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CTD Diseases (CD): Pathological Conditions, Signs and Symptoms 
(show info)
Biomedical Ontology
Like Gene Ontology (GO), biomedical ontology such as phenotype ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Biomedical ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI’s thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology Based on YP which is the major contributor to the ‘Ascomycete phenotype ontology’, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- UniProtKB KeyWords (KW) Ontology Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- CTD Diseases (CD) Ontology CD is MEDIC disease vocabulary that is modified by CTD from the "Diseases" [C] branch of Medical Subject Headings (MeSH), combined with genetic disorders from the Online Mendelian Inheritance in OMIM database.
- CTD Chemicals (CC) Ontology CC is chemical vocabulary that is adapted by CTD from the "Chemicals and Drugs" category and Supplementary Concept Records of Medical Subject Headings (MeSH, a hierarchical vocabulary used to index articles for MEDLINE/PubMed).
Jump to [ Top · Hierarchy · Annotations ]
Root: CD Hierarchy (CTD diseases from Comparative Toxicogenomics Database)
Jump to [ Top · Hierarchy ]
Superfamily( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Somatomedin B domain | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| ADC-like | 0 | DIRECT |
| DNA/RNA polymerases | 0 | DIRECT |
| Small-conductance potassium channel | 0 | DIRECT |
| FAD-linked oxidoreductase | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| Translational machinery components | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Serum albumin-like | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| Pectin lyase-like | 0 | DIRECT |
| Glutamine synthetase/guanido kinase | 0 | DIRECT |
| I/LWEQ domain | 0 | DIRECT |
| LeuD/IlvD-like | 0 | DIRECT |
| His-Me finger endonucleases | 0 | DIRECT |
| beta-lactamase/transpeptidase-like | 0 | DIRECT |
| Apolipoprotein A-I | 0 | DIRECT |
| Ferritin-like | 0 | DIRECT |
| Voltage-gated potassium channels | 0.0001057 | DIRECT |
| Family A G protein-coupled receptor-like | 0.005943 | INHERITED FROM: Seizures || Pruritus || Bradycardia || Signs and Symptoms || Neurologic Manifestations || Pain || Hyperalgesia || Memory Disorders |
| PGBD-like | 0.01211 | INHERITED FROM: Neoplastic Processes || Cerebral Hemorrhage |
| Cystine-knot cytokines | 0.01946 | INHERITED FROM: Status Epilepticus |
| Leucine zipper domain | 0.02055 | INHERITED FROM: Infarction, Middle Cerebral Artery || Status Epilepticus || Necrosis |
| ABC transporter transmembrane region | 0.02505 | INHERITED FROM: Disease Progression |
| Flavoproteins | 0.02553 | INHERITED FROM: Signs and Symptoms |
| Protein kinase-like (PK-like) | 0.03404 | INHERITED FROM: Melanosis || Failure to Thrive || Hyperalgesia || Hyperpigmentation |
| Hemopexin-like domain | 0.0346 | INHERITED FROM: Neoplastic Processes || Cerebral Hemorrhage |
| Cytokine | 0.04102 | INHERITED FROM: Body Temperature Changes || Fever |
| Integrin beta tail domain | 0.04351 | INHERITED FROM: Liver Cirrhosis, Experimental || Gliosis |
| FnI-like domain | 0.04971 | INHERITED FROM: Hypertrophy, Left Ventricular |
| 4-helical cytokines | 0.05465 | INHERITED FROM: Infarction, Middle Cerebral Artery || Weight Loss || Shock || Ischemia || Necrosis || Body Temperature Changes || Amnesia || Signs and Symptoms, Digestive || Inflammation || Pathologic Processes || Erythema Multiforme |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.0585 | INHERITED FROM: Pathological Conditions, Anatomical || Hepatomegaly |
| Thyroglobulin type-1 domain | 0.0598 | INHERITED FROM: Fibrosis || Liver Cirrhosis, Experimental || Liver Cirrhosis |
| Spectrin repeat | 0.06896 | INHERITED FROM: Cardiomyopathy, Dilated |
| DEATH domain | 0.07939 | INHERITED FROM: Suppuration |
| A DNA-binding domain in eukaryotic transcription factors | 0.1038 | INHERITED FROM: Status Epilepticus |
| Nuclear receptor ligand-binding domain | 0.1071 | INHERITED FROM: Overweight || Pathological Conditions, Anatomical || Hepatomegaly |
| Caspase-like | 0.1257 | INHERITED FROM: Postoperative Complications || Status Epilepticus || Myocardial Reperfusion Injury || Edema || Reperfusion Injury |
| Integrin domains | 0.1282 | INHERITED FROM: Gliosis || Hemorrhage || Cerebral Hemorrhage |
| Kringle-like | 0.1386 | INHERITED FROM: Infarction, Middle Cerebral Artery || Ischemia || Infarction || Neoplastic Processes || Hemorrhage || Pain || Cerebral Infarction || Cerebral Hemorrhage |
| Integrin alpha N-terminal domain | 0.1434 | INHERITED FROM: Gliosis |
| Nicotinic receptor ligand binding domain-like | 0.1447 | INHERITED FROM: Multiple pterygium syndrome || Malignant Hyperthermia || Intraoperative Complications || MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.1447 | INHERITED FROM: Multiple pterygium syndrome || Malignant Hyperthermia || Intraoperative Complications || MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE |
| Thioredoxin-like | 0.1621 | INHERITED FROM: Down Syndrome |
| Riboflavin synthase domain-like | 0.1781 | INHERITED FROM: Infarction || Myocardial Reperfusion Injury |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.1781 | INHERITED FROM: Infarction || Myocardial Reperfusion Injury |
