Forming carbon-oxygen bonds

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children)	EC term [EC ID] <#Children>	(#SF|#FA)	#Supra-domain (Single|Duplex|Triple)
+ + 2:	root [root] <6>
+ 1:	Ligases [6] <6>	(80|99)	(88|104|66)
0:	Forming carbon-oxygen bonds [6.1] <2>	(28|31)	(29|36|21)
- 1:	Ligases forming aminoacyl-tRNA and related compoun [6.1.1] <29>	(28|31)	(29|36|21)
- 1:	Acid--alcohol ligases (ester synthases [6.1.2] <1>	(0|0)	(0|0|0)

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Superfamily

Superfamily domains annotated to this EC term (Not in SDEO)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
YegP-like	0	DIRECT
Ribosomal protein L25-like	0	DIRECT
ThrRS/AlaRS common domain	0	DIRECT
Translation proteins	0	DIRECT
Anticodon-binding domain of PheRS	0	DIRECT
Alpha-L RNA-binding motif	0	DIRECT
An anticodon-binding domain of class I aminoacyl-tRNA synthetases	0	DIRECT
S15/NS1 RNA-binding domain	0	DIRECT
HD-domain/PDEase-like	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Class II aaRS and biotin synthetases	0	DIRECT
Class II aaRS ABD-related	0	DIRECT
YbaK/ProRS associated domain	0	DIRECT
C-terminal domain of ProRS	0	DIRECT
TGS-like	0	DIRECT
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	0	DIRECT
Nucleic acid-binding proteins	0	DIRECT
Nucleotidylyl transferase	0	DIRECT
tRNA-binding arm	0	DIRECT
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	0	DIRECT
Methionyl-tRNA synthetase (MetRS), Zn-domain	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
Putative DNA-binding domain	0	DIRECT
GAD domain-like	0	DIRECT
PheT/TilS domain	0.0000000005628	DIRECT
ACP-like	0.000000001399	DIRECT
"Winged helix" DNA-binding domain	1	INHERITED FROM: Phenylalanine--tRNA ligase
Acetyl-CoA synthetase-like	1	INHERITED FROM: D-alanine--poly(phosphoribitol) ligase

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Family

Family domains annotated to this (Not in SDEO)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Gln-tRNA synthetase (GlnRS), C-terminal (anticodon-binding) domain	0	DIRECT
B3/B4 domain of PheRS, PheT	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Anticodon-binding domain	0	DIRECT
Phenylalanyl-tRNA synthetase (PheRS)	0	DIRECT
Anticodon-binding domain of PheRS	0	DIRECT
YbaK/ProRS associated domain	0	DIRECT
C-terminal domain of glutamyl-tRNA synthetase (GluRS)	0	DIRECT
apo-D-alanyl carrier protein	0	DIRECT
Valyl-tRNA synthetase (ValRS) C-terminal domain	0	DIRECT
YegP-like	0	DIRECT
Tyrosyl-tRNA synthetase (TyrRS), C-terminal domain	0	DIRECT
Threonyl-tRNA synthetase (ThrRS), second 'additional' domain	0	DIRECT
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	0	DIRECT
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain	0	DIRECT
Class I aminoacyl-tRNA synthetases (RS), catalytic domain	0	DIRECT
C-terminal domain of ProRS	0	DIRECT
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	0	DIRECT
Methionyl-tRNA synthetase (MetRS), Zn-domain	0	DIRECT
Myf domain	0	DIRECT
Anticodon-binding domain of Class II aaRS	0	DIRECT
a tRNA synthase domain	0	DIRECT
Domains B1 and B5 of PheRS-beta, PheT	0	DIRECT
AlaX-M N-terminal domain-like	0	DIRECT
GAD domain	0	DIRECT
C-terminal domain of class I lysyl-tRNA synthetase	0	DIRECT
AlaX-like	0	DIRECT
Seryl-tRNA synthetase (SerRS)	0	DIRECT
TGS domain	0	DIRECT
Acetyl-CoA synthetase-like	1	INHERITED FROM: D-alanine--poly(phosphoribitol) ligase

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Supra-domain (including individual superfamily)

