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CTD Chemicals (CC): Hormones, Hormone Substitutes, and Hormone Antagonists 
(show info)
Biomedical Ontology
Like Gene Ontology (GO), biomedical ontology such as phenotype ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Biomedical ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI’s thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology Based on YP which is the major contributor to the ‘Ascomycete phenotype ontology’, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- UniProtKB KeyWords (KW) Ontology Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- CTD Diseases (CD) Ontology CD is MEDIC disease vocabulary that is modified by CTD from the "Diseases" [C] branch of Medical Subject Headings (MeSH), combined with genetic disorders from the Online Mendelian Inheritance in OMIM database.
- CTD Chemicals (CC) Ontology CC is chemical vocabulary that is adapted by CTD from the "Chemicals and Drugs" category and Supplementary Concept Records of Medical Subject Headings (MeSH, a hierarchical vocabulary used to index articles for MEDLINE/PubMed).
Jump to [ Top · Hierarchy · Annotations ]
Root: CC Hierarchy (CTD chemicals from Comparative Toxicogenomics Database)
Jump to [ Top · Hierarchy ]
Superfamily( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| DEK C-terminal domain | 0 | DIRECT |
| BAG domain | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| beta-lactamase/transpeptidase-like | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| MAPEG domain-like | 0 | DIRECT |
| P-domain of calnexin/calreticulin | 0 | DIRECT |
| AhpD-like | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | DIRECT |
| N-terminal domain of cbl (N-cbl) | 0 | DIRECT |
| WGR domain-like | 0 | DIRECT |
| A heparin-binding domain | 0 | DIRECT |
| Fibrinogen coiled-coil and central regions | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
| RGC domain-like | 0 | DIRECT |
| Nucleoporin domain | 0 | DIRECT |
| DLC | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| Cytochrome P450 | 0.000000003239 | DIRECT |
| EGF/Laminin | 0.000001499 | DIRECT |
| Growth factor receptor domain | 0.000006929 | DIRECT |
| Calponin-homology domain, CH-domain | 0.000008201 | DIRECT |
| Nuclear receptor ligand-binding domain | 0.000009333 | DIRECT |
| Protein kinase-like (PK-like) | 0.00001774 | DIRECT |
| Plexin repeat | 0.00002178 | DIRECT |
| Cystine-knot cytokines | 0.00005854 | DIRECT |
| Serpins | 0.00013 | DIRECT |
| Leucine zipper domain | 0.0001869 | DIRECT |
| MFS general substrate transporter | 0.0002517 | DIRECT |
| DEATH domain | 0.0002991 | DIRECT |
| SH2 domain | 0.0003028 | DIRECT |
| Caspase-like | 0.0004187 | DIRECT |
| Fibronectin type III | 0.0005227 | DIRECT |
| Sema domain | 0.00055 | DIRECT |
| Cytochrome b5-like heme/steroid binding domain | 0.0008657 | DIRECT |
| Arginase/deacetylase | 0.0008657 | DIRECT |
| Bcl-2 inhibitors of programmed cell death | 0.0008657 | DIRECT |
| Thyroglobulin type-1 domain | 0.0008927 | DIRECT |
| PH domain-like | 0.0009482 | DIRECT |
| Integrin domains | 0.0009662 | DIRECT |
| PGBD-like | 0.001517 | INHERITED FROM: Estradiol Congeners || Estradiol || Nandrolone || Progesterone || mibolerone |
| NAD(P)-binding Rossmann-fold domains | 0.001553 | INHERITED FROM: Cortisone || Adrenal Cortex Hormones || Androstenedione || Androstenediol || Estrone |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0.002259 | INHERITED FROM: Estradiol |
| Hemopexin-like domain | 0.003069 | INHERITED FROM: Estradiol Congeners || Estradiol || Progesterone |
| Metallothionein | 0.003576 | INHERITED FROM: Estradiol Congeners || Corpus Luteum Hormones || Progesterone Congeners || Progesterone |
| Metalloproteases ("zincins"), catalytic domain | 0.005791 | INHERITED FROM: Progesterone || mibolerone |
| VHP, Villin headpiece domain | 0.006059 | INHERITED FROM: Estradiol |
| Kringle-like | 0.007957 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Medroxyprogesterone Acetate || 17-Hydroxycorticosteroids || Progesterone || Hydroxyprogesterones || Medroxyprogesterone |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.008731 | INHERITED FROM: Goserelin || 5-alpha-Dihydroprogesterone || Juvenile Hormones || Hormone Antagonists || Corticosterone || tetraiodothyroacetic acid || Estriol || Invertebrate Hormones || Equilin || Cortodoxone || 3,3',5-triiodothyroacetic acid |
| Integrin beta tail domain | 0.0127 | INHERITED FROM: Corpus Luteum Hormones || Progesterone Congeners || Progesterone |
| C-terminal, gelsolin-like domain of Sec23/24 | 0.01375 | INHERITED FROM: Dihydrotestosterone |
| Interleukin 8-like chemokines | 0.01637 | INHERITED FROM: 11-Hydroxycorticosteroids || Corpus Luteum Hormones || Fludrocortisone || Progesterone Congeners || 17-Hydroxycorticosteroids || Fulvestrant |
| vWA-like | 0.01789 | INHERITED FROM: Medroxyprogesterone Acetate || Medroxyprogesterone |
| NAD(P)-linked oxidoreductase | 0.02108 | INHERITED FROM: Triiodothyronine || 11-Hydroxycorticosteroids || 5-alpha-Dihydroprogesterone || Medroxyprogesterone Acetate || 20-alpha-Dihydroprogesterone || Corticosterone || 4-hydroxyequilenin-o-quinone || Adrenal Cortex Hormones || Equilenin || Desoxycorticosterone || Thyronines || Estrone || 16-ketoestrone || Medroxyprogesterone || tetrahydrodeoxycorticosterone || Thyroxine |
| p53-like transcription factors | 0.02348 | INHERITED FROM: cetrorelix || Gastrointestinal Hormones || Peptide Hormones || Gastrins || Pituitary Hormone-Releasing Hormones |
| Cupredoxins | 0.02519 | INHERITED FROM: ethinyl estradiol-desogestrel combination |
| Helical domain of Sec23/24 | 0.02616 | INHERITED FROM: Dihydrotestosterone || Testosterone Congeners |
| GLA-domain | 0.02863 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Medroxyprogesterone Acetate || Estrogenic Steroids, Alkylated || norgestimate, ethinyl estradiol drug combination || estradiol valerate-dienogest || dienogest || estradiol, norethindrone drug combination || Nandrolone || Medroxyprogesterone |
| PYP-like sensor domain (PAS domain) | 0.04247 | INHERITED FROM: Triiodothyronine || Adrenal Cortex Hormones || Thyronines || Fulvestrant || Thyroxine |
| P-loop containing nucleoside triphosphate hydrolases | 0.04273 | INHERITED FROM: estradiol-17 beta-glucuronide |
| Inhibitor of apoptosis (IAP) repeat | 0.04794 | INHERITED FROM: Gastrointestinal Hormones || Peptide Hormones || Gastrins |
| FnI-like domain | 0.06019 | INHERITED FROM: Estrogenic Steroids, Alkylated || Angiotensins || Peptide Hormones |
| Kazal-type serine protease inhibitors | 0.0631 | INHERITED FROM: 3-iodothyronamine || Thyroid Hormones || Thyronines || estrone sulfate |
| Insulin-like | 0.06504 | INHERITED FROM: Hypothalamic Hormones || 11-Hydroxycorticosteroids || Hydrocortisone || Hydroxycorticosteroids || Peptide Hormones || Testosterone || 17-Hydroxycorticosteroids || Testosterone Congeners |
| Hormone receptor domain | 0.06839 | INHERITED FROM: Peptide Hormones || Pituitary Hormone-Releasing Hormones |
| Integrin alpha N-terminal domain | 0.07633 | INHERITED FROM: Corpus Luteum Hormones || Progesterone Congeners || Progesterone |
| ABC transporter transmembrane region | 0.08116 | INHERITED FROM: estradiol-17 beta-glucuronide || Methyltestosterone || Peptide Hormones || Progesterone |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.08398 | INHERITED FROM: Estrogens, Catechol || 4-hydroxyestrone || Hydroxyestrones || Pregnenolone Carbonitrile || 2-Methoxyestradiol || Estriol || Pregnenolone || Adrenal Cortex Hormones || Androsterone || 2-hydroxyestradiol || Estrone |
| Cyclin-like | 0.08494 | INHERITED FROM: 2-Methoxyestradiol || Fulvestrant |
| Acyl-CoA binding protein | 0.08603 | INHERITED FROM: Testosterone Congeners |
| 4-helical cytokines | 0.1021 | INHERITED FROM: 11-Hydroxycorticosteroids || Hydrocortisone || Medroxyprogesterone Acetate || Corpus Luteum Hormones || Pituitary Hormones, Anterior || Estrogens, Conjugated (USP) || Peptide Hormones || Progesterone Congeners || Adrenal Cortex Hormones || 17-Hydroxycorticosteroids || Medroxyprogesterone |