| NAD(P)-linked oxidoreductase | 0.1781 | INHERITED FROM: Polycystic Ovary Syndrome || Cell Transformation, Neoplastic |
| CalX-like | 0.2223 | INHERITED FROM: Seizures |
| MHC antigen-recognition domain | 0.2508 | INHERITED FROM: Proteinuria || Disease Susceptibility || Erythema Multiforme |
| Bromodomain | 0.2624 | INHERITED FROM: Neurobehavioral Manifestations |
| Actin-like ATPase domain | 0.2707 | INHERITED FROM: Spinocerebellar Ataxia 17 |
| p53-like transcription factors | 0.277 | INHERITED FROM: Liver Cirrhosis, Biliary || Cell Transformation, Neoplastic |
| BRK domain-like | 0.2825 | INHERITED FROM: Intellectual Disability |
| ARM repeat | 0.2904 | INHERITED FROM: Genomic Instability |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.2998 | INHERITED FROM: Ataxia |
| Calcium ATPase, transmembrane domain M | 0.3066 | INHERITED FROM: Ataxia |
| Calcium ATPase, transduction domain A | 0.3066 | INHERITED FROM: Ataxia |
| Heme-dependent peroxidases | 0.3175 | INHERITED FROM: Postoperative Complications || Reperfusion Injury |
| Bcl-2 inhibitors of programmed cell death | 0.3175 | INHERITED FROM: Intracranial Hemorrhages || Ischemia || Myocardial Infarction || Necrosis || Infarction || Nerve Degeneration || Hemorrhage || Cerebral Hemorrhage |
| Growth factor receptor domain | 0.3207 | INHERITED FROM: Hernia |
| GLA-domain | 0.3383 | INHERITED FROM: Hemorrhage |
| SH2 domain | 0.3675 | INHERITED FROM: Vitiligo |
| FAD/NAD(P)-binding domain | 0.4413 | INHERITED FROM: Huntington Disease |
| Interleukin 8-like chemokines | 0.4433 | INHERITED FROM: Infarction, Middle Cerebral Artery |
| Serine protease inhibitors | 0.447 | INHERITED FROM: Hearing Loss || Hearing Disorders |
| E2F-DP heterodimerization region | 0.447 | INHERITED FROM: Disease Attributes || Disease Progression |
| Myosin rod fragments | 0.457 | INHERITED FROM: Cardiomyopathy, Dilated |
| Metalloproteases ("zincins"), catalytic domain | 0.4651 | INHERITED FROM: Cerebral Hemorrhage |
| Toll/Interleukin receptor TIR domain | 0.5323 | INHERITED FROM: Postoperative Complications || Inflammation || Reperfusion Injury |
| HAD-like | 0.5596 | INHERITED FROM: Myocardial Reperfusion Injury || Ataxia |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.6961 | INHERITED FROM: Ataxia || Spinocerebellar Ataxia 17 || Spinocerebellar Ataxias || Cerebellar Ataxia |
| C-type lectin-like | 0.7805 | INHERITED FROM: Hemorrhage |
| SET domain | 0.7818 | INHERITED FROM: Cell Transformation, Neoplastic || Chromosome Aberrations |
| PDZ domain-like | 0.7995 | INHERITED FROM: Usher Syndromes || Deaf-Blind Disorders |
| vWA-like | 0.8114 | INHERITED FROM: Gliosis || Scleroatonic muscular dystrophy || Sclerosis |
| Trypsin-like serine proteases | 0.8889 | INHERITED FROM: Infarction |
| Plexin repeat | 0.9054 | INHERITED FROM: Gliosis |
| RNI-like | 0.9414 | INHERITED FROM: Inflammation |
| Chaperone J-domain | 0.9907 | INHERITED FROM: Cerebellar Ataxia |
LINKTO: Domain2BO Download and Domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Family( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Small-conductance potassium channel | 0 | DIRECT |
| Apolipoprotein A-I | 0 | DIRECT |
| PDI-like | 0 | DIRECT |
| Gonadodropin/Follitropin | 0 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | DIRECT |
| Arrestin/Vps26-like | 0 | DIRECT |
| Ribosomal protein L18 and S11 | 0 | DIRECT |
| Somatomedin B domain | 0 | DIRECT |
| C5 cytosine-specific DNA methylase, DCM | 0 | DIRECT |
| Serum albumin-like | 0 | DIRECT |
| Glyoxalase II (hydroxyacylglutathione hydrolase) | 0 | DIRECT |
| ZZ domain | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| Sir2 family of transcriptional regulators | 0 | DIRECT |
| B56-like | 0 | DIRECT |
| Cytochrome p450 reductase N-terminal domain-like | 0 | DIRECT |
| Noncollagenous (NC1) domain of collagen IV | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| I/LWEQ domain | 0 | DIRECT |
| U-box | 0 | DIRECT |
| DNA polymerase I | 0 | DIRECT |
| Neurotrophin | 0 | DIRECT |
| LeuD-like | 0 | DIRECT |
| Bactericidal permeability-increasing protein, BPI | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| p53 DNA-binding domain-like | 0 | DIRECT |
| SAND domain | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Rhodopsin-like | 0.0004539 | DIRECT |
| Voltage-gated potassium channels | 0.009346 | INHERITED FROM: Arrhythmias, Cardiac || Hernia, Diaphragmatic || Long QT Syndrome |
| MMP N-terminal domain | 0.009876 | INHERITED FROM: Neoplastic Processes || Cerebral Hemorrhage |
| ABC transporter transmembrane region | 0.01326 | INHERITED FROM: Disease Progression |
| Long-chain cytokines | 0.01536 | INHERITED FROM: Infarction || Body Temperature Changes || Body Weight Changes || Pathologic Processes |
| Leucine zipper domain | 0.0176 | INHERITED FROM: Infarction, Middle Cerebral Artery || Status Epilepticus || Necrosis || Cerebral Infarction |
| Growth factor receptor domain | 0.02086 | INHERITED FROM: Hernia |
| L domain | 0.02103 | INHERITED FROM: Disease Progression |
| Hemopexin-like domain | 0.02942 | INHERITED FROM: Neoplastic Processes || Cerebral Hemorrhage |