Supra-domains annotated to this EC term (Not in SPEO)
Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Nucleotidylyl transferase	0	DIRECT
Methionyl-tRNA synthetase (MetRS), Zn-domain	0	DIRECT
Class II aaRS ABD-related	0	DIRECT
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	0	DIRECT
Class II aaRS and biotin synthetases	0	DIRECT
Anticodon-binding domain of PheRS	0	DIRECT
GAD domain-like	0	DIRECT
Putative DNA-binding domain	0	DIRECT
Alpha-L RNA-binding motif	0	DIRECT
Nucleic acid-binding proteins	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
HD-domain/PDEase-like	0	DIRECT
YegP-like	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
Translation proteins	0	DIRECT
TGS-like	0	DIRECT
Ribosomal protein L25-like	0	DIRECT
tRNA-binding arm	0	DIRECT
ThrRS/AlaRS common domain	0	DIRECT
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	0	DIRECT
YbaK/ProRS associated domain	0	DIRECT
An anticodon-binding domain of class I aminoacyl-tRNA synthetases	0	DIRECT
S15/NS1 RNA-binding domain	0	DIRECT
C-terminal domain of ProRS	0	DIRECT
PheT/TilS domain	0.0000000004379	DIRECT
ACP-like	0.000000001103	DIRECT
GST C-terminal domain-like	0.9369	INHERITED FROM: Valine--tRNA ligase || Glutamate--tRNA ligase
Acetyl-CoA synthetase-like	1	INHERITED FROM: D-alanine--poly(phosphoribitol) ligase
"Winged helix" DNA-binding domain	1	INHERITED FROM: Phenylalanine--tRNA ligase

Supra-domains annotated to this EC term (Not in SPEO)
Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
55681,52954 55681 - Class II aaRS and biotin synthetases 52954 - Class II aaRS ABD-related	0	DIRECT
101353,55186 101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) 55186 - ThrRS/AlaRS common domain	0	DIRECT
47323,47323 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
46955,55681 46955 - Putative DNA-binding domain 55681 - Class II aaRS and biotin synthetases	0	DIRECT
47616,52374 47616 - GST C-terminal domain-like 52374 - Nucleotidylyl transferase	0	DIRECT
101353,50447 101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) 50447 - Translation proteins	0	DIRECT
50249,55681 50249 - Nucleic acid-binding proteins 55681 - Class II aaRS and biotin synthetases	0	DIRECT
50447,55186 50447 - Translation proteins 55186 - ThrRS/AlaRS common domain	0	DIRECT
55681,55826 55681 - Class II aaRS and biotin synthetases 55826 - YbaK/ProRS associated domain	0	DIRECT
52374,160113 52374 - Nucleotidylyl transferase 160113 - YegP-like	0	DIRECT
47060,55681 47060 - S15/NS1 RNA-binding domain 55681 - Class II aaRS and biotin synthetases	0	DIRECT
46589,55681 46589 - tRNA-binding arm 55681 - Class II aaRS and biotin synthetases	0	DIRECT
52374,47323 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
47060,52374 47060 - S15/NS1 RNA-binding domain 52374 - Nucleotidylyl transferase	0	DIRECT
50249,56037 50249 - Nucleic acid-binding proteins 56037 - PheT/TilS domain	0	DIRECT
52374,50715 52374 - Nucleotidylyl transferase 50715 - Ribosomal protein L25-like	0	DIRECT
52374,48163 52374 - Nucleotidylyl transferase 48163 - An anticodon-binding domain of class I aminoacyl-tRNA synthetases	0	DIRECT
55681,55261 55681 - Class II aaRS and biotin synthetases 55261 - GAD domain-like	0	DIRECT
47323,47060 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 47060 - S15/NS1 RNA-binding domain	0	DIRECT
52374,50249 52374 - Nucleotidylyl transferase 50249 - Nucleic acid-binding proteins	0	DIRECT
56037,46955 56037 - PheT/TilS domain 46955 - Putative DNA-binding domain	0	DIRECT
55190,52374 55190 - Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain 52374 - Nucleotidylyl transferase	0	DIRECT
55681,54991 55681 - Class II aaRS and biotin synthetases 54991 - Anticodon-binding domain of PheRS	0	DIRECT
52374,55174 52374 - Nucleotidylyl transferase 55174 - Alpha-L RNA-binding motif	0	DIRECT
47060,47060 47060 - S15/NS1 RNA-binding domain 47060 - S15/NS1 RNA-binding domain	0	DIRECT
50677,52374 50677 - ValRS/IleRS/LeuRS editing domain 52374 - Nucleotidylyl transferase	0	DIRECT
55186,55681 55186 - ThrRS/AlaRS common domain 55681 - Class II aaRS and biotin synthetases	0	DIRECT
109604,47323 109604 - HD-domain/PDEase-like 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
47323,50249 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 50249 - Nucleic acid-binding proteins	0	DIRECT
81271,55186 81271 - TGS-like 55186 - ThrRS/AlaRS common domain	0	DIRECT
47323,46589 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 46589 - tRNA-binding arm	0	DIRECT
57770,52374 57770 - Methionyl-tRNA synthetase (MetRS), Zn-domain 52374 - Nucleotidylyl transferase	0	DIRECT
46955,56037 46955 - Putative DNA-binding domain 56037 - PheT/TilS domain	0	DIRECT
52954,64586 52954 - Class II aaRS ABD-related 64586 - C-terminal domain of ProRS	0	DIRECT
55681,101353 55681 - Class II aaRS and biotin synthetases 101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	0	DIRECT
46785,46785 46785 - "Winged helix" DNA-binding domain 46785 - "Winged helix" DNA-binding domain	0.0003379	DIRECT