| Zn-finger domain of Sec23/24 | 0.1028 | INHERITED FROM: Dihydrotestosterone |
| TNF-like | 0.1931 | INHERITED FROM: Medroxyprogesterone Acetate || Hydroxyprogesterones |
| beta-sandwich domain of Sec23/24 | 0.1981 | INHERITED FROM: Dihydrotestosterone || Testosterone Congeners |
| HLH, helix-loop-helix DNA-binding domain | 0.2005 | INHERITED FROM: Dihydrotestosterone || testosterone-3-carboxymethyloxime-bovine serum albumin conjugate |
| GST C-terminal domain-like | 0.2258 | INHERITED FROM: 17-Ketosteroids || Androstenedione |
| Blood coagulation inhibitor (disintegrin) | 0.2717 | INHERITED FROM: Triiodothyronine || Thyronines || Thyroxine |
| "Winged helix" DNA-binding domain | 0.2991 | INHERITED FROM: mibolerone |
| Cytokine | 0.3554 | INHERITED FROM: Hydroxycorticosteroids |
| Thioredoxin-like | 0.3932 | INHERITED FROM: 17-Ketosteroids |
| Fibrinogen C-terminal domain-like | 0.5601 | INHERITED FROM: ethinyl estradiol-desogestrel combination || estradiol valerate-dienogest || dienogest || Nandrolone |
| Trypsin-like serine proteases | 0.7381 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Medroxyprogesterone Acetate || Estrogenic Steroids, Alkylated || estradiol valerate-dienogest || NuvaRing || estradiol, norethindrone drug combination || Nandrolone || Medroxyprogesterone |
| L domain-like | 0.8935 | INHERITED FROM: Insulins |
| Family A G protein-coupled receptor-like | 1 | INHERITED FROM: Peptide Hormones |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| DEK C-terminal domain | 0 | Direct |
| BAG domain | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| beta-lactamase/transpeptidase-like | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| MAPEG domain-like | 0 | Direct |
| P-domain of calnexin/calreticulin | 0 | Direct |
| AhpD-like | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | Direct |
| N-terminal domain of cbl (N-cbl) | 0 | Direct |
| WGR domain-like | 0 | Direct |
| A heparin-binding domain | 0 | Direct |
| Fibrinogen coiled-coil and central regions | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
| RGC domain-like | 0 | Direct |
| Nucleoporin domain | 0 | Direct |
| DLC | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| Cytochrome P450 | 0.000000003239 | Direct |
| EGF/Laminin | 0.000001499 | Direct |
| Growth factor receptor domain | 0.000006929 | Direct |
| Calponin-homology domain, CH-domain | 0.000008201 | Direct |
| Nuclear receptor ligand-binding domain | 0.000009333 | Direct |
| Protein kinase-like (PK-like) | 0.00001774 | Direct |
| Plexin repeat | 0.00002178 | Direct |
| Cystine-knot cytokines | 0.00005854 | Direct |
| Serpins | 0.00013 | Direct |
| Leucine zipper domain | 0.0001869 | Direct |
| MFS general substrate transporter | 0.0002517 | Direct |
| DEATH domain | 0.0002991 | Direct |
| SH2 domain | 0.0003028 | Direct |
| Caspase-like | 0.0004187 | Direct |
| Fibronectin type III | 0.0005227 | Direct |
| Sema domain | 0.00055 | Direct |
| Cytochrome b5-like heme/steroid binding domain | 0.0008657 | Direct |
| Arginase/deacetylase | 0.0008657 | Direct |
| Bcl-2 inhibitors of programmed cell death | 0.0008657 | Direct |
| Thyroglobulin type-1 domain | 0.0008927 | Direct |
| PH domain-like | 0.0009482 | Direct |
| Integrin domains | 0.0009662 | Direct |
| PGBD-like | 0.001517 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 0.001553 | Inherited |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0.002259 | Inherited |
| Hemopexin-like domain | 0.003069 | Inherited |
| Metallothionein | 0.003576 | Inherited |
| Metalloproteases ("zincins"), catalytic domain | 0.005791 | Inherited |
| VHP, Villin headpiece domain | 0.006059 | Inherited |
| Kringle-like | 0.007957 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.008731 | Inherited |
| Integrin beta tail domain | 0.0127 | Inherited |
| C-terminal, gelsolin-like domain of Sec23/24 | 0.01375 | Inherited |
| Interleukin 8-like chemokines | 0.01637 | Inherited |
| vWA-like | 0.01789 | Inherited |
| NAD(P)-linked oxidoreductase | 0.02108 | Inherited |
| p53-like transcription factors | 0.02348 | Inherited |
| Cupredoxins | 0.02519 | Inherited |
| Helical domain of Sec23/24 | 0.02616 | Inherited |
| GLA-domain | 0.02863 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.04247 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 0.04273 | Inherited |
| Inhibitor of apoptosis (IAP) repeat | 0.04794 | Inherited |
| FnI-like domain | 0.06019 | Inherited |
| Kazal-type serine protease inhibitors | 0.0631 | Inherited |
| Insulin-like | 0.06504 | Inherited |
| Hormone receptor domain | 0.06839 | Inherited |
| Integrin alpha N-terminal domain | 0.07633 | Inherited |
| ABC transporter transmembrane region | 0.08116 | Inherited |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.08398 | Inherited |
| Cyclin-like | 0.08494 | Inherited |
| Acyl-CoA binding protein | 0.08603 | Inherited |
| 4-helical cytokines | 0.1021 | Inherited |
| Zn-finger domain of Sec23/24 | 0.1028 | Inherited |
| TNF-like | 0.1931 | Inherited |
| beta-sandwich domain of Sec23/24 | 0.1981 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.2005 | Inherited |
| GST C-terminal domain-like | 0.2258 | Inherited |
| Blood coagulation inhibitor (disintegrin) | 0.2717 | Inherited |
| "Winged helix" DNA-binding domain | 0.2991 | Inherited |
| Cytokine | 0.3554 | Inherited |
| Thioredoxin-like | 0.3932 | Inherited |
| Fibrinogen C-terminal domain-like | 0.5601 | Inherited |
| Trypsin-like serine proteases | 0.7381 | Inherited |
| L domain-like | 0.8935 | Inherited |
| Family A G protein-coupled receptor-like | 1 | Inherited |
LINKTO: Domain2BO Download and Domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Family( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| Alkaline phosphatase | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| 2'-5'-oligoadenylate synthetase 1, OAS1, second domain | 0 | DIRECT |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | DIRECT |
| DEATH effector domain, DED | 0 | DIRECT |
| MAPEG domain | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | DIRECT |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | DIRECT |
| Oligoxyloglucan reducing end-specific cellobiohydrolase | 0 | DIRECT |
| DLC | 0 | DIRECT |
| P-domain of calnexin/calreticulin | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| 2'-5'-oligoadenylate synthetase 1, OAS1, N-terminal domain | 0 | DIRECT |
| DEK C-terminal domain | 0 | DIRECT |
| Troponin T | 0 | DIRECT |
| Fibrinogen coiled-coil and central regions | 0 | DIRECT |
| Tetrahydrofolate dehydrogenase/cyclohydrolase | 0 | DIRECT |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
| SelR domain | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, C-terminal domain | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | DIRECT |
| p53 DNA-binding domain-like | 0 | DIRECT |
| Transferrin | 0 | DIRECT |
| Adenylyltransferase | 0 | DIRECT |
| Retinoblastoma tumor suppressor domains | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Calnexin/calreticulin | 0 | DIRECT |
| GHMP Kinase, N-terminal domain | 0 | DIRECT |
| N-terminal domain of cbl (N-cbl) | 0 | DIRECT |
| Hsp90 middle domain | 0 | DIRECT |
| Steroid-binding domain | 0 | DIRECT |
| WGR domain | 0 | DIRECT |
| Tissue inhibitor of metalloproteinases, TIMP | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| A heparin-binding domain | 0 | DIRECT |
| HD domain | 0 | DIRECT |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| BAG domain | 0 | DIRECT |
| C-terminal domain of adenylylcyclase associated protein | 0 | DIRECT |
| RGC domain | 0 | DIRECT |
| Cytochrome P450 | 0.00000001186 | DIRECT |
| EGF-type module | 0.000005907 | DIRECT |
| Nuclear receptor ligand-binding domain | 0.0000141 | DIRECT |
| Calponin-homology domain, CH-domain | 0.00001473 | DIRECT |
| Plexin repeat | 0.0000301 | DIRECT |
| Growth factor receptor domain | 0.00003919 | DIRECT |
| Nuclear receptor | 0.00004303 | DIRECT |
| Protein kinases, catalytic subunit | 0.00009374 | DIRECT |
| Transforming growth factor (TGF)-beta | 0.0001711 | DIRECT |
| Leucine zipper domain | 0.000274 | DIRECT |
