Acetyl-CoA synthetase-like family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Multi-domain proteins (alpha and beta) [ 56572] (66)
• Fold: Acetyl-CoA synthetase-like [ 56800]
• Superfamily: Acetyl-CoA synthetase-like [ 56801]
• Family: Acetyl-CoA synthetase-like [ 56802] (6)

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Family statistics

	Genomes (2,869)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	40,105	310,548	7
Proteins	34,388	267,758	7

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	D-alanine--poly(phosphoribitol) ligase	0	2.44	--	DIRECT
Enzyme Commission (EC)	L-aminoadipate-semialdehyde dehydrogenase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Acetate--CoA ligase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Forming carbon-sulfur bonds	0	2.139	--	DIRECT
Enzyme Commission (EC)	Acyl-[acyl-carrier-protein]--phospholipid O-acyltr	0	2.741	--	DIRECT
Enzyme Commission (EC)	N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin	1.746e-16	2.264	--	DIRECT
Enzyme Commission (EC)	Photinus-luciferin 4-monooxygenase (ATP-hydrolyzin	0.00000000000002625	2.741	--	DIRECT
Enzyme Commission (EC)	Phenylalanine racemase (ATP-hydrolyzing)	0.0000000000002089	2.44	--	DIRECT
Enzyme Commission (EC)	With incorporation of one atom of oxygen	0.0000000005675	2.44	--	DIRECT
Enzyme Commission (EC)	Long-chain-fatty-acid--CoA ligase	0.000000001564	2.741	--	DIRECT
Enzyme Commission (EC)	Acyltransferases	0.000001451	0.8778	--	DIRECT
Enzyme Commission (EC)	Long-chain-fatty-acid--[acyl-carrier-protein] liga	0.000001706	2.741	--	DIRECT
Enzyme Commission (EC)	o-succinylbenzoate--CoA ligase	0.00000692	2.741	--	DIRECT
Enzyme Commission (EC)	4-coumarate--CoA ligase	0.0001425	2.741	--	DIRECT
Enzyme Commission (EC)	Butyrate--CoA ligase	0.0005546	2.741	--	DIRECT
Enzyme Commission (EC)	Forming carbon-oxygen bonds	1	1.25	--	INHERITED FROM: D-alanine--poly(phosphoribitol) ligase
Enzyme Commission (EC)	Transferases	1	0	--	INHERITED FROM: Acyltransferases || Transferring groups other than amino-acyl groups || Acyl-[acyl-carrier-protein]--phospholipid O-acyltr
Enzyme Commission (EC)	Ligases	0	0.7455	Least Informative	DIRECT
Enzyme Commission (EC)	Isomerases	1	0.6881	Least Informative	INHERITED FROM: Phenylalanine racemase (ATP-hydrolyzing)
Enzyme Commission (EC)	Oxidoreductases	1	0.3212	Least Informative	INHERITED FROM: With incorporation of one atom of oxygen || Photinus-luciferin 4-monooxygenase (ATP-hydrolyzin || L-aminoadipate-semialdehyde dehydrogenase
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0.000000007561	1.001	Moderately Informative	DIRECT
Enzyme Commission (EC)	Forming carbon-nitrogen bonds	1	0.993	Moderately Informative	INHERITED FROM: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin
Enzyme Commission (EC)	Ligases forming aminoacyl-tRNA and related compoun	0.01579	1.25	Moderately Informative	INHERITED FROM: D-alanine--poly(phosphoribitol) ligase
Enzyme Commission (EC)	Acting on the aldehyde or oxo group of donors	0.6557	1.236	Moderately Informative	INHERITED FROM: L-aminoadipate-semialdehyde dehydrogenase
Enzyme Commission (EC)	Acid--D-amino-acid ligases (peptide synthases)	0.8841	1.379	Informative	INHERITED FROM: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin
Enzyme Commission (EC)	Racemases and epimerases	0.151	1.379	Informative	INHERITED FROM: Phenylalanine racemase (ATP-hydrolyzing)
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.5241	1.662	Informative	INHERITED FROM: L-aminoadipate-semialdehyde dehydrogenase
Enzyme Commission (EC)	Acting on single donors with incorporation of mole	0.01062	1.537	Informative	INHERITED FROM: Photinus-luciferin 4-monooxygenase (ATP-hydrolyzin || With incorporation of one atom of oxygen
Enzyme Commission (EC)	Acid--thiol ligases	1	2.139	Highly Informative	INHERITED FROM: 4-coumarate--CoA ligase || Long-chain-fatty-acid--[acyl-carrier-protein] liga || Acetate--CoA ligase || Butyrate--CoA ligase || Long-chain-fatty-acid--CoA ligase || o-succinylbenzoate--CoA ligase
Enzyme Commission (EC)	Acting on amino acids and derivatives	0.01222	1.838	Highly Informative	INHERITED FROM: Phenylalanine racemase (ATP-hydrolyzing)

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.2181	0.3626	--	INHERITED FROM: abnormal lipid homeostasis
Mammalian Phenotype (MP)	abnormal homeostasis	0.1132	0.4926	Least Informative	INHERITED FROM: abnormal lipid homeostasis
Mammalian Phenotype (MP)	abnormal lipid homeostasis	0.0009044	1.141	Moderately Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	lipid metabolism variant	0.0000000002403	1.337	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: organism homeostasis metabolism variant || lethal || organism physiology variant || development variant || lipid metabolism variant || embryonic development variant || embryonic lethal || postembryonic development variant || organism development variant
Worm Phenotype (WP)	organism metabolism processing variant	0.1771	0.4899	Least Informative	INHERITED FROM: lipid metabolism variant