| Integrin beta tail domain | 0.03617 | INHERITED FROM: Liver Cirrhosis, Experimental || Gliosis |
| S100 proteins | 0.03805 | INHERITED FROM: Keloid || Cicatrix |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.0405 | INHERITED FROM: Neoplasm Metastasis |
| Extended AAA-ATPase domain | 0.04256 | INHERITED FROM: Hearing Loss || Growth Disorders |
| Matrix metalloproteases, catalytic domain | 0.04281 | INHERITED FROM: Neoplastic Processes || Cerebral Hemorrhage |
| Thyroglobulin type-1 domain | 0.05095 | INHERITED FROM: Fibrosis || Liver Cirrhosis, Experimental || Liver Cirrhosis |
| Caspase catalytic domain | 0.05928 | INHERITED FROM: Postoperative Complications || Status Epilepticus || Myocardial Reperfusion Injury || Edema || Reperfusion Injury |
| Interleukin-1 (IL-1) | 0.06343 | INHERITED FROM: Somatosensory Disorders || Body Temperature Changes || Signs and Symptoms, Digestive || Inflammation || Fever || Hyperalgesia || Sensation Disorders |
| Histone lysine methyltransferases | 0.07541 | INHERITED FROM: Carcinogenesis || Cell Transformation, Neoplastic || Chromosome Aberrations |
| Protein kinases, catalytic subunit | 0.08079 | INHERITED FROM: Melanosis || Failure to Thrive || Hyperalgesia |
| Spectrin repeat | 0.08308 | INHERITED FROM: Cardiomyopathy, Dilated |
| Caspase recruitment domain, CARD | 0.09014 | INHERITED FROM: Myocardial Reperfusion Injury |
| A DNA-binding domain in eukaryotic transcription factors | 0.09018 | INHERITED FROM: Status Epilepticus |
| Nuclear receptor | 0.09335 | INHERITED FROM: Pathological Conditions, Anatomical || Hepatomegaly |
| Nuclear receptor ligand-binding domain | 0.09713 | INHERITED FROM: Overweight || Pathological Conditions, Anatomical || Hepatomegaly |
| Integrin beta EGF-like domains | 0.1056 | INHERITED FROM: Gliosis |
| Integrin domains | 0.1139 | INHERITED FROM: Gliosis || Hemorrhage || Cerebral Hemorrhage |
| Meta-cation ATPase, catalytic domain P | 0.1273 | INHERITED FROM: Ataxia || Paralysis |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.1316 | INHERITED FROM: Multiple pterygium syndrome || Malignant Hyperthermia || Intraoperative Complications || MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE |
| Nicotinic receptor ligand binding domain-like | 0.1316 | INHERITED FROM: Multiple pterygium syndrome || Malignant Hyperthermia || Intraoperative Complications || MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE |
| Aldo-keto reductases (NADP) | 0.1586 | INHERITED FROM: Cysts || Polycystic Ovary Syndrome || Cell Transformation, Neoplastic || Ovarian Cysts |
| Pyrin domain, PYD | 0.1645 | INHERITED FROM: Inflammation |
| E2F dimerization segment | 0.1645 | INHERITED FROM: Disease Attributes || Disease Progression |
| Integrin alpha N-terminal domain | 0.1774 | INHERITED FROM: Gliosis || Hemorrhage |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1922 | INHERITED FROM: Ataxia |
| Integrin A (or I) domain | 0.2002 | INHERITED FROM: Gliosis || Scleroatonic muscular dystrophy || Sclerosis |
| CalX-beta domain | 0.2004 | INHERITED FROM: Seizures |
| Fibronectin type II module | 0.2004 | INHERITED FROM: Neoplasm Invasiveness |
| Cell cycle transcription factor e2f-dp | 0.226 | INHERITED FROM: Disease Attributes || Disease Progression |
| MHC antigen-recognition domain | 0.232 | INHERITED FROM: Proteinuria || Disease Susceptibility || Erythema Multiforme |
| Bromodomain | 0.2444 | INHERITED FROM: Intellectual Disability || Neurobehavioral Manifestations |
| 28-residue LRR | 0.2446 | INHERITED FROM: Inflammation |
| Myosin rod fragments | 0.2446 | INHERITED FROM: Cardiomyopathy, Dilated |
| BRK domain-like | 0.2572 | INHERITED FROM: Intellectual Disability |
| Calcium ATPase, transduction domain A | 0.2857 | INHERITED FROM: Ataxia |
| Myeloperoxidase-like | 0.2925 | INHERITED FROM: Postoperative Complications || Reperfusion Injury |
| Bcl-2 inhibitors of programmed cell death | 0.2925 | INHERITED FROM: Intracranial Hemorrhages || Ischemia || Myocardial Infarction || Necrosis || Infarction || Nerve Degeneration || Hemorrhage || Cerebral Hemorrhage |
| Serpins | 0.2965 | INHERITED FROM: Fibrosis |
| Annexin | 0.3133 | INHERITED FROM: Liver Cirrhosis, Experimental |
| GLA-domain | 0.3133 | INHERITED FROM: Hemorrhage |
| Motor proteins | 0.3167 | INHERITED FROM: Hearing Loss || Hearing Disorders |
| Interferons/interleukin-10 (IL-10) | 0.3289 | INHERITED FROM: Shock || Necrosis || Systemic Inflammatory Response Syndrome |
| Kringle modules | 0.3466 | INHERITED FROM: Infarction, Middle Cerebral Artery || Hemorrhage || Pain || Cerebral Infarction || Neoplasm Metastasis |
| SH2 domain | 0.3555 | INHERITED FROM: Vitiligo |
| Actin/HSP70 | 0.3563 | INHERITED FROM: Spinocerebellar Ataxia 17 || Spinocerebellar Ataxias || Cerebellar Ataxia |
| Interleukin 8-like chemokines | 0.4275 | INHERITED FROM: Infarction, Middle Cerebral Artery |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.4286 | INHERITED FROM: Somatosensory Disorders || Hyperalgesia |
| FHA domain | 0.4348 | INHERITED FROM: Ataxia |
| C1 set domains (antibody constant domain-like) | 0.4349 | INHERITED FROM: Proteinuria || Disease Susceptibility || Erythema Multiforme |