| Serpins | 0.0002996 | DIRECT |
| SH2 domain | 0.0005847 | DIRECT |
| Histone deacetylase, HDAC | 0.0006083 | DIRECT |
| Enabled/VASP homology 1 domain (EVH1 domain) | 0.0006083 | DIRECT |
| Sema domain | 0.0006843 | DIRECT |
| Matrix metalloproteases, catalytic domain | 0.0007731 | DIRECT |
| DEATH domain, DD | 0.0008903 | DIRECT |
| Bcl-2 inhibitors of programmed cell death | 0.0009174 | DIRECT |
| Thyroglobulin type-1 domain | 0.0009773 | DIRECT |
| Integrin domains | 0.001138 | INHERITED FROM: Gonadal Hormones || Triiodothyronine || Medroxyprogesterone Acetate || Corpus Luteum Hormones || Progesterone Congeners || Thyronines || Progesterone || Medroxyprogesterone |
| Integrin A (or I) domain | 0.001543 | INHERITED FROM: Triiodothyronine || Medroxyprogesterone Acetate || Corpus Luteum Hormones || Estradiol || Progesterone Congeners || Thyronines || Medroxyprogesterone |
| MMP N-terminal domain | 0.001693 | INHERITED FROM: Estradiol Congeners || Estradiol || Nandrolone || Progesterone || mibolerone |
| Caspase catalytic domain | 0.001857 | INHERITED FROM: Estradiol Congeners || Estradiol || 2-Methoxyestradiol || Peptide Hormones || Melatonin |
| Kringle modules | 0.001892 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Medroxyprogesterone Acetate || Estradiol || Medroxyprogesterone |
| ABC transporter ATPase domain-like | 0.002871 | INHERITED FROM: estradiol-17 beta-glucuronide || Methyltestosterone || Progesterone |
| Hemopexin-like domain | 0.003514 | INHERITED FROM: Estradiol Congeners || Estradiol || Progesterone |
| Metallothionein | 0.003694 | INHERITED FROM: Estradiol Congeners || Corpus Luteum Hormones || Progesterone Congeners || Progesterone |
| UDPGT-like | 0.004526 | INHERITED FROM: Estrogens, Catechol || 4-hydroxyestrone || Hydroxyestrones || Pregnenolone Carbonitrile || 2-Methoxyestradiol || Estriol || Pregnenolone || Adrenal Cortex Hormones || Androsterone || 2-hydroxyestradiol || Estrone |
| Platelet-derived growth factor-like | 0.005982 | INHERITED FROM: Medroxyprogesterone Acetate || Hydroxyprogesterones || Medroxyprogesterone |
| VHP, Villin headpiece domain | 0.005982 | INHERITED FROM: Estradiol |
| Integrin beta EGF-like domains | 0.005982 | INHERITED FROM: Estradiol || Progesterone |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.005982 | INHERITED FROM: Testosterone || Testosterone Congeners |
| Gonadodropin/Follitropin | 0.007248 | INHERITED FROM: Estradiol Congeners || Hypothalamic Hormones || Estradiol || Peptide Hormones || Pituitary Hormone-Releasing Hormones || Gonadotropin-Releasing Hormone |
| Integrin alpha N-terminal domain | 0.00789 | INHERITED FROM: Corpus Luteum Hormones || Progesterone Congeners || Progesterone |
| ets domain | 0.01066 | INHERITED FROM: Nandrolone || mibolerone |
| Short-chain cytokines | 0.01232 | INHERITED FROM: 11-Hydroxycorticosteroids || Hydrocortisone || Adrenal Cortex Hormones || 17-Hydroxycorticosteroids |
| L domain | 0.01243 | INHERITED FROM: Peptide Hormones || Pancreatic Hormones || Fulvestrant || Insulins |
| Integrin beta tail domain | 0.01243 | INHERITED FROM: Corpus Luteum Hormones || Progesterone Congeners || Progesterone |
| Cytochrome b5 | 0.01391 | INHERITED FROM: Progesterone |
| Tyrosine-dependent oxidoreductases | 0.01933 | INHERITED FROM: Glucocorticoids || Dehydroepiandrosterone || Cortisone || Adrenal Cortex Hormones || Androstenedione || Androstenediol || Estrone |
| Interleukin 8-like chemokines | 0.02024 | INHERITED FROM: Corpus Luteum Hormones || Fludrocortisone || Progesterone Congeners || 17-Hydroxycorticosteroids || Fulvestrant |
| Aldo-keto reductases (NADP) | 0.02255 | INHERITED FROM: Triiodothyronine || 11-Hydroxycorticosteroids || 5-alpha-Dihydroprogesterone || Medroxyprogesterone Acetate || 20-alpha-Dihydroprogesterone || Corticosterone || 4-hydroxyequilenin-o-quinone || Adrenal Cortex Hormones || Equilenin || Desoxycorticosterone || Thyronines || Estrone || 16-ketoestrone || Medroxyprogesterone || tetrahydrodeoxycorticosterone || Thyroxine |
| Helical domain of Sec23/24 | 0.02544 | INHERITED FROM: Dihydrotestosterone || Testosterone Congeners |
| Trunk domain of Sec23/24 | 0.02544 | INHERITED FROM: Dihydrotestosterone || Testosterone Congeners |
| C-terminal, gelsolin-like domain of Sec23/24 | 0.02544 | INHERITED FROM: Dihydrotestosterone || Testosterone Congeners |
| beta-sandwich domain of Sec23/24 | 0.02544 | INHERITED FROM: Dihydrotestosterone || Testosterone Congeners |
| GLA-domain | 0.02983 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Medroxyprogesterone Acetate || Estrogenic Steroids, Alkylated || norgestimate, ethinyl estradiol drug combination || estradiol valerate-dienogest || dienogest || estradiol, norethindrone drug combination || Nandrolone || Medroxyprogesterone |
| ABC transporter transmembrane region | 0.0352 | INHERITED FROM: estradiol-17 beta-glucuronide || Methyltestosterone || Peptide Hormones || Progesterone |
| Ovomucoid domain III-like | 0.03584 | INHERITED FROM: 3-iodothyronamine || Thyronines || estrone sulfate |
| Cell cycle transcription factor e2f-dp | 0.03865 | INHERITED FROM: Testosterone |
| Inhibitor of apoptosis (IAP) repeat | 0.04771 | INHERITED FROM: Gastrointestinal Hormones || Peptide Hormones || Gastrins |
| Long-chain cytokines | 0.04948 | INHERITED FROM: Corpus Luteum Hormones || Peptide Hormones || 17-Ketosteroids || Progesterone Congeners || Progesterone |
| Multidomain cupredoxins | 0.05071 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Estrogenic Steroids, Alkylated |
| Hexokinase | 0.05071 | INHERITED FROM: testosterone-3-carboxymethyloxime-bovine serum albumin conjugate |
| PAPS sulfotransferase | 0.05684 | INHERITED FROM: Dehydroepiandrosterone || 17-Ketosteroids || Adrenal Cortex Hormones || 2-hydroxyestradiol || Estrone |
| Insulin-like | 0.06545 | INHERITED FROM: Hypothalamic Hormones || 11-Hydroxycorticosteroids || Hydrocortisone || Hydroxycorticosteroids || Peptide Hormones || Testosterone || 17-Hydroxycorticosteroids || Testosterone Congeners |
| Pentraxin (pentaxin) | 0.06545 | INHERITED FROM: Medroxyprogesterone Acetate || Medroxyprogesterone |
| Hormone receptor domain | 0.07242 | INHERITED FROM: Peptide Hormones || Pituitary Hormone-Releasing Hormones |
| Acyl-CoA binding protein | 0.08421 | INHERITED FROM: Testosterone Congeners |
| Cyclin | 0.09073 | INHERITED FROM: 2-Methoxyestradiol || Fulvestrant |
| Zn-finger domain of Sec23/24 | 0.09825 | INHERITED FROM: Dihydrotestosterone |
| Glutathione S-transferase (GST), C-terminal domain | 0.1231 | INHERITED FROM: 17-Ketosteroids || Androstenedione |
| Myb/SANT domain | 0.1629 | INHERITED FROM: Triiodothyronine || Thyronines || Fulvestrant |
| TNF-like | 0.2214 | INHERITED FROM: Medroxyprogesterone Acetate || Hydroxyprogesterones |
| HLH, helix-loop-helix DNA-binding domain | 0.2484 | INHERITED FROM: Dihydrotestosterone || testosterone-3-carboxymethyloxime-bovine serum albumin conjugate |
| Blood coagulation inhibitor (disintegrin) | 0.28 | INHERITED FROM: Triiodothyronine || Thyronines || Thyroxine |
| Interleukin-1 (IL-1) | 0.3876 | INHERITED FROM: 11-Hydroxycorticosteroids || Hydrocortisone || Hydroxycorticosteroids || Adrenal Cortex Hormones || 17-Hydroxycorticosteroids |
| Scavenger receptor cysteine-rich (SRCR) domain | 0.4553 | INHERITED FROM: Medroxyprogesterone Acetate || Medroxyprogesterone |
| C2 set domains | 0.5137 | INHERITED FROM: 11-Hydroxycorticosteroids || Hydrocortisone || Estrogenic Steroids, Alkylated || Hydroxycorticosteroids || Adrenal Cortex Hormones || 17-Hydroxycorticosteroids |
| VWC domain | 0.5383 | INHERITED FROM: testosterone enanthate || Estrogenic Steroids, Alkylated |
| Fibrinogen C-terminal domain-like | 0.5785 | INHERITED FROM: ethinyl estradiol-desogestrel combination || estradiol valerate-dienogest || dienogest || Nandrolone |
| Fibronectin type II module | 0.6 | INHERITED FROM: Medroxyprogesterone Acetate || Medroxyprogesterone |
| N-acetyl transferase, NAT | 0.7844 | INHERITED FROM: testosterone-3-carboxymethyloxime-bovine serum albumin conjugate |
