.00001262	DIRECT
Clavaminate synthase-like	0.0002255	DIRECT
Retrovirus zinc finger-like domains	0.0002255	DIRECT
Concanavalin A-like lectins/glucanases	0.0002374	DIRECT

---

Family

Family domains annotated to this (SDEO level: Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Coronavirus NSP8-like	0	DIRECT
Nsp15 C-terminal domain-like	0	DIRECT
Class II viral fusion proteins C-terminal domain	0	DIRECT
Replicase NSP9	0	DIRECT
Viral proteases	0	DIRECT
RNA helicase	0	DIRECT
Tandem AAA-ATPase domain	0	DIRECT
Nsp15 N-terminal domain-like	0	DIRECT
RNA-dependent RNA-polymerase	0	DIRECT
Flavivirus capsid protein C	0	DIRECT
Viral glycoprotein, central and dimerisation domains	0	DIRECT
Tudor domain	0	DIRECT
NSP3A-like	0	DIRECT
SPRY domain	0	DIRECT
Macro domain	0	DIRECT
Coronavirus NSP7-like	0	DIRECT
GUCT domain	0	DIRECT
Coronavirus NSP10-like	0	DIRECT
Viral cysteine protease of trypsin fold	0	DIRECT
mRNA cap methylase	0	DIRECT
R3H domain	0.000000000003069	DIRECT
AlkB-like	0.00000000002398	DIRECT
WW domain	0.00000001048	DIRECT
Ribonuclease Rh-like	0.000001999	DIRECT
Retrovirus zinc finger-like domains	0.0001274	DIRECT

---

Supra-domain (including individual superfamily)

Supra-domains annotated to this EC term (SPEO level: Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
AN1-like Zinc finger	0	DIRECT
Coronavirus NSP8-like	0	DIRECT
Trypsin-like serine proteases	0	DIRECT
Replicase NSP9	0	DIRECT
Flavivirus capsid protein C	0	DIRECT
P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
Tudor/PWWP/MBT	0	DIRECT
NSP3A-like	0	DIRECT
EndoU-like	0	DIRECT
Macro domain-like	0	DIRECT
Coronavirus NSP10-like	0	DIRECT
Coronavirus NSP7-like	0	DIRECT
DNA/RNA polymerases	0	DIRECT
Viral glycoprotein, central and dimerisation domains	0	DIRECT
E set domains	0.000000000000004848	DIRECT
RNA-binding domain, RBD	0.0000000000008337	DIRECT
R3H domain	0.000000000005491	DIRECT
SARS Nsp1-like	0.000000004582	DIRECT
WW domain	0.00000001857	DIRECT
Ribonuclease Rh-like	0.000003253	DIRECT
S-adenosyl-L-methionine-dependent methyltransferases	0.00002511	DIRECT
Retrovirus zinc finger-like domains	0.0001904	DIRECT
Clavaminate synthase-like	0.0001904	DIRECT
Concanavalin A-like lectins/glucanases	0.0002049	DIRECT
NTF2-like	0.0003913	DIRECT

Supra-domains annotated to this EC term (SPEO level: Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
56672,52540 56672 - DNA/RNA polymerases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
52540,54928 52540 - P-loop containing nucleoside triphosphate hydrolases 54928 - RNA-binding domain, RBD	0	DIRECT
56983,81296 56983 - Viral glycoprotein, central and dimerisation domains 81296 - E set domains	0	DIRECT
53335,52949 53335 - S-adenosyl-L-methionine-dependent methyltransferases 52949 - Macro domain-like	0	DIRECT
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
52540,57756 52540 - P-loop containing nucleoside triphosphate hydrolases 57756 - Retrovirus zinc finger-like domains	0	DIRECT
52540,142877 52540 - P-loop containing nucleoside triphosphate hydrolases 142877 - EndoU-like	0	DIRECT
49899,52540 49899 - Concanavalin A-like lectins/glucanases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
53335,56672 53335 - S-adenosyl-L-methionine-dependent methyltransferases 56672 - DNA/RNA polymerases	0	DIRECT
140367,143076 140367 - Coronavirus NSP7-like 143076 - Coronavirus NSP8-like	0	DIRECT
50494,52540 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
53335,142877 53335 - S-adenosyl-L-methionine-dependent methyltransferases 142877 - EndoU-like	0	DIRECT
52540,56672 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases	0	DIRECT
52540,49899 52540 - P-loop containing nucleoside triphosphate hydrolases 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
101816,144246 101816 - Replicase NSP9 144246 - Coronavirus NSP10-like	0	DIRECT
143076,101816 143076 - Coronavirus NSP8-like 101816 - Replicase NSP9	0	DIRECT
52980,47781 52980 - Restriction endonuclease-like 47781 - RuvA domain 2-like	0	DIRECT
159936,52949 159936 - NSP3A-like 52949 - Macro domain-like	0.000000004582	DIRECT
159936,53335 159936 - NSP3A-like 53335 - S-adenosyl-L-methionine-dependent methyltransferases	0.0000001332	DIRECT
57756,57756 57756 - Retrovirus zinc finger-like domains 57756 - Retrovirus zinc finger-like domains	0.0000003058	DIRECT

Supra-domains annotated to this EC term (SPEO level: Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
50494,52540,52540 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
52540,52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
52540,49899,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 49899 - Concanavalin A-like lectins/glucanases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
51197,52540,56672 51197 - Clavaminate synthase-like 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases	0	DIRECT
140367,143076,101816 140367 - Coronavirus NSP7-like 143076 - Coronavirus NSP8-like 101816 - Replicase NSP9	0	DIRECT
52540,52540,56672 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases	0	DIRECT
56672,52540,52540 56672 - DNA/RNA polymerases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
52540,52540,142877 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 142877 - EndoU-like	0	DIRECT
143076,101816,144246 143076 - Coronavirus NSP8-like 101816 - Replicase NSP9 144246 - Coronavirus NSP10-like	0	DIRECT