| PHD domain | 0.5515 | INHERITED FROM: Neurobehavioral Manifestations |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.6762 | INHERITED FROM: Ataxia || Spinocerebellar Ataxia 17 || Spinocerebellar Ataxias || Cerebellar Ataxia || Dyskinesias |
| Toll/Interleukin receptor TIR domain | 0.6829 | INHERITED FROM: Inflammation |
| Eukaryotic proteases | 0.813 | INHERITED FROM: Hemorrhage |
| Plexin repeat | 0.8916 | INHERITED FROM: Gliosis |
| PDZ domain | 0.9405 | INHERITED FROM: Usher Syndromes || Blindness || Deaf-Blind Disorders |
| Chaperone J-domain | 0.9835 | INHERITED FROM: Cerebellar Ataxia |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Small-conductance potassium channel | 0 | Direct |
| Apolipoprotein A-I | 0 | Direct |
| PDI-like | 0 | Direct |
| Gonadodropin/Follitropin | 0 | Direct |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | Direct |
| Arrestin/Vps26-like | 0 | Direct |
| Ribosomal protein L18 and S11 | 0 | Direct |
| Somatomedin B domain | 0 | Direct |
| C5 cytosine-specific DNA methylase, DCM | 0 | Direct |
| Serum albumin-like | 0 | Direct |
| Glyoxalase II (hydroxyacylglutathione hydrolase) | 0 | Direct |
| ZZ domain | 0 | Direct |
| Proton glutamate symport protein | 0 | Direct |
| Sir2 family of transcriptional regulators | 0 | Direct |
| B56-like | 0 | Direct |
| Cytochrome p450 reductase N-terminal domain-like | 0 | Direct |
| Noncollagenous (NC1) domain of collagen IV | 0 | Direct |
| Aconitase iron-sulfur domain | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| I/LWEQ domain | 0 | Direct |
| U-box | 0 | Direct |
| DNA polymerase I | 0 | Direct |
| Neurotrophin | 0 | Direct |
| LeuD-like | 0 | Direct |
| Bactericidal permeability-increasing protein, BPI | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| p53 DNA-binding domain-like | 0 | Direct |
| SAND domain | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Rhodopsin-like | 0.0004539 | Direct |
| Voltage-gated potassium channels | 0.009346 | Inherited |
| MMP N-terminal domain | 0.009876 | Inherited |
| ABC transporter transmembrane region | 0.01326 | Inherited |
| Long-chain cytokines | 0.01536 | Inherited |
| Leucine zipper domain | 0.0176 | Inherited |
| Growth factor receptor domain | 0.02086 | Inherited |
| L domain | 0.02103 | Inherited |
| Hemopexin-like domain | 0.02942 | Inherited |
| Integrin beta tail domain | 0.03617 | Inherited |
| S100 proteins | 0.03805 | Inherited |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.0405 | Inherited |
| Extended AAA-ATPase domain | 0.04256 | Inherited |
| Matrix metalloproteases, catalytic domain | 0.04281 | Inherited |
| Thyroglobulin type-1 domain | 0.05095 | Inherited |
| Caspase catalytic domain | 0.05928 | Inherited |
| Interleukin-1 (IL-1) | 0.06343 | Inherited |
| Histone lysine methyltransferases | 0.07541 | Inherited |
| Protein kinases, catalytic subunit | 0.08079 | Inherited |
| Spectrin repeat | 0.08308 | Inherited |
| Caspase recruitment domain, CARD | 0.09014 | Inherited |
| A DNA-binding domain in eukaryotic transcription factors | 0.09018 | Inherited |
| Nuclear receptor | 0.09335 | Inherited |
| Nuclear receptor ligand-binding domain | 0.09713 | Inherited |
| Integrin beta EGF-like domains | 0.1056 | Inherited |
| Integrin domains | 0.1139 | Inherited |
| Meta-cation ATPase, catalytic domain P | 0.1273 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.1316 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.1316 | Inherited |
| Aldo-keto reductases (NADP) | 0.1586 | Inherited |
| Pyrin domain, PYD | 0.1645 | Inherited |
| E2F dimerization segment | 0.1645 | Inherited |
| Integrin alpha N-terminal domain | 0.1774 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1922 | Inherited |
| Integrin A (or I) domain | 0.2002 | Inherited |
| CalX-beta domain | 0.2004 | Inherited |
| Fibronectin type II module | 0.2004 | Inherited |
| Cell cycle transcription factor e2f-dp | 0.226 | Inherited |
| MHC antigen-recognition domain | 0.232 | Inherited |
| Bromodomain | 0.2444 | Inherited |
| 28-residue LRR | 0.2446 | Inherited |
| Myosin rod fragments | 0.2446 | Inherited |
| BRK domain-like | 0.2572 | Inherited |
| Calcium ATPase, transduction domain A | 0.2857 | Inherited |
| Myeloperoxidase-like | 0.2925 | Inherited |
| Bcl-2 inhibitors of programmed cell death | 0.2925 | Inherited |
| Serpins | 0.2965 | Inherited |
| Annexin | 0.3133 | Inherited |
| GLA-domain | 0.3133 | Inherited |
| Motor proteins | 0.3167 | Inherited |
| Interferons/interleukin-10 (IL-10) | 0.3289 | Inherited |
| Kringle modules | 0.3466 | Inherited |
| SH2 domain | 0.3555 | Inherited |
| Actin/HSP70 | 0.3563 | Inherited |
| Interleukin 8-like chemokines | 0.4275 | Inherited |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.4286 | Inherited |
| FHA domain | 0.4348 | Inherited |
| C1 set domains (antibody constant domain-like) | 0.4349 | Inherited |
| PHD domain | 0.5515 | Inherited |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.6762 | Inherited |
| Toll/Interleukin receptor TIR domain | 0.6829 | Inherited |
| Eukaryotic proteases | 0.813 | Inherited |
| Plexin repeat | 0.8916 | Inherited |
| PDZ domain | 0.9405 | Inherited |
| Chaperone J-domain | 0.9835 | Inherited |