| Eukaryotic proteases | 0.8374 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Medroxyprogesterone Acetate || estradiol valerate-dienogest || NuvaRing || estradiol, norethindrone drug combination || Nandrolone || Medroxyprogesterone |
| Interferons/interleukin-10 (IL-10) | 0.9883 | INHERITED FROM: Hydrocortisone || 17-Hydroxycorticosteroids |
| Rhodopsin-like | 1 | INHERITED FROM: Somatostatin || Pituitary Hormone Release Inhibiting Hormones |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| Alkaline phosphatase | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| 2'-5'-oligoadenylate synthetase 1, OAS1, second domain | 0 | Direct |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | Direct |
| DEATH effector domain, DED | 0 | Direct |
| MAPEG domain | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | Direct |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | Direct |
| Oligoxyloglucan reducing end-specific cellobiohydrolase | 0 | Direct |
| DLC | 0 | Direct |
| P-domain of calnexin/calreticulin | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| 2'-5'-oligoadenylate synthetase 1, OAS1, N-terminal domain | 0 | Direct |
| DEK C-terminal domain | 0 | Direct |
| Troponin T | 0 | Direct |
| Fibrinogen coiled-coil and central regions | 0 | Direct |
| Tetrahydrofolate dehydrogenase/cyclohydrolase | 0 | Direct |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
| SelR domain | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, C-terminal domain | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | Direct |
| p53 DNA-binding domain-like | 0 | Direct |
| Transferrin | 0 | Direct |
| Adenylyltransferase | 0 | Direct |
| Retinoblastoma tumor suppressor domains | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Calnexin/calreticulin | 0 | Direct |
| GHMP Kinase, N-terminal domain | 0 | Direct |
| N-terminal domain of cbl (N-cbl) | 0 | Direct |
| Hsp90 middle domain | 0 | Direct |
| Steroid-binding domain | 0 | Direct |
| WGR domain | 0 | Direct |
| Tissue inhibitor of metalloproteinases, TIMP | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| A heparin-binding domain | 0 | Direct |
| HD domain | 0 | Direct |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| BAG domain | 0 | Direct |
| C-terminal domain of adenylylcyclase associated protein | 0 | Direct |
| RGC domain | 0 | Direct |
| Cytochrome P450 | 0.00000001186 | Direct |
| EGF-type module | 0.000005907 | Direct |
| Nuclear receptor ligand-binding domain | 0.0000141 | Direct |
| Calponin-homology domain, CH-domain | 0.00001473 | Direct |
| Plexin repeat | 0.0000301 | Direct |
| Growth factor receptor domain | 0.00003919 | Direct |
| Nuclear receptor | 0.00004303 | Direct |
| Protein kinases, catalytic subunit | 0.00009374 | Direct |
| Transforming growth factor (TGF)-beta | 0.0001711 | Direct |
| Leucine zipper domain | 0.000274 | Direct |
| Serpins | 0.0002996 | Direct |
| SH2 domain | 0.0005847 | Direct |
| Histone deacetylase, HDAC | 0.0006083 | Direct |
| Enabled/VASP homology 1 domain (EVH1 domain) | 0.0006083 | Direct |
| Sema domain | 0.0006843 | Direct |
| Matrix metalloproteases, catalytic domain | 0.0007731 | Direct |
| DEATH domain, DD | 0.0008903 | Direct |
| Bcl-2 inhibitors of programmed cell death | 0.0009174 | Direct |
| Thyroglobulin type-1 domain | 0.0009773 | Direct |
| Integrin domains | 0.001138 | Inherited |
| Integrin A (or I) domain | 0.001543 | Inherited |
| MMP N-terminal domain | 0.001693 | Inherited |
| Caspase catalytic domain | 0.001857 | Inherited |
| Kringle modules | 0.001892 | Inherited |
| ABC transporter ATPase domain-like | 0.002871 | Inherited |
| Hemopexin-like domain | 0.003514 | Inherited |
| Metallothionein | 0.003694 | Inherited |
| UDPGT-like | 0.004526 | Inherited |
| Platelet-derived growth factor-like | 0.005982 | Inherited |
| VHP, Villin headpiece domain | 0.005982 | Inherited |
| Integrin beta EGF-like domains | 0.005982 | Inherited |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.005982 | Inherited |
| Gonadodropin/Follitropin | 0.007248 | Inherited |
| Integrin alpha N-terminal domain | 0.00789 | Inherited |
| ets domain | 0.01066 | Inherited |
| Short-chain cytokines | 0.01232 | Inherited |
| L domain | 0.01243 | Inherited |
| Integrin beta tail domain | 0.01243 | Inherited |
| Cytochrome b5 | 0.01391 | Inherited |
| Tyrosine-dependent oxidoreductases | 0.01933 | Inherited |
| Interleukin 8-like chemokines | 0.02024 | Inherited |
| Aldo-keto reductases (NADP) | 0.02255 | Inherited |
| Helical domain of Sec23/24 | 0.02544 | Inherited |
| Trunk domain of Sec23/24 | 0.02544 | Inherited |
| C-terminal, gelsolin-like domain of Sec23/24 | 0.02544 | Inherited |
| beta-sandwich domain of Sec23/24 | 0.02544 | Inherited |
| GLA-domain | 0.02983 | Inherited |
| ABC transporter transmembrane region | 0.0352 | Inherited |
| Ovomucoid domain III-like | 0.03584 | Inherited |
| Cell cycle transcription factor e2f-dp | 0.03865 | Inherited |
| Inhibitor of apoptosis (IAP) repeat | 0.04771 | Inherited |
| Long-chain cytokines | 0.04948 | Inherited |
| Multidomain cupredoxins | 0.05071 | Inherited |
| Hexokinase | 0.05071 | Inherited |
| PAPS sulfotransferase | 0.05684 | Inherited |
| Insulin-like | 0.06545 | Inherited |
| Pentraxin (pentaxin) | 0.06545 | Inherited |
| Hormone receptor domain | 0.07242 | Inherited |
| Acyl-CoA binding protein | 0.08421 | Inherited |
| Cyclin | 0.09073 | Inherited |
| Zn-finger domain of Sec23/24 | 0.09825 | Inherited |
| Glutathione S-transferase (GST), C-terminal domain | 0.1231 | Inherited |
| Myb/SANT domain | 0.1629 | Inherited |
| TNF-like | 0.2214 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.2484 | Inherited |
| Blood coagulation inhibitor (disintegrin) | 0.28 | Inherited |
| Interleukin-1 (IL-1) | 0.3876 | Inherited |
| Scavenger receptor cysteine-rich (SRCR) domain | 0.4553 | Inherited |
| C2 set domains | 0.5137 | Inherited |
| VWC domain | 0.5383 | Inherited |
| Fibrinogen C-terminal domain-like | 0.5785 | Inherited |
| Fibronectin type II module | 0.6 | Inherited |
| N-acetyl transferase, NAT | 0.7844 | Inherited |
| Eukaryotic proteases | 0.8374 | Inherited |
| Interferons/interleukin-10 (IL-10) | 0.9883 | Inherited |
| Rhodopsin-like | 1 | Inherited |
LINKTO: Domain2BO Download and Domain2BO Algorithm
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Supra-domain (Single)( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| P-domain of calnexin/calreticulin | 0 | DIRECT |
| N-terminal domain of cbl (N-cbl) | 0 | DIRECT |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| MAPEG domain-like | 0 | DIRECT |
| DEK C-terminal domain | 0 | DIRECT |
| Fibrinogen coiled-coil and central regions | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| DLC | 0 | DIRECT |
| beta-lactamase/transpeptidase-like | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| AhpD-like | 0 | DIRECT |
| RGC domain-like | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| BAG domain | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| A heparin-binding domain | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| Nucleoporin domain | 0 | DIRECT |
| WGR domain-like | 0 | DIRECT |
| Cytochrome P450 | 0.000000001343 | DIRECT |
| EGF/Laminin | 0.0000006972 | DIRECT |
| Growth factor receptor domain | 0.000003367 | DIRECT |
| Calponin-homology domain, CH-domain | 0.000004006 | DIRECT |
| Nuclear receptor ligand-binding domain | 0.000004577 | DIRECT |
| Protein kinase-like (PK-like) | 0.000008894 | DIRECT |
| Plexin repeat | 0.000011 | DIRECT |
| Cystine-knot cytokines | 0.00003067 | DIRECT |
| Serpins | 0.00007048 | DIRECT |
| Leucine zipper domain | 0.0001031 | DIRECT |
| MFS general substrate transporter | 0.0001405 | DIRECT |
| DEATH domain | 0.0001682 | DIRECT |
| SH2 domain | 0.0001703 | DIRECT |
| Caspase-like | 0.0002392 | DIRECT |
| Fibronectin type III | 0.000302 | DIRECT |
| Sema domain | 0.0003187 | DIRECT |
| Arginase/deacetylase | 0.0005129 | DIRECT |
| Cytochrome b5-like heme/steroid binding domain | 0.0005129 | DIRECT |
| Bcl-2 inhibitors of programmed cell death | 0.0005129 | DIRECT |
| Thyroglobulin type-1 domain | 0.0005297 | DIRECT |