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.1452	--	DIRECT
Yeast Phenotype (YP)	resistance to chemicals	0	0.3202	Least Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: multicellular anatomical structure

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || shoot system
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: shoot system
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || corolla development stage || plant organ development stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Forming carbon-sulfur bonds	0	2.452	--	DIRECT
Enzyme Commission (EC)	Acetate--CoA ligase	0	3.23	--	DIRECT
Enzyme Commission (EC)	L-2-aminoadipate reductase	3.693e-16	2.929	--	DIRECT
Enzyme Commission (EC)	N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase	3.693e-16	2.753	--	DIRECT
Enzyme Commission (EC)	L-aminoadipate-semialdehyde dehydrogenase	0.00000000000001155	2.929	--	DIRECT
Enzyme Commission (EC)	Firefly luciferase	0.0000000000000395	3.23	--	DIRECT
Enzyme Commission (EC)	Phenylalanine racemase (ATP-hydrolyzing)	0.0000000000005963	2.753	--	DIRECT
Enzyme Commission (EC)	With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidase	0.0000000002525	2.929	--	DIRECT
Enzyme Commission (EC)	Cyclo-ligases	0.000000000545	3.23	--	DIRECT
Enzyme Commission (EC)	Long-chain-fatty-acid--CoA ligase	0.0000001019	3.23	--	DIRECT
Enzyme Commission (EC)	D-alanine--[D-alanyl-carrier protein] ligase	0.00001042	3.23	--	DIRECT
Enzyme Commission (EC)	Long-chain-fatty-acid--[acyl-carrier-protein] ligase	0.00001987	3.23	--	DIRECT
Enzyme Commission (EC)	o-succinylbenzoate--CoA ligase	0.00007171	3.23	--	DIRECT
Enzyme Commission (EC)	Carnitine--CoA ligase	0.00007171	3.23	--	DIRECT
Enzyme Commission (EC)	Medium-chain acyl-CoA ligase	0.0003154	3.23	--	DIRECT
Enzyme Commission (EC)	Arachidonate--CoA ligase	0.0007329	3.23	--	DIRECT
Enzyme Commission (EC)	4-coumarate--CoA ligase	0.0009049	3.23	--	DIRECT
Enzyme Commission (EC)	Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated	0.01785	1.907	--	INHERITED FROM: With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidase || Firefly luciferase
Enzyme Commission (EC)	Acid--thiol ligases	1	2.452	--	INHERITED FROM: Medium-chain acyl-CoA ligase || Acetate--CoA ligase || Long-chain-fatty-acid--[acyl-carrier-protein] ligase || Arachidonate--CoA ligase || Long-chain-fatty-acid--CoA ligase || Carnitine--CoA ligase || D-alanine--[D-alanyl-carrier protein] ligase || 4-coumarate--CoA ligase || o-succinylbenzoate--CoA ligase
Enzyme Commission (EC)	Oxidoreductases	1	0.7328	Least Informative	INHERITED FROM: Firefly luciferase || L-2-aminoadipate reductase || With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidase || L-aminoadipate-semialdehyde dehydrogenase
Enzyme Commission (EC)	Transferases	1	0.3972	Least Informative	INHERITED FROM: Transferring groups other than amino-acyl groups || Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase
Enzyme Commission (EC)	Ligases	0	1.14	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acyltransferases	0.005554	1.034	Moderately Informative	INHERITED FROM: Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase || Transferring groups other than amino-acyl groups
Enzyme Commission (EC)	Isomerases	1	1.026	Moderately Informative	INHERITED FROM: Phenylalanine racemase (ATP-hydrolyzing)
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0.000003975	1.321	Informative	DIRECT
Enzyme Commission (EC)	Racemases and epimerases	0.1806	1.711	Informative	INHERITED FROM: Phenylalanine racemase (ATP-hydrolyzing)
Enzyme Commission (EC)	Acting on the aldehyde or oxo group of donors	0.9126	1.65	Informative	INHERITED FROM: L-aminoadipate-semialdehyde dehydrogenase || L-2-aminoadipate reductase
Enzyme Commission (EC)	Forming carbon-oxygen bonds	1	1.738	Informative	INHERITED FROM: Cyclo-ligases
Enzyme Commission (EC)	Forming carbon-nitrogen bonds	1	1.338	Informative	INHERITED FROM: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
Enzyme Commission (EC)	Acting on amino acids and derivatives	0.008419	2.188	Highly Informative	INHERITED FROM: Phenylalanine racemase (ATP-hydrolyzing)
Enzyme Commission (EC)	Acid--amino-acid ligases (peptide synthases)	0.6953	1.832	Highly Informative	INHERITED FROM: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.8028	2.054	Highly Informative	INHERITED FROM: L-2-aminoadipate reductase || L-aminoadipate-semialdehyde dehydrogenase

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UniProtKB KeyWords (KW)

Highlighted in gray are those with FDR_all>0.001

	KW term	FDR (all)	IC level	SDKW level	Annotation (direct or inherited)
Post-translational modification	Ligase	0	1.732	Informative	DIRECT

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