LINKTO: Domain2BO Download and Domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Single)( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| I/LWEQ domain | 0 | DIRECT |
| Glutamine synthetase/guanido kinase | 0 | DIRECT |
| ADC-like | 0 | DIRECT |
| Small-conductance potassium channel | 0 | DIRECT |
| Serum albumin-like | 0 | DIRECT |
| His-Me finger endonucleases | 0 | DIRECT |
| Ferritin-like | 0 | DIRECT |
| Somatomedin B domain | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| Translational machinery components | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| FAD-linked oxidoreductase | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| DNA/RNA polymerases | 0 | DIRECT |
| LeuD/IlvD-like | 0 | DIRECT |
| beta-lactamase/transpeptidase-like | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Pectin lyase-like | 0 | DIRECT |
| Apolipoprotein A-I | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| Voltage-gated potassium channels | 0.00005975 | DIRECT |
| Family A G protein-coupled receptor-like | 0.00426 | INHERITED FROM: Pain || Hyperalgesia || Pruritus || Seizures || Neurologic Manifestations || Memory Disorders || Signs and Symptoms || Bradycardia |
| PGBD-like | 0.008822 | INHERITED FROM: Neoplastic Processes || Cerebral Hemorrhage |
| Cystine-knot cytokines | 0.01467 | INHERITED FROM: Status Epilepticus |
| Leucine zipper domain | 0.01555 | INHERITED FROM: Necrosis || Status Epilepticus || Cerebral Infarction || Infarction, Middle Cerebral Artery |
| ABC transporter transmembrane region | 0.0192 | INHERITED FROM: Disease Progression |
| Flavoproteins | 0.01958 | INHERITED FROM: Signs and Symptoms |
| Protein kinase-like (PK-like) | 0.02658 | INHERITED FROM: Hyperalgesia || Melanosis || Failure to Thrive || Hyperpigmentation |
| Hemopexin-like domain | 0.02705 | INHERITED FROM: Neoplastic Processes || Cerebral Hemorrhage |
| Cytokine | 0.03234 | INHERITED FROM: Body Temperature Changes || Sensation Disorders || Fever || Signs and Symptoms, Digestive || Infarction |
| Integrin beta tail domain | 0.03453 | INHERITED FROM: Liver Cirrhosis, Experimental || Liver Cirrhosis || Gliosis |
| FnI-like domain | 0.0396 | INHERITED FROM: Hypertrophy, Left Ventricular |
| 4-helical cytokines | 0.04374 | INHERITED FROM: Pain || Inflammation || Erythema Multiforme || Body Temperature Changes || Necrosis || Headache || Ischemia || Pathologic Processes || Weight Loss || Signs and Symptoms, Digestive || Amnesia || Shock || Infarction, Middle Cerebral Artery |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.04707 | INHERITED FROM: Hepatomegaly || Pathological Conditions, Anatomical || Plaque, Atherosclerotic |
| Thyroglobulin type-1 domain | 0.04824 | INHERITED FROM: Liver Cirrhosis, Experimental || Liver Cirrhosis || Fibrosis |
| Spectrin repeat | 0.05611 | INHERITED FROM: Cardiomyopathy, Dilated |
| DEATH domain | 0.06512 | INHERITED FROM: Suppuration || Myocardial Reperfusion Injury |
| A DNA-binding domain in eukaryotic transcription factors | 0.08683 | INHERITED FROM: Status Epilepticus |
| Nuclear receptor ligand-binding domain | 0.08983 | INHERITED FROM: Hepatomegaly || Overweight || Pathological Conditions, Anatomical |
| Caspase-like | 0.1065 | INHERITED FROM: Postoperative Complications || Myocardial Reperfusion Injury || Edema || Reperfusion Injury || Status Epilepticus |
| Integrin domains | 0.1086 | INHERITED FROM: Hemorrhage || Gliosis || Cerebral Hemorrhage |
| Kringle-like | 0.1179 | INHERITED FROM: Pain || Neoplastic Processes || Ischemia || Hemorrhage || Cerebral Infarction || Infarction || Infarction, Middle Cerebral Artery || Cerebral Hemorrhage |
| Integrin alpha N-terminal domain | 0.1221 | INHERITED FROM: Hemorrhage || Gliosis |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.1233 | INHERITED FROM: MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE || Malignant Hyperthermia || Multiple pterygium syndrome || Intraoperative Complications |
| Nicotinic receptor ligand binding domain-like | 0.1233 | INHERITED FROM: MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE || Malignant Hyperthermia || Multiple pterygium syndrome || Intraoperative Complications |
| Thioredoxin-like | 0.1391 | INHERITED FROM: Down Syndrome |
| Riboflavin synthase domain-like | 0.1539 | INHERITED FROM: Myocardial Reperfusion Injury || Infarction |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.1539 | INHERITED FROM: Myocardial Reperfusion Injury || Infarction |
| NAD(P)-linked oxidoreductase | 0.1539 | INHERITED FROM: Polycystic Ovary Syndrome || Cysts || Ovarian Cysts || Cell Transformation, Neoplastic |
| DHS-like NAD/FAD-binding domain | 0.1957 | INHERITED FROM: Hypertrophy |
| CalX-like | 0.1957 | INHERITED FROM: Seizures |
| Glutathione synthetase ATP-binding domain-like | 0.1979 | INHERITED FROM: Overweight |
| MHC antigen-recognition domain | 0.2226 | INHERITED FROM: Erythema Multiforme || Disease Susceptibility || Proteinuria |
| Bromodomain | 0.2334 | INHERITED FROM: Neurobehavioral Manifestations |
| Actin-like ATPase domain | 0.2409 | INHERITED FROM: Spinocerebellar Ataxia 17 |
| p53-like transcription factors | 0.2465 | INHERITED FROM: Cell Transformation, Neoplastic || Liver Cirrhosis, Biliary |
| BRK domain-like | 0.2517 | INHERITED FROM: Intellectual Disability |