| PH domain-like | 0.000564 | DIRECT |
| Integrin domains | 0.0005752 | DIRECT |
| PGBD-like | 0.0009261 | DIRECT |
| NAD(P)-binding Rossmann-fold domains | 0.0009493 | DIRECT |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0.001406 | INHERITED FROM: Estradiol |
| Hemopexin-like domain | 0.001941 | INHERITED FROM: Progesterone || Estradiol Congeners || Estradiol |
| Metallothionein | 0.002275 | INHERITED FROM: Progesterone || Progesterone Congeners || Estradiol Congeners || Corpus Luteum Hormones |
| DBL homology domain (DH-domain) | 0.002289 | INHERITED FROM: Estradiol |
| Metalloproteases ("zincins"), catalytic domain | 0.003782 | INHERITED FROM: Progesterone || mibolerone |
| VHP, Villin headpiece domain | 0.003969 | INHERITED FROM: Estradiol Congeners || Estradiol |
| Kringle-like | 0.005296 | INHERITED FROM: ethinyl estradiol-desogestrel combination || 11-Hydroxycorticosteroids || Progesterone || 17-Hydroxycorticosteroids || Medroxyprogesterone || Hydroxyprogesterones || Medroxyprogesterone Acetate |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.005842 | INHERITED FROM: Hormone Antagonists || Goserelin || tetraiodothyroacetic acid || Equilin || 5-alpha-Dihydroprogesterone || Cortodoxone || Corticosterone || Invertebrate Hormones || 3,3',5-triiodothyroacetic acid || Estriol || Juvenile Hormones |
| Integrin beta tail domain | 0.008677 | INHERITED FROM: Progesterone || Progesterone Congeners || Corpus Luteum Hormones |
| C-terminal, gelsolin-like domain of Sec23/24 | 0.009437 | INHERITED FROM: Dihydrotestosterone |
| Interleukin 8-like chemokines | 0.01136 | INHERITED FROM: Fulvestrant || 11-Hydroxycorticosteroids || Progesterone Congeners || 17-Hydroxycorticosteroids || Fludrocortisone || Corpus Luteum Hormones |
| vWA-like | 0.01249 | INHERITED FROM: Medroxyprogesterone || Medroxyprogesterone Acetate |
| NAD(P)-linked oxidoreductase | 0.01485 | INHERITED FROM: Thyroxine || 16-ketoestrone || 4-hydroxyequilenin-o-quinone || 11-Hydroxycorticosteroids || Desoxycorticosterone || Thyronines || Triiodothyronine || Equilenin || Medroxyprogesterone || tetrahydrodeoxycorticosterone || 20-alpha-Dihydroprogesterone || 5-alpha-Dihydroprogesterone || Estrone || Corticosterone || Medroxyprogesterone Acetate || 5-dihydrodeoxycorticosterone || Adrenal Cortex Hormones |
| p53-like transcription factors | 0.01664 | INHERITED FROM: Gastrointestinal Hormones || cetrorelix || Peptide Hormones || Gastrins || Pituitary Hormone-Releasing Hormones |
| Cupredoxins | 0.01794 | INHERITED FROM: ethinyl estradiol-desogestrel combination |
| Helical domain of Sec23/24 | 0.01866 | INHERITED FROM: Dihydrotestosterone || Testosterone Congeners |
| GLA-domain | 0.0205 | INHERITED FROM: ethinyl estradiol-desogestrel combination || estradiol valerate-dienogest || estradiol, norethindrone drug combination || norgestimate, ethinyl estradiol drug combination || Estrogenic Steroids, Alkylated || Medroxyprogesterone || Nandrolone || Medroxyprogesterone Acetate || dienogest |
| PYP-like sensor domain (PAS domain) | 0.03113 | INHERITED FROM: Thyroxine || Fulvestrant || Thyronines || Triiodothyronine || Adrenal Cortex Hormones |
| P-loop containing nucleoside triphosphate hydrolases | 0.03133 | INHERITED FROM: estradiol-17 beta-glucuronide |
| Inhibitor of apoptosis (IAP) repeat | 0.03541 | INHERITED FROM: Gastrointestinal Hormones || Peptide Hormones || Gastrins |
| FnI-like domain | 0.04497 | INHERITED FROM: Angiotensins || Estrogenic Steroids, Alkylated || Peptide Hormones |
| Kazal-type serine protease inhibitors | 0.04725 | INHERITED FROM: estrone sulfate || 3-iodothyronamine || Thyroid Hormones || Thyronines |
| Insulin-like | 0.04879 | INHERITED FROM: Hypothalamic Hormones || 11-Hydroxycorticosteroids || 17-Hydroxycorticosteroids || Peptide Hormones || Hydroxycorticosteroids || Testosterone Congeners || Testosterone || Hydrocortisone |
| Hormone receptor domain | 0.05145 | INHERITED FROM: Peptide Hormones || Pituitary Hormone-Releasing Hormones |
| Integrin alpha N-terminal domain | 0.05783 | INHERITED FROM: Progesterone || Progesterone Congeners || Corpus Luteum Hormones |
| ABC transporter transmembrane region | 0.0617 | INHERITED FROM: Methyltestosterone || Progesterone || Progesterone Congeners || Corpus Luteum Hormones || Peptide Hormones || estradiol-17 beta-glucuronide |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.06391 | INHERITED FROM: 2-hydroxyestradiol || 2-Methoxyestradiol || Pregnenolone Carbonitrile || Pregnenolone || Hydroxyestrones || 4-hydroxyestrone || Androsterone || Estrone || Estriol || Estrogens, Catechol || Adrenal Cortex Hormones |
| Cyclin-like | 0.06466 | INHERITED FROM: Fulvestrant || 2-Methoxyestradiol |
| Acyl-CoA binding protein | 0.06554 | INHERITED FROM: Testosterone Congeners |
| 4-helical cytokines | 0.07864 | INHERITED FROM: Dehydroepiandrosterone || Pituitary Hormones, Anterior || 11-Hydroxycorticosteroids || Progesterone Congeners || 17-Hydroxycorticosteroids || Medroxyprogesterone || Corpus Luteum Hormones || Peptide Hormones || Estrogens, Conjugated (USP) || Medroxyprogesterone Acetate || Hydrocortisone || Adrenal Cortex Hormones |
| Zn-finger domain of Sec23/24 | 0.07917 | INHERITED FROM: Dihydrotestosterone |
| 5' to 3' exonuclease, C-terminal subdomain | 0.07917 | INHERITED FROM: Testosterone |
| GINS helical bundle-like | 0.07917 | INHERITED FROM: Testosterone |
| TNF-like | 0.1547 | INHERITED FROM: Hydroxyprogesterones || Medroxyprogesterone Acetate |
| beta-sandwich domain of Sec23/24 | 0.159 | INHERITED FROM: Dihydrotestosterone || Testosterone Congeners |
| HLH, helix-loop-helix DNA-binding domain | 0.1611 | INHERITED FROM: Dihydrotestosterone || testosterone-3-carboxymethyloxime-bovine serum albumin conjugate |
| GST C-terminal domain-like | 0.183 | INHERITED FROM: Androstenedione || 17-Ketosteroids |
| Blood coagulation inhibitor (disintegrin) | 0.223 | INHERITED FROM: Thyroxine || Thyronines || Triiodothyronine |
| "Winged helix" DNA-binding domain | 0.2472 | INHERITED FROM: mibolerone |
| Cytokine | 0.2985 | INHERITED FROM: Hydroxycorticosteroids |
| Thioredoxin-like | 0.3326 | INHERITED FROM: 17-Ketosteroids |
| Fibrinogen C-terminal domain-like | 0.4898 | INHERITED FROM: ethinyl estradiol-desogestrel combination || estradiol valerate-dienogest || Progesterone || Progesterone Congeners || Corpus Luteum Hormones || Nandrolone || dienogest |
| Trypsin-like serine proteases | 0.6665 | INHERITED FROM: ethinyl estradiol-desogestrel combination || estradiol valerate-dienogest || estradiol, norethindrone drug combination || Estrogenic Steroids, Alkylated || Medroxyprogesterone || Nandrolone || NuvaRing || Medroxyprogesterone Acetate |
| L domain-like | 0.8301 | INHERITED FROM: Insulins |
| SAP domain | 0.8406 | INHERITED FROM: testosterone-3-carboxymethyloxime-bovine serum albumin conjugate |
| Family A G protein-coupled receptor-like | 1 | INHERITED FROM: Peptide Hormones |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| P-domain of calnexin/calreticulin | 0 | Direct |
| N-terminal domain of cbl (N-cbl) | 0 | Direct |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| MAPEG domain-like | 0 | Direct |
| DEK C-terminal domain | 0 | Direct |
| Fibrinogen coiled-coil and central regions | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| DLC | 0 | Direct |
| beta-lactamase/transpeptidase-like | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| AhpD-like | 0 | Direct |
| RGC domain-like | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| BAG domain | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| A heparin-binding domain | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| Nucleoporin domain | 0 | Direct |
| WGR domain-like | 0 | Direct |
| Cytochrome P450 | 0.000000001343 | Direct |
| EGF/Laminin | 0.0000006972 | Direct |
| Growth factor receptor domain | 0.000003367 | Direct |
| Calponin-homology domain, CH-domain | 0.000004006 | Direct |
| Nuclear receptor ligand-binding domain | 0.000004577 | Direct |
| Protein kinase-like (PK-like) | 0.000008894 | Direct |
| Plexin repeat | 0.000011 | Direct |
