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Anaphylotoxins (complement system) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Anaphylotoxins (complement system) [ 47685]
Superfamily:   Anaphylotoxins (complement system) [ 47686]
Families:   Anaphylotoxins (complement system) [ 47687]

Superfamily statistics
Genomes (71) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 374 936 3
Proteins 373 929 3

Functional annotation
General category Processes_EC
Detailed category Toxins/defense

Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)connective tissue disease0Moderately InformativeDirect
Disease Ontology (DO)skin disease0.0004847Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.0009253Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.001279Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.002317Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.02158Moderately InformativeInherited
Disease Ontology (DO)periodontal disease0.000004358InformativeDirect
Disease Ontology (DO)asthma0.0001215InformativeDirect
Disease Ontology (DO)proteinuria0.0000002646Highly InformativeDirect
Disease Ontology (DO)psoriasis0.00001288Highly InformativeDirect
Disease Ontology (DO)lupus erythematosus0.0001417Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.2414Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of complement system0InformativeDirect
Phenotypic Abnormality (PA)Unusual CNS infection0.000006631InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)autoimmune response0InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to bacterial infection0InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to bacterial infection0Highly InformativeDirect

Document: MP annotation of SCOP domains

InterPro annotation
Cross references IPR000020 SSF47686 Protein matches

Complement components C3, C4 and C5 are large glycoproteins that have important functions in the immune response and host defence [PubMed1431125]. They have a wide variety of biological activities and are proteolytically activated by cleavage at a specific site, forming a- and b-fragments [PubMed2777798]. A-fragments form distinct structural domains of approximately 76 amino acids, coded for by a single exon within the complement protein gene. The C3a, C4a and C5a components are referred to as anaphylatoxins [PubMed2777798, PubMed3081348]: they cause smooth muscle contraction, histamine release from mast cells, and enhanced vascular permeability [PubMed3081348]. They also mediate chemotaxis, inflammation, and generation of cytotoxic oxygen radicals [PubMed3081348]. The proteins are highly hydrophilic, with a mainly alpha-helical structure held together by 3 disulphide bridges [PubMed3081348].

Fibulins are secreted glycoproteins that become incorporated into a fibrillar extracellular matrix when expressed by cultured cells or added exogenously to cell monolayers [PubMed2269669, PubMed12778127]. The five known members of the family share an elongated structure and many calcium-binding sites, owing to the presence of tandem arrays of epidermal growth factor-like domains. They have overlapping binding sites for several basement-membrane proteins, tropoelastin, fibrillin, fibronectin and proteoglycans, and they participate in diverse supramolecular structures. The amino-terminal domain I of fibulin consists of three anaphylatoxin-like (AT) modules, each approximately 40 residues long and containing four or six cysteines. The structure of an AT module was determined for the complement-derived anaphylatoxin C3a, and was found to be a compact alpha-helical fold that is stabilized by three disulphide bridges in the pattern Cys14, Cys25 and Cys36 (where Cys is cysteine). The bulk of the remaining portion of the fibulin molecule is a series of nine EGF-like repeats [PubMed8245130]. The ProDom signature in this entry does not hit the fibulins.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Anaphylotoxins (complement system) domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Anaphylotoxins (complement system) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Internal database links ]