| ARM repeat | 0.259 | INHERITED FROM: Genomic Instability |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.2679 | INHERITED FROM: Paralysis || Ataxia |
| Calcium ATPase, transmembrane domain M | 0.2744 | INHERITED FROM: Paralysis || Ataxia |
| Calcium ATPase, transduction domain A | 0.2744 | INHERITED FROM: Paralysis || Ataxia |
| Bcl-2 inhibitors of programmed cell death | 0.2852 | INHERITED FROM: Nerve Degeneration || Necrosis || Myocardial Infarction || Ischemia || Hemorrhage || Infarction || Cerebral Hemorrhage || Intracranial Hemorrhages |
| Heme-dependent peroxidases | 0.2852 | INHERITED FROM: Postoperative Complications || Reperfusion Injury |
| Growth factor receptor domain | 0.2883 | INHERITED FROM: Hernia |
| GLA-domain | 0.3057 | INHERITED FROM: Hemorrhage |
| Annexin | 0.3057 | INHERITED FROM: Liver Cirrhosis, Experimental |
| SH2 domain | 0.3345 | INHERITED FROM: Vitiligo |
| Serpins | 0.3506 | INHERITED FROM: Fibrosis |
| FAD/NAD(P)-binding domain | 0.4066 | INHERITED FROM: Huntington Disease || Chorea |
| Interleukin 8-like chemokines | 0.4086 | INHERITED FROM: Cerebral Infarction || Infarction, Middle Cerebral Artery |
| E2F-DP heterodimerization region | 0.4125 | INHERITED FROM: Disease Progression || Disease Attributes |
| Serine protease inhibitors | 0.4125 | INHERITED FROM: Hearing Disorders || Hearing Loss |
| Myosin rod fragments | 0.4224 | INHERITED FROM: Cardiomyopathy, Dilated |
| Metalloproteases ("zincins"), catalytic domain | 0.4305 | INHERITED FROM: Cerebral Hemorrhage |
| Toll/Interleukin receptor TIR domain | 0.4987 | INHERITED FROM: Postoperative Complications || Inflammation || Reperfusion Injury |
| Prefoldin | 0.5149 | INHERITED FROM: Cell Transformation, Neoplastic |
| HAD-like | 0.5258 | INHERITED FROM: Myocardial Reperfusion Injury || Ataxia |
| Cysteine-rich domain | 0.631 | INHERITED FROM: Hyperalgesia || Somatosensory Disorders |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.664 | INHERITED FROM: Spinocerebellar Ataxias || Spinocerebellar Ataxia 17 || Dyskinesias || Ataxia || Cerebellar Ataxia |
| C-type lectin-like | 0.7517 | INHERITED FROM: Hemorrhage |
| SET domain | 0.7529 | INHERITED FROM: Chromosome Aberrations || Cell Transformation, Neoplastic || Carcinogenesis |
| PDZ domain-like | 0.7718 | INHERITED FROM: Deaf-Blind Disorders || Usher Syndromes |
| vWA-like | 0.784 | INHERITED FROM: Sclerosis || Scleroatonic muscular dystrophy || Gliosis |
| Trypsin-like serine proteases | 0.8657 | INHERITED FROM: Ischemia || Hemorrhage || Cerebral Infarction || Infarction |
| Plexin repeat | 0.8835 | INHERITED FROM: Gliosis |
| RNI-like | 0.9232 | INHERITED FROM: Inflammation |
| Chaperone J-domain | 0.9789 | INHERITED FROM: Cerebellar Ataxia |
| Intermediate filament protein, coiled coil region | 0.9982 | INHERITED FROM: Cell Transformation, Neoplastic |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Duplex) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
53300,53300
53300 - vWA-like
53300 - vWA-like | 0 | DIRECT |
56059,52210
56059 - Glutathione synthetase ATP-binding domain-like
52210 - Succinyl-CoA synthetase domains | 0 | DIRECT |
52058,48726
52058 - L domain-like
48726 - Immunoglobulin | 0 | DIRECT |
48371,101447
48371 - ARM repeat
101447 - Formin homology 2 domain (FH2 domain) | 0 | DIRECT |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | DIRECT |
53732,52016
53732 - Aconitase iron-sulfur domain
52016 - LeuD/IlvD-like | 0 | DIRECT |
57362,57362
57362 - BPTI-like
57362 - BPTI-like | 0 | DIRECT |
48403,52540
48403 - Ankyrin repeat
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
90188,90188
90188 - Somatomedin B domain
90188 - Somatomedin B domain | 0 | DIRECT |
55394,55394
55394 - Bactericidal permeability-increasing protein, BPI
55394 - Bactericidal permeability-increasing protein, BPI | 0 | DIRECT |
47473,103506
47473 - EF-hand
103506 - Mitochondrial carrier | 0 | DIRECT |
57414,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like | 0 | DIRECT |
81324,81327
81324 - Voltage-gated potassium channels
81327 - Small-conductance potassium channel | 0 | DIRECT |
57889,49562
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
57196,57535
57196 - EGF/Laminin
57535 - Complement control module/SCR domain | 0 | DIRECT |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | DIRECT |
48552,48552
48552 - Serum albumin-like
48552 - Serum albumin-like | 0 | DIRECT |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.006073 | INHERITED FROM: Pain || Neoplastic Processes || Ischemia || Pathologic Processes || Hemorrhage || Cerebral Infarction || Infarction || Infarction, Middle Cerebral Artery || Cerebral Hemorrhage |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.008822 | INHERITED FROM: Neoplastic Processes || Cerebral Hemorrhage |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0192 | INHERITED FROM: Disease Progression |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.01958 | INHERITED FROM: Disease Progression |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.01958 | INHERITED FROM: Disease Progression |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.03453 | INHERITED FROM: Liver Cirrhosis, Experimental || Liver Cirrhosis || Gliosis |
52540,90123