| Cystine-knot cytokines | 0.00003067 | Direct |
| Serpins | 0.00007048 | Direct |
| Leucine zipper domain | 0.0001031 | Direct |
| MFS general substrate transporter | 0.0001405 | Direct |
| DEATH domain | 0.0001682 | Direct |
| SH2 domain | 0.0001703 | Direct |
| Caspase-like | 0.0002392 | Direct |
| Fibronectin type III | 0.000302 | Direct |
| Sema domain | 0.0003187 | Direct |
| Arginase/deacetylase | 0.0005129 | Direct |
| Cytochrome b5-like heme/steroid binding domain | 0.0005129 | Direct |
| Bcl-2 inhibitors of programmed cell death | 0.0005129 | Direct |
| Thyroglobulin type-1 domain | 0.0005297 | Direct |
| PH domain-like | 0.000564 | Direct |
| Integrin domains | 0.0005752 | Direct |
| PGBD-like | 0.0009261 | Direct |
| NAD(P)-binding Rossmann-fold domains | 0.0009493 | Direct |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0.001406 | Inherited |
| Hemopexin-like domain | 0.001941 | Inherited |
| Metallothionein | 0.002275 | Inherited |
| DBL homology domain (DH-domain) | 0.002289 | Inherited |
| Metalloproteases ("zincins"), catalytic domain | 0.003782 | Inherited |
| VHP, Villin headpiece domain | 0.003969 | Inherited |
| Kringle-like | 0.005296 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.005842 | Inherited |
| Integrin beta tail domain | 0.008677 | Inherited |
| C-terminal, gelsolin-like domain of Sec23/24 | 0.009437 | Inherited |
| Interleukin 8-like chemokines | 0.01136 | Inherited |
| vWA-like | 0.01249 | Inherited |
| NAD(P)-linked oxidoreductase | 0.01485 | Inherited |
| p53-like transcription factors | 0.01664 | Inherited |
| Cupredoxins | 0.01794 | Inherited |
| Helical domain of Sec23/24 | 0.01866 | Inherited |
| GLA-domain | 0.0205 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.03113 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 0.03133 | Inherited |
| Inhibitor of apoptosis (IAP) repeat | 0.03541 | Inherited |
| FnI-like domain | 0.04497 | Inherited |
| Kazal-type serine protease inhibitors | 0.04725 | Inherited |
| Insulin-like | 0.04879 | Inherited |
| Hormone receptor domain | 0.05145 | Inherited |
| Integrin alpha N-terminal domain | 0.05783 | Inherited |
| ABC transporter transmembrane region | 0.0617 | Inherited |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.06391 | Inherited |
| Cyclin-like | 0.06466 | Inherited |
| Acyl-CoA binding protein | 0.06554 | Inherited |
| 4-helical cytokines | 0.07864 | Inherited |
| Zn-finger domain of Sec23/24 | 0.07917 | Inherited |
| 5' to 3' exonuclease, C-terminal subdomain | 0.07917 | Inherited |
| GINS helical bundle-like | 0.07917 | Inherited |
| TNF-like | 0.1547 | Inherited |
| beta-sandwich domain of Sec23/24 | 0.159 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.1611 | Inherited |
| GST C-terminal domain-like | 0.183 | Inherited |
| Blood coagulation inhibitor (disintegrin) | 0.223 | Inherited |
| "Winged helix" DNA-binding domain | 0.2472 | Inherited |
| Cytokine | 0.2985 | Inherited |
| Thioredoxin-like | 0.3326 | Inherited |
| Fibrinogen C-terminal domain-like | 0.4898 | Inherited |
| Trypsin-like serine proteases | 0.6665 | Inherited |
| L domain-like | 0.8301 | Inherited |
| SAP domain | 0.8406 | Inherited |
| Family A G protein-coupled receptor-like | 1 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Duplex) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
142921,47587
142921 - WGR domain-like
47587 - Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
55486,49854
55486 - Metalloproteases ("zincins"), catalytic domain
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
48452,57850
48452 - TPR-like
57850 - RING/U-box | 0 | DIRECT |
49899,63887
49899 - Concanavalin A-like lectins/glucanases
63887 - P-domain of calnexin/calreticulin | 0 | DIRECT |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | DIRECT |
53098,56672
53098 - Ribonuclease H-like
56672 - DNA/RNA polymerases | 0 | DIRECT |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
55550,57850
55550 - SH2 domain
57850 - RING/U-box | 0 | DIRECT |
69012,55874
69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | DIRECT |
57850,48452
57850 - RING/U-box
48452 - TPR-like | 0 | DIRECT |
53300,57184
53300 - vWA-like
57184 - Growth factor receptor domain | 0 | DIRECT |
57889,50729
57889 - Cysteine-rich domain
50729 - PH domain-like | 0 | DIRECT |
56491,89811
56491 - A heparin-binding domain
89811 - Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
48403,47986
48403 - Ankyrin repeat
47986 - DEATH domain | 0 | DIRECT |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
53300,49899
53300 - vWA-like
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
47473,55550
47473 - EF-hand
55550 - SH2 domain | 0 | DIRECT |
47862,47862
47862 - Saposin
47862 - Saposin | 0 | DIRECT |
57184,57610
57184 - Growth factor receptor domain
57610 - Thyroglobulin type-1 domain | 0 | DIRECT |
47473,57610
47473 - EF-hand
57610 - Thyroglobulin type-1 domain | 0 | DIRECT |
100934,100934
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
48371,-7
48371 - ARM repeat
-7 - CATH | 0 | DIRECT |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | DIRECT |
57414,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like | 0 | DIRECT |
63748,57903
63748 - Tudor/PWWP/MBT
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
47587,56399
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | DIRECT |
53850,53850
53850 - Periplasmic binding protein-like II
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
47668,47473
47668 - N-terminal domain of cbl (N-cbl)
47473 - EF-hand | 0 | DIRECT |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0 | DIRECT |
64268,56112
64268 - PX domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57850,88697
57850 - RING/U-box
88697 - PUA domain-like | 0 | DIRECT |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.00002826 | DIRECT |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.0001246 | DIRECT |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.000265 | DIRECT |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.0003169 | DIRECT |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0.0003187 | DIRECT |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.0009261 | DIRECT |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0.001781 | INHERITED FROM: Melatonin || Estradiol Congeners || Estradiol |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.001787 | INHERITED FROM: Estradiol Congeners || Estradiol |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.002189 | INHERITED FROM: Hypothalamic Hormones || Dehydroepiandrosterone || Estrogens || Fulvestrant || Melatonin || Medroxyprogesterone || tetraiodothyroacetic acid || 17-Ketosteroids || Estrone || 3,3',5-triiodothyroacetic acid || 17-alpha-Hydroxyprogesterone || Medroxyprogesterone Acetate || Estriol || Adrenal Cortex Hormones |
81296,81296
81296 - E set domains
81296 - E set domains | 0.002608 | INHERITED FROM: Estradiol |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.003166 | INHERITED FROM: Estradiol |
103473,100895
103473 - MFS general substrate transporter
100895 - Kazal-type serine protease inhibitors | 0.004688 | INHERITED FROM: estrone sulfate || 3-iodothyronamine || Thyroid Hormones || Thyronines || 17-Ketosteroids || Estrone || Adrenal Cortex Hormones |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0.008496 | INHERITED FROM: Progesterone || Progesterone Congeners || Corpus Luteum Hormones |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.008496 | INHERITED FROM: Progesterone || Progesterone Congeners || Corpus Luteum Hormones |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.008677 | INHERITED FROM: Fulvestrant || Insulins || Pancreatic Hormones || Peptide Hormones |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.008677 | INHERITED FROM: Fulvestrant || Insulins || Pancreatic Hormones || Peptide Hormones |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0.008677 | INHERITED FROM: Progesterone |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.008677 | INHERITED FROM: Progesterone || Progesterone Congeners || Corpus Luteum Hormones |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.01485 | INHERITED FROM: Thyroxine || Fulvestrant || Thyroid Hormones || testosterone-3-carboxymethyloxime-bovine serum albumin conjugate || Thyronines || Triiodothyronine || Adrenal Cortex Hormones |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.01858 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Progesterone || Progesterone Congeners || Medroxyprogesterone || Corpus Luteum Hormones || Medroxyprogesterone Acetate |