Supra-domains annotated to this EC term (Not in SPEO)
Highlighted in gray are those with FDR>0.001

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
47616,52374,50715 47616 - GST C-terminal domain-like 52374 - Nucleotidylyl transferase 50715 - Ribosomal protein L25-like	0	DIRECT
50249,55681,55261 50249 - Nucleic acid-binding proteins 55681 - Class II aaRS and biotin synthetases 55261 - GAD domain-like	0	DIRECT
52374,47323,50249 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 50249 - Nucleic acid-binding proteins	0	DIRECT
55186,55681,52954 55186 - ThrRS/AlaRS common domain 55681 - Class II aaRS and biotin synthetases 52954 - Class II aaRS ABD-related	0	DIRECT
46955,55681,54991 46955 - Putative DNA-binding domain 55681 - Class II aaRS and biotin synthetases 54991 - Anticodon-binding domain of PheRS	0	DIRECT
47060,55681,52954 47060 - S15/NS1 RNA-binding domain 55681 - Class II aaRS and biotin synthetases 52954 - Class II aaRS ABD-related	0	DIRECT
55681,52954,64586 55681 - Class II aaRS and biotin synthetases 52954 - Class II aaRS ABD-related 64586 - C-terminal domain of ProRS	0	DIRECT
52374,47323,47060 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 47060 - S15/NS1 RNA-binding domain	0	DIRECT
50249,56037,46955 50249 - Nucleic acid-binding proteins 56037 - PheT/TilS domain 46955 - Putative DNA-binding domain	0	DIRECT
50677,52374,47323 50677 - ValRS/IleRS/LeuRS editing domain 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
57770,52374,47323 57770 - Methionyl-tRNA synthetase (MetRS), Zn-domain 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
81271,55186,55681 81271 - TGS-like 55186 - ThrRS/AlaRS common domain 55681 - Class II aaRS and biotin synthetases	0	DIRECT
47060,47060,55681 47060 - S15/NS1 RNA-binding domain 47060 - S15/NS1 RNA-binding domain 55681 - Class II aaRS and biotin synthetases	0	DIRECT
101353,50447,55186 101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) 50447 - Translation proteins 55186 - ThrRS/AlaRS common domain	0	DIRECT
55681,101353,55186 55681 - Class II aaRS and biotin synthetases 101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) 55186 - ThrRS/AlaRS common domain	0	DIRECT
56037,46955,55681 56037 - PheT/TilS domain 46955 - Putative DNA-binding domain 55681 - Class II aaRS and biotin synthetases	0	DIRECT
55681,101353,50447 55681 - Class II aaRS and biotin synthetases 101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) 50447 - Translation proteins	0	DIRECT
47060,47060,47060 47060 - S15/NS1 RNA-binding domain 47060 - S15/NS1 RNA-binding domain 47060 - S15/NS1 RNA-binding domain	0	DIRECT
52374,47323,46589 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 46589 - tRNA-binding arm	0	DIRECT
55190,52374,47323 55190 - Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
46955,56037,46955 46955 - Putative DNA-binding domain 56037 - PheT/TilS domain 46955 - Putative DNA-binding domain	0	DIRECT