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0.03845 | INHERITED FROM: Disease Progression |
57184,57610
57184 - Growth factor receptor domain
57610 - Thyroglobulin type-1 domain | 0.06134 | INHERITED FROM: Body Weight |
53822,53850
53822 - Periplasmic binding protein-like I
53850 - Periplasmic binding protein-like II | 0.06134 | INHERITED FROM: Intellectual Disability |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0.0629 | INHERITED FROM: Postoperative Complications || Myocardial Reperfusion Injury || Reperfusion Injury |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.07641 | INHERITED FROM: Hepatomegaly || Hernia, Diaphragmatic |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0.08683 | INHERITED FROM: Status Epilepticus |
46579,64593
46579 - Prefoldin
64593 - Intermediate filament protein, coiled coil region | 0.1025 | INHERITED FROM: Cell Transformation, Neoplastic |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0.1082 | INHERITED FROM: Hypertrophy || Pathological Conditions, Anatomical |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.1233 | INHERITED FROM: MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE || Malignant Hyperthermia || Multiple pterygium syndrome || Intraoperative Complications |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.1317 | INHERITED FROM: Pain || Hemorrhage || Neoplasm Metastasis || Cerebral Infarction || Infarction || Infarction, Middle Cerebral Artery |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0.1609 | INHERITED FROM: Liver Cirrhosis, Experimental || Liver Cirrhosis |
47986,52540
47986 - DEATH domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1609 | INHERITED FROM: Inflammation |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0.1717 | INHERITED FROM: Hemorrhage || Gliosis |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.1717 | INHERITED FROM: Hemorrhage || Gliosis |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.2334 | INHERITED FROM: Spinocerebellar Ataxias || Spinocerebellar Ataxia 17 |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0.2501 | INHERITED FROM: Hemorrhage |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.26 | INHERITED FROM: Paralysis || Ataxia |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0.2679 | INHERITED FROM: Paralysis || Ataxia |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.3447 | INHERITED FROM: Erythema Multiforme || Disease Susceptibility || Proteinuria |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.3781 | INHERITED FROM: Gliosis |
141072,141072
141072 - CalX-like
141072 - CalX-like | 0.4019 | INHERITED FROM: Seizures |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0.4125 | INHERITED FROM: Disease Progression || Disease Attributes |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.4275 | INHERITED FROM: Nails, Malformed |
50156,50156
50156 - PDZ domain-like
50156 - PDZ domain-like | 0.7518 | INHERITED FROM: Deafness || Deaf-Blind Disorders || Blindness || Vision Disorders || Usher Syndromes |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
53300,53300
53300 - vWA-like
53300 - vWA-like | 0 | Direct |
56059,52210
56059 - Glutathione synthetase ATP-binding domain-like
52210 - Succinyl-CoA synthetase domains | 0 | Direct |
52058,48726
52058 - L domain-like
48726 - Immunoglobulin | 0 | Direct |
48371,101447
48371 - ARM repeat
101447 - Formin homology 2 domain (FH2 domain) | 0 | Direct |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | Direct |
53732,52016
53732 - Aconitase iron-sulfur domain
52016 - LeuD/IlvD-like | 0 | Direct |
57362,57362
57362 - BPTI-like
57362 - BPTI-like | 0 | Direct |
48403,52540
48403 - Ankyrin repeat
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
90188,90188
90188 - Somatomedin B domain
90188 - Somatomedin B domain | 0 | Direct |
55394,55394
55394 - Bactericidal permeability-increasing protein, BPI
55394 - Bactericidal permeability-increasing protein, BPI | 0 | Direct |
47473,103506
47473 - EF-hand
103506 - Mitochondrial carrier | 0 | Direct |
57414,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like | 0 | Direct |
81324,81327
81324 - Voltage-gated potassium channels
81327 - Small-conductance potassium channel | 0 | Direct |
57889,49562
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
57196,57535
57196 - EGF/Laminin
57535 - Complement control module/SCR domain | 0 | Direct |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | Direct |
48552,48552
48552 - Serum albumin-like
48552 - Serum albumin-like | 0 | Direct |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.006073 | Inherited |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.008822 | Inherited |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0192 | Inherited |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.01958 | Inherited |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.01958 | Inherited |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.03453 | Inherited |
52540,90123
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0.03845 | Inherited |
57184,57610
57184 - Growth factor receptor domain
57610 - Thyroglobulin type-1 domain | 0.06134 | Inherited |
53822,53850
53822 - Periplasmic binding protein-like I