57630,57196
57630 - GLA-domain
57196 - EGF/Laminin | 0.01866 | INHERITED FROM: estradiol, norethindrone drug combination || Progesterone || Progesterone Congeners || Estrogenic Steroids, Alkylated || Medroxyprogesterone || Corpus Luteum Hormones || Medroxyprogesterone Acetate |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0.01866 | INHERITED FROM: Dihydrotestosterone || Testosterone Congeners |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.02762 | INHERITED FROM: ethinyl estradiol-desogestrel combination || 11-Hydroxycorticosteroids || Progesterone || Progesterone Congeners || Estrogenic Steroids, Alkylated || 17-Hydroxycorticosteroids || Medroxyprogesterone || Hydroxyprogesterones || Corpus Luteum Hormones || Hydroxycorticosteroids || Medroxyprogesterone Acetate |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.03541 | INHERITED FROM: Testosterone |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0.03892 | INHERITED FROM: Gastrointestinal Hormones || Peptide Hormones || Gastrins |
49503,49503
49503 - Cupredoxins
49503 - Cupredoxins | 0.03892 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Estrogenic Steroids, Alkylated |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0617 | INHERITED FROM: Methyltestosterone || Progesterone || Progesterone Congeners || Corpus Luteum Hormones || Peptide Hormones || estradiol-17 beta-glucuronide |
111418,81321
111418 - Hormone receptor domain
81321 - Family A G protein-coupled receptor-like | 0.06737 | INHERITED FROM: Peptide Hormones || Pituitary Hormone-Releasing Hormones |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0.07917 | INHERITED FROM: Dihydrotestosterone |
81995,81811
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0.07917 | INHERITED FROM: Dihydrotestosterone |
53300,81995
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24 | 0.07917 | INHERITED FROM: Dihydrotestosterone |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.08372 | INHERITED FROM: Thyroxine || Fulvestrant || Thyroid Hormones || testosterone-3-carboxymethyloxime-bovine serum albumin conjugate || Thyronines || Triiodothyronine || 17-Ketosteroids || Adrenal Cortex Hormones |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.08819 | INHERITED FROM: Androstenedione || 17-Ketosteroids || Adrenal Cortex Hormones |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.1158 | INHERITED FROM: Dihydrotestosterone |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0.223 | INHERITED FROM: Thyroxine || Thyronines || Triiodothyronine |
53300,69318
53300 - vWA-like
69318 - Integrin alpha N-terminal domain | 0.2296 | INHERITED FROM: Progesterone || Progesterone Congeners || Medroxyprogesterone || Corpus Luteum Hormones || Medroxyprogesterone Acetate |
56487,56487
56487 - SRCR-like
56487 - SRCR-like | 0.2331 | INHERITED FROM: Medroxyprogesterone || Medroxyprogesterone Acetate |
49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0.3352 | INHERITED FROM: Estrogenic Steroids, Alkylated |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.3375 | INHERITED FROM: Fulvestrant || 2-Methoxyestradiol || Thyronines || Triiodothyronine |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
142921,47587
142921 - WGR domain-like
47587 - Domain of poly(ADP-ribose) polymerase | 0 | Direct |
55486,49854
55486 - Metalloproteases ("zincins"), catalytic domain
49854 - Spermadhesin, CUB domain | 0 | Direct |
48452,57850
48452 - TPR-like
57850 - RING/U-box | 0 | Direct |
49899,63887
49899 - Concanavalin A-like lectins/glucanases
63887 - P-domain of calnexin/calreticulin | 0 | Direct |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | Direct |
53098,56672
53098 - Ribonuclease H-like
56672 - DNA/RNA polymerases | 0 | Direct |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
55550,57850
55550 - SH2 domain
57850 - RING/U-box | 0 | Direct |
69012,55874
69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | Direct |
57850,48452
57850 - RING/U-box
48452 - TPR-like | 0 | Direct |
53300,57184
53300 - vWA-like
57184 - Growth factor receptor domain | 0 | Direct |
57889,50729
57889 - Cysteine-rich domain
50729 - PH domain-like | 0 | Direct |
56491,89811
56491 - A heparin-binding domain
89811 - Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
48403,47986
48403 - Ankyrin repeat
47986 - DEATH domain | 0 | Direct |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
53300,49899
53300 - vWA-like
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
47473,55550
47473 - EF-hand
55550 - SH2 domain | 0 | Direct |
47862,47862
47862 - Saposin
47862 - Saposin | 0 | Direct |
57184,57610
57184 - Growth factor receptor domain
57610 - Thyroglobulin type-1 domain | 0 | Direct |
47473,57610
47473 - EF-hand
57610 - Thyroglobulin type-1 domain | 0 | Direct |
100934,100934
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
48371,-7
48371 - ARM repeat
-7 - CATH | 0 | Direct |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | Direct |
57414,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like | 0 | Direct |
63748,57903
63748 - Tudor/PWWP/MBT
57903 - FYVE/PHD zinc finger | 0 | Direct |
47587,56399
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | Direct |
53850,53850
53850 - Periplasmic binding protein-like II
53850 - Periplasmic binding protein-like II | 0 | Direct |
47668,47473
47668 - N-terminal domain of cbl (N-cbl)
47473 - EF-hand | 0 | Direct |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0 | Direct |
64268,56112
64268 - PX domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
57850,88697
57850 - RING/U-box
88697 - PUA domain-like | 0 | Direct |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.00002826 | Direct |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.0001246 | Direct |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.000265 | Direct |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.0003169 | Direct |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0.0003187 | Direct |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.0009261 | Direct |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0.001781 | Inherited |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.001787 | Inherited |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.002189 | Inherited |
81296,81296
81296 - E set domains
81296 - E set domains | 0.002608 | Inherited |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.003166 | Inherited |
103473,100895
103473 - MFS general substrate transporter
100895 - Kazal-type serine protease inhibitors | 0.004688 | Inherited |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0.008496 | Inherited |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.008496 | Inherited |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.008677 | Inherited |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.008677 | Inherited |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0.008677 | Inherited |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.008677 | Inherited |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.01485 | Inherited |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.01858 | Inherited |
57630,57196
57630 - GLA-domain
57196 - EGF/Laminin | 0.01866 | Inherited |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0.01866 | Inherited |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.02762 | Inherited |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.03541 | Inherited |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0.03892 | Inherited |
49503,49503
49503 - Cupredoxins
49503 - Cupredoxins | 0.03892 | Inherited |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0617 | Inherited |
