Acting on acid anhydrides; involved in cellular an

Enzyme Commission (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed. To navigate hierarchical structure of EC, we display all parental EC terms to the current EC term of interest ordered by their shortest distances to the current term. Also, only direct children EC terms of the current EC term are listed.

Structural Classification of Proteins (SCOP)
SCOP classifies evolutionary-related domains into Superfamily level and Family level. Accordingly, we have generated the domain-centric EC annotations for each of the three concepts at each of the two domain levels.

Structural Domain Enzyme Commission Ontology (SDEO)
As domain-centric ontology, SDEO only refers to those EC terms which are the most informative to annotate SCOP domains.

EC annotations for SCOP domains
For details, please visit Documentation: EC annotations for SCOP domains. Therein, we provide several relevant files (Data Availability) for the download, including an annotation file (i.e., Domain2EC.txt) and the corresponding ontology (i.e., SDEO.txt).

Supra-domain Enzyme Commission Ontology (SPEO)
As an extension, SPEO includes those EC terms which are the most informative to annotate supra-domains and individual SCOP domains at the Superfamily level.

EC annotations for Supra-domains
For details, please visit Documentation: EC annotations for Supra-domains. Therein, we provide several relevant files (Data Availability) for the download, including a annotation file (i.e., SP2EC.txt) and an ontology (i.e., SPEO.txt). For the sake of being browsable, listed below are those supra-domains (single, dual, triple, quad).

Superfamily

Family

Trees by TreeVector

A presence/absence matrix is generated using protein domains and supradomains for all genomes in SUPERFAMILY. The RAxML software is used to produce a single, large tree topology using heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as if individual trees had been produced. However, this data is extracted from the single large tree. This produces a higher quality topology than if the trees had been produced on their own, and allows the trees to be displayed instantly.

Supra-domain (including individual superfamily)

Supra-domains annotated to this EC term (SPEO level: Moderately Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
100939,68906 100939 - SPOC domain-like 68906 - SAP domain	0	DIRECT
56672,52540 56672 - DNA/RNA polymerases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
52540,54928 52540 - P-loop containing nucleoside triphosphate hydrolases 54928 - RNA-binding domain, RBD	0	DIRECT
50692,54585 50692 - ADC-like 54585 - Cdc48 domain 2-like	0	DIRECT
50249,52540 50249 - Nucleic acid-binding proteins 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
56983,81296 56983 - Viral glycoprotein, central and dimerisation domains 81296 - E set domains	0	DIRECT
53335,52949 53335 - S-adenosyl-L-methionine-dependent methyltransferases 52949 - Macro domain-like	0	DIRECT
52540,46785 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain	0	DIRECT
160481,160481 160481 - BRK domain-like 160481 - BRK domain-like	0	DIRECT
158702,81296 158702 - Sec63 N-terminal domain-like 81296 - E set domains	0	DIRECT
50916,46785 50916 - Rap30/74 interaction domains 46785 - "Winged helix" DNA-binding domain	0	DIRECT
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
52540,57756 52540 - P-loop containing nucleoside triphosphate hydrolases 57756 - Retrovirus zinc finger-like domains	0	DIRECT
52540,56712 52540 - P-loop containing nucleoside triphosphate hydrolases 56712 - Prokaryotic type I DNA topoisomerase	0	DIRECT
52540,142877 52540 - P-loop containing nucleoside triphosphate hydrolases 142877 - EndoU-like	0	DIRECT
100939,101420 100939 - SPOC domain-like 101420 - C-terminal domain of Ku80	0	DIRECT
46785,47819 46785 - "Winged helix" DNA-binding domain 47819 - HRDC-like	0	DIRECT
56731,52540 56731 - DNA primase core 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
46785,158702 46785 - "Winged helix" DNA-binding domain 158702 - Sec63 N-terminal domain-like	0	DIRECT
49899,52540 49899 - Concanavalin A-like lectins/glucanases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
158702,52540 158702 - Sec63 N-terminal domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
48024,52540 48024 - N-terminal domain of DnaB helicase 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
52540,47819 52540 - P-loop containing nucleoside triphosphate hydrolases 47819 - HRDC-like	0	DIRECT
53335,56672 53335 - S-adenosyl-L-methionine-dependent methyltransferases 56672 - DNA/RNA polymerases	0	DIRECT
140367,143076 140367 - Coronavirus NSP7-like 143076 - Coronavirus NSP8-like	0	DIRECT
47781,46929 47781 - RuvA domain 2-like 46929 - DNA helicase RuvA subunit, C-terminal domain	0	DIRECT
54160,52540 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
53300,100939 53300 - vWA-like 100939 - SPOC domain-like	0	DIRECT
54585,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
53335,142877 53335 - S-adenosyl-L-methionine-dependent methyltransferases 142877 - EndoU-like	0	DIRECT
52540,56672 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases	0	DIRECT
55464,52540 55464 - Origin of replication-binding domain, RBD-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
50249,47781 50249 - Nucleic acid-binding proteins 47781 - RuvA domain 2-like	0	DIRECT
52540,49899 52540 - P-loop containing nucleoside triphosphate hydrolases 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
101816,144246 101816 - Replicase NSP9 144246 - Coronavirus NSP10-like	0	DIRECT
55608,56712 55608 - Homing endonucleases 56712 - Prokaryotic type I DNA topoisomerase	0	DIRECT
54160,54160 54160 - Chromo domain-like 54160 - Chromo domain-like	0	DIRECT
143076,101816 143076 - Coronavirus NSP8-like 101816 - Replicase NSP9	0	DIRECT
52980,47781 52980 - Restriction endonuclease-like 47781 - RuvA domain 2-like	0	DIRECT
51197,52540 51197 - Clavaminate synthase-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0.0000000000006623	DIRECT
50494,52540 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases	0.000000000003485	DIRECT
56712,51294 56712 - Prokaryotic type I DNA topoisomerase 51294 - Hedgehog/intein (Hint) domain	0.0000003012	DIRECT
159936,52949 159936 - NSP3A-like 52949 - Macro domain-like	0.0000003464	DIRECT
159936,53335 159936 - NSP3A-like 53335 - S-adenosyl-L-methionine-dependent methyltransferases	0.000004252	DIRECT
57756,57756 57756 - Retrovirus zinc finger-like domains 57756 - Retrovirus zinc finger-like domains	0.000009655	DIRECT
52540,51294 52540 - P-loop containing nucleoside triphosphate hydrolases 51294 - Hedgehog/intein (Hint) domain	0.03342	INHERITED FROM: DNA helicase
51294,55608 51294 - Hedgehog/intein (Hint) domain 55608 - Homing endonucleases	0.0361	INHERITED FROM: DNA helicase

Trees by TreeVector

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Acting on acid anhydrides; involved in cellular an

Superfamily

Family

Supra-domain (including individual superfamily)