53850 - Periplasmic binding protein-like II | 0.06134 | Inherited |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0.0629 | Inherited |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.07641 | Inherited |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0.08683 | Inherited |
46579,64593
46579 - Prefoldin
64593 - Intermediate filament protein, coiled coil region | 0.1025 | Inherited |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0.1082 | Inherited |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.1233 | Inherited |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.1317 | Inherited |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0.1609 | Inherited |
47986,52540
47986 - DEATH domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1609 | Inherited |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0.1717 | Inherited |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.1717 | Inherited |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.2334 | Inherited |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0.2501 | Inherited |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.26 | Inherited |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0.2679 | Inherited |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.3447 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.3781 | Inherited |
141072,141072
141072 - CalX-like
141072 - CalX-like | 0.4019 | Inherited |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0.4125 | Inherited |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.4275 | Inherited |
50156,50156
50156 - PDZ domain-like
50156 - PDZ domain-like | 0.7518 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Triple) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
64268,50044,50044
64268 - PX domain
50044 - SH3-domain
50044 - SH3-domain | 0 | DIRECT |
57414,57440,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
52058,48726,48726
52058 - L domain-like
48726 - Immunoglobulin
48726 - Immunoglobulin | 0 | DIRECT |
48552,48552,48552
48552 - Serum albumin-like
48552 - Serum albumin-like
48552 - Serum albumin-like | 0 | DIRECT |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
57889,57889,49562
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
54768,54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | DIRECT |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.01958 | INHERITED FROM: Disease Progression |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.03453 | INHERITED FROM: Liver Cirrhosis, Experimental || Liver Cirrhosis || Gliosis |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0.03453 | INHERITED FROM: Neoplastic Processes || Liver Cirrhosis, Experimental || Neoplasm Metastasis |
52540,90123,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.03845 | INHERITED FROM: Disease Progression |
90123,52540,90123
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0.03845 | INHERITED FROM: Disease Progression |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0.1717 | INHERITED FROM: Hemorrhage || Gliosis |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0.2378 | INHERITED FROM: Hemorrhage || Gliosis |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.2679 | INHERITED FROM: Paralysis || Ataxia |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
64268,50044,50044
64268 - PX domain
50044 - SH3-domain
50044 - SH3-domain | 0 | Direct |
57414,57440,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
52058,48726,48726
52058 - L domain-like
48726 - Immunoglobulin
48726 - Immunoglobulin | 0 | Direct |
48552,48552,48552
48552 - Serum albumin-like
48552 - Serum albumin-like
48552 - Serum albumin-like | 0 | Direct |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
57889,57889,49562
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
54768,54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | Direct |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.01958 | Inherited |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.03453 | Inherited |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0.03453 | Inherited |
52540,90123,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.03845 | Inherited |
90123,52540,90123
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0.03845 | Inherited |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0.1717 | Inherited |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0.2378 | Inherited |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.2679 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Plot distribution on species Tree Of Life (sTOL) for Superfamily and/or Family domains annotated by this CD term
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Plot tree as:
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Download Newick format tree:
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( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Plot distribution on species Tree Of Life (sTOL) for single supra-domains annotated by this CD term
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Plot tree as:
| |
Download Newick format tree:
| |
Browsing in TREE OF LIFE:
|
( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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> BO Hierarchy > Pathological Conditions, Signs and Symptoms