111418,81321
111418 - Hormone receptor domain
81321 - Family A G protein-coupled receptor-like | 0.06737 | Inherited |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0.07917 | Inherited |
81995,81811
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0.07917 | Inherited |
53300,81995
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24 | 0.07917 | Inherited |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.08372 | Inherited |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.08819 | Inherited |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.1158 | Inherited |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0.223 | Inherited |
53300,69318
53300 - vWA-like
69318 - Integrin alpha N-terminal domain | 0.2296 | Inherited |
56487,56487
56487 - SRCR-like
56487 - SRCR-like | 0.2331 | Inherited |
49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0.3352 | Inherited |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.3375 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Triple) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
49265,49265,53300
49265 - Fibronectin type III
49265 - Fibronectin type III
53300 - vWA-like | 0 | DIRECT |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | DIRECT |
55486,49854,49854
55486 - Metalloproteases ("zincins"), catalytic domain
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
57414,57440,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
142921,47587,56399
142921 - WGR domain-like
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | DIRECT |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | DIRECT |
48452,57850,88697
48452 - TPR-like
57850 - RING/U-box
88697 - PUA domain-like | 0 | DIRECT |
63748,57903,57903
63748 - Tudor/PWWP/MBT
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
57196,57535,57535
57196 - EGF/Laminin
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
100895,47473,57610
100895 - Kazal-type serine protease inhibitors
47473 - EF-hand
57610 - Thyroglobulin type-1 domain | 0 | DIRECT |
47668,47473,55550
47668 - N-terminal domain of cbl (N-cbl)
47473 - EF-hand
55550 - SH2 domain | 0 | DIRECT |
57850,48452,57850
57850 - RING/U-box
48452 - TPR-like
57850 - RING/U-box | 0 | DIRECT |
47473,55550,57850
47473 - EF-hand
55550 - SH2 domain
57850 - RING/U-box | 0 | DIRECT |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0.001073 | INHERITED FROM: Gonadal Hormones || Progesterone || Progesterone Congeners || Corpus Luteum Hormones |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.006338 | INHERITED FROM: Estradiol Congeners || Estradiol |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0.008496 | INHERITED FROM: Progesterone || Progesterone Congeners || Corpus Luteum Hormones |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.008677 | INHERITED FROM: Progesterone || Progesterone Congeners || Corpus Luteum Hormones |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.008677 | INHERITED FROM: Fulvestrant || Insulins || Pancreatic Hormones || Peptide Hormones |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.01866 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Progesterone || Estrogenic Steroids, Alkylated || Medroxyprogesterone || Medroxyprogesterone Acetate |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.03541 | INHERITED FROM: Thyroxine || Fulvestrant || Thyroid Hormones || testosterone-3-carboxymethyloxime-bovine serum albumin conjugate || Thyronines || Triiodothyronine || 17-Ketosteroids || Adrenal Cortex Hormones |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0.06554 | INHERITED FROM: Medroxyprogesterone || Medroxyprogesterone Acetate |
100895,100895,100895
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors | 0.07917 | INHERITED FROM: Progesterone || Progesterone Congeners || Corpus Luteum Hormones |
53300,81995,81811
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0.07917 | INHERITED FROM: Dihydrotestosterone |
49503,49503,49503
49503 - Cupredoxins
49503 - Cupredoxins
49503 - Cupredoxins | 0.07917 | INHERITED FROM: Testosterone |
81995,81811,82754
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0.07917 | INHERITED FROM: Dihydrotestosterone |
47769,47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0.117 | INHERITED FROM: Dihydrotestosterone |
56487,56487,56487
56487 - SRCR-like
56487 - SRCR-like
56487 - SRCR-like | 0.2296 | INHERITED FROM: Progesterone || Progesterone Congeners || Medroxyprogesterone || Corpus Luteum Hormones || Medroxyprogesterone Acetate |
53300,69318,69179
53300 - vWA-like
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.2296 | INHERITED FROM: Progesterone || Progesterone Congeners || Medroxyprogesterone || Corpus Luteum Hormones || Medroxyprogesterone Acetate |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.2324 | INHERITED FROM: Dihydrotestosterone |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
49265,49265,53300
49265 - Fibronectin type III
49265 - Fibronectin type III
53300 - vWA-like | 0 | Direct |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | Direct |
55486,49854,49854
55486 - Metalloproteases ("zincins"), catalytic domain
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | Direct |
57414,57440,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
142921,47587,56399
142921 - WGR domain-like
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | Direct |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | Direct |
48452,57850,88697
48452 - TPR-like
57850 - RING/U-box
88697 - PUA domain-like | 0 | Direct |
63748,57903,57903
63748 - Tudor/PWWP/MBT
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0 | Direct |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
57196,57535,57535
57196 - EGF/Laminin
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | Direct |
100895,47473,57610
100895 - Kazal-type serine protease inhibitors
47473 - EF-hand
57610 - Thyroglobulin type-1 domain | 0 | Direct |
47668,47473,55550
47668 - N-terminal domain of cbl (N-cbl)
47473 - EF-hand
55550 - SH2 domain | 0 | Direct |
57850,48452,57850
57850 - RING/U-box
48452 - TPR-like
57850 - RING/U-box | 0 | Direct |
47473,55550,57850
47473 - EF-hand
55550 - SH2 domain
57850 - RING/U-box | 0 | Direct |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0.001073 | Inherited |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.006338 | Inherited |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0.008496 | Inherited |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.008677 | Inherited |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.008677 | Inherited |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.01866 | Inherited |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.03541 | Inherited |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0.06554 | Inherited |
100895,100895,100895
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors | 0.07917 | Inherited |
53300,81995,81811
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0.07917 | Inherited |
49503,49503,49503
49503 - Cupredoxins
49503 - Cupredoxins
49503 - Cupredoxins | 0.07917 | Inherited |
81995,81811,82754
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0.07917 | Inherited |
47769,47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0.117 | Inherited |
56487,56487,56487
56487 - SRCR-like
56487 - SRCR-like
56487 - SRCR-like | 0.2296 | Inherited |
53300,69318,69179
53300 - vWA-like
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.2296 | Inherited |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.2324 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Plot distribution on species Tree Of Life (sTOL) for Superfamily and/or Family domains annotated by this CC term
 |
Plot tree as:
| |
Download Newick format tree:
|
( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Plot distribution on species Tree Of Life (sTOL) for single supra-domains annotated by this CC term
|
Plot tree as:
| |
Download Newick format tree:
| |
Browsing in TREE OF LIFE:
|
( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|
|
> BO Hierarchy > Hormones, Hormone Substitutes, and Hormone Antagonists
